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Paid summer research internship, Biochemistry

Ansök    Feb 24    Pretzel Therapeutics Sweden AB    Molekylärbiolog
Form of employment: 8-12 week internship in June-Aug. Starting date: Flexible; 1st of June preferred. Location: GoCo Health Innovation City, Mölndal Industry: Biotechnology, Science, Medicine. Position: We are looking for a talented summer intern to join our Biochemistry & In Vitro biology department team and contribute to the exciting growth of our biotech company. If you are a driven student with significant experience in the field, then Pretzel Thera... Visa mer
Form of employment: 8-12 week internship in June-Aug.
Starting date: Flexible; 1st of June preferred.
Location: GoCo Health Innovation City, Mölndal

Industry: Biotechnology, Science, Medicine.
Position: We are looking for a talented summer intern to join our Biochemistry & In Vitro biology department team and contribute to the exciting growth of our biotech company.
If you are a driven student with significant experience in the field, then Pretzel Therapeutics might be for you.
Pretzel Therapeutics is a biotechnology company headquartered in Boston, Massachusetts, with research facilities in Mölndal at GoCo House, part of GoCo Health Innovation City. Pretzel Therapeutics is dedicated to developing life-changing medicines with a broad pipeline of first-in-class treatments addressing novel targets within the mitochondria. By harnessing cellular energetics to modulate disease processes and improve survival, function and quality of life, we are ushering in a new treatment paradigm for a breadth of conditions spanning neurological, muscle, metabolic and rare diseases.
Role overview: In this role, the intern will be involved in in vitro assays and various molecular biology tasks, supporting our efforts for drug discovery around mitochondrial targets, as well as performing associated laboratory duties. To excel in this position, the ideal candidate should have hands-on experience in a laboratory environment and a keen enthusiasm for acquiring new knowledge. Previous experience in working with in vitro assays is advantageous. Collaboration will be a key aspect of this role, as the intern will work with a team of scientists located in both the USA and Sweden, underscoring the importance of effective communication and teamwork.

Responsibilities
As part of this laboratory-based role, you will be actively engaged in multiple ongoing projects, with your primary responsibility being the execution of routine biochemistry assays. In addition, you will support downstream cell-based assay screening, contribute to laboratory organization and maintenance, and assist the core science team with various research activities. This internship presents an opportunity to contribute to experiments aimed at identifying new drug targets.

· Biochemistry tasks: The intern will play a pivotal role in small molecule screening efforts. Main tasks will include enzymatic assays at high and low throughput, preparation and quality check of recombinant protein and other assay components/reagents.
· Molecular biology tasks: The intern will contribute to a wide range of molecular biology tasks, including DNA and RNA isolation, PCR amplification, and other molecular techniques as required to support ongoing projects.
· Documentation and Reporting: Maintaining records of experimental procedures and outcomes in electronic notebook will be a key responsibility. Additionally, the intern will support data analysis and contribute to the preparation of reports and presentations summarizing experimental findings.

Qualifications
· Currently enrolled as a master student in disciplines such as molecular biology, biochemistry, biomedical analysis, or biotechnology engineering.
· Prior laboratory experience is essential, preferably in a biochemistry/molecular biology laboratory setting.
· Experience with aseptic techniques is desirable.
· Proficiency in English communication (both verbal and written) is necessary, as the role involves working in a multicultural environment within a global company.

What can Pretzel Therapeutics offer?
This paid internship is a great opportunity to learn and acquire new laboratory techniques and develop both your professional and personal skills. By getting a glimpse into drug discovery and the biotech industry, you’ll gain valuable experience for opportunities in your future career. As part of our team, you will both collaborate with talented scientists and become responsible for important tasks to support our ongoing projects.
Our growing team is committed to build the world’s leading platform to develop therapeutics harnessing the intricacies of mitochondrial biology. Pretzel’s culture fosters a work environment built on respect, integrity, quality, and, of course, fun! We also work in close cooperation with collaborators and service providers in countries all over the world. Pretzel Therapeutics is growing rapidly, and we hope that you will join us on this exciting journey.

The last day of application is 20th of March, but the position can be filled before the application deadline, which is why we ask you to apply as soon as possible.
You are welcome to submit your application by sending your CV and cover letter to [email protected]
Questions about the position can be sent to Cindy Phan or Mattias Stamgren: [email protected] and [email protected] Visa mindre
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Paid Summer Research Internship, Cell biologist

Ansök    Feb 24    Pretzel Therapeutics Sweden AB    Molekylärbiolog
Form of employment: 8-12 week internship in June-September. Starting date: Flexible, June 1st preferred. Location: GoCo Health Innovation City, Mölndal. Industry: Biotechnology, Science, Medicine. Position: We are looking for a talented summer intern to join our team, who is eager to contribute to the exciting growth of our biotech company. If you are a driven student with hands-on experience in molecular cell biology, then Pretzel Therapeutics might be ... Visa mer
Form of employment: 8-12 week internship in June-September.
Starting date: Flexible, June 1st preferred.
Location: GoCo Health Innovation City, Mölndal.
Industry: Biotechnology, Science, Medicine.
Position: We are looking for a talented summer intern to join our team, who is eager to contribute to the exciting growth of our biotech company.
If you are a driven student with hands-on experience in molecular cell biology, then Pretzel Therapeutics might be for you.
Pretzel Therapeutics is a biotechnology company headquartered in Boston, Massachusetts, with research facilities in Mölndal at GoCo House, part of GoCo Health Innovation City. Pretzel Therapeutics is dedicated to developing life-changing medicines with a broad pipeline of first-in-class treatments addressing novel targets within the mitochondria. By harnessing cellular energetics to modulate disease processes and improve survival, function and quality of life, we are ushering in a new treatment paradigm for a breadth of conditions spanning neurological, muscle, metabolic and rare diseases.
Role overview: We are actively seeking a motivated and passionate student to join our team for a summer internship focused on cellular and molecular biology. The main role of the intern will be to assist in cell culture experiments and various molecular biology tasks to support the team during periods of reduced activity due to holiday schedules.
To excel in this position, the ideal candidate should have hands-on experience in cell culture and a keen enthusiasm for acquiring new knowledge. Collaboration will be a key aspect of this role, as the intern will work with a team of scientists located in both the USA and Sweden, underscoring the importance of effective communication and teamwork.
Responsibilities
As part of this laboratory-based role, you will be actively engaged in multiple ongoing projects, assuming responsibility for conducting experiments involving various cell types. This internship presents an opportunity to contribute to experiments aimed at identifying new drug targets.
• Cell Culture: The intern will play an important role in the cultivation and maintenance of diverse cell lines under sterile conditions. This entails routine tasks such as cell passaging, cell seeding for experiments, treating cells with various types of drug modalities, and monitoring cell growth and viability.
• Molecular Biology Tasks: The intern will contribute to a range of molecular biology tasks, including DNA, RNA and protein isolation, PCR amplification, Western Blot, and other molecular techniques as required to support ongoing projects.
• Documentation and Reporting: Maintaining records of experimental procedures, data analysis and outcomes in electronic notebook will be a key responsibility. Additionally, the intern will contribute to the preparation of reports and presentations summarizing experimental findings.


Qualifications
· Prior laboratory experience and independence in working in a laboratory setting are essential. Cell culture skills are highly merited.
· You are currently enrolled as a master’s student or have completed your bachelor’s degree in disciplines such as cell biology, molecular biology, biotechnology engineering or biomedical analysis.
· Proficiency in English communication (both verbal and written) is necessary, as the role involves working in a multicultural environment within a global company.

What can Pretzel Therapeutics offer?
This paid internship is a great opportunity to learn and acquire new laboratory techniques and develop both your professional and personal skills. By getting a glimpse into drug discovery and the biotech industry, you’ll gain valuable experience for opportunities in your future career. As part of our team, you will both collaborate with talented scientists and become responsible for important tasks to support our ongoing projects.
Our growing team is committed to building the world’s leading platform to develop therapeutics harnessing the intricacies of mitochondrial biology. Pretzel’s culture fosters a work environment built on respect, integrity, quality, and, of course, fun! We also work in close cooperation with collaborators and service providers in countries all over the world. Pretzel Therapeutics is growing rapidly, and we hope that you will join us on this exciting journey.
The last day of application is the 31st of March, but the position can be filled before the application deadline, which is why we encourage you to apply as soon as possible.
You are welcome to submit your application by sending your CV and cover letter to [email protected] Visa mindre
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Senior Scientist - NGS Molecular Biologist

Ansök    Aug 25    Randstad AB    Molekylärbiolog
Job description NGS Molecular Biologist - Oligonucleotide therapies Are you an experienced scientist with great expertise in Next Generation Sequencing and Molecular Biology? Do you want to use this expertise to contribute to the discovery of novel oligonucleotide therapies? We have an opening suitable for you! Right now, we are looking for a passionate and hard-working Molecular Biologist with NGS skills to join our NGS & Transcriptomics function within t... Visa mer
Job description
NGS Molecular Biologist - Oligonucleotide therapies
Are you an experienced scientist with great expertise in Next Generation Sequencing and Molecular Biology? Do you want to use this expertise to contribute to the discovery of novel oligonucleotide therapies? We have an opening suitable for you!
Right now, we are looking for a passionate and hard-working Molecular Biologist with NGS skills to join our NGS & Transcriptomics function within the Centre of Genomic Research Department at AstraZeneca in Gothenburg, as one of our group members is going on parental leave. You will contribute with your expertise in applying molecular biology and NGS to the discovery of novel oligonucleotide therapies.
AstraZeneca’s ambition is to become world-leading in in the field of oligonucleotide therapies. We are achieving this through advances in oligonucleotide science and innovation internally and through the establishment of key collaborations outside AstraZeneca. To this end, we currently have a portfolio of very high-profile projects at different phases of drug discovery within AstraZeneca, and you will directly contribute to their successful progression to oligonucleotide therapies.
This is a consultant assignment with Randstad Life Sciences. Randstad Life Sciences is specialized in competences within Life Science. As a consultant you get a competitive salary, benefits and collective agreements. Your consultant manager ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Responsibilities
This lab-based role is for a Molecular Biologist with significant NGS expertise, which you will apply to the characterization and profiling of the effects of oligonucleotide treatments in in vitro and in vivo cellular assays and models in support of novel drug discovery projects.
Our team is a collaborative group, and you will engage in the supervision and mentorship of other scientists, ensuring that methods run expertly and accurately, developing and guiding the setup of new techniques. Included in the role is also to nurture strong collaborative relationships with the project investigators, key partners, and data scientists to ensure the smooth running of projects.
Deadline 2025-09-05 - the selection process and interviews will be ongoing, so please apply as soon as possible!

Qualifications
Essential for the role:
Ph.D. degree or MSc with corresponding experience in a relevant scientific discipline.
Hands-on lab-based experience in utilizing advanced molecular biology RNA-sequencing techniques.
Experience covering all relevant aspects from hypothesis generation, through experimental design and execution, large-scale RNA and DNA extraction, sample and library preparation, sequencing, data handling, post-sequencing QC, and troubleshooting.
Experience in the detection of nucleic acids in high-throughput assays and approaches.

Desirable for the role:
Working with laboratory automation / liquid handling systems, method and technology development and optimization.
Knowledge of Oligonucleotide therapies (siRNAs and/or ASO)
Hands-on laboratory experience running NGS platforms (Illumina, Oxford Nanopore etc).
Sample Tracking by LIMS systems.

You should also have the ability to communicate, interact, and collaborate with your direct team members, as well as across our global AZ functions and fields. Alongside this, our ideal candidate enjoys working in an innovative, proactive, forward-thinking,?project-focused?and?goal-oriented?way and shares our excitement about the molecular biology RNA-sequencing techniques.

About the company

Randstad
At Randstad, we see the possible in people. With business all over Sweden and in all areas of expertise, we help people find work that feels good, where they get the opportunity to develop and realize their true potential.

With close to 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry. Our mission is to become the world’s most valued working life partner. By combining our passion for people with the power of today’s technology, we support people and organizations in realizing their true potential. We call it Human Forward. Visa mindre
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Senior Scientist - NGS Molecular Biologist

Ansök    Jan 21    Randstad AB    Molekylärbiolog
Job description Are you an experienced scientist with great expertise in Next Generation Sequencing and Molecular Biology? We have an opening suitable for you! Right now, we are looking for a passionate and hard-working Molecular Biologist with NGS skills to join our NGS & Transcriptomics function within the Centre of Genomic Research Department at AstraZeneca in Gothenburg, as one of our group members is going on parental leave. You will contribute with y... Visa mer
Job description
Are you an experienced scientist with great expertise in Next Generation Sequencing and Molecular Biology? We have an opening suitable for you!
Right now, we are looking for a passionate and hard-working Molecular Biologist with NGS skills to join our NGS & Transcriptomics function within the Centre of Genomic Research Department at AstraZeneca in Gothenburg, as one of our group members is going on parental leave. You will contribute with your expertise in applying molecular biology and NGS to progress drug development pipelines and disease/biology understanding.
What you will do:
This is a hands-on laboratory-based role to effectively support and deliver various clinical and preclinical projects across multiple diseases, species and drug modalities.
Our team is a collaborative group, and you will engage in the supervision and mentorship of other scientists, ensuring that methods run expertly and accurately, developing and guiding the set-up of new techniques. Included in the role is also to nurture strong collaborative relationships with the project investigators, key partners, and data scientists to ensure the smooth running of projects.
This is a consultant assignment with Randstad Life Sciences. Randstad Life Sciences is specialized in competences within Life Science. As a consultant you get a competitive salary, benefits and collective agreements. Your consultant manager ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.
Deadline 2026-01-30 - the selection process and interviews will be ongoing, so please apply as soon as possible!

Responsibilities
In this role you will:
Utilize prior practical laboratory experience in transcriptomics data generation with a strong emphasis on automation technologies.
Contribute to planning and execution of projects involving new omics technologies.
Provide experimental support to project teams.
Ensure compliance with Safety, Health, and Environmental regulations as well as AstraZeneca’s corporate responsibility policies.
Develop a comprehensive understanding of the pharmaceutical industry and identify opportunities for new business initiatives.
Collaborate with a wide range of scientists from different backgrounds to ensure the highest quality of research.
Develop and validate cutting edge protocols for the simplification of multiomic research.



Why AstraZeneca?
At AstraZeneca, we are driven by our desire to understand and reveal new insights. We are free from fear of failure, free to ask the right questions, make bold decisions, and dig deep into the biology of complex diseases. We are committed to making an impact on patients' lives by improving patient access to healthcare globally. Our values guide everything we do at AstraZeneca. They power our belief in What Science Can Do - a belief in its potential to redefine what's possible.
So, what’s next? If this sounds like your next challenge – please don’t hesitate to apply!

Qualifications
Essential for the role:
Ph.D. degree or MSc with corresponding experience in a relevant scientific discipline.
Hands on lab-based experience in utilizing advanced molecular biology RNA-sequencing techniques.
Experience covering all relevant aspects from hypothesis generation, through experimental design and execution, large scale RNA and DNA extraction, sample and library preparation, sequencing, data handling, post sequencing QC and trouble shooting.

You should also have the ability to communicate, interact and collaborate with your direct team members, as well as across our global AZ functions and fields. Alongside this, our ideal candidate enjoys working in an innovative, proactive, forward-thinking,?project-focused?and?goal-oriented?way and shares our excitement about the molecular biology RNA-sequencing techniques.
Highly desirable for the role:
Experience using laboratory automation / liquid handling systems.
Hands-on laboratory experience running NGS platforms (Illumina, Oxford Nanopore etc).
Sample Tracking by LIMS systems.


About the company

Randstad
At Randstad, we see the possible in people. With business all over Sweden and in all areas of expertise, we help people find work that feels good, where they get the opportunity to develop and realize their true potential.
With close to 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry. Our mission is to become the world’s most valued working life partner. By combining our passion for people with the power of today’s technology, we support people and organizations in realizing their true potential. We call it Human Forward. Visa mindre
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Paid summer research internship, Molecular biologist

Ansök    Feb 14    Pretzel Therapeutics Sweden AB    Molekylärbiolog
Form of employment: 8-12 week internship in June-Aug. Starting date: Flexible; 2nd of June preferred. Location: GoCo Health Innovation City, Mölndal. We are looking for a talented summer intern to join our Biochemistry & In Vitro biology department team and contribute to the exciting growth of our biotech company. If you are a driven student with significant experience in the field, then Pretzel Therapeutics might be for you. Role overview: In this role, t... Visa mer
Form of employment: 8-12 week internship in June-Aug.
Starting date: Flexible; 2nd of June preferred.
Location: GoCo Health Innovation City, Mölndal.
We are looking for a talented summer intern to join our Biochemistry & In Vitro biology department team and contribute to the exciting growth of our biotech company.
If you are a driven student with significant experience in the field, then Pretzel Therapeutics might be for you.
Role overview: In this role, the intern will be involved in in vitro assays and various molecular biology tasks, supporting our efforts for drug discovery around mitochondrial targets, as well as performing associated laboratory duties.
To excel in this position, the ideal candidate should have hands-on experience in a laboratory environment and a keen enthusiasm for acquiring new knowledge. Previous experience in working with in vitro assays is advantageous. Collaboration will be a key aspect of this role, as the intern will work with a team of scientists located in both the USA and Sweden, underscoring the importance of effective communication and teamwork.
Responsibilities: As part of this laboratory-based role, you will be actively engaged in multiple ongoing projects, assuming responsibility for conducting routine biochemistry- and downstream processes of cell assay screening, laboratory organization and assisting the core science team. This internship presents an opportunity to contribute to experiments aimed at identifying new drug targets.
Biochemistry tasks: The intern will play a pivotal role in small molecule screening efforts. Main tasks will include enzymatic assays at high and low throughput, preparation and quality check of recombinant protein and other assay components/reagents as well as communicating & collaborating with relevant CROs.
Molecular biology tasks: The intern will contribute to a wide range of molecular biology tasks, including DNA and RNA isolation, PCR amplification, and other molecular techniques as required to support ongoing projects.
Documentation and Reporting: Maintaining records of experimental procedures and outcomes in electronic notebook will be a key responsibility. Additionally, the intern will contribute to the preparation of reports and presentations summarizing experimental findings.

Qualifications:
Prior laboratory experience is essential, preferably in a biochemistry/molecular biology laboratory setting.
Currently enrolled as a master’s student or have completed your bachelor’s degree in disciplines such as molecular biology, biochemistry, biomedical analysis, or biotechnology engineering.
Proficiency in English communication (both verbal and written) is necessary, as the role involves working in a multicultural environment within a global company.

What can Pretzel Therapeutics offer?
This paid internship is a great opportunity to learn and acquire new laboratory techniques and develop both your professional and personal skills. By getting a glimpse into drug discovery and the biotech industry, you’ll gain valuable experience for opportunities in your future career. As part of our team, you will both collaborate with talented scientists and become responsible for important tasks to support our ongoing projects.
Our growing team is committed to build the world’s leading platform to develop therapeutics harnessing the intricacies of mitochondrial biology. Pretzel’s culture fosters a work environment built on respect, integrity, quality, and, of course, fun! We also work in close cooperation with collaborators and service providers in countries all over the world.
The last day of application is 31st of March, but the position can be filled before the application deadline, which is why we ask you to apply as soon as possible.
You are welcome to submit your application by sending your CV and cover letter to [email protected]
The Human Resources department oversees all recruitment and employment activities for Pretzel. Please note that unsolicited resumes sent to Pretzel, by recruiters and/or recruiting agencies, do not establish any form of relationship between the recruiter/recruiting agency and Pretzel. Submission of unsolicited resumes also does not impose any obligation on Pretzel to pay fees should we choose to hire from those resumes.
We kindly request that external recruiters/agencies not contact or directly present candidates to our hiring manager or employees. Visa mindre
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Discovery Safety Scientist/Senior Scientist In Vitro Biology

Ansök    Maj 30    Randstad AB    Molekylärbiolog
Job description Are you a motivated cell biologist with experience of in vitro work in molecular biology, omics and oligonucleotides? Do you also enjoy working hands-on in the lab with a great group of colleagues by your side? If yes, this might be the next position for you! Right now, we are looking for a highly engaged and enthusiastic cell biologist to join as a Discovery Safety Scientist and complement us in our In Vitro Safety group at AstraZeneca in ... Visa mer
Job description
Are you a motivated cell biologist with experience of in vitro work in molecular biology, omics and oligonucleotides? Do you also enjoy working hands-on in the lab with a great group of colleagues by your side? If yes, this might be the next position for you!
Right now, we are looking for a highly engaged and enthusiastic cell biologist to join as a Discovery Safety Scientist and complement us in our In Vitro Safety group at AstraZeneca in Gothenburg, Sweden. The ideal candidate will have a passion for in vitro lab based experimentation and analysis and value the utility of early drug safety investigations. We are looking for someone with strong communication and collaboration drive, who can adopt a brave and forward-thinking approach to drive our predictive in vitro safety assay design to support drug discovery and development projects.
Why AstraZeneca?
We are working towards treating, preventing, modifying and even curing some of the world’s most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.
Does this sound like your next challenge? Apply today!
This is a consulting assignment with Randstad Life Sciences. Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.
Deadline: 2024-06-11 selection and interviews will be ongoing. For more information: Please contact Malin Fridholm, [email protected]





Responsibilities
What you’ll do:
Working in an industry-leading in vitro safety lab you will work with internal research groups to identify potential off-target risks for siRNA/antisense oligonucleotide (ASO) projects. Develop in vitro assays to explore those potential off targets in a variety of different mammalian cell types via gene expression analysis. You will also be required to summarize safety related literature relating to modulation of off-target genes to help inform decisions and support the development of safer oligonucleotide-based drug products.

Qualifications
Essential for the role:
PhD in biology, biotechnology, toxicology or pharmacology or a related field.
Strong background in mammalian cell biology and in vitro work in molecular biology & omics including gene expression modulation via siRNA/ASOs and qPCR measurements. Additional in vitro techniques would be advantageous including fluidigm qPCR, high content cell imaging, western blot, ELISA & FACs.
Experience of complex in vitro cell models or MPS systems would be desirable.
Track record of scientific literature review with an ability to pull together various sources of data to inform on potential safety questions & targets of interest.
Strong communication skills: including presenting, communicating data analysis, influencing and building partnerships with internal and external research groups.


About the company

Randstad
At Randstad, we see the possible in people. With business all over Sweden and in all areas of expertise, we help people find work that feels good, where they get the opportunity to develop and realize their true potential. With close to 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry. Our mission is to become the world’s most valued working life partner. By combining our passion for people with the power of today’s technology, we support people and organizations in realizing their true potential. We call it Human Forward. Visa mindre
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Paid Summer Research Internship, Cell biologist

Ansök    Feb 13    Pretzel Therapeutics Sweden AB    Molekylärbiolog
Form of employment: 8-12 week internship in June-September. Starting date: Flexible, June 2nd preferred. Location: GoCo Health Innovation City, Mölndal. We are looking for a talented summer intern to join our team, who is eager to contribute to the exciting growth of our biotech company. If you are a driven student with hands-on experience in molecular cell biology, then Pretzel Therapeutics might be for you. Role overview: We are actively seeking a motiva... Visa mer
Form of employment: 8-12 week internship in June-September.
Starting date: Flexible, June 2nd preferred.
Location: GoCo Health Innovation City, Mölndal.
We are looking for a talented summer intern to join our team, who is eager to contribute to the exciting growth of our biotech company.
If you are a driven student with hands-on experience in molecular cell biology, then Pretzel Therapeutics might be for you.
Role overview: We are actively seeking a motivated and passionate student to join our team for a summer internship focused on cellular and molecular biology. The main role of the intern will be to assist in cell culture experiments and various molecular biology tasks to support the team during periods of reduced activity due to holiday schedules.
To excel in this position, the ideal candidate should have hands-on experience in cell culture and a keen enthusiasm for acquiring new knowledge. Collaboration will be a key aspect of this role, as the intern will work with a team of scientists located in both the USA and Sweden, underscoring the importance of effective communication and teamwork.
Responsibilities: As part of this laboratory-based role, you will be actively engaged in multiple ongoing projects, assuming responsibility for conducting experiments involving various cell types. This internship presents an opportunity to contribute to experiments aimed at identifying new drug targets.
Cell Culture: The intern will play an important role in the cultivation and maintenance of diverse cell lines under sterile conditions. This entails routine tasks such as cell passaging, cell seeding for experiments, and monitoring cell growth and viability.
Molecular Biology Tasks: The intern will contribute to a range of molecular biology tasks, including DNA and RNA isolation, PCR amplification, Western Blot, and other molecular techniques as required to support ongoing projects.
Documentation and Reporting: Maintaining records of experimental procedures and outcomes in electronic notebook will be a key responsibility. Additionally, the intern will contribute to the preparation of reports and presentations summarizing experimental findings.

Qualifications:
Prior laboratory experience and independence in working in a laboratory setting are essential. Cell culture skills are highly merited.
You are currently enrolled as a master’s student or have completed your bachelor’s degree in disciplines such as cell biology, molecular biology, biotechnology engineering or biomedical analysis.
Proficiency in English communication (both verbal and written) is necessary, as the role involves working in a multicultural environment within a global company.

What can Pretzel Therapeutics offer?
This paid internship is a great opportunity to learn and acquire new laboratory techniques and develop both your professional and personal skills. By getting a glimpse into drug discovery and the biotech industry, you’ll gain valuable experience for opportunities in your future career. As part of our team, you will both collaborate with talented scientists and become responsible for important tasks to support our ongoing projects.
Our growing team is committed to building the world’s leading platform to develop therapeutics harnessing the intricacies of mitochondrial biology. Pretzel’s culture fosters a work environment built on respect, integrity, quality, and, of course, fun! We also work in close cooperation with collaborators and service providers in countries all over the world.
The last day of application is the 31st of March, but the position can be filled before the application deadline, which is why we encourage you to apply as soon as possible.
You are welcome to submit your application by sending your CV and cover letter to [email protected].
The Human Resources department oversees all recruitment and employment activities for Pretzel. Please note that unsolicited resumes sent to Pretzel, by recruiters and/or recruiting agencies, do not establish any form of relationship between the recruiter/recruiting agency and Pretzel. Submission of unsolicited resumes also does not impose any obligation on Pretzel to pay fees should we choose to hire from those resumes.
We kindly request that external recruiters/agencies not contact or directly present candidates to our hiring manager or employees. Visa mindre
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Research Scientist position – in vitro compound profiling

Ansök    Jul 1    Randstad AB    Molekylärbiolog
Job description Research Scientist position – in vitro compound profiling We are looking for a Research Scientist to join our Mechanistic Biology & Profiling function within the Discovery Sciences organization in Gothenburg, Sweden. You will apply proven biochemistry and cell biology expertise to perform in vitro assays, including independent planning, analysis and reporting. Routine profiling will be combined with tailored mechanism of action studies in s... Visa mer
Job description
Research Scientist position – in vitro compound profiling
We are looking for a Research Scientist to join our Mechanistic Biology & Profiling function within the Discovery Sciences organization in Gothenburg, Sweden. You will apply proven biochemistry and cell biology expertise to perform in vitro assays, including independent planning, analysis and reporting. Routine profiling will be combined with tailored mechanism of action studies in support of chemistry optimisation across different drug discovery projects.
As an individual you are passionate about laboratory work and want to apply this in a setting where team work and flexibility is critical. You will join a team whose remit is to support our drug discovery projects globally with early DMPK assessment, SAR profiling and detailed mechanism of action data. We offer a highly rewarding scientific environment with ample learning opportunities.
You will be strongly encouraged and supported to think creatively in our dynamic environment. Here, we are free from fear of failure, free to ask the right questions and make bold decisions.
Why AstraZeneca in Gothenburg?
You can ask anybody who has ever set foot here – our Gothenburg site has a vibrant culture that pulls you in! It is a mix of both local and international talent. We welcome the contribution of people from all backgrounds, beliefs and walks of life.
So, what’s next? If this sounds like your next challenge - please apply today!


Deadline 11th of July - the selection process and interviews will be ongoing. The starting date will be in August.
For more information: Please contact Katan Ali, [email protected].
Please note that applications sent through email will not be processed and deleted due to GDPR.
This is an consultant assignment with Randstad Life Sciences. Randstad Life Sciences is specialized in competences within Life Science. As a consultant you get a competitive salary, benefits and collective agreements. Your consultant manager ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.





Responsibilities
This is a lab-based role focused on generating routine screening data and bespoke in vitro pharmacology studies in support of drug discovery projects. The work includes independent troubleshooting and timely reporting of data according to agreed timelines. All work is conducted in close dialog with project teams, specifically in support of the Cardiovascular, Renal and Metabolism as well as Respiratory & Immunology disease area organisations locally in Gothenburg.

Qualifications
Essential for the role:
A strong passion for laboratory work.
MSc or PhD within a relevant scientific discipline or demonstrated relevant experience in the Life Science industry.
Proven track record of in vitro pharmacology studies.
Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment.
Independent analysis and evaluation of complex data and delivery of data to agreed timelines.
First-rate decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity.



Desirable in the role:
Compound profiling in a screening environment using microtiter plates and automation.
Experience with either enzymology studies or mechnistic cell-based studies.


About the company

Randstad
At Randstad, we see the possible in people. With business all over Sweden and in all areas of expertise, we help people find work that feels good, where they get the opportunity to develop and realize their true potential. With close to 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry. Our mission is to become the world’s most valued working life partner. By combining our passion for people with the power of today’s technology, we support people and organizations in realizing their true potential. We call it Human Forward. Visa mindre
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Senior Scientist in Genome Engineering

Ansök    Feb 28    Randstad AB    Molekylärbiolog
Job description Here at AstraZeneca, we are working towards turning novel state-of-art technologies into effective and safe medicines for severe genetic disease. Do you want to be part of this effort? Welcome to join our exciting journey! We are looking for a new team member to join our Screening and Automation team in Genome Engineering Department. The role is based in Gothenburg, Sweden, where you will join an international team that develops novel gen... Visa mer
Job description
Here at AstraZeneca, we are working towards turning novel state-of-art technologies into effective and safe medicines for severe genetic disease. Do you want to be part of this effort? Welcome to join our exciting journey!


We are looking for a new team member to join our Screening and Automation team in Genome Engineering Department. The role is based in Gothenburg, Sweden, where you will join an international team that develops novel genome engineering technologies and applies these technologies for generation of therapeutic agents. We provide a stimulating environment for innovation and translational application of genome engineering tools. We continually push the boundaries of science to deliver medicines that treat diseases across our main therapy areas.


Why AstraZeneca?
If you are passionate about translating scientific advances into next generation medicines, AstraZeneca is the right place for you. Join the team for unlocking the power of what science can do. You have the potential to grow yourself, our pipeline, and positively impact the lives of billions of patients around the world.


What’s next? If this sounds like your next challenge – welcome to apply!


This is a consulting assignment with Randstad Life Sciences. Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.




