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Do you have expertise in, and passion for drug safety and real-world evidence (RWE)?

Hays Life Sciences is now looking to recruit 2 Pharmacoepidemiologist / Senior Pharmacoepidemiologists for 1-year contract assignments to work at AstraZeneca in Gothenburg or remotely in Sweden.

Do you have expertise in, and passion for drug safety and real-world evidence (RWE)? Would you like to apply your expertise to evaluate the safety of medicines in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you! At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

Why AstraZeneca?
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey. Are you already imagining yourself joining our team? Good, because we can't wait to hear from you.

The Pharmacoepidemiologist / Senior Pharmacoepidemiologist works independently in the design, execution, analysis, interpretation, and internal and external communication of specific epidemiological studies and literature reviews. This role requires taking a leadership role in a range of activities, including delivery of experienced epidemiology strategy, support, and scientific leadership to project teams and the epidemiology global skills group, at all stages of pharmaceutical development.

They will manage externally commissioned research projects, which includes establishing, maintaining, and expanding relationships to partner effectively with external experts and research groups to negotiate time frames, provide recommendations on resource requirements, and ensure delivery of the tasks as agreed. They will promote good epidemiological practice and represents the company's position when interacting with external experts, collaborative groups, and contract research organizations; and will keep abreast of epidemiological developments within academia, regulatory, and among key opinion leaders.

Essential Requirements

* MSc. or Ph.D. or equivalent in pharmacoepidemiology, epidemiology or related health science field and substantial experience in the health care environment.
* Hands-on experience in utilizing secondary data and primary data collection studies and knowledge of patient safety databases for use in generating RWE.
* Ability to apply advanced epidemiological theory and techniques
* Able to provide critical appraisal to study designs and published studies
* Ability to work effectively with internal & external experts, collaborative groups and contract research organizations (CROs)

Desirable Requirements

* A broad global pharmacovigilance knowledge including knowledge of PASS studies, post-marketing commitments and reporting requirements
* Understanding of drug safety and medical terminology and ability to summarize medical information drug safety experience in a clinical or post-marketing environment.
* Ability to effectively represent epidemiology and pharmacovigilance operations on multidisciplinary teams
* Good therapeutic and disease area knowledge and knowledge of drug development and life cycle management
* Knowledge and experience with drug safety reporting and regulatory compliance and experience with international drug safety reporting/regulations, including PASS and RWE studies, Risk Management Plans and Signal Management
* Previous experience in managing communication with EMA and FDA
* Substantial knowledge and experience in epidemiological methods and research in drug development or in a closely related academic research area
* Knowledge of clinical trial activities and reporting requirements
* Experience managing complex medical evidence programmes, including studies such as pragmatic trials or/and PASS Visa mindre

Experienced protein scientist for consulting assignment at AstraZeneca

Hays Life Science is now looking for an experienced protein scientist for a consulting assignment at AstraZeneca in Gothenburg. The assignment is initially for 1 year. Send your application no later than August 20th.

Are you truly passionate about the magic that happens in the lab? Could you see yourself applying your protein science knowledge in a successful pharmaceutical company? Would you like to join a team of highly skilled scientists where both your professional and personal skills are valued?
We have an exciting opportunity for you to join us working within a dynamic scientific environment to support drug discovery with a focus on membrane protein targets. The Discovery Biology department within Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in all phases of the drug discovery pipeline. We focus on scientific advances in small molecules, oligonucleotides and other new technologies and drug discovery platforms across our different core disease areas.
Our stunning campus in Gothenburg is one of AstraZeneca's three strategic science centres. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide variety of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally. And the site itself is designed with collaboration in mind. From the Coffee Lab to exercise areas, we've built a series of environments where innovation can happen.

Main duties and responsibilities
You will be responsible for producing and characterizing recombinant membrane protein complexes primarily for Cryo-EM structure based drug discovery applications. The purified complexes may further be applied for biophysical assays and affinity screening methods. Mutagenesis and pharmacological profiling will be relevant to optimize bioreagents and in support of molecular mode of action studies. Since this position is predominantly lab based, we expect that you have a true passion for practical duties and high quality data and reagent generation.

We will rely on you to
* Work in a cross functional setting to deliver high-quality membrane protein reagents to projects
* Deliver expertise in protein expression, purification and characterization with a focus on G-protein coupled receptors (GPCRs)
* Contribute with novel ideas and using discernment and knowledge where appropriate to influence the work of the project
* Maintain an awareness of current developments in the literature and contribute to the continuous improvement process
* Achieve personal as well as company scientific visibility through project contributions, presentations, publications and poster & oral conference presentations

Essential requirements
* MSc degree with significant experience from pharmaceutical or biotechnology industry or PhD in Biology, Pharmacology, Biochemistry or other a related discipline
* Expertise in protein science of membrane proteins through a demonstrable knowledge of construct design, molecular biology, protein expression, extraction/solublization, purification, characterization and structure function relationship
* Proven knowledge of a wide range of methods and technologies applied to the expression, purification as well as characterization of membrane proteins, e.g. Eukaryotic expression systems, liquid chromatography, mass spectrometry and biophysical techniques
* Excellent analytical skills, good scientific judgement and communication skills
* Good team working and networking skills with experience of interacting effectively across disciplines and in multi-cultural settings

Desirable requirements
* Experience of GPCRs and cellular pharmacological profiling
* Experience with non-detergent based formulations for purified membrane proteins
* Experience with structure determination methods in particular Cryo-EM Visa mindre