Deadline: 2024-03-11, selection and interviews will be ongoing. For more information: Please contact Katan Ali, [email protected]


Welcome with your application! Placement: AstraZeneca R&D, Gothenburg, Sweden

Responsibilities


You will bring your scientific expertise in molecular biology and innovative thinking to drive genome editing approaches that can lead to therapies. You will be a part of cross-functional project teams with various backgrounds and expertise, where you will contribute to development of gene editing strategies.
Accountabilities will include experimental optimization of genome engineering tools to facilitate efficient gene editing, developing relevant assays, analyzing gene editing outcomes, documenting, interpreting, and communicating results to relevant partners. You will collaborate with others to develop streamlined platforms for high-throughput screening and optimization of genome editing components. This is a very exciting role that will give you exceptional professional and technical development opportunities in this state-of-the art scientific discipline.


We also believe that our new colleague is a person who thinks in a creative way and find innovative approaches to scientific problems. You are enthusiastic and curiosity-driven towards finding answers to scientific questions, coming up with solutions to technical problems and learning new skills. You can work in an independent and goal-oriented way, but you also enjoy team work and have the ability to communicate and collaborate in a global setting with cross-functional groups.

Qualifications
Essential requirements:
PhD degree?in molecular/cell biology, genetics or relevant areas, or MSc with 2+ years' experience in academia or industry
Strong molecular biology background and relevant hands-on skills.
Expertise with mammalian cell culture and cellular assays, such as genetic manipulation and evaluating genetic & functional outcomes using next generation sequencing, qPCR etc.



Desirable for the role:
Solid understanding of genome engineering and current technologies.
Experience with automation and high-throughput application
Experience with producing and using viral vectors (lenti/AAV) for gene delivery in mammalian cells.


About the company

Kelly Services (UK) Limited
Randstad Life Sciences is specialized in competencies within Life Science. As a consultant with us, you get a competitive salary, benefits, and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many activities. Visa mindre
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Thesis work: Genome-wide NGS approaches

Ansök    Okt 2    Randstad AB    Molekylärbiolog
Job description Thesis Work: Genome-wide NGS approaches for CRISPR off-target detection  Are you passionate for the development of advanced Next Generation Sequencing (NGS) technologies to support gene editing programs strategy? Would you like to apply expertise to innovate sequencing-based techniques in a company that turns ideas into life changing medicines? Then AstraZeneca might be of interest to you! Thesis type: 30 or 60 credits Project start: Janu... Visa mer
Job description
Thesis Work: Genome-wide NGS approaches for CRISPR off-target detection 

Are you passionate for the development of advanced Next Generation Sequencing (NGS) technologies to support gene editing programs strategy? Would you like to apply expertise to innovate sequencing-based techniques in a company that turns ideas into life changing medicines? Then AstraZeneca might be of interest to you!

Thesis type: 30 or 60 credits
Project start: January 2024
Student location: On Site, Gothenburg Sweden

Translation of CRISPR-Cas9 technologies into therapies requires sensitive detection of unintended mutations across the genome. Developing state-of-the-art NGS-based methods to discover CRISPR off-targets genome-wide is of high priority for developing safe editing programs at Discovery Sciences.

To help us in this challenge, we are looking for a highly motivated and engaged Master student to join our collaborative Disease Molecular Profiling team - NGS/Transcriptomics Function at AstraZeneca, in Gothenburg. You will be part of a dynamic team working on transformative NGS platforms to enable acceleration and innovation of our R&D pipeline.

To this end, you will be actively involved in the establishment and evaluation of customized NGS workflows, as well as in the enhancement and troubleshooting of existing ones. An important part of your work will include data interpretation in collaboration with our team of computational biologists and effective communication of progress and milestones to stakeholders.

You will be expected to work collaboratively within a multidisciplinary department, sharing insights and contributing to the discussion of the team’s projects. Keeping up to date with relevant scientific literature and technological advancements in the CRISPR field will be part of your tasks.

At AstraZeneca, all of our employees make a difference to patients’ lives every day. We operate in more than 100 countries around the world and are one of Sweden’s most important export companies.
 
With more than 2,400 employees from 50 countries, the vibrant Gothenburg site helps to support the entire life-cycle of AstraZeneca medicines, from drug discovery and clinical trials, to global commercialisation and product maintenance. Gothenburg is one of AstraZeneca’s three strategic, global R&D centres, alongside Cambridge and Gaithersburg, and plays a central role in our mission to deliver life-changing medicines to patients.

Application
Randstad Life Sciences is collaborating with AstraZeneca in this recruitment process. Please send your application in English and we only accept applications through Randstad’s website.

Deadline for application: 2023-10-22, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

All chosen candidates need to pass a background check and an alcohol and drug test before starting the project.



Responsibilities
We are looking for a highly motivated and engaged Master student to join our collaborative Disease Molecular Profiling team - NGS/Transcriptomics Function at AstraZeneca, in Gothenburg. You will be part of a dynamic team working on transformative NGS platforms to enable acceleration and innovation of our R&D pipeline.

To this end, you will be actively involved in the establishment and evaluation of customized NGS workflows, as well as in the enhancement and troubleshooting of existing ones. An important part of your work will include data interpretation in collaboration with our team of computational biologists and effective communication of progress and milestones to stakeholders.

You will be expected to work collaboratively within a multidisciplinary department, sharing insights and contributing to the discussion of the team’s projects. Keeping up to date with relevant scientific literature and technological advancements in the CRISPR field will be part of your tasks.

Qualifications
Essential Requirements
• Hands on experience in molecular biology or genomics-focused setting
• Familiarity with CRISPR-Cas9 technology and its applications

Desirable Requirements  
• Familiarity with NGS technology and automated liquid handling systems.
• Prior experience in multidisciplinary work environment

About the company
If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us! 

At AstraZeneca we are guided in our work by a strong set of values, and we’re resetting expectations of what a bio-pharmaceutical company can be. By truly following the science, we pioneer new methods, new thinking and bring unexpected teams together. From scientists to sales, lab techs to legal, we’re on a mission to turn ideas into life-changing medicines that transform lives. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you’re swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. Visa mindre
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Thesis work: Supply of high-quality protein complexes

Ansök    Okt 18    Randstad AB    Molekylärbiolog
Job description Thesis work: Supply of high-quality protein complexes to drive early drug discovery Thesis type: 30 credits Project start: February 2024 Student location: On Site, Gothenburg Sweden Are you a student with interest and experience in protein sciences? Would you like to contribute to reagent strategies to enable early drug discovery projects? Do you want to be part of a collaborative team and push the boundaries of science? Then you should... Visa mer
Job description
Thesis work: Supply of high-quality protein complexes to drive early drug discovery


Thesis type: 30 credits
Project start: February 2024
Student location: On Site, Gothenburg Sweden


Are you a student with interest and experience in protein sciences? Would you like to contribute to reagent strategies to enable early drug discovery projects? Do you want to be part of a collaborative team and push the boundaries of science? Then you should consider this master thesis project in Discovery Biology at AstraZeneca!



You will be part of Discovery Biology department within the Discovery Sciences organization and will be placed at our vibrant R&D site in Gothenburg, Sweden. The department works with early drug discovery projects in a company that turns ideas into life changing medicines for patients worldwide. The Protein Science team is responsible for protein reagent supply, a fundamental but often rate-limiting step in early project phases. Our work enables multiple key deliveries on the way to new drugs, such as structural and biophysical studies, biochemical assay development and High-Throughput-Screening.



An early but often rate-limiting step for early drug discovery projects is supply of high-quality proteins in sufficient quantities. Your work will contribute to our constant strive to work with challenging protein targets enabling unprecedented reagent supply. Aim of this project is a better understanding of how to establish supply of protein complexes that are of interest to drug discovery.



At AstraZeneca, all of our employees make a difference to patients’ lives every day. We operate in more than 100 countries around the world and are one of Sweden’s most important export companies.


With more than 2,400 employees from 50 countries, the vibrant Gothenburg site helps to support the entire life-cycle of AstraZeneca medicines, from drug discovery and clinical trials, to global commercialisation and product maintenance. Gothenburg is one of AstraZeneca’s three strategic, global R&D centres, alongside Cambridge and Gaithersburg, and plays a central role in our mission to deliver life-changing medicines to patients.



Randstad Life Sciences is collaborating with AstraZeneca in this recruitment process. Please send your application in English and we only accept applications through Randstad’s website.

Deadline for application: 2023-11-01, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


All chosen candidates need to pass a background check and an alcohol and drug test before starting the project. 



Responsibilities
Your responsibilities and tasks will be:
Expression, purification and characterization of recombinant proteins and protein complexes
Formation and characterization of protein-protein complexes
Independently plan and conduct experiments under the supervision by an experienced scientist
Interpretation and documentation of experiments and results.


Qualifications
Essential: 


Hands-on experience and general understanding of methods and technologies applied to expression, purification and characterization of recombinant proteins.
Written and oral communication skills in English
Ability to interact and communicate in a multicultural setting



Desirable: 


Experience of construct design for protein production
Previous experience of protein-protein-interaction studies
Previous knowledge of structural biology
Understanding of cellular signalling pathways relevant for drug discovery




About the company
If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us! 


At AstraZeneca we are guided in our work by a strong set of values, and we’re resetting expectations of what a bio-pharmaceutical company can be. By truly following the science, we pioneer new methods, new thinking and bring unexpected teams together. From scientists to sales, lab techs to legal, we’re on a mission to turn ideas into life-changing medicines that transform lives. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you’re swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.


AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. Visa mindre
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Scientist, Early R&I Research and Early Development, Bioscience

Ansök    Mar 20    Hays AB    Molekylärbiolog
AstraZeneca Hays Life Sciences is now looking to recruit a Scientist to work with Early R&I Research and Early Development, Bioscience In Vivo for a contract assignment until with 2023-12-22 with a chance of extension at AstraZeneca in Gothenburg. Job description Are you an experienced scientist ready to apply your skills in a diverse and dynamic organization? If you can envision providing scientific expertise in a role that can impact patients' live... Visa mer
AstraZeneca

Hays Life Sciences is now looking to recruit a Scientist to work with Early R&I Research and Early Development, Bioscience In Vivo for a contract assignment until with 2023-12-22 with a chance of extension at AstraZeneca in Gothenburg.

Job description
Are you an experienced scientist ready to apply your skills in a diverse and dynamic organization? If you can envision providing scientific expertise in a role that can impact patients' lives - join us now!

At AstraZeneca, we believe in the potential of our people and you'll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.

We are now looking to recruit an In Vivo Scientist with excellent laboratory skills and a drive for innovation to join the Bioscience in vivo department within the Early Respiratory and Immunology (eR&I) R&D unit located in Gothenburg, Sweden.

Respiratory and immunology are two of AstraZeneca's main therapy areas. From a research perspective we work to understand, treat, modify and ultimately cure respiratory disease with an emphasis on four respiratory diseases with significant unmet medical need; asthma, COPD, Idiopathic Pulmonary Fibrosis (IPF) and Chronic Cough. In addition, we also focus on immunology-driven disease areas including rheumatology, dermatology, gastrointestinal and inflammatory diseases driven by eosinophilic immune dysfunction.

The successful candidate will join a highly motivated team that works closely together with other departments focusing on target identification, drug formulation, translational science, in vitro assay development and drug metabolism/pharmacokinetics to support discovery projects and to drive new exciting research. Are you ready to join us?

What you'll do
As a vital member of the in vivo team you will contribute to progress our drug discovery projects. Your role will be mainly lab-based in which you will be actively involved and responsible to coordinate and perform in vivo experiments. While we expect you to be independent we are also looking for someone that thrives in a team setting and contributes to the success of others.

Essential for the role

* B.Sc. or M.Sc. degree in relevant subjects or equivalent level of understanding developed through experience in drug discovery or early development
* Excellent technical and experimental In vivo experience and skills, including rodent handling, drug administration and collection of biological samples. Ability to coordinate and perform respiratory disease and mechanistic models.
* Valid certificates to work with live animals in Sweden
* Be respectful, communicate openly and show effective collaborative behavior to obtain high quality study results
* Excellent written and oral communication skills in English.
* Excellent organization skills
* Ability to incorporate the views of others in your communication
* Maintain the highest standards of animal welfare and ethical compliance and ensure integrity of generated data. Familiar with using Good Statistical Practice in animal research and applying the 3R's (reduction, refinement and replacement) across the full range of studies
* Good generic computer proficiency including Microsoft Office.

Desirable for the role

* Experience in basic cellular and molecular biology techniques (e.g. ELISA,western blot, FACS, Meso Scale Discovery (MSD) technology platform), and RNA (qRT-PCR, RNASeq)
* Ability to interpret and analyze generated data
* Good written and oral communication skills in Swedish and experience in writing ethical applications for animal work in Sweden
* Good understanding of pharmacology, physiology, immunology, respiratory diseases (COPD, asthma, cough, IPF) and PKPD relationships

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey. Visa mindre
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Sr Scientist Bioscience - CVRM Research

Ansök    Sep 12    Hays AB    Molekylärbiolog
Hays Life Science / Sr. Scientist Bioscience in CVRM Research / AstraZeneca / 12-months / Gothenburg, Sweden AstraZeneca Cardiovascular Renal and Metabolism (CVRM) Research - Metabolism In Vitro Team At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because an opportunity no matter how small can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and... Visa mer
Hays Life Science / Sr. Scientist Bioscience in CVRM Research / AstraZeneca / 12-months / Gothenburg, Sweden

AstraZeneca

Cardiovascular Renal and Metabolism (CVRM) Research - Metabolism In Vitro Team

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because an opportunity no matter how small can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential.

The AstraZeneca CVRM Research group in Gothenburg is seeking to recruit a high calibre scientist to enable progression of a growing drug project portfolio. Highly motivated scientists are encouraged to apply for the opportunity to join our team of professionals who are passionate about advancing science, to discover and develop novel therapeutics that will benefit patients.

Hays Life Science is now looking for a Senior Scientist Bioscience in CVRM Research at our client AstraZeneca. This is a 12-month assignment in Gothenburg, Sweden.

Your new role

You will play an active role in implementing and executing scientific research within a CVRM Metabolism project, enabling studies aimed at exploring disease modifying mechanisms linked to pharmacological inhibition of the biological target of interest. This is a "hands-on," laboratory based scientific and technical role in our in vitro metabolism team supporting projects from target validation to lead optimisation phases.

This position will be laboratory based, and you will be responsible for several technical and experimental processes to support the CVRM Research group.



Responsibilities:

* Responsibility for design, execution and analysis of in vitro and ex vivo assays.
* Communicate results, conclusions and recommendations to colleagues, line manager and the project team.
* Record experiments in lab books and databases according to AstraZeneca policy.
* Play a leading role in assay development and optimisation of in vitro assays.

You would report to an expert member of staff and would be encouraged to be able to plan your daily work within direction set by your supervisor.

You will:

* Be asked to provide interpretation of assay results.
* Work within a line and/or matrix/project team.
* Demonstrates scientific rigour in assessing own data and that of others.
* Be a "hands-on" expert with in vitro models and methodologies.



What you'll need to succeed

Essential:

* Ability to develop new methods, technologies, and processes
* Enthusiasm for laboratory work, scientific curiosity.
* Experience in running in vitro biochemical and cellular assays to provide potency and activity readouts, including use of primary and recombinant cell lines.
* Significant cell culture experience.
* Experience with disease relevant cell types such as primary hepatocytes or hepatocyte-like cell lines in 2D cultures.
* Experience with ex vivo analysis of blood/tissue samples (including qPCR for gene expression, Western blots, and ELISA).
* Experience in data analysis and interpretation and enthusiasm for problem-solving for scientifically challenging work.
* Demonstrable ability to work within a line and/or matrix/ cross-functional project team.
* Strong interest in providing materials and data for scientifically challenging work.
* Strong organisational, time management and communication skills.
* Strong, demonstrable analytical ability.
* Good oral and written communications skills.

Desirable:

* Background in metabolic disease research areas.
* Experience with 3D spheroid models and expertise to establish and evaluate models of liver disease in the context of steatosis and fibrosis.
* Knowledge and experience with automation and robotic methods for increasing throughput and medium to high density microtitre plate technologies.
* An understanding of biological sciences, familiarity with the drug discovery process.
* Experience working in pharmaceutical or biotech environment.

Behavioural competencies:

* Hard-working, organised, balanced and meticulous with an ability to work well under pressure.
* Adaptable and a team player with a conscientious attitude and enthusiasm.
* Desire to learn and build on the role.

Education:

* Degree in one of the Life Sciences disciplines and equivalent post-graduate or industry experience.



What you need to do now

If you're interested in this role, click 'apply now' to forward an up-to-date copy of your CV, or call us now.
If this job isn't quite right for you, but you are looking for a new position, please contact us for a confidential discussion on your career. Visa mindre
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Thesis work: CRISPR approach to improve antisense oligonucleotide

Ansök    Okt 2    Randstad AB    Molekylärbiolog
Job description Genome-wide CRISPR screen to identify the Antisense Oligonucleotides (ASO)-interacting proteins involved in ASO efficacy Would you like to apply your cell biology expertise to improve the efficacy of innovative medicines in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be of interest to you!   Thesis type: 30 or 60 credits Project start: January 2024 Student location: On Site, Got... Visa mer
Job description
Genome-wide CRISPR screen to identify the Antisense Oligonucleotides (ASO)-interacting proteins involved in ASO efficacy


Would you like to apply your cell biology expertise to improve the efficacy of innovative medicines in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be of interest to you!
 
Thesis type: 30 or 60 credits
Project start: January 2024
Student location: On Site, Gothenburg Sweden




Antisense oligonucleotides (ASO) therapy can be created for any patient, any target, including targets that have long been considered “un-druggable” by traditional therapies. More than 12,000 patients have been safety treated with ASO medicines across many disease areas. Even though these molecules are currently prescribed, their mechanisms of entry and action remain poorly understood. Moreover, the majority of diseases targeted by ASO requires recurrent ASO injections. Thus, ASO efficiency should be improved to reduce the amounts of delivered-ASO and their consecutive toxicities. Our ultimate goal is to better know the ASO route(s) and proteins involved in these routes to design ASO favouring one route to improve ASO efficiency. Previous studies are mainly based on mass spectrometry analysis to identify ASO-interacting proteins. Here, we plan to perform a functional characterization of all coding genes to identify the proteins improving or limiting the ASO efficiency. The originality of the project is based on three key elements: our skills to perform genome wide CRISPR based screens (Gautron A., Embo Mol Med 2021), our collaboration with SciLifeLab (Stockholm) and our capability to perform biochemical validations of ASO-protein interactions (assays already developed in our team). Beyond the elucidation of the molecular mechanism of ASO internalization and cell trafficking, identifying key ASO-protein partners can impact future ASO-biomedical applications.
 


At AstraZeneca, all of our employees make a difference to patients’ lives every day. We operate in more than 100 countries around the world and are one of Sweden’s most important export companies.



With more than 2,400 employees from 50 countries, the vibrant Gothenburg site helps to support the entire life-cycle of AstraZeneca medicines, from drug discovery and clinical trials, to global commercialisation and product maintenance. Gothenburg is one of AstraZeneca’s three strategic, global R&D centres, alongside Cambridge and Gaithersburg, and plays a central role in our mission to deliver life-changing medicines to patients.
 


Application


Randstad Life Sciences is collaborating with AstraZeneca in this recruitment process. Please send your application in English and we only accept applications through Randstad’s website.



Deadline for application: 2023-10-22, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.




Responsibilities
Our goal is to 1) Identify the proteins involved in ASO uptake and ASO guidance to their RNA-targets using a genome wide approach (CRISPR screen), 2) Confirm the ASO-protein partners by biochemical approaches and imaging. You will mainly involve in the first part of the project by assuming the cell culture part of the CRSIPR screen with your supervisor.

Qualifications
Essential Requirements 
Cell biology or Genetic background
Cell culture experience
Knowledges on CRISPR approaches



Desirable Requirements 
Knowledges on Oligonucleotides


About the company
If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us! 


At AstraZeneca we are guided in our work by a strong set of values, and we’re resetting expectations of what a bio-pharmaceutical company can be. By truly following the science, we pioneer new methods, new thinking and bring unexpected teams together. From scientists to sales, lab techs to legal, we’re on a mission to turn ideas into life-changing medicines that transform lives. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you’re swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.


AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. Visa mindre
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Senior Scientist human induced-pluripotent stem cell biology

Ansök    Feb 13    Hays AB    Molekylärbiolog
Applied Stem Cell Sciences team in Discovery Sciences Hays Life Sciences is now looking to recruit a Senior Research Scientist - Human Induced-Pluripotent Stem Cell Biology to join the Applied Stem Cell Sciences team in Discovery Sciences for a 9-month contract assignment at AstraZeneca in Gothenburg. Are you an experienced scientist in the field of pluripotent stem cells (PSC)? Would you like to use your scientific skills to drive the development of ... Visa mer
Applied Stem Cell Sciences team in Discovery Sciences

Hays Life Sciences is now looking to recruit a Senior Research Scientist - Human Induced-Pluripotent Stem Cell Biology to join the Applied Stem Cell Sciences team in Discovery Sciences for a 9-month contract assignment at AstraZeneca in Gothenburg.

Are you an experienced scientist in the field of pluripotent stem cells (PSC)? Would you like to use your scientific skills to drive the development of stem-cell derived models for therapeutic development? If these goals resonate with you, we may be your Team!

At AstraZeneca in Gothenburg, Sweden we have an exciting opportunity for you to join us in the Applied Stem Cell Sciences Team in Discovery Sciences, Biopharmaceuticals R&D, as a 9-months contract bench-based Senior Research Scientist (from March 1st, 2023, to November 30th, 2023) and impact the development of stem cell models.

The role
You will be based in Gothenburg Sweden, working alongside with our stem cell scientists, disease area specialists and the genome editing group. Using your strong knowledge and experience in stem cell biology and cell model development you will have the opportunity to work on development of in vitro models and assays that will be applied to study various targets of relevance to disease. You will maintain and differentiate induced pluripotent stem cells (iPSCs) and carry out gene editing experiments where necessary.

The role is focused on laboratory-based activities. Your biggest impact will be through significant contributions to the practical delivery to projects in compliance with AstraZeneca corporate responsibility, policies and relevant safety standards.

It is essential to have good social and communication skills, be collaborative and a dedicated team player. Candidates should be able to work independently, take their own initiatives and have a positive, goal oriented and problem-solving attitude.

Good organizational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Key Skills and Responsibilities:

* BSc/MSc/PhD degree with extensive experience in Developmental and Cell Biology
* Proven experience with human PSC biology and differentiation to kidney and lung cell types
* Experience in developing molecular biology, biochemical and cell-based assays (including qPCR, ELISA, Western blotting, Flow cytometry, immunofluorescence) in iPSC-derived cultures.
* Perform in vitro studies to investigate the effects of CRISPR-based gene editing on gene and protein expression and cellular readouts.
* Effectively collaborate within a matrixed research team to facilitate the success of projects.
* Maintain complete experimental records.

The following skills are highly desirable:

* Experience with CRISPR gene editing, clonal cell line generation
* Expertise with liquid handling automation technologies
* Experience of setting up cell based pharmacological assays

About AstraZeneca
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. At AstraZeneca, we are proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives and are made to feel valued, energized and rewarded for their ideas and creativity.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. Visa mindre
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Senior Scientist - Stem Cell Engineering

Ansök    Feb 6    Hays AB    Molekylärbiolog
Biopharmaceuticals R&D Cell Therapy department Hays Life Sciences is now looking to recruit a Senior Scientist - Stem Cell Engineering to join the Biopharmaceuticals R&D Cell Therapy department for a 1 year contract assignment at AstraZeneca in Gothenburg. Are you an experienced scientist in the field of cell biology and advanced cell culture? Do you have understanding of molecular switches, cloning, gene engineering (CRISPR) and other technologies wi... Visa mer
Biopharmaceuticals R&D Cell Therapy department

Hays Life Sciences is now looking to recruit a Senior Scientist - Stem Cell Engineering to join the Biopharmaceuticals R&D Cell Therapy department for a 1 year contract assignment at AstraZeneca in Gothenburg.

Are you an experienced scientist in the field of cell biology and advanced cell culture? Do you have understanding of molecular switches, cloning, gene engineering (CRISPR) and other technologies within synthetic biology that you are keen to apply for the development of novel cell-based therapies? Join us and be a key player in the build of our Biopharmaceuticals R&D Cell Therapy department. Together we will push the boundaries of Science!

At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. The role is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden, where you will work in an international setting at the fore front of Cell Therapy science.

Biopharmaceuticals R&D is committed to the development of next generation innovative medicines, and we are building a Cell Therapy department with the goal to establish AstraZeneca as a world-leader in Cell Therapy across disease areas within Cardiovascular, Renal and Metabolism (CVRM) and Respiratory and Inflammation (R&I). The department will bring together ?50 specialists to support the organization with cell therapy expertise and capabilities, and we are working in close collaboration with experts across AstraZeneca globally to leverage the existing and emerging platforms in cell technologies, new modalities, universal cell lines and CRISPR-mediated genome editing.

What you'll do
This role provides an opportunity to work in an international, highly cross disciplinary environment with ground-breaking techniques and technologies within areas such as stem cell biology and precise genome editing. You will work together with our in vitro scientists and collaborate with disease area specialists, in vivo scientists and advanced imaging experts to develop our scientific capabilities and ensure efficient progress of Cell Therapy projects.

The role is focused on laboratory-based activities and you will use your scientific expertise to design and execute experiments and to deliver high quality data. Your biggest impact will be through practical and scientific contributions to support projects in compliance with AstraZeneca corporate responsibility, policies and relevant safety standards.

In this role it is essential to have good social and communication skills, be collaborative and a strong team player. You should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude. Good organizational, data management and documentation skills are required, and you should be comfortable in presenting your results internally as well as at external meetings.

Accountability includes:

* Culture and differentiate pluripotent stem cells using small molecules/cytokines to physiological relevant cell types that can be used for cell therapy applications.
* Implement CRISPR, molecular switches and synthetic mRNA technologies in stem cells to improve the differentiation capacity.
* Implement receptor design and engineering strategies for immune cell types (e.g., CAR-T, CAR-M).
* Characterize and quantify cell phenotype/identity using readouts like qPCR, flow cytometry and imaging-based readouts.
* Develop and troubleshoot protocols for in vitro culture and differentiation of various cell types including pluripotent stem cells.
* Independently analyse and report data to support project decisions and communicate relevant information to project teams within the bioscience department as well as across other functions.

Essential for the role

* Ph.D. in Cell Biology or a related field with relevant academic or industrial experience.
* Experience with genome editing and developing reporter lines.
* Hands-on experience with mammalian cell culture and/or stem cell culture.
* Ability to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude
* Good organizational, data management and documentation skills
* Good scientific presentation skills and ability to comfortably present and discuss scientific data.

Desirable for the role

* Hands-on experience of hESC or hiPSC culture and differentiation. Experience in using synthetic mRNAs for driving stem cell differentiation.
* Experience in cellular analysis platforms like imaging (e.g. confocal, incucyte), flow cytometry or qPCR.

So, what's next? Are you already imagining yourself joining us?
Good, because we can't wait to hear from you!

About AstraZeneca
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. At AstraZeneca, we are proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives and are made to feel valued, energized and rewarded for their ideas and creativity.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. Visa mindre
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Scientist in Genome Medicines?

Ansök    Jan 10    Hays AB    Molekylärbiolog
Genome Editing team Hays Life Sciences is now looking to recruit a Scientist in Genome Medicines to join the Genome Editing team for a contract assignment until 2023-12-31 at AstraZeneca in Gothenburg. We are developing state-of-the-art technologies and models to advance gene and cell therapy approaches. AstraZeneca's Genome Editing Team in Gothenburg, Sweden, is now looking for a passionate Scientist to innovate in the field of genome medicines. If y... Visa mer
Genome Editing team

Hays Life Sciences is now looking to recruit a Scientist in Genome Medicines to join the Genome Editing team for a contract assignment until 2023-12-31 at AstraZeneca in Gothenburg.

We are developing state-of-the-art technologies and models to advance gene and cell therapy approaches. AstraZeneca's Genome Editing Team in Gothenburg, Sweden, is now looking for a passionate Scientist to innovate in the field of genome medicines. If you are looking for a fast-paced environment where your scientific insights can translate into meaningful impacts on patient lives, this is the position for you!

Meet us:
As a Scientist in the Genome Editing Team, you will join an international group of energetic researchers of various backgrounds who are excited about science and challenge its dogmas. We create a supportive and inclusive environment, and a fun atmosphere for everyone independent of their preferences, experiences and beliefs. Our work focuses on basic yet translational research that is designed to reach the clinics. Especially, we are passionate about modifying genomes at will for therapeutic purposes.

Essential for this role:

* Multidisciplinary laboratory experience (minimum 3 years hands-on work) and meticulous scientific knowledge in cell biology, molecular biology and genetics
* Cell culture work (plasmid transfection, generating cell lines with CRISPR)
* Molecular biology (DNA extraction, PCR, western blot)
* Cell biology (immunofluorescence, FACS)

Our successful candidate needs the ability to communicate, interact and collaborate with other team members, as well as across our AZ global functions and fields. Alongside this, our ideal candidate enjoys working in an innovative, proactive, forward-thinking, project-focused and goal-oriented way and shares our excitement about the latest gene-editing techniques.

Why AstraZeneca?
We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. Visa mindre
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Scientist - NGS for High-Throughput Transcriptomics

Ansök    Nov 29    Hays AB    Molekylärbiolog
Disease Molecular Profiling - NGS & Transcriptomics team Hays Life Sciences is now looking to recruit a Scientist - NGS for High-Throughput Transcriptomics to join the Disease Molecular Profiling - NGS & Transcriptomics team for a 6-month contract assignment at AstraZeneca in Gothenburg. Are you a Molecular Biologist with experience in Next Generation Sequencing (NGS)? Do you wish to apply this knowledge in a role that is connected to our wider missio... Visa mer
Disease Molecular Profiling - NGS & Transcriptomics team

Hays Life Sciences is now looking to recruit a Scientist - NGS for High-Throughput Transcriptomics to join the Disease Molecular Profiling - NGS & Transcriptomics team for a 6-month contract assignment at AstraZeneca in Gothenburg.

Are you a Molecular Biologist with experience in Next Generation Sequencing (NGS)? Do you wish to apply this knowledge in a role that is connected to our wider mission to show what science can do? If yes, we might have the role for you!

We seek a talented and highly engaged Molecular Biology/NGS scientist to join the Disease Molecular Profiling - NGS & Transcriptomics team at AstraZeneca in Gothenburg, Sweden. You will contribute with applying molecular biology and NGS expertise to our drug discovery portfolio and working on cutting edge technologies within the field.

What you will do:

* To deliver according to plans over agreed timelines such that the objectives of the project are met, including delivery of more than one agreed area of work in parallel where appropriate.
* To be an effective member of Drug Discovery Project Teams, contributing novel ideas and using judgment and knowledge where appropriate to influence the work of the project.
* To work in partnership with colleagues in Discovery Sciences and across therapy areas and sites to ensure the delivery of high-quality sequencing data to projects.
* Proposing experimental strategies, troubleshooting and contributing to the practical delivery of NGS projects.

Extensive hands on NGS experimental techniques including:

* Bi-weekly coordinated Amplicon-seq
* RNA preparation.
* NA isolation and fragmentation.
* Fragment analysis and nucleic acid Q.C.
* Library preparation of various protocols.
* Operation of NGS instrumentation.
* Processing, handling and movement of large sets of data.
* Using Automation to process samples for NGS library preparation.
* Significant molecular biology skills, including PCR, analysis and Q.C.

Essential for the role:

* MSc/PhD degree with significant molecular biology relevant experience, preferably in the pharmaceutical or biotechnology industry.
* Experience of wet-lab work of various NGS library prep methods (e.g., Amp-seq & RNA-seq).
* A practical understanding of a wide range of methods and technologies as applied to cellular engineering. For example, mammalian cell growth, Precise genome editing.
* Measuring off-target effects of precise genome edited cells.
* Good problem-solving skills, good scientific judgement and communication skills.
* Excellent team working and networking skills with effective interaction across teams.

Desirable for the role:

* Working with laboratory automation / liquid handling systems, method and technology development and optimization.
* Hands-on experience with Single Cell Transcriptomics or Spatial Transcriptomics.
* Tissue dissection, single cell dissociation, microscopy, flow cytometry/FACS
* Hands-on laboratory experience running NGS platforms (Illumina, Oxford Nanopore etc).
* Sample Tracking by LIMS systems. Visa mindre
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Research Scientist - CVRM Research group

Ansök    Dec 16    Hays AB    Molekylärbiolog
CVRM research group Hays Life Sciences is now looking to recruit a Research Scientist to join the CVRM Research group for 1-year contract assignment at AstraZeneca in Gothenburg. At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because an opportunity no matter how small can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their ... Visa mer
CVRM research group

Hays Life Sciences is now looking to recruit a Research Scientist to join the CVRM Research group for 1-year contract assignment at AstraZeneca in Gothenburg.

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because an opportunity no matter how small can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential.

The AstraZeneca CVRM Research group in Gothenburg is seeking to recruit a high calibre scientist to enable progression of a growing drug project portfolio. Highly motivated scientists are encouraged to apply for the opportunity to join our team of professionals who are passionate about advancing science, to discover and develop novel therapeutics that will benefit patients.

Role Overview
You will play an active role in implementing and executing scientific research within a CVRM Metabolism project, enabling studies aimed at exploring disease modifying mechanisms linked to pharmacological inhibition of the biological target of interest. This is a "hands-on," laboratory based scientific and technical role in our in vitro metabolism team supporting one of our clinical program.

Role specifics
This position will be laboratory based and you will be responsible for several technical and experimental processes to support the CVRM Research group.

Responsibilities

* Responsibility for design, execution and analysis of in vitro 3D liver spheroid assays.
* Communicate results, conclusions and recommendations to colleagues, line manager and the project team.
* Record experiments in electronic lab books and databases according to AstraZeneca policy.
* Play a leading role in assay development and optimisation of in 3D liver spheroid assays.
* You would report to an expert member of staff and would be encouraged to be able to plan your daily work within direction set by your supervisor.

You will:

* Be asked to provide interpretation of assay results.
* Work within a line and/or matrix/project team.
* Demonstrates scientific rigor in assessing own data and that of others.

Requirements
Education

* Degree in one of the Life Sciences disciplines and equivalent post-graduate or industry experience .

Essential

* Be a "hands-on" expert with in vitro models and methodologies.
* Ability to develop new methods, technologies, and processes
* Experience in running in vitro biochemical and cellular assays to provide potency and activity readouts
* Significant cell culture experience, including experience with disease relevant cell types such as primary hepatocytes or hepatocyte-like cell lines in 2D/3D cultures.
* Background in metabolic disease research areas.
* Experience with qPCR for gene expression, Western blots, and ELISA for protein quantification).
* Experience in data analysis and interpretation and enthusiasm for problem solving for scientifically challenging work.
* Demonstrable ability to work within a line and/or matrix/ cross-functional project team.
* Strong organizational, time management with good oral and written communications skills.

Desirable

* Experience with 3D spheroid models and expertise to establish and evaluate models of liver disease in the context of steatosis and fibrosis.
* Knowledge and experience with automation and robotic methods for increasing throughput and medium to high density microtitre plate technologies.
* An understanding of biological sciences, familiarity with the drug discovery process.
* Experience working in pharmaceutical or biotech environment.

Behavioral competencies

* Hard working, organized, balanced and meticulous with an ability to work well under pressure.
* Adaptable and a team player with a conscientious attitude and enthusiasm.
* Desire to learn and build on the role. Visa mindre
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Scientist - CVRM Research

Ansök    Jan 9    Randstad AB    Molekylärbiolog
Job description Cardiovascular Renal and Metabolism (CVRM) Research – Metabolism In Vitro Team At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because an opportunity no matter how small can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. The AstraZeneca CVRM Research group in Gothenburg is seeking to recruit a hi... Visa mer
Job description
Cardiovascular Renal and Metabolism (CVRM) Research – Metabolism In Vitro Team

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because an opportunity no matter how small can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential.

The AstraZeneca CVRM Research group in Gothenburg is seeking to recruit a high calibre scientist to enable progression of a growing drug project portfolio. Highly motivated scientists are encouraged to apply for the opportunity to join our team of professionals who are passionate about advancing science, to discover and develop novel therapeutics that will benefit patients.

Role Overview
You will play an active role in implementing and executing scientific research within a CVRM Metabolism project, enabling studies aimed at exploring disease modifying mechanisms linked to pharmacological inhibition of the biological target of interest. This is a "hands-on," laboratory based scientific and technical role in our in vitro metabolism team supporting one of our clinical program.

Role specifics
This position will be laboratory based and you will be responsible for several technical and experimental processes to support the CVRM Research group.

This is a consulting assignment at Randstad Life Sciences with the daily workplace at AstraZeneca. As a consultant at Randstad Life Sciences, we are your employer, but you have your daily workplace with one of our customers. Your consulting manager is always close at hand, both during and between assignments to help you develop your career in the direction you dream of. As a consultant with us, you get a competitive salary, benefits and collectively agreed terms.



Responsibilities
Responsibility for design, execution and analysis of in vitro 3D liver speroid assays.
Communicate results, conclusions and recommendations to colleagues, line manager and the project team.
Record experiments in electronic lab books and databases according to AstraZeneca policy.
Play a leading role in assay development and optimisation of in 3D liver speroid assays.
You would report to an expert member of staff and would be encouraged to be able to plan your daily work within direction set by your supervisor.


You will:
Be asked to provide interpretation of assay results.
Work within a line and/or matrix/project team.
Demonstrates scientific rigor in assessing own data and that of others.


Qualifications
Education
Degree in one of the Life Sciences disciplines and equivalent post-graduate or industry experience .

Essential
Be a "hands-on" expert with in vitro models and methodologies.
Ability to develop new methods, technologies, and processes
Experience in running in vitro biochemical and cellular assays to provide potency and activity readouts
Significant cell culture experience, including experience with disease relevant cell types such as primary hepatocytes or hepatocyte-like cell lines in 2D/3Dcultures.
Background in metabolic disease research areas.
Experience with qPCR for gene expression, Western blots, and ELISA for protein quantification).
Experience in data analysis and interpretation and enthusiasm for problem solving for scientifically challenging work.
Demonstrable ability to work within a line and/or matrix/ cross-functional project team.
Strong organizational, time management with good oral and written communications skills.

Desirable
Experience with 3D spheroid models and expertise to establish and evaluate models of liver disease in the context of steatosis and fibrosis.
Knowledge and experience with automation and robotic methods for increasing throughput and medium to high density microtitre plate technologies.
An understanding of biological sciences, familiarity with the drug discovery process.
Experience working in pharmaceutical or biotech environment.


Behavioral competencies
Hard working, organized, balanced and meticulous with an ability to work well under pressure.
Adaptable and a team player with a conscientious attitude and enthusiasm.
Desire to learn and build on the role.


About the company
Randstad Life Sciences is specialized in competencies within Life Science. As a consultant with us, you get a competitive salary, benefits, and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many activities. With more than 600 000 employees in 38 countries, 

Randstad is the global leader in the HR services industry and offers staffing, consulting and recruitment solutions in all areas of expertise. We also offer interim management, executive search and outplacement services. We have a broad network of clients and candidates, which means we convey hundreds of jobs within different industries all over Sweden. Our ambition is to be the best employer in the market. By combining our passion for people with the power of today’s technology, we help people and organizations to reach their true potential. We call it Human Forward. Visa mindre
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Cardiovascular Renal and Metabolism (CVRM) Research Scientist

Ansök    Okt 31    Hays AB    Molekylärbiolog
Metabolism In Vitro Team Hays Life Sciences is now looking to recruit a Cardiovascular Renal and Metabolism (CVRM) Research Scientist to join the Metabolism In Vitro Team for a 1-year contract assignment starting January 2023 at AstraZeneca in Gothenburg. At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because an opportunity no matter how small can be the start of something big. Delivering life-changing medicines ... Visa mer
Metabolism In Vitro Team

Hays Life Sciences is now looking to recruit a Cardiovascular Renal and Metabolism (CVRM) Research Scientist to join the Metabolism In Vitro Team for a 1-year contract assignment starting January 2023 at AstraZeneca in Gothenburg.

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because an opportunity no matter how small can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential.

The AstraZeneca CVRM Research group in Gothenburg is seeking to recruit a high calibre scientist to enable progression of a growing drug project portfolio. Highly motivated scientists are encouraged to apply for the opportunity to join our team of professionals who are passionate about advancing science, to discover and develop novel therapeutics that will benefit patients.

Role Overview
You will play an active role in implementing and executing scientific research within a CVRM Metabolism project, enabling studies aimed at exploring disease modifying mechanisms linked to pharmacological inhibition of the biological target of interest. This is a "hands-on," laboratory based scientific and technical role in our in vitro metabolism team supporting projects from target validation to lead optimisation phases.

Role specifics
This position will be laboratory based and you will be responsible for several technical and experimental processes to support the CVRM Research group.

Responsibilities

* Responsibility for design, execution and analysis of in vitro and ex vivo assays.
* Communicate results, conclusions and recommendations to colleagues, line manager and the project team.
* Record experiments in lab books and databases according to AstraZeneca policy.
* Play a leading role in assay development and optimisation of in vitro assays.
* You would report to an expert member of staff and would be encouraged to be able to plan your daily work within direction set by your supervisor.

You will:

* Be asked to provide interpretation of assay results.
* Work within a line and/or matrix/project team.
* Demonstrates scientific rigor in assessing own data and that of others.

Requirements
Education
Degree in one of the Life Sciences disciplines and equivalent post-graduate or industry experience.

Essential

* Be a "hands-on" expert with in vitro models and methodologies.
* Ability to develop new methods, technologies, and processes
* Enthusiasm for laboratory work, scientific curiosity.
* Experience in running in vitro biochemical and cellular assays to provide potency and activity readouts, including use of primary and recombinant cell lines.
* Significant cell culture experience.
* Experience with disease relevant cell types such as primary hepatocytes or hepatocyte-like cell lines in 2D cultures.
* Experience with ex vivo analysis of blood/tissue samples (including qPCR for gene expression, Western blots, and ELISA).
* Experience in data analysis and interpretation and enthusiasm for problem solving for scientifically challenging work.
* Demonstrable ability to work within a line and/or matrix/ cross-functional project team.
* Strong interest in providing materials and data for scientifically challenging work.
* Strong organizational, time management and communication skills.
* Strong, demonstrable analytical ability.
* Good oral and written communications skills.

Desirable

* Background in metabolic disease research areas.
* Experience with 3D spheroid models and expertise to establish and evaluate models of liver disease in the context of steatosis and fibrosis.
* Knowledge and experience with automation and robotic methods for increasing throughput and medium to high density microtitre plate technologies.
* An understanding of biological sciences, familiarity with the drug discovery process.
* Experience working in pharmaceutical or biotech environment.

Behavioral competencies

* Hard working, organized, balanced and meticulous with an ability to work well under pressure.
* Adaptable and a team player with a conscientious attitude and enthusiasm.
* Desire to learn and build on the role. Visa mindre
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Molecular Biologist

Ansök    Nov 23    Clavic Consulting AB    Molekylärbiolog
We are in an exclusive position to develop a whole portfolio of pioneering products and services, based on our dISA* technology. *dISA= dynamic Inhibition in Solution Assay (our patent pending technology) Our mission is to provide the most sensitive and productive bio-sensing technology for drug development, diagnostics, and quality control. We enable our partners to deliver a high-quality output while securing operational excellence and cost-efficiency. ... Visa mer
We are in an exclusive position to develop a whole portfolio of pioneering products and services, based on our dISA* technology. *dISA= dynamic Inhibition in Solution Assay (our patent pending technology)
Our mission is to provide the most sensitive and productive bio-sensing technology for drug development, diagnostics, and quality control.
We enable our partners to deliver a high-quality output while securing operational excellence and cost-efficiency.
With our leading technology, humanity will gain access to new and more effective medicines much faster
Insingulo is based in Gothenburg and was founded in October 2017 after a five-year collaboration between Chalmers University of Technology and AstraZeneca
Documented experience in designing protein expression constructs,
Experience in cell membrane purification and membrane protein purification
Experience in functional GPCR assays e.g. cAMP, BRET
Curiosity to learn and develop new methods in a multidisciplinary team Visa mindre
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Research Scientist - in vivo CVRM Bioscience

Ansök    Nov 16    Hays AB    Molekylärbiolog
Diabetes/NASH in vivo group Hays Life Sciences is now looking to recruit a Research Scientist - in vivo CVRM Bioscience to join the Diabetes/NASH in vivo group for a 1-year contract assignment at AstraZeneca in Gothenburg. AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. At AstraZeneca, we are p... Visa mer
Diabetes/NASH in vivo group

Hays Life Sciences is now looking to recruit a Research Scientist - in vivo CVRM Bioscience to join the Diabetes/NASH in vivo group for a 1-year contract assignment at AstraZeneca in Gothenburg.

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. At AstraZeneca, we are proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives and are made to feel valued, energized and rewarded for their ideas and creativity.

The Role
We are looking for a highly motivated and creative in vivo scientists to join the Diabetes/NASH in vivo group at AstraZeneca, Gothenburg, for a one-year assignment. As an In Vivo Research Scientist, you will support AstraZeneca's industry-leading drug portfolio within the Diabetes/NASH in vivo Bioscience Team. You will work in a cross-functional and highly matrixed environment and deliver in vivo pharmacology studies for both early and late-stage projects to support the development of new and successful diabetes and NASH therapies.

Key Responsibilities

* Execute and deliver preclinical in vivo and ex vivo studies for new drug target programs within diabetes/NASH.
* Deliver comprehensive in vivo pharmacology data packages for new drug candidates, including PK/PD and efficacy studies, dose and schedule optimization.
* Establish new technologies and approaches to improve or replace existing disease models that better predict clinical response.
* Work collaboratively with colleagues to develop and implement work plans and timelines.

Minimum Requirements

* At least "Naturbruksgymnasium" or similar education with a minimum of 2 years relevant experience within life sciences and in vivo pharmacology.
* Experience delivering in vivo pharmacology studies in rodent models, PK/PD studies, and efficacy studies.
* Experience in developing and working with in vivo rodent models.
* Proficiency and up to date hand-on experience in rodent animal handling techniques, including different dosing regimens and blood sampling procedures. Surgical skills are desirable.
* Laboratory Animal education by NCLASET or other relevant Laboratory animal science (LAS) course is desirable. Visa mindre
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Thesis work: Profiling the translatome to unleash new therapeutic

Ansök    Okt 11    Randstad AB    Molekylärbiolog
Job description Profiling the translatome to unleash new therapeutics If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us!   Thesis type: 30 credits Project start: January 2023 Student location: On Site, Gothenburg Sweden   Do you have a passion for Next Generation Sequencing (NGS) and gene expression control? Would you like to apply your expertise to innovate sequencing technologies in a... Visa mer
Job description
Profiling the translatome to unleash new therapeutics
If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us!
 
Thesis type: 30 credits
Project start: January 2023
Student location: On Site, Gothenburg Sweden
 

Do you have a passion for Next Generation Sequencing (NGS) and gene expression control? Would you like to apply your expertise to innovate sequencing technologies in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be of interest to you!


Translation is one of the most energy demanding cellular process, which plays a key role in determining gene expression. In fact, while transcription regulates which mRNAs are expressed, ultimately translation determines which proteins are produced. As such, translation is tightly regulated to avoid wasting cellular energy and precisely synthetize only the proteins needed in a spatial and temporal manner. Notably, dysregulation of the translation machinery drives aberrant production of proteins and is a leading cause in many human diseases and cancers. All of this makes it extremely important to advance technologies that would allow us monitoring translation at a mRNA-specific level. 
 
At AstraZeneca, all of our employees make a difference to patients’ lives every day. We operate in more than 100 countries around the world and are one of Sweden’s most important export companies.
 
With more than 2,400 employees from 50 countries, the vibrant Gothenburg site helps to support the entire life-cycle of AstraZeneca medicines, from drug discovery and clinical trials, to global commercialisation and product maintenance. Gothenburg is one of AstraZeneca’s three strategic, global R&D centres, alongside Cambridge and Gaithersburg, and plays a central role in our mission to deliver life-changing medicines to patients.

Responsibilities
To help us in this challenge, we are looking for a highly motivated and enthusiastic Master student to join our NGS/Transcriptomics team at AstraZeneca, Göteborg. As part of your Master thesis, you will develop and optimize technologies to visualize translation and the position of individual ribosomes on mRNAs transcriptome-wide. You will then apply this knowledge to identify novel disease-causing genes and evaluate the effect of innovative therapeutics at the translational level. Finally, you will be part of a diverse team, working on transformative NGS platforms with the ultimate goal of delivering new medicines and changing people’s lives.

Qualifications
 Essential Requirements 
Experience in molecular biology.
Knowledge in gene expression control. 
Organized and detailed-oriented.
Curious and motivated to learn. 



Desirable Requirements 
Handling of RNA samples. 
RNA sequencing knowledge and/or experience.
Knowlede of basic bioinformatics tool.
Experience in cell culturing and harvesting.



For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2022-10-25, welcome with your application at www.randstad.se.


For more information: contact Malin Fridholm, [email protected]

About the company
If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us! 


At AstraZeneca we are guided in our work by a strong set of values, and we’re resetting expectations of what a bio-pharmaceutical company can be. By truly following the science, we pioneer new methods, new thinking and bring unexpected teams together. From scientists to sales, lab techs to legal, we’re on a mission to turn ideas into life-changing medicines that transform lives. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you’re swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.
 
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. Visa mindre
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Research Scientist at AstraZeneca, Gothenburg

Ansök    Okt 3    Randstad AB    Molekylärbiolog
Job description Are you an enthusiastic lab-based cell and molecular biologist looking for a position where your technical expertise can make a difference to patients through experimental evaluation of potential new drug targets? If you are also familiar with immunology or respiratory biology, all the better! Come and join the team that passionately follows the science and puts the patients first. We have an exciting opportunity for an engaged and passion... Visa mer
Job description
Are you an enthusiastic lab-based cell and molecular biologist looking for a position where your technical expertise can make a difference to patients through experimental evaluation of potential new drug targets? If you are also familiar with immunology or respiratory biology, all the better! Come and join the team that passionately follows the science and puts the patients first.

We have an exciting opportunity for an engaged and passionate cell and molecular biologist to play an important part as a Research Scientist in our Target Science team within Early Respiratory and Immunology (R&I). The position will be placed at AstraZeneca in Gothenburg (Swe). In Target Science we focus on the identification and validation of novel targets and mechanisms addressing key biological disease drivers to enable a precision medicine approach to treating respiratory and immune-driven diseases. We are committed to selecting the right targets for the right patients.

In this role you’ll be part of our broader Translational Science and Experimental Medicine (TSEM) organisation. Within TSEM, we are working in an open environment with a strong science focus and our work bridges basic science with clinical development. Our mission is to understand disease mechanisms at the molecular level closing the gap between bench science and bedside clinical practice.

Why AstraZeneca?
Our workforce reflects the people we serve – diversity is embedded in everything we do. We’re at our best and most creative when drawing on our different views, experiences, and strengths. Thrive in an energising environment where challenging work goes hand in hand with opportunities for individual development.

This is a consulting assignment with Randstad Life Sciences. Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Responsibilities
You will join a team of dedicated Target Scientists and have a key role in successfully validating therapeutic target ideas enabling important milestone investment decisions (Target Selection Investment Decision (TSID)). In the everyday work you will:
Generate high quality experimental data that enables validation of potential new candidate targets.
Use and develop disease-relevant cell models to enable experimental validation of new targets.
Use standard cell and molecular biology methodology, for instance culture of mammalian cells and cell lines, qPCR, Western Blotting, ELISA, FACS and microscopy.
Analyse your data and present your conclusions to the team.


Qualifications
To take on this role, you need to have good networking and communication skills, with the ability to work efficiently in a team environment where you and your team support each other to deliver. You should also have:
PhD or corresponding research experience , a strong experimental drive and a background in basic science related to immunology or respiratory research.
Industry experience and a good understanding of the drug development process is an advantage.
Basic understanding of immunology and/or respiratory disease biology, including cell types, molecular pathways, and mechanisms.
Broad understanding of and the ability to apply state-of-the-art target validation technologies and methodologies along with excellent laboratory skills and the ability to experimentally address key scientific questions.

This is a laboratory-based role, requiring technical expertise and strong organisational skills. Your data will enable effective decision-making and ensure timely prosecution of pre-TSID projects. In this highly collaborative role, you need to have proven track record of scientific and experimental excellence and robust delivery of results.

Application
2022-10-13, welcome with your application at www.randstad.se.


For more information: contact Malin Fridholm, [email protected]

About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Assoc. Director; Patient Safety Technical Solutions

Ansök    Sep 7    Hays AB    Molekylärbiolog
Patient Safety Technical Solutions Team Hays Life Sciences is now looking to recruit 2 Assoc. Director; Patient Safety Technical Solutions to join the Patient Safety Technical Solutions Team for a 1-year contract assignment at AstraZeneca in Gothenburg. The Patient Safety Technical Solutions Team as a part of the wider Patient Safety Operations, Technology and Analytics Team (OTA) is accountable for managing the information assets and systems owned by... Visa mer
Patient Safety Technical Solutions Team

Hays Life Sciences is now looking to recruit 2 Assoc. Director; Patient Safety Technical Solutions to join the Patient Safety Technical Solutions Team for a 1-year contract assignment at AstraZeneca in Gothenburg.

The Patient Safety Technical Solutions Team as a part of the wider Patient Safety Operations, Technology and Analytics Team (OTA) is accountable for managing the information assets and systems owned by the Chief Medical Office (CMO), ensuring they are effectively supported and governed across the enterprise.

Reporting to the 'Associate Director/Director; PS Technical Solutions', the 'Associate Director; Patient Safety Technical Solutions' provides Pharmacovigilance (PV) subject matter and technical expertise across AstraZeneca's enterprise business-critical PV systems. The role holder works within a team of peers, all of whom employ an in-depth knowledge of business requirements, PV and regulatory policies, industry standards and trends as well as an understanding of the related assets to support effective governance, maintenance and development of the enterprise-wide systems that enable PV compliance and reporting. The role holder will work within the Patient Safety Technical Solutions Team and will directly support the design, development, implementation, continuous improvement, and/or optimal utilization of AZ safety systems and assets. He / She will understand how current and future components of the information and systems portfolio can be developed to ensure optimal benefit for the user community and the organization.

The role has specific responsibility for informing and supporting the technical evolution of the PV systems estate throughout its lifecycle, ensuring it addresses changing external requirements and business goals (i.e. regulatory obligations, technological advancements, core business processes and information standards). The role holder will also lead the capture and development of user requirements and protect AZ's License to Operate (LtO) by ensuring that all change is conducted in line with applicable standards (e.g. GxP requirements, systems validation, privacy and security, etc).

Typical Accountabilities

* Serves as a Subject Matter Expert (SME) across multiple functions within the Patient Safety Technical Solutions Team (Business Objects Reporting, Business Rules Management, Periodic Reports), ensuring it is capable of delivering high quality expertise and services across the PV systems estate, ensuring prioritized requirements and the strategic goals of stakeholders are understood and supported.
* Manages applicable tools, documentation and methodologies to ensure processes and systems fully address the needs of organization.
* Responsible for maintaining and evolving PV technology inclusive of relevant system processes, ensuring that the:
* Technology is changed in an effective and timely manner to meet new health authority requirements and / or changed business demands (e.g. divestment, in-licensing, partnership etc.).
* Technical components of the system are upgraded in a compliant and risk-minimized manner.
* Lead and coordinate routine system maintenance activities (e.g. MedDRA, WHODD, Ontology updates)
* System enhancement requests are identified and prioritized (change control and major change projects).
* Access to data is controlled, training requirements are defined and use of the system is compliant with all applicable regulations.
* User support arrangements (e.g. training, helpdesk) and Service Level Agreements are in place, irrespective of whether delivered internally or by external vendors / providers.
* Supports the ongoing business utilization of PS technology, including troubleshooting problems and developing solutions.
* Provides technical input and guidance on the development of strategic plans for PS technology across the enterprise.
* Evaluates new modules and software upgrades and assesses the impact on system validation, the user community and PV processes.
*

Day-to-Day Duties

* Manages applicable tools, documentation and methodologies to ensure processes and systems fully address the needs of organization.
* Lead and coordinate routine system maintenance activities (e.g. MedDRA, WHODD, Ontology updates)
* Contributes to the development of procedures, work instructions, system specifications related to the use of Patient Safety Technical Solutions owned information sources and toolsets.

Required Skills/ Experience/ Education/ Qualifications

* Bachelor's degree in a scientific discipline
* Significant experience in Pharmacovigilance with proven record of supporting safety tools / solutions.
* Proven competence, with extensive involvement in the successful design, delivery, validation, deployment or maintenance of information/systems solutions in support of safety.
* Experience in working across different geographic locations, organizations, and cultures.

Desirable Skills/ Experience/ Education/ Qualifications

* Excellent interpersonal and communication skills with ability to efficiently communicate with all levels of the organization.
* Knowledge of the procedures, processes and standards governing clinical trial data (documents and data) with health authorities worldwide, and experience of implementing these within the business.
* Higher degree in a clinical or safety-related discipline.

Required/Desired Technical Proficiencies (i.e. Excel, SAP, etc.)

* Microsoft Office Suite
* Business Objects experience (desired) Visa mindre
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Scientist: Transgenic model generation

Ansök    Aug 30    Hays AB    Molekylärbiolog
Transgenics In Vivo model generation team Hays Life Sciences is now looking to recruit a Scientist Transgenic Model Generation to join the Transgenics In Vivo Model Generation team for a contract assignment until 2023-05-27 at AstraZeneca in Gothenburg. The Transgenics In Vivo model generation team provides transgenic model generation services to all Therapy Areas within AstraZeneca, and to secure our immediate business needs, we are seeking a motivat... Visa mer
Transgenics In Vivo model generation team

Hays Life Sciences is now looking to recruit a Scientist Transgenic Model Generation to join the Transgenics In Vivo Model Generation team for a contract assignment until 2023-05-27 at AstraZeneca in Gothenburg.

The Transgenics In Vivo model generation team provides transgenic model generation services to all Therapy Areas within AstraZeneca, and to secure our immediate business needs, we are seeking a motivated In Vivo/In Vitro scientist with experience in In Vivo model generation and validation. We are looking for an individual with preferably both In Vivo skills, animal handling and the expertise in embryonic stem cell culture.

Key responsibilities:
The key responsibilities for this role will be to support the existing team with embryonic stem cell culture, transfection and clone picking. It is desirable if you can assist the team with In Vivo experiments as needed. In this role you will also assist the team in the service of global transport of transgenic lines.

Requirements:

* Embryonic stem cell culturing, including transfection and clone picking
* Demonstrated experience in Rodent studies
* Strong written and oral communication skills sufficient to permit clear and effective exchange of information with people representing a wide diversity of disciplines.

Desirable skills:

* Experience of rodent surgery
* Genotyping of transgenic models Visa mindre
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Scientist: Transgenic model generation at AstraZeneca, Gothenburg

Ansök    Aug 30    Randstad AB    Molekylärbiolog
Job description Scientist: Transgenic model generation The Transgenics In Vivo model generation team provides transgenic model generation services to all Therapy Areas within AstraZeneca, and to secure our immediate business needs, we are seeking a motivated In Vivo/In Vitro scientist with experience in In Vivo model generation and validation. We are looking for an individual with preferably both In Vivo skills, animal handling and the expertise in embryo... Visa mer
Job description
Scientist: Transgenic model generation

The Transgenics In Vivo model generation team provides transgenic model generation services to all Therapy Areas within AstraZeneca, and to secure our immediate business needs, we are seeking a motivated In Vivo/In Vitro scientist with experience in In Vivo model generation and validation. We are looking for an individual with preferably both In Vivo skills, animal handling and the expertise in embryonic stem cell culture.

Responsibilities
The key responsibilities for this role will be to support the existing team with embryonic stem cell culture, transfection and clone picking. It is desirable if you can assist the team with In Vivo experiments as needed. In this role you will also assist the team in the service of global transport of transgenic lines.

Qualifications
Requirements
Embryonic stem cell culturing, including transfection and clone picking
Demonstrated experience in Rodent studies
Strong written and oral communication skills sufficient to permit clear and effective exchange of information with people representing a wide diversity of disciplines.



Desirable skills
Experience of rodent surgery
Genotyping of transgenic models


Application
2022-09-09, welcome with your application at www.randstad.se.
For more information contact: Jimmy Wadie, [email protected] or Malin Fridholm, [email protected]



About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Research Scientist

Ansök    Sep 7    Hays AB    Molekylärbiolog
Target Science Team Hays Life Sciences is now looking to recruit a Research Scientist to join the Target Science Team for a 6-month contract assignment at AstraZeneca. Are you an enthusiastic lab-based scientist looking for a position where your technical expertise can make a difference to patients through experimental evaluation of potential new drug targets? If you are also familiar with immunology or respiratory biology, all the better! Come and jo... Visa mer
Target Science Team

Hays Life Sciences is now looking to recruit a Research Scientist to join the Target Science Team for a 6-month contract assignment at AstraZeneca.

Are you an enthusiastic lab-based scientist looking for a position where your technical expertise can make a difference to patients through experimental evaluation of potential new drug targets? If you are also familiar with immunology or respiratory biology, all the better! Come and join the team that passionately follows the science and puts the patients first.

We have an exciting opportunity for an engaged and passionate scientist to play an important part as a Research Scientist in our Target Science team within Early Respiratory and Immunology (R&I). The position will be placed at AstraZeneca in Gothenburg (Swe). In Target Science we focus on the identification and validation of novel targets and mechanisms addressing key biological disease drivers to enable a precision medicine approach to treating respiratory and immune-driven diseases. We are committed to selecting the right targets for the right patients.

In this role you'll be part of our broader Translational Science and Experimental Medicine (TSEM) organisation. Within TSEM, we are working in an open environment with a strong science focus and our work bridges basic science with clinical development. Our mission is to understand disease mechanisms at the molecular level closing the gap between bench science and bedside clinical practice.

What you will do:
You will join a team of dedicated Target Scientists and have a key role in successfully validating therapeutic target ideas enabling important milestone investment decisions (Target Selection Investment Decision (TSID)). In the everyday work you will:

* Experimentally evaluate new candidate targets resulting from unbiased approaches to target identification including genomics, phenotypic screening, and the application of artificial intelligence and machine learning.
* Validate potential new drug targets by generating high quality experimental data.
* Use and develop disease-relevant experimental model systems to enable experimental validation of new targets.
* Analyse your data and present your conclusions to the team.

Essential in the role:
To take on this role, you need to have good networking and communication skills, with the ability to work efficiently in a team environment where you and your team support each other to deliver. You should also have:

* Academic qualifications at least at postgraduate level or equivalent with a strong experimental drive and background in basic science related to immunology or respiratory research.
* A PhD or otherwise relevant scientific research training and experience is an advantage.
* Industry experience and a good understanding of the drug development process is an advantage.
* Basic understanding of immunology and/or respiratory disease biology, including cell types, molecular pathways, and mechanisms.
* Broad understanding of and the ability to apply state-of-the-art target validation technologies and methodologies along with excellent laboratory skills and the ability to experimentally address key scientific questions.

This is a laboratory-based role, requiring technical expertise and strong organisational skills. Your data will enable effective decision-making and ensure timely prosecution of pre-TSID projects. In this highly collaborative role, you need to have proven track record of scientific and experimental excellence and robust delivery of results. Visa mindre
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Senior Scientist - Protein production & protein biochemistry

Ansök    Aug 23    Hays AB    Molekylärbiolog
Discovery Biology Department Hays Life Sciences is now looking to recruit a Senior Scientist - Protein production & protein biochemistry to join the Discovery Biology Department for a 1-year contract assignment at AstraZeneca in Gothenburg. Are you truly passionate about the magic that happens in the lab and could see yourself applying your protein science knowledge in a successful pharmaceutical company? Would you like to join a team of highly skille... Visa mer
Discovery Biology Department

Hays Life Sciences is now looking to recruit a Senior Scientist - Protein production & protein biochemistry to join the Discovery Biology Department for a 1-year contract assignment at AstraZeneca in Gothenburg.

Are you truly passionate about the magic that happens in the lab and could see yourself applying your protein science knowledge in a successful pharmaceutical company? Would you like to join a team of highly skilled scientists where both your professional and personal skills are valued? If yes, this might be the spot for you!

We have an exciting opportunity for a Senior Scientist with protein science skills to join us, working within a dynamic scientific environment to support drug discovery. The Discovery Biology department within Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in all phases of the drug discovery pipeline. We focus on scientific advances in small molecules, oligonucleotides and other new technologies and drug discovery platforms across our different core areas.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you will do:
You will be responsible for producing and characterizing recombinant proteins including enzymes, secreted proteins, transcription factors and proteins with less characterized functions. These proteins are used to enable drug discovery projects. Since this position is lab based, we expect that you get a lot of energy from being in the lab and have a true real passion for practical duties. We also want you to contribute to our specific field developments in the team.

In the daily work, we rely on you to deliver expertise in recombinant protein production and characterization, of different target class proteins. As well as work in partnership with global colleagues to ensure the delivery of high-quality protein reagents to projects and contribute with novel ideas and using discernment and knowledge where appropriate to influence project progression.

You will regularly work across functional boundaries to define what is needed for discovery projects and lead protein work to deliver to that. With your knowledge in a range of procedures relating to construct design, protein expression and purification of a diverse set of target proteins, you will plan and conduct laboratory projects and experimental strategies, develop methods and technologies, generate, interpret and report scientific data autonomously.

Essential in the role:

* PhD in biochemistry, biology or pharmacology or other a related field, or an MSc degree with significant relevant experience from pharmaceutical or biotechnology industry.
* Expertise and proven knowledge of a wide range of methods and technologies applied to the expression, purification and characterization of a diverse set of target proteins. E.g. construct design and protein engineering, bacterial expression, liquid chromatography, SDS-PAGE, mass spectrometry and biophysical techniques.

To be successful in this role you also need to enjoy collaboration and team work - and have the skill to interact and communicate efficiently across interfaces of global functions and fields in a multi-cultural settings. This goes hand in hand with your problem-solving and critical thinking skills, and strong delivery focus.

Why AstraZeneca in Gothenburg?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centres. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies. We nurture this collaboration and openness, by creating a site that has space for meetings, socialising and relaxation - where spontaneous moments can spark innovation. Visa mindre
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Senior Scientist Translational Genomics InVivo Physiology

Ansök    Aug 29    Hays AB    Molekylärbiolog
In vivo target validation team within the Transgenic Models team Hays Life Sciences is now looking to recruit a Senior Research Scientist - Translational Genomics In Vivo Physiology to join the In Vivo Target Validation team for a contract assignment until 2022-05-01 at AstraZeneca in Gothenburg. The Discovery Sciences, Translational Genomics department is looking for a senior research scientist to be a part of our In vivo target validation team withi... Visa mer
In vivo target validation team within the Transgenic Models team

Hays Life Sciences is now looking to recruit a Senior Research Scientist - Translational Genomics In Vivo Physiology to join the In Vivo Target Validation team for a contract assignment until 2022-05-01 at AstraZeneca in Gothenburg.

The Discovery Sciences, Translational Genomics department is looking for a senior research scientist to be a part of our In vivo target validation team within the Transgenic Models team. The position is based at the AstraZeneca R&D site in Gothenburg, Sweden and we are seeking a scientific and technical specialist in the mouse physiology field. As a successful candidate you are experimentally focused, with strong troubleshooting skills. By planning and performing experiments within the in vivo target validation discipline you will significantly contribute to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards. You will have good social and communication skills, be collaborative and be a strong team player. Candidates should further be able to work independently with a positive, goal oriented and problem-solving attitude. Good organizational skills are required and you should be comfortable in presenting your results. Excellent English is required, both spoken and written.

Specific responsibilities:

* Perform hands-on experiments within the in vivo target validation discipline
* Support the in vivo studies by performing genotyping, qPCR and ELISAs
* Compile, interpret and present data orally and in written reports
* Deliver data according to stipulated time lines and project requirements

Minimum Requirements -Education and Experience

* Ph.D degree or Master degree in a relevant scientific discipline with experience in working with mice and molecular biology techniques

The following skills would be a definite advantage:

* Experience in dosing mice (subcutaneous, intraperitoneal, per oral, intravenous injections)
* Experience in in collecting blood samples from mice
* Experience in metabolic phenotyping in mice
* Experience in behavioural phenotyping in mice Visa mindre
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Senior Research Scientist, Translational Genomics In Vivo

Ansök    Aug 29    Randstad AB    Molekylärbiolog
Job description Senior Research Scientist, Translational Genomics In Vivo Physiology at AstraZeneca The Discovery Sciences, Translational Genomics department is looking for a senior research scientist to be a part of our In vivo target validation team within the Transgenic Models team. The position is based at the AstraZeneca R&D site in Gothenburg, Sweden and we are seeking a scientific and technical specialist in the mouse physiology field.  As a succe... Visa mer
Job description
Senior Research Scientist, Translational Genomics In Vivo Physiology at AstraZeneca
The Discovery Sciences, Translational Genomics department is looking for a senior research scientist to be a part of our In vivo target validation team within the Transgenic Models team. The position is based at the AstraZeneca R&D site in Gothenburg, Sweden and we are seeking a scientific and technical specialist in the mouse physiology field. 


As a successful candidate you are experimentally focused, with strong troubleshooting skills. By planning and performing experiments within the in vivo target validation discipline you will significantly contribute to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards. 


You will have good social and communication skills, be collaborative and be a strong team player. Candidates should further be able to work independently with a positive, goal oriented and problem-solving attitude. Good organizational skills are required and you should be comfortable in presenting your results. Excellent English is required, both spoken and written.


This is a consulting assignment at AstraZeneca with Randstad Life Sciences. Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Responsibilities
Perform hands-on experiments within the in vivo target validation discipline
Support the in vivo studies by performing genotyping, qPCR and ELISAs
Compile, interpret and present data orally and in written reports
Deliver data according to stipulated time lines and project requirements


Qualifications
Minimum Requirements –Education and Experience:
Ph.D degree or Master degree in a relevant scientific discipline with experience in working with mice and molecular biology techniques



The following skills would be a definite advantage:
Experience in dosing mice (subcutaneaous, intraperitoneal, per oral, intraveneous injections)
Experience in in collecting blood samples from mice
Experience in metabolic phenotyping in mice
Experience in behavioural phenotyping in mice



For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2022-09-08, welcome with your application at www.randstad.se.


For more information contact: Jimmy Wadie, [email protected] or Malin Fridholm, [email protected] 

About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
Ansök

Senior Scientist - Protein Production & Protein Biochemistry

Ansök    Jun 20    Hays Specialist Recruitment AB    Molekylärbiolog
Join The Discovery Biology Department Hays Life Sciences is now looking to recruit a Senior Scientist - Protein Production & Protein Biochemistry to join the Discovery Biology Department for a 1-year contract assignment at AstraZeneca in Gothenburg. Are you truly passionate about the magic that happens in the lab and could see yourself applying your protein science knowledge in a successful pharmaceutical company? Would you like to join a team of high... Visa mer
Join The Discovery Biology Department

Hays Life Sciences is now looking to recruit a Senior Scientist - Protein Production & Protein Biochemistry to join the Discovery Biology Department for a 1-year contract assignment at AstraZeneca in Gothenburg.

Are you truly passionate about the magic that happens in the lab and could see yourself applying your protein science knowledge in a successful pharmaceutical company? Would you like to join a team of highly skilled scientists where both your professional and personal skills are valued? If yes, this might be the spot for you!

We have an exciting opportunity for a Senior Scientist with protein science skills to join us, working within a dynamic scientific environment to support drug discovery. The Discovery Biology department within Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in all phases of the drug discovery pipeline. We focus on scientific advances in small molecules, oligonucleotides and other new technologies and drug discovery platforms across our different core areas.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you will do:
You will be responsible for producing and characterizing recombinant proteins including enzymes, secreted proteins, transcription factors and proteins with less characterized functions. These proteins are used to enable drug discovery projects. Since this position is lab based, we expect that you get a lot of energy from being in the lab and have a true real passion for practical duties. We also want you to contribute to our specific field developments in the team.

In the daily work, we rely on you to deliver expertise in recombinant protein production and characterization, of different target class proteins. As well as work in partnership with global colleagues to ensure the delivery of high-quality protein reagents to projects and contribute with novel ideas and using discernment and knowledge where appropriate to influence project progression.

You will regularly work across functional boundaries to define what is needed for discovery projects and lead protein work to deliver to that. With your knowledge in a range of procedures relating to construct design, protein expression and purification of a diverse set of target proteins, you will plan and conduct laboratory projects and experimental strategies, develop methods and technologies, generate, interpret and report scientific data autonomously.

Essential in the role:

* PhD in biochemistry, biology or pharmacology or other a related field, or an MSc degree with significant relevant experience from pharmaceutical or biotechnology industry.
* Expertise and proven knowledge of a wide range of methods and technologies applied to the expression, purification and characterization of a diverse set of target proteins. E.g. construct design and protein engineering, bacterial expression, liquid chromatography, SDS-PAGE, mass spectrometry and biophysical techniques.

To be successful in this role you also need to enjoy collaboration and team work - and have the skill to interact and communicate efficiently across interfaces of global functions and fields in a multi-cultural settings. This goes hand in hand with your problem-solving and critical thinking skills, and strong delivery focus.

Why AstraZeneca in Gothenburg?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centres. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies. We nurture this collaboration and openness, by creating a site that has space for meetings, socialising and relaxation - where spontaneous moments can spark innovation. Visa mindre
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Scientist, Bioscience In Vivo

Ansök    Jun 7    Hays Specialist Recruitment AB    Molekylärbiolog
Early R&I Research and Early Development, Bioscience In Vivo Hays Life Sciences is now looking to recruit a Scientist to join the Early R&I Research and Early Development, Bioscience In Vivo team for a contract assignment until 2022-12-23 with the possibility for an extension at AstraZeneca in Gothenburg. Job description Are you an experienced scientist ready to apply your skills in a diverse and dynamic organization? If you can envision providing sc... Visa mer
Early R&I Research and Early Development, Bioscience In Vivo

Hays Life Sciences is now looking to recruit a Scientist to join the Early R&I Research and Early Development, Bioscience In Vivo team for a contract assignment until 2022-12-23 with the possibility for an extension at AstraZeneca in Gothenburg.

Job description
Are you an experienced scientist ready to apply your skills in a diverse and dynamic organization? If you can envision providing scientific expertise in a role that can impact patients' lives - join us now!
At AstraZeneca, we believe in the potential of our people and you'll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.

We are now looking for an In Vivo Scientist with excellent laboratory skills and a drive for innovation to join the Bioscience in vivo department within the Early Respiratory and Immunology (eR&I) R&D unit located in Gothenburg, Sweden.

Respiratory and immunology are two of AstraZeneca's main therapy areas. From a research perspective we work to understand, treat, modify and ultimately cure respiratory disease with an emphasis on four respiratory diseases with significant unmet medical need; asthma, COPD, Idiopathic Pulmonary Fibrosis (IPF) and Chronic Cough. In addition, we also focus on immunology-driven disease areas including rheumatology, dermatology, gastrointestinal and inflammatory diseases driven by eosinophilic immune dysfunction.

The successful candidate will join a highly motivated team that works closely together with other departments focusing on target identification, drug formulation, translational science, in vitro assay development and drug metabolism/pharmacokinetics to support discovery projects and to drive new exciting research. Are you ready to join us?

What you'll do
As a vital member of the in vivo team you will contribute to progress our drug discovery projects. Your role will be mainly lab-based in which you will be actively involved and responsible to coordinate and perform in vivo experiments. While we expect you to be independent we are also looking for someone that thrives in a team setting and contributes to the success of others.

Essential for the role

* B.Sc. or M.Sc. degree in relevant subjects or equivalent level of understanding developed through experience in drug discovery or early development
* Excellent technical and experimental In vivo experience and skills, including rodent handling, drug administration and collection of biological samples. Ability to coordinate and perform respiratory disease and mechanistic models.
* Valid certificates to work with live animals in Sweden
* Be respectful, communicate openly and show effective collaborative behavior to obtain high quality study results
* Excellent written and oral communication skills in English.
* Excellent organization skills
* Ability to incorporate the views of others in your communication
* Maintain the highest standards of animal welfare and ethical compliance and ensure integrity of generated data. Familiar with using Good Statistical Practice in animal research and applying the 3R's (reduction, refinement and replacement) across the full range of studies
* Good generic computer proficiency including Microsoft Office.

Desirable for the role

* Experience in basic cellular and molecular biology techniques (e.g. ELISA, western blot, FACS, Meso Scale Discovery (MSD) technology platform), and RNA (qRT-PCR, RNASeq)
* Ability to interpret and analyze generated data
* Good written and oral communication skills in Swedish and experience in writing ethical applications for animal work in Sweden
* Good understanding of pharmacology, physiology, immunology, respiratory diseases (COPD, asthma, cough, IPF) and PKPD relationships

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey.
So, what's next!
Are you already imagining yourself joining our team? Good, because we can't wait to hear from you. Visa mindre
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Senior Scientist - NGS for High-Throughput Transcriptomics

Ansök    Aug 22    Randstad AB    Molekylärbiolog
Job description Are you an experienced Molecular Biologist with expertise in Next Generation Sequencing (NGS)? Do you wish to apply this knowledge in a role that is connected to our wider mission to show what science can do? If yes, we might have the role for you! We seek a talented and highly engaged Molecular Biology/NGS scientist to join the Disease Molecular Profiling - NGS & Transcriptomics team at AstraZeneca in Gothenburg, Sweden. You will contri... Visa mer
Job description
Are you an experienced Molecular Biologist with expertise in Next Generation Sequencing (NGS)? Do you wish to apply this knowledge in a role that is connected to our wider mission to show what science can do? If yes, we might have the role for you!


We seek a talented and highly engaged Molecular Biology/NGS scientist to join the Disease Molecular Profiling - NGS & Transcriptomics team at AstraZeneca in Gothenburg, Sweden. You will contribute with applying molecular biology and NGS expertise to our drug discovery portfolio and working on cutting edge technologies within the field.



Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Responsibilities
Work collaboratively with scientists from our team, different therapy areas, and computational biology to apply genomic technologies to further drug discovery.
Develop, evaluate, or implement customized NGS workflows for specific drug discovery projects.
Plan, design, run, enhance and troubleshoot existing NGS workflows such as bulk RNA-seq (e.g. mRNA-seq, totRNA-seq, ultra low-input) and high-throughput transcriptomics (e.g. 384-well-based methods).
Understand and interpret data analyzed by computational biology colleagues and communicate it effectively to project partners and stakeholders.
Keep records of all lab and technology development work and write technical reports and SOPs.
Effectively manage timelines and deliver projects according to deadlines.


Qualifications
Essential for the role:


Ph.D. degree or MSc with experience in Molecular Biology, Biotechnology, Biomedicine or in a relevant scientific discipline.
Hands-on lab-based experience in utilizing advanced molecular biology RNA-sequencing, DNA-sequencing or Epigenetic sequencing techniques.
This experience will cover all relevant aspects from hypothesis generation, through experimental design and execution, RNA and DNA extraction, sample and library preparation, sequencing (ideally with Illumina or Nanopore), data handling, post-sequencing QC and troubleshooting.
Scientifically-driven scientist with attention to details and excellent critical thinking skills.



Desirable for the role:


Background in applying a broad range of wet-lab techniques, such as mammalian cell-culture, high-throughput in-vitro drug testing, qPCR or automated liquid handling.
Working with laboratory automation / liquid handling systems, method and technology development and optimization.
Hands-on experience with Single Cell Transcriptomics or Spatial Transcriptomics.
Tissue dissection, single cell dissociation, microscopy, flow cytometry/FACS
Hands-on laboratory experience running NGS platforms (Illumina, Oxford Nanopore etc).
Sample Tracking by LIMS systems.



For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2022-09-01, welcome with your application at www.randstad.se.


For more information contact: Malin Fridholm, [email protected] or Maria del Carmen Leiva Arrabal, [email protected].

About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Senior Scientist Pharmacology

Ansök    Maj 9    Hays Specialist Recruitment AB    Molekylärbiolog
Bioscience In Vivo Department Hays Life Sciences is now looking to recruit a Senior Scientist Pharmacology to join the Bioscience In Vivo Department for a contract assignment beginning 2022-08-15 until 2022-12-21 with a possibility of an extension at AstraZeneca in Gothenburg. Are you an experienced Scientist ready to apply your skills in a diverse and dynamic company? If your passion is science and you want to be part of a team that makes a bigger im... Visa mer
Bioscience In Vivo Department

Hays Life Sciences is now looking to recruit a Senior Scientist Pharmacology to join the Bioscience In Vivo Department for a contract assignment beginning 2022-08-15 until 2022-12-21 with a possibility of an extension at AstraZeneca in Gothenburg.

Are you an experienced Scientist ready to apply your skills in a diverse and dynamic company? If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be.

At AstraZeneca, we believe in the potential of our people and make the most of your skills and passion. Respiratory & Immunology is one of AstraZeneca's main therapy areas. From a research perspective we work to understand, treat, modify and ultimately cure respiratory and autoimmune diseases such as asthma, COPD, IPF, IBD, RA and SLE.

We are looking to onboard an experienced histologist with background in image analysis and ideally some pathological assessment. A successful applicant would need to have a drive for innovation and idea generation as well as excellent laboratory skills to join the Bioscience In Vivo Department within the Early Respiratory and Immunology R&D unit located in Gothenburg, Sweden.

The successful candidate will join a highly motivated team that works closely together with other departments focusing on Target Translational Science, Bioscience In vitro assays and Drug Metabolism/Pharmacokinetics to support discovery projects and to drive new exciting research. Are you ready to join us?

What you'll do
Contribute as a vital member of the department and in various working teams to progress our respiratory and immunological drug discovery projects. You will actively take part in scientific discussions, gain input from others and be involved in multiple project meetings to present and discuss experimental plans and data.

This is a partly lab-based role where you will be actively involved in experimental phase of histological analyses, with responsibility to coordinate, perform and evaluate experiments as well as drive the establishment of new techniques. Characterization and validation of target expression and subsequent evaluation of engagement of the target by drug treatment in both patient and in vivo tissue samples will be the key areas of your daily work. You will independently assess and report data with a clear understanding of its reliability, interpretation of findings and draw appropriate conclusions with input from others.

We are looking for a team player with strong background in histology and related image analysis techniques, ideally complemented by some experience in pathology and preclinical drug discovery processes.

Essential for the role

* PhD in a relevant discipline (area of Bioscience) ideally complemented by experience of working in a drug discovery environment or molecular pathology laboratory
* Strong experimental histology skills in performing immunohistochemistry, histochemistry and in situ hybridization (RNAscope)
* Knowledge in histology scoring and histomorphometry
* Proven knowledge and experience in image analysis using commercial software solutions
* To conduct where appropriate in parallel more than one area of work to agreed timelines
* Be respectful, communicate openly and show effective collaborative behavior to obtain high quality study results
* Excellent written and oral communication skills, including presentation skills. You are organized and incorporate the views of others in your communication and collaboration

Desirable for the role

* Respiratory and immunology disease knowledge, including target and mechanism knowledge and basic understanding of pharmacokinetics
* Some experience in pathology
* Understanding and experience with molecular biology
* Independent experimental design, including understanding of statistical methods, quality control and data reporting/archiving
* Good understanding of pharmacology, physiology and immunology

Why AstraZeneca?
At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development. Visa mindre
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Scientist - Early Product Development and Manufacturing

Ansök    Maj 9    Hays Specialist Recruitment AB    Molekylärbiolog
Early Product Development and Manufacturing (EPDM) team Hays Life Sciences in now looking to recruit 2 Scientists to join the Early Product Development and Manufacturing (EPDM) team for 6-month contract assignments with a chance of extension at AstraZeneca in Gothenburg. At AstraZeneca, we unlock the power of What Science Can Do. Empowered to explore, every day we work towards our ultimate aim - treating, preventing, modifying and even curing complex ... Visa mer
Early Product Development and Manufacturing (EPDM) team

Hays Life Sciences in now looking to recruit 2 Scientists to join the Early Product Development and Manufacturing (EPDM) team for 6-month contract assignments with a chance of extension at AstraZeneca in Gothenburg.

At AstraZeneca, we unlock the power of What Science Can Do. Empowered to explore, every day we work towards our ultimate aim - treating, preventing, modifying and even curing complex diseases. Be part of the team where you are empowered to follow the science!

The arena
Pharmaceutical Sciences (PharmSci) is accountable for the design and development of synthetic routes, preclinical and phase I/II formulations, encompassing both small molecules and new modalities such as mRNA and oligonucleotides, across the whole range of AstraZeneca's therapeutic areas.

Within Early Product Development and Manufacture (EPDM) in Gothenburg, Sweden, the manufacturing teams are accountable for delivery of clinical trial material for a vast project portfolio. We have a wide range of manufacturing assets in three separate facilities, supplying different types of products and dosage forms to studies across the globe.

The role
Within the EPDM manufacturing teams, in the GMP (Good Manufacturing Practice) arena, you will make an important contribution in delivering clinical results in the development of new medicines. This role revolves around the manufacturing of drug product where all activities below will have a significant impact on the speed, quality and cost of the AZ development portfolio.

We expect the successful candidate to:

* Assume responsibilities toward timely manufacture of various drug products in line with the plans agreed within EPDM and surrounding stakeholders.
* Work with practical hands-on processes in our GMP facilities following manufacturing batch records and perform transactions in material management systems.
* Rapidly develop strong competence within relevant process technologies and build credibility and ability to work independently with a high degree of autonomy.
* Support documentation activities, e.g. by authoring manufacturing batch records, taking part in deviation investigations, authoring SOPs, and other guidance documents, change control processes etc.
* Monitor, secure and follow up on other regulatory requirements according to GMP through associated IT-systems.
* Assess records and report manufacturing and validation data accurately according to GMP.
* Ensure that SHE (Safety, Health and Environment) and GMP standards are upheld and ensure AZ Policies and Standards are understood and followed.
* Be entrepreneurial and drive initiatives to further improve flexibility and productivity, resulting in shorter lead times or increased value for our customers and patients.

In joining the EPDM and PharmSci, you will be part of an amazing group of skilled and driven colleagues who truly embrace team spirit, who you will exchange knowledge and collaborate with on many levels in various contexts. This provides excellent opportunities for your professional development, and possibilities to take on further accountabilities in line with your personal growth.

Experience/requirements
MSc in pharmacy/engineering and/or extensive GMP-manufacturing experience from the pharmaceutical industry is essential for this role. Hands on experience with pharmaceutical manufacturing equipment, automation, complex production lines (e.g. continuous) are merits.

We are looking for a Scientist with excellent collaboration, communication, and planning skills with a strong sense of responsibility, team work and delivery focus.

Strong verbal and documentation skills in English is a requirement. We expect you to have a keen interest to learn and operate both simple and complex manufacturing equipment and develop your expertise in pharmaceutical process technology. Visa mindre
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Senior Scientist, In Vivo Cardiovascular Biology

Ansök    Maj 31    Hays Specialist Recruitment AB    Molekylärbiolog
In Vivo Cardiovascular Biology Hays Life Sciences is now looking to recruit a Senior Scientist for In Vivo Cardiovascular Biology for a 12-month contract assignment at AstraZeneca in Gothenburg. Senior Scientist, In Vivo Cardiovascular Biology, is a lab-based role where you will explore novel drug targets and support existing projects with key in vivo and ex vivo data. Collaboration is critical for successful delivery of drug projects and you will wor... Visa mer
In Vivo Cardiovascular Biology

Hays Life Sciences is now looking to recruit a Senior Scientist for In Vivo Cardiovascular Biology for a 12-month contract assignment at AstraZeneca in Gothenburg.

Senior Scientist, In Vivo Cardiovascular Biology, is a lab-based role where you will explore novel drug targets and support existing projects with key in vivo and ex vivo data. Collaboration is critical for successful delivery of drug projects and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators. Your in vivo work will include experimental work in small animals to broaden the pharmacodynamic and pharmacokinetic understanding of our new drug candidates as well as cardiovascular disease. You will have the opportunity to explore novel techniques and ideas required for progressing existing portfolio and novel science. Some in vitro work can also be part of the role description.

Responsibilities include:

* Independently design, develop, and run experiments as well as analyse results, interpret data and report in vivo studies and ex vivo assays for projects from pre-target identification to clinical stage
* Communicate data and scientific findings at internal and external meetings and through publications in scientific journals
* Proactively contribute to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared

Essential for the role

* Master or PhD in biology, pharmacology, cardiovascular biology or similar
* Hands-on experience and expertise in handling mice and rats and performing in vivo experiments accordingly
* Entrepreneurial, collaborative and flexible ways of working
* Strong oral and written communication skills
* Excellent English, both spoken and in writing

Desirable for the role

* Scientific background in any of the following fields: cardiovascular disease, heart failure, cardiac regenerative medicine, cardiac metabolism, genetic cardiomyopathies
* Experience with performing open chest surgeries , such as myocardial infarction and intramyocardial injections
* Knowledge and experience in ultrasound imaging and/or MRI imaging
* Background in drug discovery and development in the pharmaceutical industry Visa mindre
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Senior Scientist Protein Production and Protein Biochemistry

Ansök    Feb 22    Hays Specialist Recruitment AB    Molekylärbiolog
Discovery Biology Department Hays Life Sciences is now looking to recruit a Senior Scientist Protein Production and Protein Biochemistry to join the Discovery Biology Department for 1-year contract assignment at AstraZeneca in Gothenburg. Are you truly passionate about the magic that happens in the lab? Could you see yourself applying your protein science knowledge in a successful pharmaceutical company? Would you like to join a team of highly skilled... Visa mer
Discovery Biology Department

Hays Life Sciences is now looking to recruit a Senior Scientist Protein Production and Protein Biochemistry to join the Discovery Biology Department for 1-year contract assignment at AstraZeneca in Gothenburg.

Are you truly passionate about the magic that happens in the lab? Could you see yourself applying your protein science knowledge in a successful pharmaceutical company? Would you like to join a team of highly skilled scientists where both your professional and personal skills are valued?
We have an exciting opportunity for you to join us working within a dynamic scientific environment to support drug discovery. The Discovery Biology department within Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in all phases of the drug discovery pipeline. We focus on scientific advances in small molecules, oligonucleotides and other new technologies and drug discovery platforms across our different core areas.

Our stunning campus in Gothenburg is one of AstraZeneca's three strategic science centres. The site is home to several thousand employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide variety of professionals. Our science teams in Gothenburg collaborate with academic and industry partners in Sweden and globally. And the site itself is designed with collaboration in mind. From the Coffee Lab to exercise areas, we've built a series of environments where innovation can happen.

Main Duties and Responsibilities
You will be responsible for producing and characterizing recombinant precise genome editing enzymes and to characterize for different applications to enable drug discovery. These proteins are used to enable new exciting modalities such as cell therapy and precise genome editing. Since this position is lab based, we expect that you have a true real passion for practical duties.

We will rely on you to:

* Deliver expertise in recombinant protein expression purification and characterization
* Work in partnership with colleagues in a cross functional setting to ensure the delivery of high-quality protein reagents to projects
* Contribute with novel ideas and using discernment and knowledge where appropriate to influence the work of the project
* Maintain an awareness of current developments in the literature and contribute to the continuous improvement process
* Achieve personal as well as company scientific visibility through project contributions, presentations, publications and poster & oral conference presentations

Essential Requirements

* MSc degree with significant experience from pharmaceutical or biotechnology industry or PhD in Biology, Pharmacology, Biochemistry or other a related discipline
* Expertise in Protein Science through a demonstrable knowledge of construct design, molecular biology, protein expression, purification, characterization and structure function
* Proven knowledge of a wide range of methods and technologies applied to the expression, purification as well as characterization of recombinant proteins. E.g. bacterial expression, liquid chromatography, SDS-PAGE, mass spectrometry and biophysical techniques
* Excellent analytical skills, good scientific judgement and communication skills
* Excellent team working and networking skills with experience of interacting effectively in multi-disciplinary and cultural settings

Desirable Requirements

* Experience of producing and characterising nucleic acid binding proteins Visa mindre
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(Senior) Research Scientist - Molecular and Cell Biology

Ansök    Maj 9    Hays Specialist Recruitment AB    Molekylärbiolog
Cell and Molecular Pharmacology (CMP) team Hays Life Sciences is now looking to recruit a Senior Research Scientist - Molecular and Cell Biology to join the Cell and Molecular Pharmacology (CMP) team for a 1-year contract assignment at AstraZeneca in Gothenburg. Do you have a background in biochemistry or cell biology, aren't afraid of trying new paths and doing things differently? Do you also feel passionate about the possibilities of science to chan... Visa mer
Cell and Molecular Pharmacology (CMP) team

Hays Life Sciences is now looking to recruit a Senior Research Scientist - Molecular and Cell Biology to join the Cell and Molecular Pharmacology (CMP) team for a 1-year contract assignment at AstraZeneca in Gothenburg.

Do you have a background in biochemistry or cell biology, aren't afraid of trying new paths and doing things differently? Do you also feel passionate about the possibilities of science to change lives? Perfect, your next challenge might be this role at AstraZeneca!

A position has arisen for a highly motivated (Senior) Research Scientist - Molecular and Cell Biology to join the Cell and Molecular Pharmacology (CMP) team within the Early Cardiovascular, Renal and Metabolic (CVRM) disease area in Gothenburg, Sweden.

Early CVRM is one of three main therapeutic research areas within AstraZeneca that deliver candidate drugs into late-stage clinical development. The CMP team delivers key data based on histology, imaging, biomarker, FACS and bioassay automation to support projects across the Cardiovascular, Renal and Metabolism disease areas.

The role is lab-based, providing dedicated experimental support to our drug discovery programs. The successful candidate will deliver high-quality molecular biology data to build a detailed understanding of pharmacological response and mode of action for small molecules, PROTACs and ASOs. The work includes independent planning and execution of experiments, troubleshooting and timely reporting/presentation of data according to agreed timelines.

Essential Requirements:

* BSc/MSc degree in Molecular Biology, Biomedical, Pharmacology, Biochemistry or a related discipline with significant practical experience.
* Extensive experience in molecular and cellular biology techniques including protein and gene expression analysis, Western Blot, qPCR and cell culture. Ideally applied to relevant cellular assays and in vivo samples.
* Excellent communication skills and an ability to operate in a multi-disciplinary research environment.
* Independent analysis and evaluation of complex data and delivery of data to agreed timelines.

Desirable Experiences and Abilities:

* Experience within Cardiovascular, Renal and/or Metabolic disease areas.
* Expertise in the design, development and validation of assays for compound profiling.
* Experience in flow cytometry.
* Experience working with PROTACs and/or antisense oligonucleotides (ASOs) in Mode of Action studies and pharmacological profiling.
* Proven ability in providing technical leadership and guidance to others.
* Scientific visibility and leadership through project contributions and scientific publications.

The successful candidate demonstrates a passion for driving scientific questions through experimental work, combined with strong team working ethics. You have good social and communication skills, is collaborative and a great team player. You should also be able to work independently and have a positive, goal oriented and problem-solving attitude. Excellent English is required, both spoken and written, and good organizational skills are of use. Visa mindre
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Senior Scientist, In Vivo Cardiovascular Biology

Ansök    Feb 21    Hays Specialist Recruitment AB    Molekylärbiolog
Senior Scientist, In Vivo Cardiovascular Biology Hays Life Sciences is now looking to recruit a Scientist/ Senior Scientist, In Vivo Cardiovascular Biology for a 1-year contract assignment at AstraZeneca in Gothenburg. Senior Scientist, In Vivo Cardiovascular Biology, is a lab-based role where you will explore novel drug targets and support existing projects with key in vivo and ex vivo data. Collaboration is critical for successful delivery of drug p... Visa mer
Senior Scientist, In Vivo Cardiovascular Biology

Hays Life Sciences is now looking to recruit a Scientist/ Senior Scientist, In Vivo Cardiovascular Biology for a 1-year contract assignment at AstraZeneca in Gothenburg.

Senior Scientist, In Vivo Cardiovascular Biology, is a lab-based role where you will explore novel drug targets and support existing projects with key in vivo and ex vivo data. Collaboration is critical for successful delivery of drug projects and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators. Your in-vivo work will include experimental work in small animals to broaden the pharmacodynamic and pharmacokinetic understanding of our new drug candidates as well as cardiovascular disease. You will have the opportunity to explore novel techniques and ideas required for progressing existing portfolio and novel science. Some in vitro work can also be part of the role description.

Responsibilities include:

* Independently design, develop, and run experiments as well as analyse results, interpret data and report in vivo studies and ex vivo assays for projects from pre-target identification to clinical stage
* Communicate data and scientific findings at internal and external meetings and through publications in scientific journals
* Proactively contribute to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared

Essential for the role

* Bachelor Degree, Master or PhD in biology, pharmacology, cardiovascular biology or similar
* Hands-on experience and expertise in handling mice and rats and performing in vivo experiments accordingly
* Entrepreneurial, collaborative and flexible ways of working
* Strong oral and written communication skills
* Excellent English, both spoken and in writing

Desirable for the role

* Scientific background in any of the following fields: cardiovascular disease, heart failure, cardiac regenerative medicine, cardiac metabolism, genetic cardiomyopathies
* Experience with performing open chest surgeries , such as myocardial infarction and intramyocardial injections
* Knowledge and experience in ultrasound imaging and/or MRI imaging
* Background in drug discovery and development in the pharmaceutical industry Visa mindre
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Senior Research Scientist - In vitro cardiac disease modelling

Ansök    Feb 7    Hays Specialist Recruitment AB    Molekylärbiolog
Translational Genomics team Hays Life Sciences is now looking to recruit a Senior Research Scientist - In vitro cardiac disease modelling to join the Translational Genomics team for a 1-year contract assignment at AstraZeneca in Gothenburg. Are you an experienced scientist in the field of stem cells and gene editing? Would you like to contribute to the development of novel therapies? This might be the next challenge for you! At AstraZeneca in Go... Visa mer
Translational Genomics team

Hays Life Sciences is now looking to recruit a Senior Research Scientist - In vitro cardiac disease modelling to join the Translational Genomics team for a 1-year contract assignment at AstraZeneca in Gothenburg.

Are you an experienced scientist in the field of stem cells and gene editing? Would you like to contribute to the development of novel therapies?

This might be the next challenge for you!

At AstraZeneca in Gothenburg, Sweden we have an exciting opportunity for you to join us in Applied Stem Cell Sciences group in Translational Genomics, Discovery Sciences, Biopharmaceuticals R&D, as a bench-based Senior Research Scientist to be a key player in developing therapeutics to change patients' lives.

The role
You will be based in Gothenburg Sweden, working alongside our stem cell scientists, disease area specialists and genome editing group. Using your strong knowledge and experience in stem cell biology, cell model development and CRISPR technology you will have the opportunity to work on in vitro aspects of therapeutic genome editing projects. This includes culture, genome-engineering and differentiation of induced pluripotent stem cells (iPSCs) and genetic and functional validation of engineered lines.

The role is focused on laboratory-based activities. Your biggest impact will be through significant contributions to the practical delivery to projects in compliance with AstraZeneca corporate responsibility, policies and relevant safety standards.

It is essential to have good social and communication skills, be collaborative and a strong team player. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude.

Good organizational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Key Responsibilities:

* Culture and differentiation of human iPSC lines to cardiac and skeletal muscle
* Perform molecular biology, biochemical, and cellular assays to evaluate the outcomes of gene editing experiments on genomic DNA, mRNA, protein, and functional levels.
* Culture of human primary cells and various mammalian cell lines.
* Effectively collaborate within a matrixed research team to facilitate the success of projects.
* Maintain complete experimental records.

Minimum Requirements:

* PhD in Developmental Biology, Cell Biology, Gene Editing or a BSc/MSc degree with significant experience
* Proven experience with PSC biology and directed-differentiation to cardiac and/or skeletal muscle
* Demonstrable experience with cell line engineering using CRISPR/CAS9
* Design, develop, and optimize in vitro transfection/transduction experiments using a variety of perturbagens, including lentivirus/AAV-mediated infection
* Hands-on experience with the following assay platforms: RT-qPCR, ddPCR, Flow Cytometry, ELISA, Western blots, and cellular functional assays
* Experience with the culture of multiple mammalian cell types including primary cells
* Excellent communication skills with ability to build open and collaborative relationships and work effectively as a member of a multidisciplinary team
* Excellent organizational skills and documentation practices

The following skills are highly desirable:

* Experience with NGS library prep, bioinformatic analysis, and cutting-edge molecular biology methods
* Expertise with liquid handling automation technologies
* Experience of setting up cell based pharmacological assays Visa mindre
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Senior Scientist Translational Genomics In Vivo Physiology

Ansök    Feb 16    Hays Specialist Recruitment AB    Molekylärbiolog
Translational Genomics team Hays Life Sciences is now looking to recruit a Senior Research Scientist, Translational Genomics In Vivo Physiology to join the Translational Genomics team for a contract assignment until 2022-12-31 at AstraZeneca in Gothenburg. The Discovery Sciences, Translational Genomics department is looking for a senior research scientist to be a part of our In vivo target validation team within the Transgenic Models team. The positio... Visa mer
Translational Genomics team

Hays Life Sciences is now looking to recruit a Senior Research Scientist, Translational Genomics In Vivo Physiology to join the Translational Genomics team for a contract assignment until 2022-12-31 at AstraZeneca in Gothenburg.

The Discovery Sciences, Translational Genomics department is looking for a senior research scientist to be a part of our In vivo target validation team within the Transgenic Models team. The position is based at the AstraZeneca R&D site in Gothenburg, Sweden and we are seeking a scientific and technical specialist in the animal in vivo physiology field. As a successful candidate you are experimentally focused, with strong troubleshooting skills and adept at putting ideas into practice. By planning and performing animal experiments you will significantly contribute to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards. You will have good social and communication skills, be collaborative and be a strong team player. Candidates should further be able to work independently with a positive, goal oriented and problem-solving attitude. Good organizational skills are required and you should be comfortable in presenting your results. Excellent English is required, both spoken and written.

Specific responsibilities

* Perform hands-on experiments within the in vivo target validation discipline, using metabolic, cardiac and behavioural platforms to support all core disease areas
* Ensure that studies are conducted with high quality, dedication and data delivered according to stipulated time lines and project requirements
* Compile, interpret, present and discuss data with the key project teams

The following skills would be a definite advantage:

* Experience in metabolic phenotyping platforms and analysis of metabolic function in mice, for example indirect calorimetry, DEXA and oral glucose tolerance tests (OGTT)
* Experience in assessing heart function in mice by using for example ECG, ultrasound and blood pressure measurements
* Experience in behavioural phenotyping in mice
* Experience in stereotactic brain injections in mice

Minimum Requirements -Education and Experience

* Ph.D degree or corresponding experience in a relevant scientific discipline with expertise in phenotyping mice or, alternatively, a first degree and significant relevant experience in phenotyping mice Visa mindre
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Senior Research Scientist, Bioscience In Vivo

Ansök    Jan 31    Hays Specialist Recruitment AB    Molekylärbiolog
Bioscience In Vivo Hays Life Sciences is now looking to recruit a Senior Research Scientist to join the Bioscience In Vivo team for a 4-month contract assignment at AstraZeneca in Gothenburg. AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires ... Visa mer
Bioscience In Vivo

Hays Life Sciences is now looking to recruit a Senior Research Scientist to join the Bioscience In Vivo team for a 4-month contract assignment at AstraZeneca in Gothenburg.

AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity

Respiratory & Immunology is one of AstraZeneca's main therapy areas. From a research perspective we work to understand, treat, modify and ultimately cure respiratory and autoimmune diseases with an emphasis on diseases with significant unmet medical need, such as asthma, COPD, Idiopathic Pulmonary Fibrosis (IPF), Chronic Cough and autoimmune diseases (systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), rheumatoid arthritis (RA)).

To further strengthen our expertise and capacity we are looking for a strong scientist with a great drive for innovation and idea generation as well as excellent laboratory skills to join the Bioscience In vivo Department within the Early Respiratory and Immunology R&D unit located in Gothenburg, Sweden. The team works closely together with other departments focusing on Target Translational Science, Bioscience In vitro assays and Drug Metabolism/Pharmacokinetics to support drug discovery projects and to drive new exciting research. Are you ready to join us?

Key Duties and Responsibilities
As part of the team you will plan and execute in vitro experiments to progress our drug discovery projects and generate publishable scientific insights. You will actively take part in scientific discussions to add valuable input in experimental design and data interpretation.

This is a mainly lab-based role where you will be involved in ongoing projects focusing on pre-clinical experiments, with responsibility to design, perform and analyse in vitro experiments as well as presenting and discussing data and scientific rationales. We are looking for someone with experience in in vitro skills in cellular and molecular biology techniques.

Accountabilities

* You will be an effective and innovative team member in supporting drug discovery projects to meet their objectives
* To conduct where appropriate in parallel more than one area of work to agreed timelines
* You will be responsible for maintaining the highest standards of data integrity
* You will work alongside committed scientists and perform hands-on in vitro work
* You will be responsible for the analysis of mediators in several matrixes from in vivo studies
* You will contribute to the evaluation and interpretation of primary data and write reports, summaries and present in meetings

Essential requirements

* PhD in a relevant discipline (area of Bioscience) or MSc complemented with an extensive proven track record of in vitro work
* Experience and ability to independently plan, execute, analyze and interpret results from various cellular and molecular biology techniques, such as for the measurement of protein expression and activation (including FACS analysis, protein isolation from tissues, ELISA, Meso Scale Discovery (MSD) technology platform) and RNA analysis (extraction, qRT-PCR).
* Familiarity with column-based cell isolation techniques (such as MACS, Stem Cell technology)
* Basic understanding of pharmacology, physiology and immunology
* Understanding of statistical methods, quality control and data reporting/archiving
* Problem-solving skills related to in vitro research and data analysis
* Good written and oral communication skills in English
* Positive and goal-oriented attitude
* Good social and communication skills and strong team player incorporating the views of others
* Good organisational skills

Desirable requirements

* A proven track record of demonstrating a well-organized customer focused approach, preferably gained within a drug discovery environment.
* Experience on pre-clinical work within autoimmune diseases such as IBD, RA and SLE, and respiratory disease knowledge, including target and mechanistic comprehension of COPD, asthma, cough, IPF, tissue regeneration. Visa mindre
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Senior / Research Scientist - NGS and Molecular Biology

Ansök    Jan 11    Hays Specialist Recruitment AB    Molekylärbiolog
Applied Stem Cell Sciences in Discovery Sciences team Hays Life Sciences is now looking to recruit a Research Scientist / Senior Research Scientist - NGS and Molecular Biology to join the Applied Stem Cell Sciences in Discovery Sciences team for a 9-month contract assignment at AstraZeneca in Gothenburg. Are you an experienced scientist in the field of NGS applications and molecular biology? Would you like to use your scientific skills to support deve... Visa mer
Applied Stem Cell Sciences in Discovery Sciences team

Hays Life Sciences is now looking to recruit a Research Scientist / Senior Research Scientist - NGS and Molecular Biology to join the Applied Stem Cell Sciences in Discovery Sciences team for a 9-month contract assignment at AstraZeneca in Gothenburg.

Are you an experienced scientist in the field of NGS applications and molecular biology? Would you like to use your scientific skills to support development of new therapeutics? This might be the next challenge for you!

At AstraZeneca in Gothenburg, Sweden we have an exciting opportunity for you to join us in the Applied Stem Cell Sciences in Discovery Sciences, Biopharmaceuticals R&D, as a bench-based Research Scientist to support NGS applications across multiple projects.

The role
You will be based in Gothenburg Sweden, working alongside our stem cell scientists, disease area specialists and genome editing groups. The role is focused on laboratory-based activities. Your biggest impact will be through significant contributions to the practical delivery to projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards.

It is essential to have good social and communication skills, be collaborative and a strong team player. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude.

Good organizational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Primary Responsibilities

* Develop and troubleshoot protocols using molecular biology techniques including RT-PCR, cDNA generation, qPCR, primer design, and ddPCR.
* Execute sequencing of large number of samples
* Assist with the development of new sequencing and molecular biology approaches from bulk and single cells
* Document and summarize results that are clear and actionable
* Required Skills & Experience
* Recent M. S. or B. S. in Molecular Biology with 2+ years of relevant experience in a research or industry position
* Strong experience with molecular biology techniques: PCR, RT-PCR and NGS library preparation including RNA-seq and DNA-seq
* Use of molecular biology techniques with low sample inputs, such as single cells.
* Demonstrable expertise with NGS sequencing platforms including Illumina sequencing.
* Expertise with liquid handling automation technologies
* Excellent collaboration and interpersonal skills to work well with scientists from divergent backgrounds

Additional Skills & Experience

* Familiarity with tools to analyze NGS data and the ability to perform data management functions in R or Python
* Experience in molecular cloning and plasmid purification
* Experience with mammalian cell culture Visa mindre
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Senior Scientist Translational Genomics In Vivo Physiology

Ansök    Jan 17    Hays Specialist Recruitment AB    Molekylärbiolog
Translational Genomics In Vivo Physiology Hays Life Sciences is now looking to recruit a Senior Research Scientist - Translational Genomics In Vivo Physiology for a 10-month contract assignment at AstraZeneca in Gothenburg. The Discovery Sciences, Translational Genomics department is looking for a senior research scientist to be a part of our In vivo target validation team within the Transgenic Models team. The position is based at the AstraZeneca R&D... Visa mer
Translational Genomics In Vivo Physiology

Hays Life Sciences is now looking to recruit a Senior Research Scientist - Translational Genomics In Vivo Physiology for a 10-month contract assignment at AstraZeneca in Gothenburg.

The Discovery Sciences, Translational Genomics department is looking for a senior research scientist to be a part of our In vivo target validation team within the Transgenic Models team. The position is based at the AstraZeneca R&D site in Gothenburg, Sweden and we are seeking a scientific and technical specialist in the animal in vivo physiology field. As a successful candidate you are experimentally focused, with strong troubleshooting skills and adept at putting ideas into practice. By planning and performing animal experiments you will significantly contribute to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards. You will have good social and communication skills, be collaborative and be a strong team player. Candidates should further be able to work independently with a positive, goal oriented and problem-solving attitude. Good organizational skills are required, and you should be comfortable in presenting your results. Excellent English is required, both spoken and written.

Specific responsibilities

* Perform hands-on experiments within the in vivo target validation discipline, using behavioural and metabolic platforms to support all core disease areas
* Ensure that studies are conducted with high quality, dedication and data delivered according to stipulated time lines and project requirements
* Compile, interpret, present and discuss data with the key project teams
* Help out with ex vivo tissue culture experiments when needed

The following skills would be a definite advantage:

* Experience of behavioural phenotyping in mice
* Experience of stereotactic brain injections in mice
* Experience in metabolic phenotyping platforms and analysis of metabolic function in mice, for example indirect calorimetry, DEXA and oral glucose tolerance tests (OGTT)
* Use of viral vectors and non-viral delivery vehicles for in vivo genetic engineering

Minimum Requirements -Education and Experience
Ph.D. degree or corresponding experience in a relevant scientific discipline with expertise in phenotyping transgenic mice or, alternatively, a first degree and significant relevant experience in phenotyping of transgenic mice. Visa mindre
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CVRM Safety Scientist

Ansök    Jan 31    Hays Specialist Recruitment AB    Molekylärbiolog
Scientist - Molecular biology, Cell & Regenerative Medicine Safety Hays Life Sciences is now looking to recruit a CVRM Safety Scientist to work the Molecular biology, Cell & Regenerative Medicine Safety for a 10-month contract assignment at AstraZeneca in Gothenburg. Job Description Do you have a background in Cellular biology, wants to work hands-on in the lab and is up for a challenge? Do you want to expand your knowledge of the non-clinical safety... Visa mer
Scientist - Molecular biology, Cell & Regenerative Medicine Safety

Hays Life Sciences is now looking to recruit a CVRM Safety Scientist to work the Molecular biology, Cell & Regenerative Medicine Safety for a 10-month contract assignment at AstraZeneca in Gothenburg.

Job Description
Do you have a background in Cellular biology, wants to work hands-on in the lab and is up for a challenge? Do you want to expand your knowledge of the non-clinical safety assessment of the next generation of cell therapies and regenerative medicines? If yes, AstraZeneca might have the position for you!

We are searching for a highly motivated laboratory-based cell biologist to join our team as a Senior Scientist. In this role you will play an important part in our Cardiovascular, renal and metabolic (CVRM) Safety Group within the broader Clinical Pharmacology and Safety Sciences department. The scientist will be based in Gothenburg, Sweden, where we are significantly investing in the Lab4Life design of our R&D building. This will create the collaborative environment across our disciplines to drive the innovation required for 21st century pharmaceutical research.

We value our differences because we recognize that a team is at its most creative when it is made up of people who think differently from one another, in an environment where different views and perspectives are welcomed and valued. This is how we foster continuous innovation, constant learning and growth for us as individuals and for our patients.

What you will do:
Your role will be to primarily support our growing stem cell therapy portfolio but will also include mechanistic safety investigations across CVRM therapeutics. You need experience in the field of safety assays and/or cell biology - and will be responsible for investigating improved ways to assess the safety of AstraZeneca's cell therapy and CVRM therapeutic portfolio and other novel modalities that are rapidly changing the therapeutic landscape.

One of your key research activities will be the development of new in vitro models to predict and assess the toxicity, immunogenicity and tumorigenicity of cell and regenerative medicines. You will also be involved in and gain wider experience of the general toxicological assessment of CVRM therapeutics. Other responsibilities:

* Identify and solve problems and championing science and technology innovations to develop our strategic capabilities.
* Collaborate with leading academics and actively contribute to scientific discipline networks.
* Driving innovation by contributing to presentations and publications you will develop your own and AstraZeneca's scientific position.

In this role you will work closely with other engaged scientists from every part of Clinical Pharmacology and Safety Sciences. You will support pioneering therapeutics by discovering and applying fundamental biological principles to help answer the critical questions the field faces today.

Essential in the role:

* Degree or equivalent scientific qualification in cellular biology or a related subject
* Previous experience of cell biology, cell therapies and/or safety/toxicology assessment would be useful.
* Demonstrated ability and enjoy working in multi-disciplinary teams with effective communication skills: including presenting and relationship building.
* Ability to comply with Good Laboratory Science standards, Safety, Health and Environment standards and other relevant external regulation.

Why AstraZeneca?
It's our combination of curiosity and courage that drives us, inspired by the possibility of doing things that have never been done before. Empowered to step up, we free ourselves from fear of failure to dig deep into the biology of complex diseases and make bold decisions. Celebrating our successes and failures along the way. Visa mindre
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Biomarker Scientist

Ansök    Sep 27    Hays Specialist Recruitment AB    Molekylärbiolog
Biomarker team within Translational Science & Experimental Medicine (TS&EM;) department Hays Specialist Recruitment is now looking to recruit a Biomarker Scientist to join the Biomarker team for a 1-year contract assignment at AstraZeneca in Gothenburg. Do you have expertise in Biomarker Discovery and Development in Cardiovascular, Metabolic and Renal Diseases? Would you like to apply your expertise at a company that are following the science and turn... Visa mer
Biomarker team within Translational Science & Experimental Medicine (TS&EM;) department

Hays Specialist Recruitment is now looking to recruit a Biomarker Scientist to join the Biomarker team for a 1-year contract assignment at AstraZeneca in Gothenburg.

Do you have expertise in Biomarker Discovery and Development in Cardiovascular, Metabolic and Renal Diseases? Would you like to apply your expertise at a company that are following the science and turn ideas into life changing medicines? Then you might be the one we are looking for!

We are now looking for a Senior Scientist, Biomarkers Discovery and Development to join the Biomarker team within Translational Science & Experimental Medicine (TS&EM;) department in the Cardiovascular Renal and Metabolic Diseases (CVRM) therapeutic area at AstraZeneca in Gothenburg, Sweden.

CVRM is one of the three main therapeutic research areas within Innovative Medicines and Early Development, AstraZeneca's small molecule biotech unit that deliver candidate drugs into late-stage clinical development. CVRM TS&EM; has the remit to bridge pre-clinical, early and late drug development by providing early target validation in humans and by driving precision medicine approaches through biomarker discovery and development based on understanding of human diseases and access to human patient samples.
The biomarker team has the accountability from pre-clinical to clinical biomarker delivery which include biomarker discovery for identification of target engagement and proof-of-mechanism biomarkers, generation of target related precision medicine hypothesis, analysis of explorative biomarkers in clinical projects, and for outsourcing biomarkers according to good clinical practice for internal decisions in clinical studies.

As a Senior Scientist in the Biomarker team, you will play a key role from preclinical to clinical biomarker delivery for progressing projects and science. This role will be primarily lab based and contribute to building the biomarker strategy i.e. driving biomarker discovery for identification of target-related biomarkers and precision medicine hypothesis generation. You will be responsible for delivering high quality and robust biomarker data package to support project progression across the CVRM project portfolio. This involves implementation of novel biomarker methods, e.g. ligand binding or mass spectrometry-based approaches using state of the art analytical techniques, biomarker analysis, reporting biomarker data and evaluation to the project teams

Collaboration is critical for successful delivery of drug projects and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca. In this role, you will have the opportunity to try novel techniques and ideas for identification of new biomarkers.

Requirements

* Deep expertise in a range of analytical techniques for biomarker analysis (proteins, peptides, mRNA), specifically immunoassay/ELISA platforms (MSD, Luminex, SIMOA etc.), Taqman analysis and proteomics based on liquid chromatography mass spectrometry
* Experience in development of novel bioanalytical methods for quantification of biomarkers
* Experience in biomarker discovery and development within cardiovascular, renal and metabolism
* Ability to plan and report all work to appropriate standards (Good Laboratory Standard, GLS)
* Maintain awareness of relevant areas of research, drug discover/development technologies and regulatory requirements through reading scientific literature and guidelines
* Perform problem solving studies by identification of issues and where necessary designing experiments to overcome problems.
* Good project management and matrix leadership skills, ability to collaborate well cross functions
* Passion for delivering and promoting excellence in science.
* Excellent English communication skills, both verbal and written Visa mindre
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Covid-19 Assessment Laboratory Scientist

Ansök    Sep 29    Hays Specialist Recruitment AB    Molekylärbiolog
Covid-19 Assessment Team Hays Specialist Recruitment is now looking to recruit a Laboratory Scientist to join the Covid-19 Assessment Team for a contract assignment ending 2022-06-30 at AstraZeneca in Gothenburg. This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week - Tuesda... Visa mer
Covid-19 Assessment Team

Hays Specialist Recruitment is now looking to recruit a Laboratory Scientist to join the Covid-19 Assessment Team for a contract assignment ending 2022-06-30 at AstraZeneca in Gothenburg.

This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week - Tuesday to Saturday and some weeks Mondays as well. Hours are 7am-4pm, 12pm-9pm. Please apply only if you are satisfied you can accommodate these shift patterns.

This role covers responsibilities in two main areas: The Sample Handling Laboratories and the Molecular Biology Laboratories. Applicants can specify a preference to work in either area, or to flex across both.

Sample Handling: Scientists working in the Sample handling Laboratories are responsible for all process stages from arrival of human assessment specimens (currently saliva or nasal swabs) at the sample handling labs to the transfer of virally inactivated samples to the adjacent molecular biology labs. This work is performed to Biological Safety Level 2 (BSL2) in LAF containment facilities with appropriate PPE. Prior experience of working with infectious biological material to BS2 and with PPE is a key requirement for working in the sample handling laboratories.

Primary responsibilities include: visually inspecting specimens for packaging integrity (correct intact number of barrier layers, no evidence of leakage/spillage); assessment suitability (e.g., rejecting samples not properly labelled, containing foreign matter, incorrect volumes etc.); ensuring they are accounted for on the specimen manifest; following inspection, the removal of specimen transport tubes from the kit packaging; scanning into the LIMS system; and transfer to racks for further processing in suitably contained liquid handling automation. Tube to plate transfer, sample lysis and inactivation will be performed on the automation, and once completed the plates will be transferred to the adjacent molecular biology laboratories. On occasion this process may be run manually requiring experience with manual pipetting. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:

* Work in BSL2 lab with previous experience of aseptic technique preferred.
* Work with human biological specimens. HepB Vaccination advised.
* Work with infectious samples, ideally experience that may contain SARS-Cov-2 would be desirable
* Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
* Working and communicating across a fast-paced cross organisational team.
* Experience of liquid handling automation would be desirable

Molecular Biology: Scientists working in the Molecular Biology Laboratories are responsible for all process stages from fully automated RNA extraction and RT-PCR workflows to the delivery of PCR based results to data analysts. This work is performed to Biological Safety Level 1 (BSL1) with appropriate PPE. Applicants should be comfortable performing this process while using PPE.

Primary responsibilities include: the operation of Beckman I series robotics to perform automated magnetic bead RNA extraction procedures; tracking samples through the LIMS system; RT-PCR reaction setup including manual pipetting as well as automated plate preparation using benchtop automation equipment; setting up molecular assays on qPCR instruments; and inspection and exporting of primary and QC results for subsequent downstream analysis by Data/QC analysts. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:

* Work in BSL1 lab with previous experience of automation and molecular biology techniques preferred.
* Work with human biological specimens. HepB Vaccination advised.
* Work with samples which may contain SARS-Cov-2 would be desirable.
* Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
* Working and communicating across a fast-paced cross organisational team.
* Experience with RT-PCR data analysis would be desirable Visa mindre
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Protein Structure Scientist

Ansök    Okt 18    Hays Specialist Recruitment AB    Molekylärbiolog
Mechanistic & Structural Biology (M&SB;) department Hays Life Sciences is now looking to recruit a Protein Structure Scientist for a 10-month contract assignment starting January 2022 at AstraZeneca in Gothenburg. Are you an enthusiastic scientist with expertise in protein crystallography? Would you like to apply your expertise at a company that are following the science and turn ideas into life changing medicines? Then you might be the one we are loo... Visa mer
Mechanistic & Structural Biology (M&SB;) department

Hays Life Sciences is now looking to recruit a Protein Structure Scientist for a 10-month contract assignment starting January 2022 at AstraZeneca in Gothenburg.

Are you an enthusiastic scientist with expertise in protein crystallography? Would you like to apply your expertise at a company that are following the science and turn ideas into life changing medicines? Then you might be the one we are looking for!

This is an opportunity for a collaborative, creative and hardworking lab-based protein structure scientist to play an influential role in drug discovery projects at AstraZeneca in Gothenburg, Sweden. The role is based in the Protein structure team within the Mechanistic & Structural Biology (M&SB;) department based in Gothenburg, Sweden supporting biopharma drug discovery projects. In this position you will be a part of Discovery Sciences in AstraZeneca's BioPharmaceuticals organization.

The M&SB; department has leading capabilities in mechanistic biology, compound profiling, biophysics, crystallography and cryo-EM. The Protein structure team has expertise in protein crystallography and is building a capability in cryo-electron microscopy. We have a highly automated lab for protein crystallography and cryo-EM sample preparation and are constantly pushing the limits for what type of molecular targets can be subjected to structural studies, ranging from small single domain proteins to membrane proteins and large multi-protein complexes. The protein structure information is used to guide design of our lead molecules and to provide key mode of action information.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you will do:
Working collaboratively in drug discovery projects alongside mechanistic and structural biologists, protein scientists, biopharma bioscientists and chemists with responsibility for the protein structure aspect within a drug discovery project. The role also includes you to develop crystal systems enabling iterative structure-based drug design programs, fragment-based lead discovery and mode of action studies. You will support multiple crystallization projects in parallel, work closely with other crystallographers as part of a dynamic team environment.
Other responsibilities:

* Perform crystallization screening of proteins, protein ligands complexes, biological macromolecules and biological macromolecule complexes.
* Collect X-ray data using a number of synchrotron beamlines.
* Support 'in crystal' fragment screens, HTS read out, and other hit finding strategies.
* Identify improvements and innovations in crystallization techniques.
* Work as a team player to ensure delivery of quality leads for projects.

Essential in the role:

* Ph.D. in biochemistry, molecular biology or a related discipline or a BSc/MSc degree with significant proven experience, preferably in the Pharmaceutical or Biotechnology industry.
* Expertise in protein crystallisation and X-ray data collection.
* Significant experience in protein characterisation.
* Independent analysis and evaluation of complex data and delivery of data to agreed timelines.
* The successful candidate should also enjoy collaborating and communicating with all. As well as have the ability to operate effectively in a multi-disciplinary research environment and team.

Desirable in the role:

* Experience in protein structure refinement and interpretation.
* Experience in related areas, such as protein science and biophysics.
* Experience with other techniques for structural studies (Cryo-EM, SAXS).

Why AstraZeneca in Gothenburg?
With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life. We nurture this collaboration and openness, by creating a site that has space for meetings, socialising and relaxation - where spontaneous moments can spark innovation.

If this sounds like the job and place for your - apply today! Visa mindre
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Senior Scientist - Mechanistic & Structural Biology

Ansök    Sep 14    Hays Specialist Recruitment AB    Molekylärbiolog
Mechanistic & Structural Biology Hays Specialist Recruitment is now looking to recruit a Senior Research Scientist to join the Mechanistic and Structural Biology team for a contract assignment until 2022-05-31 at AstraZeneca in Gothenburg. At AstraZeneca we win through science, it's at the heart of our every success. That science is only possible when we work together - we'll always make sure you're clear about how your role is connected to our wider ... Visa mer
Mechanistic & Structural Biology

Hays Specialist Recruitment is now looking to recruit a Senior Research Scientist to join the Mechanistic and Structural Biology team for a contract assignment until 2022-05-31 at AstraZeneca in Gothenburg.

At AstraZeneca we win through science, it's at the heart of our every success. That science is only possible when we work together - we'll always make sure you're clear about how your role is connected to our wider mission to show what science can do.

We are seeking a highly motivated and scientifically curious scientist to join Mechanistic & Structural Biology as a Senior Research Scientist. You will have the opportunity to utilize your scientific capabilities to contribute to the progression of key drug discovery programs in a highly collaborative environment. The position will be located at our vibrant R&D site in Gothenburg, Sweden. You will apply proven cell biology expertise for profiling of the effects and mechanism of action of compound treatment in in vitro cellular assays.

In this position, you will join a department whose remit is to support our BioPharmaceuticals drug discovery projects globally with early DMPK assessment, SAR profiling and detailed mechanism of action data. We offer a highly rewarding scientific environment and strong team working ethics. Mechanistic & Structural Biology (MSB) is a part of Discovery Sciences - a multidisciplinary department which drives early drug discovery across AstraZeneca's global Research and Development portfolio.

Main Duties and Responsibilities:
This is a lab-based role focused on generating in vitro pharmacology data in support of drug discovery projects globally with focus on SAR profiling and detailed mechanism of action data in cellular models across multiple modalities including small molecules, PROTACS and therapeutic oligonucleotides. We offer a highly rewarding scientific environment with ample learning opportunities and an expectation to publish new findings. You will be an experienced lab-based scientist, able to interact across a broad range of therapeutic projects and global initiatives within Discovery Sciences and externally. You will also represent the group on Project Teams and drive scientific and technical innovation in our strategic area, including the identification and development of innovative processes and workflows to deliver high quality and detailed data efficiently.

Essential Requirements:

* Ph.D. in Pharmacology, Biochemistry or a related discipline or a BSc/MSc degree with significant proven experience, preferably in the Pharmaceutical or Biotechnology industry
* Extensive experience in molecular and cellular biology techniques, including qPCR, applied to physiologically relevant cellular assays.
* Excellent communication and collaborative skills and an ability to operate effectively in a multi-disciplinary research environment and team
* Independent analysis and evaluation of complex data and delivery of data to agreed timelines
* First-rate decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity
* Scientific visibility and leadership through project contributions and external publications

Desirable Experiences and Abilities:

* Expertise in the design, development and validation of cellular assays for compound profiling
* Experience with additional technologies for quantifying levels and turn-over of nucleic acids in cells is considered meriting
* Proven ability in providing technical leadership and guidance to others
* Track record of identifying and adopting scientific and technical advances
* Excellent problem-solving skills not limited to own area of expertise Visa mindre
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Senior Scientist - Mechanistic & Structural Biology, AstraZeneca

Ansök    Sep 14    Randstad AB    Molekylärbiolog
Job description At AstraZeneca we win through science, it’s at the heart of our every success. That science is only possible when we work together – we’ll always make sure you’re clear about how your role is connected to our wider mission to show what science can do. We are seeking a highly motivated and scientifically curious scientist to join Mechanistic & Structural Biology as a Senior Research Scientist. You will have the opportunity to utilize your s... Visa mer
Job description
At AstraZeneca we win through science, it’s at the heart of our every success. That science is only possible when we work together – we’ll always make sure you’re clear about how your role is connected to our wider mission to show what science can do.

We are seeking a highly motivated and scientifically curious scientist to join Mechanistic & Structural Biology as a Senior Research Scientist. You will have the opportunity to utilize your scientific capabilities to contribute to the progression of key drug discovery programs in a highly collaborative environment. This consulting position will be located at our vibrant R&D site in Gothenburg, Sweden. You will apply proven cell biology expertise for profiling of the effects and mechanism of action of compound treatment in in vitro cellular assays.

In this position, you will join a department whose remit is to support our BioPharmaceuticals drug discovery projects globally with early DMPK assessment, SAR profiling and detailed mechanism of action data. We offer a highly rewarding scientific environment and strong team working ethics. Mechanistic & Structural Biology (MSB) is a part of Discovery Sciences - a multidisciplinary department which drives early drug discovery across AstraZeneca’s global Research and Development portfolio.

Responsibilities
This is a lab-based role focused on generating in vitro pharmacology data in support of drug discovery projects globally with focus on SAR profiling and detailed mechanism of action data in cellular models across multiple modalities including small molecules, PROTACS and therapeutic oligonucleotides. We offer a highly rewarding scientific environment with ample learning opportunities and an expectation to publish new findings. You will be an experienced lab-based scientist, able to interact across a broad range of therapeutic projects and global initiatives within Discovery Sciences and externally. You will also represent the group on Project Teams and drive scientific and technical innovation in our strategic area, including the identification and development of innovative processes and workflows to deliver high quality and detailed data efficiently.

Qualifications
Essential Requirements:
Ph.D. in Pharmacology, Biochemistry or a related discipline or a BSc/MSc degree with significant proven experience, preferably in the Pharmaceutical or Biotechnology industry
Extensive experience in molecular and cellular biology techniques, including qPCR, applied to physiologically relevant cellular assays.
Excellent communication and collaborative skills and an ability to operate effectively in a multi-disciplinary research environment and team
Independent analysis and evaluation of complex data and delivery of data to agreed timelines
First-rate decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity
Scientific visibility and leadership through project contributions and external publications

Desirable Experiences and Abilities:
Expertise in the design, development and validation of cellular assays for compound profiling
Experience with additional technologies for quantifying levels and turn-over of nucleic acids in cells is considered meriting
Proven ability in providing technical leadership and guidance to others
Track record of identifying and adopting scientific and technical advances
Excellent problem-solving skills, not limited to own area of expertise

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-09-24, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Kerstin Karlsson, [email protected] or Veronika Knudsen [email protected]

About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Senior Research Scientist - Translational Genomics, AstraZeneca

Ansök    Sep 13    Randstad AB    Molekylärbiolog
Job description Translational Genomics at AstraZeneca in Gothenburg, Sweden, have an exciting opportunity for a Senior Research Scientist to be part of the Transgenic Mouse Models team. The position is a consulting assignment available immediately for a highly skilled and motivated molecular biologist with extensive experience and state-of-the-art knowledge in the design and generation of DNA based constructs using a wide range of cloning techniques and th... Visa mer
Job description
Translational Genomics at AstraZeneca in Gothenburg, Sweden, have an exciting opportunity for a Senior Research Scientist to be part of the Transgenic Mouse Models team. The position is a consulting assignment available immediately for a highly skilled and motivated molecular biologist with extensive experience and state-of-the-art knowledge in the design and generation of DNA based constructs using a wide range of cloning techniques and their application in science & technology. If this sounds like the challenge for you, apply today! 

Responsibilities
We are looking for an expert in the area of molecular biology, experienced in a variety of cloning techniques used for the generation of complex DNA constructs and their application in the development of transgenic models. This person will devise, champion and develop scientific areas aligned with project needs and be an authority in the area of molecular biology and precise genome editing using the latest techniques to lead projects from a lab-based perspective and to make significant contributions to the practical delivery of AstraZeneca project goals.

You will provide disciplinary scientific expertise and will propose experimental strategies, troubleshoot problems and make significant contributions to the delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards.

We see that you have good social and communication skills, are collaborative and a strong team player. You should also be able to work independently and have a positive, goal oriented and problem-solving attitude. Excellent English is required, both spoken and written, and good organizational skills are essential.

Qualifications
The following skills are highly desirable:
Molecular biology expertise with extensive DNA cloning experience
Experience of working with cell culture.
Working knowledge of the latest precise genome engineering tools such as CRISPR.

The following skills, although not essential, would be an advantage
Experience of working with preclinical mouse models.
Experience of working with Bacterial Homologous Recombination.
Knowledge around the generation and phenotypic characterization of transgenic animal models.
Experience in drug discovery.

Minimum experience
You should have a Ph.D. degree or corresponding experience in a relevant scientific discipline or, alternatively, a first degree and significant relevant experience.

Generic component of SRS role descriptor
Accountabilities
To design genome editing-based strategies and tools required to generate DNA based reagents to facilitate the generation of transgenic mouse models
To perform genetic screens in vitro and in vivo using genome editing tools
To perform confirmation assays of genetic manipulation

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-09-23, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Kerstin Karlsson, [email protected] or Veronika Knudsen [email protected]

About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Research Scientist Precise Genome Editing, AstraZeneca Gothenburg

Ansök    Sep 6    Randstad AB    Molekylärbiolog
Job description At AstraZeneca we use scientific excellence as our foundation for driving success in our drug discovery pipeline. We underpin this with strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery. An exciting opportunity is now available to join the Precise Genome Editing team within Discovery Sciences, which has responsibility for the generation of novel genome editing technologies to supp... Visa mer
Job description
At AstraZeneca we use scientific excellence as our foundation for driving success in our drug discovery pipeline. We underpin this with strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery.

An exciting opportunity is now available to join the Precise Genome Editing team within Discovery Sciences, which has responsibility for the generation of novel genome editing technologies to support projects in all phases of the drug discovery pipeline. We have a focus on target identification, target validation, disease model generation and the therapeutic use of stem cells. We are seeking a scientist to join our team where the role will focus on generating genetically engineered mouse and cell models. This is a consulting assignment at AstraZeneca in Gothenburg.

Responsibilities
The role
Leveraging your strong knowledge and experience in genome editing you will have the opportunity apply your knowledge to gene therapy projects. This includes design of genome editing strategies, implement them using techniques including CRISPR/Cas9 and to validate the results. The role is focused on conducting laboratory-based activities, applying your knowledge and skills to drive project delivery and scientific innovation, participating actively in problem solving and working globally with Astrazeneca colleagues and collaborators.

It is essential to have good social and communication skills, be collaborative and a strong team player and be an innovative thinker. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude. Good organisational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Tasks
Perform in vivo genetic manipulation and validation of engineered mouse models
To assist in the design and implement delivery tools for genome editing-based strategies to generate in vitro and in vivo models
To improve the efficiency of genome editing in vivo


Qualifications
Essential skills for the job:
Proficiency in ‘hands on’ in vivo work and delivery of reagents
Strong knowledge and experience with core molecular biology techniques
Experience with cell culture, preferable to have knowledge of primary cell culture

The following skills are highly desirable but not essential
Expertise with CRISPR based editing and NGS analysis of genome editing outcomes

Minimum experience
You should hold a degree or have significant relevant experience working in with small animals and a precise genome editing / molecular biology environment.

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-09-16, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Kerstin Karlsson, [email protected]

About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Senior Scientist Protein Expression

Ansök    Sep 6    Hays Specialist Recruitment AB    Molekylärbiolog
1-year consulting assignment at AstraZeneca in Gothenburg within protein expression Hays is now recruiting a senior scientist for a consulting assignment at AstraZeneca in Gothenburg. The role is within the Protein Expression Team in Discovery Biology. The assignment is for 12 months and deadline for application is September 15th. About the assignment At AstraZeneca we use scientific excellence as the foundation to drive success of our drug discovery... Visa mer
1-year consulting assignment at AstraZeneca in Gothenburg within protein expression

Hays is now recruiting a senior scientist for a consulting assignment at AstraZeneca in Gothenburg. The role is within the Protein Expression Team in Discovery Biology. The assignment is for 12 months and deadline for application is September 15th.

About the assignment
At AstraZeneca we use scientific excellence as the foundation to drive success of our drug discovery pipeline. Such excellence stems from strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery.

An opportunity is now available for a highly motivated Scientist/Senior Scientist to join the Protein Expression Team within Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D in Gothenburg, Sweden. Leading from the bench, you will apply proven skills in molecular biology, recombinant protein expression, a passion for investigating scientific questions, combined with strong team working ethics, to drug discovery projects. You will join our team whose remit is to support drug discovery projects globally with delivery of impactful recombinant protein reagents used for disease target identification and validation right through to clinical candidate evaluation.

As part of a team within the Discovery Sciences organisation, you will be working within a vibrant scientific environment to support drug discovery. We push scientific advances in small molecules, oligonucleotides as well as other emerging technologies, always with a view to providing medicines to improve patient care. The Discovery Biology Department of Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in the drug discovery pipeline from target discovery all the way to clinical candidate.

Main duties & responsibilities
This is a lab-based role, generating bespoke protein reagents to support projects in all phases of the discovery process. The role involves application of leading molecular biology techniques to design expression constructs, make DNA constructs for protein expression, producing recombinant proteins that impact projects, as well as troubleshooting. In addition, you will be required to make a significant contribution to the development and application of novel science to advance our capabilities in the production of molecular biology tools used in early drug discovery.

Essential requirements
* Master or Ph. D in Molecular Biology, Biotechnology, Cell Biology, Biochemistry or a related discipline, or 3 years of relevant working experience within Biotechnology
* Substantial expertise in cell culture for recombinant protein expression in a variety of eukaryotic cell types, at scales from 1ml to 20L
* Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment
* Independent analysis and evaluation of complex data and delivery of data to agreed timelines
* Proven ability in providing technical leadership and guidance to others
* Maintain an awareness of relevant scientific and technical advances to help identify opportunities for capability development

Desirable requirements
* Experience in design of DNA construct for recombinant protein expression is highly desirable
* Experience in use of automation equipment such as liquid handling platforms is desirable
* Experience in expression of recombinant expressed proteins in baculovirus-infected insect cells
* Good understanding of drug discovery and how to contribute with scientific expertise within own area of expertise to drive project progression
* Excellent problem-solving skills, not limited to own area of expertise
* Clear and firm decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity Visa mindre
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Senior Research Scientist - Translational Genomics

Ansök    Sep 13    Hays Specialist Recruitment AB    Molekylärbiolog
Translational Genomics Team Hays Specialist Recruitment is now looking to recruit a Senior Research Scientist to join the Translational Genomics team for a 12-month contract assignment at AstraZeneca in Gothenburg. Translational Genomics at AstraZeneca in Gothenburg, Sweden, have an exciting opportunity for a Senior Research Scientist to be part of the Transgenic Mouse Models team. The position is available immediately for a highly skilled and motivat... Visa mer
Translational Genomics Team

Hays Specialist Recruitment is now looking to recruit a Senior Research Scientist to join the Translational Genomics team for a 12-month contract assignment at AstraZeneca in Gothenburg.

Translational Genomics at AstraZeneca in Gothenburg, Sweden, have an exciting opportunity for a Senior Research Scientist to be part of the Transgenic Mouse Models team. The position is available immediately for a highly skilled and motivated molecular biologist with extensive experience and state-of-the-art knowledge in the design and generation of DNA based constructs using a wide range of cloning techniques and their application in science & technology. If this sounds like the challenge for you, apply today!

We are looking for an expert in the area of molecular biology, experienced in a variety of cloning techniques used for the generation of complex DNA constructs and their application in the development of transgenic models. This person will devise, champion and develop scientific areas aligned with project needs and be an authority in the area of molecular biology and precise genome editing using the latest techniques to lead projects from a lab-based perspective and to make significant contributions to the practical delivery of AstraZeneca project goals.

You will provide disciplinary scientific expertise and will propose experimental strategies, troubleshoot problems and make significant contributions to the delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards.

We see that you have good social and communication skills, are collaborative and a strong team player. You should also be able to work independently and have a positive, goal oriented and problem-solving attitude. Excellent English is required, both spoken and written, and good organizational skills are essential.

The following skills are highly desirable:

* Molecular biology expertise with extensive DNA cloning experience
* Experience of working with cell culture.
* Working knowledge of the latest precise genome engineering tools such as CRISPR.

The following skills, although not essential, would be an advantage

* Experience of working with preclinical mouse models.
* Experience of working with Bacterial Homologous Recombination.
* Knowledge around the generation and phenotypic characterization of transgenic animal models.
* Experience in drug discovery.

Minimum experience

* You should have a Ph.D. degree or corresponding experience in a relevant scientific discipline or, alternatively, a first degree and significant relevant experience.

Generic component of SRS role descriptor
Accountabilities

* To design genome editing-based strategies and tools required to generate DNA based reagents to facilitate the generation of transgenic mouse models
* To perform genetic screens in vitro and in vivo using genome editing tools
* To perform confirmation assays of genetic manipulation Visa mindre
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Covid-19 Assessment Laboratory Scientist AstraZeneca Gothenburg

Ansök    Aug 16    Randstad AB    Molekylärbiolog
Job description We are now looking for a Covid-19 Assessment Laboratory Scientist for a consultant assignment at AstraZeneca starting as soon as possible. You will be a part of a facility that performes high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday and some weeks Mondays as well. ... Visa mer
Job description
We are now looking for a Covid-19 Assessment Laboratory Scientist for a consultant assignment at AstraZeneca starting as soon as possible. You will be a part of a facility that performes high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday and some weeks Mondays as well. Hours are 7am-4pm, 12pm-9pm. Please apply only if you are satisfied you can accommodate these shift patterns.

Responsibilities
This role covers responsibilities in two main areas: the Sample Handling Laboratories and the Molecular Biology Laboratories. Applicants can specify a preference to work in either area, or to flex across both.

Qualifications
Sample Handling: Scientists working in the Sample handling Laboratories are responsible for all process stages from arrival of human assessment specimens (currently saliva or nasal swabs) at the sample handling labs to the transfer of virally inactivated samples to the adjacent molecular biology labs. This work is performed to Biological Safety Level 2 (BSL2) in LAF containment facilities with appropriate PPE. Prior experience of working with infectious biological material to BS2 and with PPE is a key requirement for working in the sample handling laboratories.


Primary responsibilities include: visually inspecting specimens for packaging integrity (correct intact number of barrier layers, no evidence of leakage/spillage); assessment suitability (e.g., rejecting samples not properly labelled, containing foreign matter, incorrect volumes etc.); ensuring they are accounted for on the specimen manifest; following inspection, the removal of specimen transport tubes from the kit packaging; scanning into the LIMS system; and transfer to racks for further processing in suitably contained liquid handling automation. Tube to plate transfer, sample lysis and inactivation will be performed on the automation, and once completed the plates will be transferred to the adjacent molecular biology laboratories. On occasion this process may be run manually requiring experience with manual pipetting. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.


 Key Requirements for this role:
Work in BSL2 lab with pervious experience of aseptic technique preferred.
Work with human biological specimens. HepB Vaccination advised.
Work with infectious samples, ideally experience that may contain SARS-Cov-2 would be desirable
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team.
Experience of liquid handling automation would be desirable



Molecular Biology: Scientists working in the Molecular Biology Laboratories are responsible for all process stages from fully automated RNA extraction and RT-PCR workflows to the delivery of PCR based results to data analysts. This work is performed to Biological Safety Level 1 (BSL1) with appropriate PPE. Applicants should be comfortable performing this process while using PPE.


Primary responsibilities include: the operation of Beckman I series robotics to perform automated magnetic bead RNA extraction procedures; tracking samples through the LIMS system; RT-PCR reaction setup including manual pipetting as well as automated plate preparation using benchtop automation equipment; setting up molecular assays on qPCR instruments; and inspection and exporting of primary and QC results for subsequent downstream analysis by Data/QC analysts. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.


Key Requirements for this role:
Work in BSL1 lab with previous experience of automation and molecular biology techniques preferred.
Work with human biological specimens. HepB Vaccination advised.
Work with samples which may contain SARS-Cov-2 would be desirable.
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team.
Experience with RT-PCR data analysis would be desirable

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-08-26, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Eleonor Ehrman 0733434109 or Kerstin Karlsson [email protected]

About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Senior Research Scientist - Mechanistic & Structural Biology

Ansök    Jul 26    Randstad AB    Molekylärbiolog
Job description At AstraZeneca we win through science, it’s at the heart of our every success. That science is only possible when we work together – we’ll always make sure you’re clear about how your role is connected to our wider mission to show what science can do. We are seeking a highly motivated and scientifically curious scientist to join Mechanistic & Structural Biology as a Senior Research Scientist. You will have the opportunity to utilize your s... Visa mer
Job description
At AstraZeneca we win through science, it’s at the heart of our every success. That science is only possible when we work together – we’ll always make sure you’re clear about how your role is connected to our wider mission to show what science can do.

We are seeking a highly motivated and scientifically curious scientist to join Mechanistic & Structural Biology as a Senior Research Scientist. You will have the opportunity to utilize your scientific capabilities to contribute to the progression of key drug discovery programs in a highly collaborative environment. The position will be located at our vibrant R&D site in Gothenburg, Sweden. You will apply proven cell biology expertise for profiling of the effects and mechanism of action of compound treatment in in vitro cellular assays. This is a consulting position at AstraZeneca in Gothenburg.

Responsibilities
In this position, you will join a department whose remit is to support our BioPharmaceuticals drug discovery projects globally with early DMPK assessment, SAR profiling and detailed mechanism of action data. We offer a highly rewarding scientific environment and strong team working ethics. Mechanistic & Structural Biology (MSB) is a part of Discovery Sciences - a multidisciplinary department which drives early drug discovery across AstraZeneca’s global Research and Development portfolio.

Main Duties and Responsibilities:
This is a lab-based role focused on generating in vitro pharmacology data in support of drug discovery projects globally with focus on SAR profiling and detailed mechanism of action data in cellular models across multiple modalities including small molecules, PROTACS and therapeutic oligonucleotides. We offer a highly rewarding scientific environment with ample learning opportunities and an expectation to publish new findings. You will be an experienced lab-based scientist, able to interact across a broad range of therapeutic projects and global initiatives within Discovery Sciences and externally. You will also represent the group on Project Teams and drive scientific and technical innovation in our strategic area, including the identification and development of innovative processes and workflows to deliver high quality and detailed data efficiently.

Qualifications
Essential Requirements:
Ph.D. in Pharmacology, Biochemistry or a related discipline or a BSc/MSc degree with significant proven experience, preferably in the Pharmaceutical or Biotechnology industry
Extensive experience in molecular and cellular biology techniques, including qPCR, applied to physiologically relevant cellular assays.
Excellent communication and collaborative skills and an ability to operate effectively in a multi-disciplinary research environment and team
Independent analysis and evaluation of complex data and delivery of data to agreed timelines
First-rate decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity
Scientific visibility and leadership through project contributions and external publications

Desirable Experiences and Abilities:
Experience with additional technologies for quantifying levels and turn-over of nucleic acids in cells is considered meriting
Expertise in the design, development and validation of cellular assays for compound profiling
Experience with cells grown in 3D cultures and organoids
Proven ability in providing technical leadership and guidance to others
Track record of identifying and adopting scientific and technical advances
Excellent problem-solving skills, not limited to own area of expertise
A proven publication track-record from several labs, such as a postdoctoral experience, in a relevant area

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-08-05, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible. 

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.
 
 Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Scientist/Senior Scientist – Protein Expression Team, AstraZeneca

Ansök    Sep 6    Randstad AB    Molekylärbiolog
Job description At AstraZeneca we use scientific excellence as the foundation to drive success of our drug discovery pipeline. Such excellence stems from strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery. An opportunity is now available for a highly motivated Scientist/Senior Scientist to join the Protein Expression Team within Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D in Goth... Visa mer
Job description
At AstraZeneca we use scientific excellence as the foundation to drive success of our drug discovery pipeline. Such excellence stems from strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery.

An opportunity is now available for a highly motivated Scientist/Senior Scientist to join the Protein Expression Team within Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D in Gothenburg, Sweden. Leading from the bench, you will apply proven skills in molecular biology, recombinant protein expression, a passion for investigating scientific questions, combined with strong team working ethics, to drug discovery projects. You will join our team whose remit is to support drug discovery projects globally with delivery of impactful recombinant protein reagents used for disease target identification and validation right through to clinical candidate evaluation. This is a consulting position at AstraZeneca in Gothenburg.

As part of a team within the Discovery Sciences organisation, you will be working within a vibrant scientific environment to support drug discovery. We push scientific advances in small molecules, oligonucleotides as well as other emerging technologies, always with a view to providing medicines to improve patient care. The Discovery Biology Department of Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in the drug discovery pipeline from target discovery all the way to clinical candidate.

Responsibilities
This is a lab-based role, generating bespoke protein reagents to support projects in all phases of the discovery process. The role involves application of leading molecular biology techniques to design expression constructs, make DNA constructs for protein expression, producing recombinant proteins that impact projects, as well as troubleshooting. In addition, you will be required to make a significant contribution to the development and application of novel science to advance our capabilities in the production of molecular biology tools used in early drug discovery.

Qualifications
Essential Requirements
Master or Ph. D in Molecular Biology, Biotechnology, Cell Biology, Biochemistry or a related discipline, or 3 years of relevant working experience within Biotechnology
Substantial expertise in cell culture for recombinant protein expression in a variety of eukaryotic cell types, at scales from 1ml to 20L
Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment
Independent analysis and evaluation of complex data and delivery of data to agreed timelines
Proven ability in providing technical leadership and guidance to others
Maintain an awareness of relevant scientific and technical advances to help identify opportunities for capability development

Desirable Requirements
Experience in design of DNA construct for recombinant protein expression is highly desirable
Experience in use of automation equipment such as liquid handling platforms is desirable
Experience in expression of recombinant expressed proteins in baculovirus-infected insect cells
Good understanding of drug discovery and how to contribute with scientific expertise within own area of expertise to drive project progression
Excellent problem-solving skills, not limited to own area of expertise
Clear and firm decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-09-16, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Kerstin Karlsson, [email protected]

About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Stem Cell Biologist, AstraZeneca Gothenburg

Ansök    Jul 1    Randstad AB    Molekylärbiolog
Job description Are you an experienced scientist in the field of stem cells and target validation? Would you like to combine your scientific skills & drive the development genome-engineered pluripotent stem cells for in vitro disease-modelling? This might be the next challenge for you! At AstraZeneca in Gothenburg, Sweden we have an exciting opportunity for you to join us in the Applied Stem Cell Sciences in Discovery Sciences, Biopharmaceuticals R&D, as ... Visa mer
Job description
Are you an experienced scientist in the field of stem cells and target validation? Would you like to combine your scientific skills & drive the development genome-engineered pluripotent stem cells for in vitro disease-modelling? This might be the next challenge for you!

At AstraZeneca in Gothenburg, Sweden we have an exciting opportunity for you to join us in the Applied Stem Cell Sciences in Discovery Sciences, Biopharmaceuticals R&D, as a bench-based Research Scientist to be a key player in developing stem cell models for target discovery and validation. This is a consulting assignment at AstraZeneca in Gothenburg.

Responsibilities
You will be based in Gothenburg Sweden, working alongside our stem cell scientists, disease area specialists and genome editing group. Using your strong knowledge and experience in stem cell biology, cell model development and CRISPR technology you will have the opportunity to work on in vitro validation aspects of target validation and gene editing projects. This includes culture and differentiation of induced pluripotent stem cells (iPSCs) and carrying out gene editing experiments to validate target hypothesis.

The role is focused on laboratory-based activities. Your biggest impact will be through significant contributions to the practical delivery to projects in compliance with AstraZeneca corporate responsibility, policies and relevant safety standards.

It is essential to have good social and communication skills, be collaborative and a strong team player. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude.

Good organizational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Key Responsibilities:
Culture and differentiate hPSC lines to target cell types.
Culture human primary cells and various mammalian cell lines.
Perform in vitro studies to investigate the effects of CRISPR-based gene editing on gene and protein expression, cellular readouts and muscle function.
Perform molecular biology protocols in support of in-house quantitative PCR, digital PCR and NGS assays.
Effectively collaborate within a matrixed research team to facilitate the success of projects. Maintain complete experimental records.


Qualifications
Minimum Requirements:
BSc/MSc or equivalent degree with a minimum of 1 year experience in Developmental Biology, Cell Biology, Gene Editing
Proven experience with PSC biology and directed-differentiation to skeletal and cardiac muscle
Experience with the culture of multiple mammalian cell types including primary cells
Hands-on experience with the following assay platforms: RT-qPCR, ELISA, Western blots, Flow cytometry and/or cell- based functional/ potency assays.
Excellent communication skills with ability to build open and collaborative relationships and work effectively as a member of a multidisciplinary team.
Excellent organizational skills and documentation practices.

The following skills are highly desirable:
Experience with CRISPR gene editing, clonal cell line generation, and NGS library prep
Expertise with liquid handling automation technologies
Experience of setting up cell based pharmacological assays

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-07-11, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information please contact Galia Nyström, [email protected] or Linnea Öster, [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
Ansök

Senior Research Scientist Stem Cell Biology, AstraZeneca

Ansök    Jul 1    Randstad AB    Molekylärbiolog
Job description Are you an experienced senior scientist in the field of stem cells and target validation? Would you like to combine your scientific skills & drive the development genome-engineered pluripotent stem cells for in vitro disease-modelling? This might be the next challenge for you! At AstraZeneca in Gothenburg, Sweden we have an exciting opportunity for you to join us in the Applied Stem Cell Sciences in Discovery Sciences, Biopharmaceuticals R... Visa mer
Job description
Are you an experienced senior scientist in the field of stem cells and target validation? Would you like to combine your scientific skills & drive the development genome-engineered pluripotent stem cells for in vitro disease-modelling? This might be the next challenge for you!

At AstraZeneca in Gothenburg, Sweden we have an exciting opportunity for you to join us in the Applied Stem Cell Sciences in Discovery Sciences, Biopharmaceuticals R&D, as a bench-based Research Scientist to be a key player in developing stem cell models for target discovery and validation. This is a consulting assignment at AstraZeneca in Gothenburg

Responsibilities
You will be based in Gothenburg Sweden, working alongside our stem cell scientists, disease area specialists and genome editing group. Using your strong knowledge and experience in stem cell biology, cell model development and CRISPR technology you will have the opportunity to work on in vitro validation aspects of target validation and gene editing projects. This includes culture and differentiation of induced pluripotent stem cells (iPSCs) and carrying out gene editing experiments to validate target hypothesis.

The role is focused on laboratory-based activities. Your biggest impact will be through significant contributions to the practical delivery to projects in compliance with AstraZeneca corporate responsibility, policies and relevant safety standards.

It is essential to have good social and communication skills, be collaborative and a strong team player. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude.

Good organizational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Key Responsibilities:
Culture and differentiate hPSC lines to target cell types.
Culture human primary cells and various mammalian cell lines.
Perform in vitro studies to investigate the effects of CRISPR-based gene editing on gene and protein expression, cellular readouts and muscle function.
Perform molecular biology protocols in support of in-house quantitative PCR, digital PCR and NGS assays.
Effectively collaborate within a matrixed research team to facilitate the success of projects. Maintain complete experimental records.


Qualifications
Minimum Requirements:
PhD or equivalent degree with a minimum of 1 year experience in Developmental Biology, Cell Biology, Gene Editing
Proven experience with PSC biology and directed-differentiation to skeletal and cardiac muscle
Experience with the culture of multiple mammalian cell types including primary cells
Hands-on experience with the following assay platforms: RT-qPCR, ELISA, Western blots, Flow cytometry and/or cell- based functional/ potency assays. 
Excellent communication skills with ability to build open and collaborative relationships and work effectively as a member of a multidisciplinary team.
Excellent organizational skills and documentation practices.

The following skills are highly desirable:
Experience with CRISPR gene editing, clonal cell line generation, and NGS library prep
Expertise with liquid handling automation technologies
Experience of setting up cell based pharmacological assays

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-07-11, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information please contact Galia Nyström, [email protected] or Linnea Öster, [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Senior Research Scientist - Mechanistic & Structural Biology

Ansök    Jul 26    Hays Specialist Recruitment AB    Molekylärbiolog
Discovery Sciences, Gothenburg, Sweden Hays Specialist Recruitment is now looking to recruit a Senior Research Scientist for the Mechanistic & Structural Biology team for a 9-month contract assignment at AstraZeneca in Gothenburg. At AstraZeneca we win through science, it's at the heart of our every success. That science is only possible when we work together - we'll always make sure you're clear about how your role is connected to our wider mission t... Visa mer
Discovery Sciences, Gothenburg, Sweden

Hays Specialist Recruitment is now looking to recruit a Senior Research Scientist for the Mechanistic & Structural Biology team for a 9-month contract assignment at AstraZeneca in Gothenburg.

At AstraZeneca we win through science, it's at the heart of our every success. That science is only possible when we work together - we'll always make sure you're clear about how your role is connected to our wider mission to show what science can do.

We are seeking a highly motivated and scientifically curious scientist to join Mechanistic & Structural Biology as a Senior Research Scientist. You will have the opportunity to utilize your scientific capabilities to contribute to the progression of key drug discovery programs in a highly collaborative environment. The position will be located at our vibrant R&D site in Gothenburg, Sweden. You will apply proven cell biology expertise for profiling of the effects and mechanism of action of compound treatment in in vitro cellular assays.

In this position, you will join a department whose remit is to support our BioPharmaceuticals drug discovery projects globally with early DMPK assessment, SAR profiling and detailed mechanism of action data. We offer a highly rewarding scientific environment and strong team working ethics. Mechanistic & Structural Biology (MSB) is a part of Discovery Sciences - a multidisciplinary department which drives early drug discovery across AstraZeneca's global Research and Development portfolio.

Main Duties and Responsibilities:
This is a lab-based role focused on generating in vitro pharmacology data in support of drug discovery projects globally with focus on SAR profiling and detailed mechanism of action data in cellular models across multiple modalities including small molecules, PROTACS and therapeutic oligonucleotides. We offer a highly rewarding scientific environment with ample learning opportunities and an expectation to publish new findings. You will be an experienced lab-based scientist, able to interact across a broad range of therapeutic projects and global initiatives within Discovery Sciences and externally. You will also represent the group on Project Teams and drive scientific and technical innovation in our strategic area, including the identification and development of innovative processes and workflows to deliver high quality and detailed data efficiently.

Essential Requirements:

* Ph.D. in Pharmacology, Biochemistry or a related discipline or a BSc/MSc degree with significant proven experience, preferably in the Pharmaceutical or Biotechnology industry
* Extensive experience in molecular and cellular biology techniques, including qPCR, applied to physiologically relevant cellular assays.
* Excellent communication and collaborative skills and an ability to operate effectively in a multi-disciplinary research environment and team
* Independent analysis and evaluation of complex data and delivery of data to agreed timelines
* First-rate decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity
* Scientific visibility and leadership through project contributions and external publications

Desirable Experiences and Abilities:

* Experience with additional technologies for quantifying levels and turn-over of nucleic acids in cells is considered meriting
* Expertise in the design, development and validation of cellular assays for compound profiling
* Experience with cells grown in 3D cultures and organoids
* Proven ability in providing technical leadership and guidance to others
* Track record of identifying and adopting scientific and technical advances
* Excellent problem-solving skills, not limited to own area of expertise
* A proven publication track-record from several labs, such as a postdoctoral experience, in a relevant area Visa mindre
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Covid-19 Assessment Laboratory Scientist

Ansök    Jun 21    Hays Specialist Recruitment AB    Molekylärbiolog
Covid-19 Assessment team Hays Specialist Recruitment is now looking to recruit a Laboratory Scientist to join the Covid-19 Assessment team for a contract assignment starting as soon as possible until 2021-12-31 at AstraZeneca in Gothenburg. This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation a... Visa mer
Covid-19 Assessment team

Hays Specialist Recruitment is now looking to recruit a Laboratory Scientist to join the Covid-19 Assessment team for a contract assignment starting as soon as possible until 2021-12-31 at AstraZeneca in Gothenburg.

This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week - Tuesday to Saturday and some weeks Mondays as well. Hours are 7am-4pm, 12pm-9pm. Please apply only if you are satisfied you can accommodate these shift patterns.

This role covers responsibilities in two main areas: the Sample Handling Laboratories and the Molecular Biology Laboratories. Applicants can specify a preference to work in either area, or to flex across both.

Sample Handling: Scientists working in the Sample handling Laboratories are responsible for all process stages from arrival of human assessment specimens (currently saliva or nasal swabs) at the sample handling labs to the transfer of virally inactivated samples to the adjacent molecular biology labs. This work is performed to Biological Safety Level 2 (BSL2) in LAF containment facilities with appropriate PPE. Prior experience of working with infectious biological material to BS2 and with PPE is a key requirement for working in the sample handling laboratories.

Primary responsibilities include: visually inspecting specimens for packaging integrity (correct intact number of barrier layers, no evidence of leakage/spillage); assessment suitability (e.g., rejecting samples not properly labelled, containing foreign matter, incorrect volumes etc.); ensuring they are accounted for on the specimen manifest; following inspection, the removal of specimen transport tubes from the kit packaging; scanning into the LIMS system; and transfer to racks for further processing in suitably contained liquid handling automation. Tube to plate transfer, sample lysis and inactivation will be performed on the automation, and once completed the plates will be transferred to the adjacent molecular biology laboratories. On occasion this process may be run manually requiring experience with manual pipetting. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:

* Work in BSL2 lab with previous experience of aseptic technique preferred.
* Work with human biological specimens. HepB Vaccination advised.
* Work with infectious samples, ideally experience that may contain SARS-Cov-2 would be desirable
* Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
* Working and communicating across a fast-paced cross organisational team.
* Experience of liquid handling automation would be desirable

Molecular Biology: Scientists working in the Molecular Biology Laboratories are responsible for all process stages from fully automated RNA extraction and RT-PCR workflows to the delivery of PCR based results to data analysts. This work is performed to Biological Safety Level 1 (BSL1) with appropriate PPE. Applicants should be comfortable performing this process while using PPE.
Primary responsibilities include: the operation of Beckman I series robotics to perform automated magnetic bead RNA extraction procedures; tracking samples through the LIMS system; RT-PCR reaction setup including manual pipetting as well as automated plate preparation using benchtop automation equipment; setting up molecular assays on qPCR instruments; and inspection and exporting of primary and QC results for subsequent downstream analysis by Data/QC analysts. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:

* Work in BSL1 lab with previous experience of automation and molecular biology techniques preferred.
* Work with human biological specimens. HepB Vaccination advised.
* Work with samples which may contain SARS-Cov-2 would be desirable.
* Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
* Working and communicating across a fast-paced cross organisational team.
* Experience with RT-PCR data analysis would be desirable Visa mindre
Ansök

Senior Research Scientist - Molecular and Cell Biology

Ansök    Jun 14    Hays Specialist Recruitment AB    Molekylärbiolog
Cell and Molecular Pharmacology (CMP) team Hays Specialist Recruitment is now looking to recruit a Senior Research Scientist - Molecular and Cell Biology to join the Cell and Molecular Pharmacology (CMP) team for a 1-year contract assignment at AstraZeneca in Gothenburg. Do you have a background in biochemistry or cell biology, aren't afraid of trying new paths and doing things differently? Do you also feel passionate about the possibilities of scienc... Visa mer
Cell and Molecular Pharmacology (CMP) team

Hays Specialist Recruitment is now looking to recruit a Senior Research Scientist - Molecular and Cell Biology to join the Cell and Molecular Pharmacology (CMP) team for a 1-year contract assignment at AstraZeneca in Gothenburg.

Do you have a background in biochemistry or cell biology, aren't afraid of trying new paths and doing things differently? Do you also feel passionate about the possibilities of science to change lives? Perfect, your next challenge might be this role at AstraZeneca!

A position has arisen for a highly motivated (Senior) Research Scientist - Molecular and Cell Biology to join the Cell and Molecular Pharmacology (CMP) team within the Early Cardiovascular, Renal and Metabolic (CVRM) disease area in Gothenburg, Sweden.

Early CVRM is one of three main therapeutic research areas within AstraZeneca that deliver candidate drugs into late-stage clinical development. The CMP team delivers key data based on histology, imaging, biomarker, FACS and bioassay automation to support projects across the Cardiovascular, Renal and Metabolism disease areas.

The role is lab-based, providing dedicated experimental support to our drug discovery programs. The successful candidate will deliver high-quality molecular biology data to build a detailed understanding of pharmacological response and mode of action for small molecules, PROTACs and ASOs. The work includes independent planning and execution of experiments, troubleshooting and timely reporting/presentation of data according to agreed timelines.

Essential Requirements:

* BSc/MSc degree in Molecular Biology, Biomedical, Pharmacology, Biochemistry or a related discipline with significant practical experience.
* Extensive experience in molecular and cellular biology techniques including protein and gene expression analysis, Western Blot, qPCR and cell culture. Ideally applied to relevant cellular assays and in vivo samples.
* Excellent communication skills and an ability to operate in a multi-disciplinary research environment.
* Independent analysis and evaluation of complex data and delivery of data to agreed timelines.

Desirable Experiences and Abilities:

* Experience within Cardiovascular, Renal and/or Metabolic disease areas.
* Expertise in the design, development and validation of assays for compound profiling.
* Experience in flow cytometry.
* Experience working with PROTACs and/or antisense oligonucleotides (ASOs) in Mode of Action studies and pharmacological profiling.
* Proven ability in providing technical leadership and guidance to others.
* Scientific visibility and leadership through project contributions and scientific publications.

The successful candidate demonstrates a passion for driving scientific questions through experimental work, combined with strong team working ethics. You have good social and communication skills, is collaborative and a great team player. You should also be able to work independently and have a positive, goal oriented and problem-solving attitude. Excellent English is required, both spoken and written, and good organizational skills are of use. Visa mindre
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Covid-19 Assessment Laboratory Scientist, AstraZeneca Gothenburg

Ansök    Jun 21    Randstad AB    Molekylärbiolog
Job description This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday and some weeks Mondays as well. Hours are 7am-4pm, 12pm-9pm. Please apply only if you are satisfied you can accommodate these shift patterns. This is a consulting assignment at AstraZeneca... Visa mer
Job description
This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday and some weeks Mondays as well. Hours are 7am-4pm, 12pm-9pm. Please apply only if you are satisfied you can accommodate these shift patterns. This is a consulting assignment at AstraZeneca in Gothenburg.

Responsibilities
This role covers responsibilities in two main areas: the Sample Handling Laboratories and the Molecular Biology Laboratories. Applicants can specify a preference to work in either area, or to flex across both.

Qualifications
Sample Handling: Scientists working in the Sample handling Laboratories are responsible for all process stages from arrival of human assessment specimens (currently saliva or nasal swabs) at the sample handling labs to the transfer of virally inactivated samples to the adjacent molecular biology labs. This work is performed to Biological Safety Level 2 (BSL2) in LAF containment facilities with appropriate PPE. Prior experience of working with infectious biological material to BS2 and with PPE is a key requirement for working in the sample handling laboratories.
Primary responsibilities include: visually inspecting specimens for packaging integrity (correct intact number of barrier layers, no evidence of leakage/spillage); assessment suitability (e.g., rejecting samples not properly labelled, containing foreign matter, incorrect volumes etc.); ensuring they are accounted for on the specimen manifest; following inspection, the removal of specimen transport tubes from the kit packaging; scanning into the LIMS system; and transfer to racks for further processing in suitably contained liquid handling automation. Tube to plate transfer, sample lysis and inactivation will be performed on the automation, and once completed the plates will be transferred to the adjacent molecular biology laboratories. On occasion this process may be run manually requiring experience with manual pipetting. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:
Work in BSL2 lab with pervious experience of aseptic technique preferred
Work with human biological specimens. HepB Vaccination advised
Work with infectious samples, ideally experience that may contain SARS-Cov-2 would be desirable
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team.
Experience of liquid handling automation would be desirable


Molecular Biology: Scientists working in the Molecular Biology Laboratories are responsible for all process stages from fully automated RNA extraction and RT-PCR workflows to the delivery of PCR based results to data analysts. This work is performed to Biological Safety Level 1 (BSL1) with appropriate PPE. Applicants should be comfortable performing this process while using PPE.
Primary responsibilities include: the operation of Beckman I series robotics to perform automated magnetic bead RNA extraction procedures; tracking samples through the LIMS system; RT-PCR reaction setup including manual pipetting as well as automated plate preparation using benchtop automation equipment; setting up molecular assays on qPCR instruments; and inspection and exporting of primary and QC results for subsequent downstream analysis by Data/QC analysts. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:
Work in BSL1 lab with previous experience of automation and molecular biology techniques preferred.
Work with human biological specimens. HepB Vaccination advised.
Work with samples which may contain SARS-Cov-2 would be desirable.
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team.
Experience with RT-PCR data analysis would be desirable

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-07-01, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Galia Nyström [email protected] 

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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(Senior) Research Scientist Molecular & Cell Biology, AstraZeneca

Ansök    Jun 14    Randstad AB    Molekylärbiolog
Job description Do you have a background in biochemistry or cell biology, aren’t afraid of trying new paths and doing things differently? Do you also feel passionate about the possibilities of science to change lives? Perfect, your next challenge might be this role at AstraZeneca! A position has arisen for a highly motivated (Senior) Research Scientist – Molecular and Cell Biology to join the Cell and Molecular Pharmacology (CMP) team within the Early Car... Visa mer
Job description
Do you have a background in biochemistry or cell biology, aren’t afraid of trying new paths and doing things differently? Do you also feel passionate about the possibilities of science to change lives? Perfect, your next challenge might be this role at AstraZeneca!

A position has arisen for a highly motivated (Senior) Research Scientist – Molecular and Cell Biology to join the Cell and Molecular Pharmacology (CMP) team within the Early Cardiovascular, Renal and Metabolic (CVRM) disease area in Gothenburg, Sweden.

Early CVRM is one of three main therapeutic research areas within AstraZeneca that deliver candidate drugs into late-stage clinical development. The CMP team delivers key data based on histology, imaging, biomarker, FACS and bioassay automation to support projects across the Cardiovascular, Renal and Metabolism disease areas. 

Responsibilities
The role is lab-based, providing dedicated experimental support to our drug discovery programs. The successful candidate will deliver high-quality molecular biology data to build a detailed understanding of pharmacological response and mode of action for small molecules, PROTACs and ASOs. The work includes independent planning and execution of experiments, troubleshooting and timely reporting/presentation of data according to agreed timelines. This is a consulting assignment at AstraZeneca in Gothenburg.

Qualifications
Essential Requirements:
BSc/MSc degree in Molecular Biology, Biomedical, Pharmacology, Biochemistry or a related discipline with significant practical experience.
Extensive experience in molecular and cellular biology techniques including protein and gene expression analysis, Western Blot, qPCR and cell culture. Ideally applied to relevant cellular assays and in vivo samples.
Excellent communication skills and an ability to operate in a multi-disciplinary research environment.
Independent analysis and evaluation of complex data and delivery of data to agreed timelines.

Desirable Experiences and Abilities:
Experience within Cardiovascular, Renal and/or Metabolic disease areas.
Expertise in the design, development and validation of assays for compound profiling.
Experience in flow cytometry.
Experience working with PROTACs and/or antisense oligonucleotides (ASOs) in Mode of Action studies and pharmacological profiling.
Proven ability in providing technical leadership and guidance to others.
Scientific visibility and leadership through project contributions and scientific publications.

The successful candidate demonstrates a passion for driving scientific questions through experimental work, combined with strong team working ethics. You have good social and communication skills, is collaborative and a great team player. You should also be able to work independently and have a positive, goal oriented and problem-solving attitude. Excellent English is required, both spoken and written, and good organizational skills are of use.

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-06-24, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Galia Nyström [email protected] or Linnea Öster [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Covid-19 Assessment Laboratory Lead, AstraZeneca Gothenburg

Ansök    Jun 7    Randstad AB    Molekylärbiolog
Job description This role is to lead one of the shifts within the AZ Sweden Covid-19 Assessment Laboratory, responsible for COVID-19 screening of AstraZeneca employees. Staff within this laboratory will be expected to work a shift pattern to enable 14 hours a day operation across 5 days a week – Tuesday to Saturday. Shift hours for this role will primarily be from 7am-4pm, and occasionally 12pm-9pm. Please only apply for this role if you are satisfied you ... Visa mer
Job description
This role is to lead one of the shifts within the AZ Sweden Covid-19 Assessment Laboratory, responsible for COVID-19 screening of AstraZeneca employees. Staff within this laboratory will be expected to work a shift pattern to enable 14 hours a day operation across 5 days a week – Tuesday to Saturday. Shift hours for this role will primarily be from 7am-4pm, and occasionally 12pm-9pm. Please only apply for this role if you are satisfied you can accommodate these working hours. This is a consulting assignment at AstraZeneca in Gothenburg.

Responsibilities
The COVID-19 Laboratory Lead will be responsible for the day to day running of the COVID-19 screening operation, and will report to the Swedish Covid-19 Assessment Laboratory Head. The shift period overlaps with the shift pattern of other appointed lab lead(s).

Primary responsibilities:
As a Laboratory Lead you will ensure team delivery of service in line with the predefined standard operating procedures (SOPs) and ISO 17025 accreditation. You will be responsible for the planning of staff daily activities, maximizing the deployment of available people and equipment resources. You will ensure both laboratory staff and data analysis staff have the information they need to perform their work by holding regular team meetings/1:1s and ad hoc discussions. You are expected to actively work in the lab as a part of the team, thereby gaining insight of everyday challenges whilst supporting the team with decision making.

Qualifications


Excellent communication skills
That you enjoy working with people in an agile environment
Onboarding and training new staff
Experience in planning lab work, working to SOPs and local and national regulations
Previous team leader experience is desirable
Work in BSL1 and BSL2 lab with previous experience of aseptic technique preferred
Work with human biological specimens. HepB Vaccination advised
Work with infectious samples, ideally experience that may contain SARS-Cov-2 would be desirable
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team
Experience with RT-PCR data analysis would be desirable
Experience of liquid handling automation would be desirable

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-06-17, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Eleonor Ehrman +46733434109 or Galia Nyström [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
Ansök

Senior Research Scientist - Translational Genomics

Ansök    Jun 1    Hays Specialist Recruitment AB    Molekylärbiolog
Translational Genomics Hays Specialist Recruitment is now looking to recruit a Senior Research Scientist to the Translational Genomics team for 1-year contract assignment at AstraZeneca in Gothenburg. Translational Genomics at AstraZeneca in Gothenburg, Sweden, have an exciting opportunity and is seeking a Senior Research Scientist to be part of the Transgenic Models team. The position is available immediately for a highly skilled and motivated cell a... Visa mer
Translational Genomics

Hays Specialist Recruitment is now looking to recruit a Senior Research Scientist to the Translational Genomics team for 1-year contract assignment at AstraZeneca in Gothenburg.

Translational Genomics at AstraZeneca in Gothenburg, Sweden, have an exciting opportunity and is seeking a Senior Research Scientist to be part of the Transgenic Models team. The position is available immediately for a highly skilled and motivated cell and molecular biologist/rodent in vivo physiologist with extensive experience and state-of-the-art knowledge in transgenic science & technology. If this sounds like the challenge for you, apply today!

We are looking for an expert in the area of murine transgenesis and its application in both transgenic animal model generation and in vivo phenotyping. This person will devise, champion and develop scientific areas aligned with project needs and be an authority in the area of molecular biology, in vivo science and precise genome editing - to lead this from a lab-based perspective and to make significant contributions to the practical delivery of AstraZeneca project goals.

You will provide disciplinary scientific leadership and represent the department at internal interdisciplinary meetings in addition to external meetings and to publish novel science in high impact journals. Along with this, you will propose experimental strategies, troubleshoot problems and make significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards.

We see that you have good social and communication skills, are collaborative and a strong team player. You should also be able to work independently and have a positive, goal oriented and problem-solving attitude. Excellent English is required, both spoken and written, and good organizational skills are essential.

The following skills are highly desirable:

* Molecular biology expertise and experience of working with mouse embryonic stem cells.
* Working knowledge of the latest precise genome engineering tools both in vitro and in vivo.
* Expertise in the generation and phenotypic characterization of transgenic animal models

The following skills would be an advantage:

* Experience in metabolic phenotyping platforms and analysis of metabolic function in mouse models e.g. performing indirect calorimetry and intraperitoneal glucose tolerance tests (IPGTT) to diagnose metabolic function in genetically-engineered mice.
* Experience of murine behavioural phenotyping
* Experience of preclinical mouse models for therapeutic gene editing delivery and efficacy approaches.

Minimum experience

* You should have a Ph.D. degree or corresponding experience in a relevant scientific discipline with experience in drug discovery or, alternatively, a first degree and significant relevant experience in drug discovery.

Generic component of SRS role descriptor
Accountabilities

* To design genome editing-based strategies and tools required to generate in vivo and in vitro reagents to create disease models
* To perform genetic screens in vitro and in vivo using genome editing tools
* To perform confirmation assays of genetic manipulation and functional validation of engineered animals
* To perform in vivo target validation studies in early projects Visa mindre
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Senior Research Scientist, AstraZeneca Gothenburg

Ansök    Maj 31    Randstad AB    Molekylärbiolog
Job description Senior Research Scientist - Mechanistic & Structural Biology At AstraZeneca we win through science, it’s at the heart of our every success. That science is only possible when we work together – we’ll always make sure you’re clear about how your role is connected to our wider mission to show what science can do. We are seeking a highly motivated and scientifically curious scientist to join Mechanistic & Structural Biology as a Senior Resea... Visa mer
Job description
Senior Research Scientist - Mechanistic & Structural Biology

At AstraZeneca we win through science, it’s at the heart of our every success. That science is only possible when we work together – we’ll always make sure you’re clear about how your role is connected to our wider mission to show what science can do.

We are seeking a highly motivated and scientifically curious scientist to join Mechanistic & Structural Biology as a Senior Research Scientist. You will have the opportunity to utilize your scientific capabilities to contribute to the progression of key drug discovery programs in a highly collaborative environment. The position will be located at our vibrant R&D site in Gothenburg, Sweden. You will apply proven cell biology expertise for profiling of the effects and mechanism of action of compound treatment in in vitro cellular assays. This is a consulting assignment at AstraZeneca in Gothenburg.

In this position, you will join a department whose remit is to support our BioPharmaceuticals drug discovery projects globally with early DMPK assessment, SAR profiling and detailed mechanism of action data. We offer a highly rewarding scientific environment and strong team working ethics. Mechanistic & Structural Biology (MSB) is a part of Discovery Sciences - a multidisciplinary department which drives early drug discovery across AstraZeneca’s global Research and Development portfolio.

Responsibilities
This is a lab-based role focused on generating in vitro pharmacology data in support of drug discovery projects globally with focus on SAR profiling and detailed mechanism of action data in cellular models across multiple modalities including small molecules, PROTACS and therapeutic oligonucleotides. We offer a highly rewarding scientific environment with ample learning opportunities and an expectation to publish new findings. You will be an experienced lab-based scientist, able to interact across a broad range of therapeutic projects and global initiatives within Discovery Sciences and externally. You will also represent the group on Project Teams and drive scientific and technical innovation in our strategic area, including the identification and development of innovative processes and workflows to deliver high quality and detailed data efficiently.

Qualifications
Essential Requirements:
Ph.D. in Pharmacology, Biochemistry or a related discipline or a BSc/MSc degree with significant proven experience, preferably in the Pharmaceutical or Biotechnology industry
Extensive experience in molecular and cellular biology techniques, including qPCR, applied to physiologically relevant cellular assays.
Excellent communication and collaborative skills and an ability to operate effectively in a multi-disciplinary research environment and team
Independent analysis and evaluation of complex data and delivery of data to agreed timelines
First-rate decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity
Scientific visibility and leadership through project contributions and external publications


Desirable Experiences and Abilities:
Experience with additional technologies for quantifying levels and turn-over of nucleic acids in cells is considered meriting
Expertise in the design, development and validation of cellular assays for compound profiling
Experience with cells grown in 3D cultures and organoids
Proven ability in providing technical leadership and guidance to others
Track record of identifying and adopting scientific and technical advances
Excellent problem-solving skills, not limited to own area of expertise
A proven publication track-record from several labs, such as a postdoctoral experience, in a relevant area

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-06-10, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Galia Nyström [email protected] 

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
Ansök

Senior Research Scientist - Mechanistic & Structural Biology

Ansök    Maj 31    Hays Specialist Recruitment AB    Molekylärbiolog
Discovery Sciences Hays Specialist Recruitment is now looking to recruit at Senior Research Scientist - Mechanistic & Structural Biology to join the Discovery Sciences team for a 9-month contract assignment starting 2021-09-01 at AstraZeneca in Gothenburg. At AstraZeneca we win through science, it's at the heart of our every success. That science is only possible when we work together - we'll always make sure you're clear about how your role is connec... Visa mer
Discovery Sciences

Hays Specialist Recruitment is now looking to recruit at Senior Research Scientist - Mechanistic & Structural Biology to join the Discovery Sciences team for a 9-month contract assignment starting 2021-09-01 at AstraZeneca in Gothenburg.

At AstraZeneca we win through science, it's at the heart of our every success. That science is only possible when we work together - we'll always make sure you're clear about how your role is connected to our wider mission to show what science can do.

We are seeking a highly motivated and scientifically curious scientist to join Mechanistic & Structural Biology as a Senior Research Scientist. You will have the opportunity to utilize your scientific capabilities to contribute to the progression of key drug discovery programs in a highly collaborative environment. The position will be located at our vibrant R&D site in Gothenburg, Sweden. You will apply proven cell biology expertise for profiling of the effects and mechanism of action of compound treatment in in vitro cellular assays.

In this position, you will join a department whose remit is to support our BioPharmaceuticals drug discovery projects globally with early DMPK assessment, SAR profiling and detailed mechanism of action data. We offer a highly rewarding scientific environment and strong team working ethics. Mechanistic & Structural Biology (MSB) is a part of Discovery Sciences - a multidisciplinary department which drives early drug discovery across AstraZeneca's global Research and Development portfolio.

Main Duties and Responsibilities:
This is a lab-based role focused on generating in vitro pharmacology data in support of drug discovery projects globally with focus on SAR profiling and detailed mechanism of action data in cellular models across multiple modalities including small molecules, PROTACS and therapeutic oligonucleotides. We offer a highly rewarding scientific environment with ample learning opportunities and an expectation to publish new findings. You will be an experienced lab-based scientist, able to interact across a broad range of therapeutic projects and global initiatives within Discovery Sciences and externally. You will also represent the group on Project Teams and drive scientific and technical innovation in our strategic area, including the identification and development of innovative processes and workflows to deliver high quality and detailed data efficiently.

Essential Requirements:

* Ph.D. in Pharmacology, Biochemistry or a related discipline or a BSc/MSc degree with significant proven experience, preferably in the Pharmaceutical or Biotechnology industry
* Extensive experience in molecular and cellular biology techniques, including qPCR, applied to physiologically relevant cellular assays.
* Excellent communication and collaborative skills and an ability to operate effectively in a multi-disciplinary research environment and team
* Independent analysis and evaluation of complex data and delivery of data to agreed timelines
* First-rate decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity
* Scientific visibility and leadership through project contributions and external publications

Desirable Experiences and Abilities:

* Experience with additional technologies for quantifying levels and turn-over of nucleic acids in cells is considered meriting
* Expertise in the design, development and validation of cellular assays for compound profiling
* Experience with cells grown in 3D cultures and organoids
* Proven ability in providing technical leadership and guidance to others
* Track record of identifying and adopting scientific and technical advances
* Excellent problem-solving skills, not limited to own area of expertise
* A proven publication track-record from several labs, such as a postdoctoral experience, in a relevant area Visa mindre
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Senior Research Scientist - Translational Genomics, AstraZeneca

Ansök    Jun 1    Randstad AB    Molekylärbiolog
Job description Translational Genomics at AstraZeneca in Gothenburg, Sweden, have an exciting opportunity and is seeking a Senior Research Scientist to be part of the Transgenic Models team. The position is available immediately for a highly skilled and motivated cell and molecular biologist/rodent in vivo physiologist with extensive experience and state-of-the-art knowledge in transgenic science & technology. If this sounds like the challenge for you, app... Visa mer
Job description
Translational Genomics at AstraZeneca in Gothenburg, Sweden, have an exciting opportunity and is seeking a Senior Research Scientist to be part of the Transgenic Models team. The position is available immediately for a highly skilled and motivated cell and molecular biologist/rodent in vivo physiologist with extensive experience and state-of-the-art knowledge in transgenic science & technology. If this sounds like the challenge for you, apply today!

Responsibilities
We are looking for an expert in the area of murine transgenesis and its application in both transgenic animal model generation and in vivo phenotyping. This person will devise, champion and develop scientific areas aligned with project needs and be an authority in the area of molecular biology, in vivo science and precise genome editing - to lead this from a lab-based perspective and to make significant contributions to the practical delivery of AstraZeneca project goals. This is a consulting position at AstraZeneca in Gothenburg.

You will provide disciplinary scientific leadership and represent the department at internal interdisciplinary meetings in addition to external meetings and to publish novel science in high impact journals. Along with this, you will propose experimental strategies, troubleshoot problems and make significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards.

We see that you have good social and communication skills, are collaborative and a strong team player. You should also be able to work independently and have a positive, goal oriented and problem-solving attitude. Excellent English is required, both spoken and written, and good organizational skills are essential.

Qualifications
The following skills are highly desirable:
Molecular biology expertise and experience of working with mouse embryonic stem cells.
Working knowledge of the latest precise genome engineering tools both in vitro and in vivo.
Expertise in the generation and phenotypic characterization of transgenic animal models.

The following skills would be an advantage:
Experience in metabolic phenotyping platforms and analysis of metabolic function in mouse models e.g. performing indirect calorimetry and intraperitoneal glucose tolerance tests (IPGTT) to diagnose metabolic function in genetically-engineered mice.
Experience of murine behavioural phenotyping.
Experience of preclinical mouse models for therapeutic gene editing delivery and efficacy approaches.

Minimum experience:
You should have a Ph.D. degree or corresponding experience in a relevant scientific discipline with experience in drug discovery or, alternatively, a first degree and significant relevant experience in drug discovery.

Generic component of SRS role descriptor
Accountabilities
To design genome editing-based strategies and tools required to generate in vivo and in vitro reagents to create disease models.
To perform genetic screens in vitro and in vivo using genome editing tools.
To perform confirmation assays of genetic manipulation and functional validation of engineered animals.
To perform in vivo target validation studies in early projects.

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-06-11, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Galia Nyström [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Senior Scientist Translational Science, AstraZeneca Gothenburg

Ansök    Maj 11    Randstad AB    Molekylärbiolog
Job description The RIA Translational Science and Experimental Medicine department is an agile environment, with a culture that is science and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population, and close the gap between bench science and bedside clinical practice. A key role of Precision Medicine Discovery is to lead the human validation of our targe... Visa mer
Job description
The RIA Translational Science and Experimental Medicine department is an agile environment, with a culture that is science and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population, and close the gap between bench science and bedside clinical practice.

A key role of Precision Medicine Discovery is to lead the human validation of our targets, identify Proof-of Mechanism (PoM) biomarkers and deliver precision medicine approach. Underpinned by a robust understanding of respiratory disease relevant pathways and drivers, the Senior scientist translational science is a key scientific role, building mechanistic understanding of the target and disease through innovative application of experimental methods and technologies. She/he is a laboratory-based scientist, with the critical accountabilities for identifying and enabling PoM biomarkers to demonstrate target engagement at First-Time-In-Man (FITM) and leading the pre-clinical target validation strategy from TSID. Working closely with the Biomarker Discovery Scientists, other decision making and exploratory biomarkers will be identified and developed for each project.

The role is laboratory based, requiring flexibility to ensure all translational aspects of the projects are supported in a timely fashion. This is a consulting position at AstraZeneca in Gothenburg.

Responsibilities
Accountable for delivery of human target validation in relevant models by experimentally demonstrating presence and functional implication of the target in relevant disease mechanisms, mechanistic understanding of target and disease.
Accountable to identify and develop PoM biomarkers, Decision Making and other Exploratory Biomarkers as required for each target.
Will effectively communicate results, plans, and strategies via scientific reports, regulatory documents, oral and written methods of communication.
Will use judgment and knowledge where appropriate to influence the work of projects, teams, section and departments.
Will be an effective team member in supporting projects to meet their objectives striving for continuous improving processes by identifying, championing, and/or contributing to the development of solutions that hinder efficiency and effectiveness.


Qualifications
Education
PhD or equivalent with a strong experimental drive and background in basic science related to respiratory research.
Post-doc experience or otherwise relevant scientific research experience.
Experience in pharmaceutical R&D.
Strong publication record.

Experience and skills
Broad understanding of several technologies and methodologies along with excellent scientific laboratory skills and ability to experimentally address key scientific questions, including Cell culture: cell lines and primary cells, Nucleic acid isolation, RT-qPCR, ELISA, MSD assays, FACS.
Understanding of the Respiratory therapy area and disease biology, including molecular pathways and mechanisms related to respiratory diseases.
Excellent skills in hypothesis forming and testing, able to draw conclusions and suggest next steps based on the experimental data.
Strong leadership skills ability to be a self-starter.
A good understanding of the drug development process, from lead identification through clinical development.
Ability to work productively in a matrix team environment and excellent collaborative skills.
Good networking and communication (written and oral) skills and a strong delivery focus.

Other responsibilities and Business Impact
Will have a good working knowledge of all relevant company policies - ensure GLS compliance, compliance with corporate code of conduct and adherence to best SHE practice for self and others - and national regulations, and ensure that industry standards are applied to working for self and others within the discipline team.

Culture
Contributes to a science-driven and entrepreneurial organization hungry for new ideas, innovative ways of working and continuous learning.
Positive can-do attitude, with respect for the individuals with different skillset and knowledge, eager to learn in each interaction.
Collaborate closely with other teams to drive efficiency and take advantage of knowledge and experiences.

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-05-20, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Galia Nyström [email protected] or Eleonor Ehrman +46733434109

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Senior Molecular Biology Scientist

Ansök    Maj 26    Hays Specialist Recruitment AB    Molekylärbiolog
Discovery Sciences Organisation Hays Specialist Recruitment is now looking to recruit a Senior Molecular Biology Scientist to join the Discovery Sciences Organisation for a 5-month contract assignment at AstraZeneca in Gothenburg. As part of a team within the Discovery Sciences organization, you will be working within a vibrant scientific environment to support drug discovery. We push scientific advances in small molecules, oligonucleotides as well as... Visa mer
Discovery Sciences Organisation

Hays Specialist Recruitment is now looking to recruit a Senior Molecular Biology Scientist to join the Discovery Sciences Organisation for a 5-month contract assignment at AstraZeneca in Gothenburg.

As part of a team within the Discovery Sciences organization, you will be working within a vibrant scientific environment to support drug discovery. We push scientific advances in small molecules, oligonucleotides as well as other emerging technologies, always with a view to providing medicines to improve patient care. The Discovery Biology Department of Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in the drug discovery pipeline from target discovery all the way to clinical candidate.

Main Duties & Responsibilities
This is a lab-based role, generating bespoke protein reagents to support projects in all phases of the discovery process. The role involves application of leading molecular biology techniques to design expression constructs, make DNA constructs for protein expression, producing recombinant proteins that impact projects, as well as troubleshooting. In addition, you might be asked to contribute to projects in other related areas such as running cell-based assays.

Essential Requirements

* Master or Ph.D. in Molecular Biology, Biotechnology, Cell Biology, Biochemistry or a related discipline, or 5 years of relevant working experience within Biotechnology
* Expertise in molecular biology using a variety of techniques (Golden Gate, Gibson assembly or similar techniques)
* Experience in design of DNA constructs for recombinant protein production
* Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment
* Independent analysis and evaluation of complex data and delivery of data to agreed timelines

Desirable Requirements

* Experience in design of DNA constructs for other applications such as cell line generation for assay is highly desirable
* Experience in use of automation equipment such as liquid handling platforms
* Experience in handling eukaryotic cells and running cell-based assays such as reporter gene assays Visa mindre
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Senior Scientist Molecular Biology, AstraZeneca Gothenburg

Ansök    Maj 26    Randstad AB    Molekylärbiolog
Job description As part of a team within the Discovery Sciences organization, you will be working within a vibrant scientific environment to support drug discovery. We push scientific advances in small molecules, oligonucleotides as well as other emerging technologies, always with a view to providing medicines to improve patient care. The Discovery Biology Department of Discovery Sciences is responsible for the generation of novel reagents and assays to su... Visa mer
Job description
As part of a team within the Discovery Sciences organization, you will be working within a vibrant scientific environment to support drug discovery. We push scientific advances in small molecules, oligonucleotides as well as other emerging technologies, always with a view to providing medicines to improve patient care. The Discovery Biology Department of Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in the drug discovery pipeline from target discovery all the way to clinical candidate. This is a consulting assignment at AstraZeneca in Gothenburg.

Responsibilities
This is a lab-based role, generating bespoke protein reagents to support projects in all phases of the discovery process. The role involves application of leading molecular biology techniques to design expression constructs, make DNA constructs for protein expression, producing recombinant proteins that impact projects, as well as troubleshooting. In addition, you might be asked to contribute to projects in other related areas such as running cell-based assays.

Qualifications
Essential Requirements
Master or Ph. D in Molecular Biology, Biotechnology, Cell Biology, Biochemistry or a related discipline, or 5 years of relevant working experience within Biotechnology
Expertise in molecular biology using a variety of techniques (Golden Gate, Gibson assembly or similar techniques)
Experience in design of DNA constructs for recombinant protein production
Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment
Independent analysis and evaluation of complex data and delivery of data to agreed timelines


Desirable Requirements
Experience in design of DNA constructs for other applications such as cell line generation for assay is highly desirable
Experience in use of automation equipment such as liquid handling platforms
Experience in handling eukaryotic cells and running cell-based assays such as reporter gene assays

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-06-03, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Galia Nyström [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Covid-19 Assessment Laboratory Data Analyst, AstraZeneca

Ansök    Apr 19    Randstad AB    Molekylärbiolog
Job description This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours for this role is 12pm- 9pm. Please apply only if you are satisfied you can accommodate these working hours. This  is a consulting assignment at AstraZeneca in Gothenburg.  Responsi... Visa mer
Job description
This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours for this role is 12pm- 9pm. Please apply only if you are satisfied you can accommodate these working hours. This  is a consulting assignment at AstraZeneca in Gothenburg. 

Responsibilities
This role covers responsibilities in two main areas: the Analysis of PCR data generated from human specimens to assess the presence/absence of SARS-Cov-2 virus and generation of the data at the Molecular Biology Laboratories.

Qualifications
Analysis of PCR data: Primary responsibilities include: liaising with Covid-19 Assessment Laboratory Scientists to receive exported PCR data; data QC analysts of PCR data and correct tracking and recording of the analysis in the appropriate LIMS database (utilising a proprietary off the shelf data analysis package).

Key Requirements for this role:
Experience in RT-PCR data analysis.
Previous experience of data analysis software and use of LIMS and databases desirable.
Attention to detail, strictly adhering to SOPs.
Working and communicating across a fast-paced cross organisational team.


Molecular Biology: Scientists working in the Molecular Biology Laboratories are responsible for all process stages from fully automated RNA extraction and RT-PCR workflows to the delivery of PCR based results to data analysts. This work is performed to Biological Safety Level 1 (BSL1) with appropriate PPE. Applicants should be comfortable performing this process while using PPE.
Primary responsibilities include: the operation of Beckman I series robotics to perform automated magnetic bead RNA extraction procedures; tracking samples through the LIMS system; RT-PCR reaction setup including manual pipetting as well as automated plate preparation using benchtop automation equipment; setting up molecular assays on qPCR instruments; and inspection and exporting of primary and QC results for subsequent downstream analysis by Data/QC analysts. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:
Work in BSL1 lab with previous experience of automation and molecular biology techniques preferred.
Work with human biological specimens. HepB Vaccination advised.
Work with samples which may contain SARS-Cov-2 would be desirable.
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team.
Experience with RT-PCR data analysis would be desirable.

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-04-27, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Eleonor Ehrman +46733 434109

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Research Scientist NGS/Transcriptomics, AstraZeneca Gothenburg

Ansök    Apr 12    Randstad AB    Molekylärbiolog
Job description Are you an engaged scientist with molecular biology experience? Do you want to explore and develop the science of oligonucleotide treatment, and have a passion to drive scientific questions? Welcome to join us at AstraZeneca! We seek a highly motivated Research Scientist to join the NGS & Transcriptomics team within the Translational Genomics Department in our Discovery Sciences R&D organization in Gothenburg, Sweden. You will apply proven... Visa mer
Job description
Are you an engaged scientist with molecular biology experience? Do you want to explore and develop the science of oligonucleotide treatment, and have a passion to drive scientific questions? Welcome to join us at AstraZeneca!

We seek a highly motivated Research Scientist to join the NGS & Transcriptomics team within the Translational Genomics Department in our Discovery Sciences R&D organization in Gothenburg, Sweden. You will apply proven molecular biology expertise to the characterization and profiling of the effects of oligonucleotide treatment with in vitro biochemical and cellular assays.

The NGS & Transcriptomics team’s remit is the development and application of nucleic acid “omics” technologies and processes to generate smart data that will enrich our understanding of drug pharmacology, target mechanisms, model systems, patients and disease. We offer a highly exciting scientific environment with ample learning opportunities and an expectation to publish new findings.

Responsibilities
This role is a scientific specialist in the NGS/Transcriptomics area - a hands-on lab-based role at the forefront of NGS /Transcriptomics technology with a focus on effective delivery, troubleshooting and putting ideas into action. In this role, you will apply high throughput methods and strategies to projects sought at identifying novel oligonucleotide based therapies. This is a consulting assignment at AstraZeneca in Gothenburg.

With your significant expertise within the molecular biology field you will actively be involved in the planning and execution of scientific projects centered around oligonucleotide therapy. You will apply cutting edge technologies and methodologies to establish a high efficiency qPCR oligonucleotide screening capability in the NGS & Transcriptomics team. As well as design and execute NGS experiments to explore the science of selected oligonucleotide; including – primary and secondary mechanistic impacts and off target effects.

We also rely you to:
Apply this HT-qPCR capability to the activity screening of oligonucleotide libraries to discover novel hits.
Apply NGS technologies to identify on-target and off-target transcripts.
Build strong collaborative relationships with the project investigators, key partners, project bioinformaticians and data scientists to ensure the smooth running of projects.


Qualifications
Candidates should have a Master degree.
Hands on experience with a broad range of molecular biology methodologies (e.g. extraction and purification of nucleic acids from cells and tissues, PCR and RT-qPCR, electrophoresis of DNA and RNA molecules).
Hands on experience with design and execution of high-throughput experiments.
Prior experience with NGS technologies is considered as an advantage.
This experience will cover all relevant aspects from hypothesis generation, through experimental design and execution, sample and library preparation, sequencing, data handling, post sequencing QC and trouble shooting.

We also see that the successful candidate has great communication skills and an ability to operate effectively in a multi-disciplinary research environment. You are a person who demonstrate a passion for driving scientific questions, combined with strong team working ethics, to drug discovery projects.

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-04-20 selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Galia Nyström [email protected] or Eleonor Ehrman +46733 434109

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Covid-19 Assessment Laboratory Scientist, AstraZeneca Gothenburg

Ansök    Maj 6    Randstad AB    Molekylärbiolog
Job description This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday and some weeks Mondays as well. Hours are 7am-4pm, 12pm-9pm. Please apply only if you are satisfied you can accommodate these shift patterns. This is a consulting assignment at AstraZeneca... Visa mer
Job description
This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday and some weeks Mondays as well. Hours are 7am-4pm, 12pm-9pm. Please apply only if you are satisfied you can accommodate these shift patterns. This is a consulting assignment at AstraZeneca in Gothenburg.

Responsibilities
This role covers responsibilities in two main areas: the Sample Handling Laboratories and the Molecular Biology Laboratories. Applicants can specify a preference to work in either area, or to flex across both.

Qualifications
Sample Handling: Scientists working in the Sample handling Laboratories are responsible for all process stages from arrival of human assessment specimens (currently saliva or nasal swabs) at the sample handling labs to the transfer of virally inactivated samples to the adjacent molecular biology labs. This work is performed to Biological Safety Level 2 (BSL2) in LAF containment facilities with appropriate PPE. Prior experience of working with infectious biological material to BS2 and with PPE is a key requirement for working in the sample handling laboratories.

Primary responsibilities include: visually inspecting specimens for packaging integrity (correct intact number of barrier layers, no evidence of leakage/spillage); assessment suitability (e.g., rejecting samples not properly labelled, containing foreign matter, incorrect volumes etc.); ensuring they are accounted for on the specimen manifest; following inspection, the removal of specimen transport tubes from the kit packaging; scanning into the LIMS system; and transfer to racks for further processing in suitably contained liquid handling automation. Tube to plate transfer, sample lysis and inactivation will be performed on the automation, and once completed the plates will be transferred to the adjacent molecular biology laboratories. On occasion this process may be run manually requiring experience with manual pipetting. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:
Work in BSL2 lab with pervious experience of aseptic technique preferred
Work with human biological specimens. HepB Vaccination advised
Work with infectious samples, ideally experience that may contain SARS-Cov-2 would be desirable
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team
Experience of liquid handling automation would be desirable


Molecular Biology: Scientists working in the Molecular Biology Laboratories are responsible for all process stages from fully automated RNA extraction and RT-PCR workflows to the delivery of PCR based results to data analysts. This work is performed to Biological Safety Level 1 (BSL1) with appropriate PPE. Applicants should be comfortable performing this process while using PPE.

Primary responsibilities include: the operation of Beckman I series robotics to perform automated magnetic bead RNA extraction procedures; tracking samples through the LIMS system; RT-PCR reaction setup including manual pipetting as well as automated plate preparation using benchtop automation equipment; setting up molecular assays on qPCR instruments; and inspection and exporting of primary and QC results for subsequent downstream analysis by Data/QC analysts. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:
Work in BSL1 lab with previous experience of automation and molecular biology techniques preferred
Work with human biological specimens. HepB Vaccination advised
Work with samples which may contain SARS-Cov-2 would be desirable
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team
Experience with RT-PCR data analysis would be desirable

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-05-13, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Eleonor Ehrman +46733434109 or Galia Nyström [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Research Scientist Therapeutic Genome Editing, AstraZeneca

Ansök    Mar 22    Randstad AB    Molekylärbiolog
Job description At AstraZeneca we use scientific excellence as our foundation for driving success in our drug discovery pipeline. We underpin this with strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery. An exciting opportunity is now available to join the Precise Genome Editing team within Discovery Sciences, which has responsibility for the generation of novel genome editing technologies to supp... Visa mer
Job description
At AstraZeneca we use scientific excellence as our foundation for driving success in our drug discovery pipeline. We underpin this with strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery.

An exciting opportunity is now available to join the Precise Genome Editing team within Discovery Sciences, which has responsibility for the generation of novel genome editing technologies to support projects in all phases of the drug discovery pipeline. We have a focus on target identification, target validation, disease model generation and the therapeutic use of stem cells. We are seeking a scientist for a consultant assignment to join our team in Gothenburg Sweden, where the role will focus on developing gene editing strategies for potential therapeutic use.

The role
Leveraging your strong knowledge and experience in genome editing you will have the opportunity apply your knowledge to gene therapy projects. This includes design of genome editing strategies, implement them using techniques including CRISPR/Cas9 and validate the results. The role is focused on conducting laboratory-based activities, applying your knowledge and skills to drive project delivery and scientific innovation, participating actively in problem solving and working globally with Astrazeneca colleagues and collaborators.

It is essential to have good social and communication skills, be collaborative and a strong team player and be an innovative thinker. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude. Good organisational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Responsibilities
To design and develop genome editing-based strategies and tools required to generate in vitro and in vivo models
To implement delivery tools to improve the efficiency of genome editing
To perform confirmation of genetic manipulation and functional validation of engineered models
To develop novel engineering tools based on CRISPR/Cas9, base/prime editors


Qualifications
Essential skills for the job:
Strong knowledge and hands on experience with genome editing tools (including base or prime editors)
Expertise with CRISPR based manipulation of cell lines and/or stem cells
Expertise with NGS analysis of genome editing outcomes (Amplicon Seq, Guide-Seq, CIRCLE-Seq, Discover-Seq)


The following skills are highly desirable but not essential
Basic programming skills with the ability to use and develop in silico genetic analysis tool


Minimum experience
You should hold a Ph.D. in Molecular Biology, Cellular Biology or a related degree or have significant relevant experience working in a precise genome editing/molecular biology environment.

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-03-31, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information, please contact Galia Nyström [email protected] or Eleonor Ehrman +46733434109

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Biomarker Scientist, AstraZeneca Gothenburg

Ansök    Feb 4    Randstad AB    Molekylärbiolog
Job description Do you have expertise in Biomarker Discovery and Development in Cardiovascular and Metabolic Diseases? Would you like to apply your expertise at a company that are following the science and turn ideas into life changing medicines? Then you might be the one we are looking for! We are now looking for a Senior Scientist, Biomarkers Discovery and Development to join the Biomarker team within Translational Science & Experimental Medicine (TS&EM... Visa mer
Job description
Do you have expertise in Biomarker Discovery and Development in Cardiovascular and Metabolic Diseases? Would you like to apply your expertise at a company that are following the science and turn ideas into life changing medicines? Then you might be the one we are looking for!

We are now looking for a Senior Scientist, Biomarkers Discovery and Development to join the Biomarker team within Translational Science & Experimental Medicine (TS&EM;) department in the Cardiovascular Renal and Metabolic Diseases (CVRM) therapeutic area. This is a consultant assignment at AstraZeneca in Gothenburg, Sweden.

CVRM is one of the three main therapeutic research areas within Innovative Medicines and Early Development, AstraZeneca’s small molecule biotech unit that deliver candidate drugs into late-stage clinical development. CVRM TS&EM; has the remit to bridge pre-clinical, early and late drug development by providing early target validation in humans and by driving precision medicine approaches through biomarker discovery and development based on understanding of human diseases and access to human patient samples.

The biomarker team has the accountability from pre-clinical to clinical biomarker delivery which include biomarker discovery for identification of target engagement and proof-of-mechanism biomarkers, generation of target related precision medicine hypothesis, analysis of explorative biomarkers in clinical projects, and for outsourcing biomarkers according to good clinical practice for internal decisions in clinical studies.

Responsibilities
As a Senior Scientist in the Biomarker team, you will play a key role from preclinical to clinical biomarker delivery for progressing projects and science. You will be responsible for delivering high quality and robust biomarker data package to support project progression across the CVRM project portfolio. This involves implementation of novel biomarker methods, e.g. ligand binding approaches using state of the art analytical techniques, biomarker analysis, reporting biomarker data and evaluation to the project teams. You will also be responsible for outsourcing decision-making biomarkers (Good clinical practise, GCP) as well as explorative mechanistic biomarkers in the clinical projects. This process involves CRO selection, Due Diligence process, contracts, assay validation, and sample monitoring.

Collaboration is critical for successful delivery of drug projects and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators. In this role, you will have the opportunity to try novel techniques and ideas required for progressing existing portfolio and novel science
The role requires interactive, effective communication providing clear data and interpretation to projects and contribution to the translational scientific strategy. You will make judgements about complex scientific information, developing innovative solutions and applying comprehensive cross-functional understanding.

Qualifications
Expertise in a range of analytical techniques for biomarker analysis, specifically, immunoassay/ELISA platforms (MSD, SIMOA, Luminex, Erenna, etc), mRNA analysis, flow cytometry etc.
Experience in development of novel bioanalytical methods for quantification of biomarkers
Plan and report all work to appropriate standards (Good Laboratory Standard, GLS) and Good clinical practise for outsourcing clinical biomarkers
Experience in biomarker discovery and development in cardiovascular, renal and metabolism.
Maintain awareness of relevant areas of research, drug discover/development technologies and regulatory requirements through reading scientific literature and guidelines
Perform problem solving studies by identification of issues and where necessary designing experiments to overcome problems.
Good project management and matrix leadership skills, ability to collaborate well cross functions
Passion for delivering and promoting excellence in science.
Excellent English communication skills, both verbal and written

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-02-11, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Eleonor Ehrman +46733434109

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Research Scientist Biosamples Biobank AstraZeneca Gothenburg

Ansök    Apr 7    Randstad AB    Molekylärbiolog
Job description We are currently recruiting for a temporary Research Scientist in the AZ Gothenburg Biobank group within the global Precision Medicine and Biosamples organization. This position will provide the opportunity to work in a dynamic and enthusiastic environment whilst supplying a critical service to drug discovery projects. The work is highly collaborative with the team having a collective responsibility for the overall delivery. This is a consu... Visa mer
Job description
We are currently recruiting for a temporary Research Scientist in the AZ Gothenburg Biobank group within the global Precision Medicine and Biosamples organization. This position will provide the opportunity to work in a dynamic and enthusiastic environment whilst supplying a critical service to drug discovery projects. The work is highly collaborative with the team having a collective responsibility for the overall delivery. This is a consulting position at AstraZeneca in Gothenburg.

Responsibilities
Biobank scientists are responsible for the storage and timely supply of human biological samples (HBS) to AZ research projects. HBS are received from e.g. clinical studies or academic collaborations, stored in local biobanks and distributed to projects. The group primarily supports the Sweden Region but partners with other Biobank groups within the Biosamples department globally to provide efficient support across AZ and our partner organisations.


The Biobank group works collaboratively to provide support within agreed service levels with a strong focus on our customers. We strive hard to understand what fits their needs best and to add value through our services. With an increased focus on the value and use of biobank samples we actively seek ways to improve our process or exploit new technology to build a cutting edge facility.


The role is focused on supporting drug discovery projects within R&D Gothenburg by maintaining a high quality handling and storage of HBS and support projects with requested samples in a timely manner.


As a Biobank Research Scientist you will be expected to:
Work as part of the team rotating between the following typical tasks
Receive and register incoming HBS
Process requests for HBS to customers
Manage customer orders using specialized informatics systems as well as databases
Responding to customer queries via mail or telephone
Partner with Biobank groups globally as well as internal and external customers
Act upon day-to-day issues that occur whilst processing HBS samples to ensure continuous improvement

The group has a strong emphasis on continuous improvement which takes the form of individual and group projects within the team, the department and across Biobank groups within AZ.

Qualifications
Minimum experience
You should ideally have a degree in a Bioscience or Chemistry discipline and previous experience of laboratory work handling biological samples. Previous knowledge and experience (>1 year) of biobanking in a current setting is a clear advantage. Experience of working with various IT solutions, including extensive knowledge of Excel, LIMS systems and database usage, is also an advantage.


The biobank team is a highly collaborative group working to tight delivery schedules so the ability to be comfortable working at a fast pace with a goal orientated and team focussed attitude is essential. Excellent communication skills with a proactive and service minded approach is key.


Preferred experience/requirements
Key Attributes
Ability to plan, perform and evaluate experiments to investigate improvement possibilities in a process
Knowledge of the drug discovery process
Interest in logistics and developing processes through customer interactions and technology awareness
Drive and enthusiasm to solve the root cause of problems and not only overcome the presenting problem
Thrive on working in a committed team and gain satisfaction from the overall performance of the group 

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-04-17 selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Eleonor Ehrman +46733 434109

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Research Scientist, Translational Genomics In Vivo Physiology

Ansök    Jan 19    Hays Specialist Recruitment AB    Molekylärbiolog
Research Scientist, Translational Genomics In Vivo Physiology Hays Specialist Recruitment is now looking for a Research Scientist to join the Translational Genomics In Vivo Physiology team for a contract assignment starting as soon as possible and ending 2021-06-30 at AstraZeneca in Gothenburg. The Discovery Sciences, Translational Genomics department is looking for a research scientist to be part of our in vivo physiology discipline within the Transg... Visa mer
Research Scientist, Translational Genomics In Vivo Physiology

Hays Specialist Recruitment is now looking for a Research Scientist to join the Translational Genomics In Vivo Physiology team for a contract assignment starting as soon as possible and ending 2021-06-30 at AstraZeneca in Gothenburg.

The Discovery Sciences, Translational Genomics department is looking for a research scientist to be part of our in vivo physiology discipline within the Transgenic Models team. This position is based at the AstraZeneca R&D site in Gothenburg, Sweden and we are seeking a scientific and technical specialist in the animal in vivo physiology field. As a successful candidate you are experimentally focused, with strong troubleshooting skills and adept at putting ideas into practice. You will perform experimental strategies and make significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards and of central importance is experience with murine in vivo experimentation. You will have good social and communication skills, be collaborative and be a strong team player. Candidates should be able to work independently and have a positive, goal oriented and problem-solving attitude. Good organizational skills are required, and you should be comfortable in presenting your results. Excellent English is required, both spoken and written.

Specific responsibilities

* Perform studies within the in vivo physiology discipline with full engagement with stakeholders to ensure the discipline operates at the scientific forefront, using world leading technologies and infrastructure to support all core disease areas
* Ensure that studies are conducted with quality, dedication and data delivered according to stipulated time lines and project requirements
* Compile, interpret, present and discuss data with key project teams and stakeholders
* Actively promote the in vivo physiology discipline activities to ensure visibility in the wider AstraZeneca organization
* Hands on activity in the lab when required for timely project progression

The following skills would be an advantage:

* Experience in metabolic phenotyping platforms and analysis of metabolic function in mouse models e.g. performing indirect calorimetry and intraperitoneal glucose tolerance tests (IPGTT) to diagnose metabolic function in genetically-engineered mice, phenotyping platforms such as hyperinsulinemic-euglycemic clamps.
* Molecular biology expertise and a working knowledge of the latest precise genome engineering tools both in vitro and in vivo.
* Expertise in the generation and characterization of transgenic animal models
* Generation and use of viral vectors for in vivo genetic engineering

Minimum Requirements -Education and Experience

* You should have a Ph.D degree or corresponding experience in a relevant scientific discipline with experience in drug discovery or, alternatively, a first degree and significant relevant experience in drug discovery.

We look forward to receiving your application!

Hays Specialist Recruitment Visa mindre
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Holiday work Life Science, AstraZeneca Gothenburg

Ansök    Feb 2    Randstad AB    Molekylärbiolog
Job description Are you interested in the development of pharmaceuticals and curious about what it is like to work at AstraZeneca? Do you have a summer break and would like to learn new skills in an exciting environment? Welcome with your application for Holiday Work at AstraZeneca in Gothenburg!   At AstraZeneca, all of our employees make a difference to patients’ lives every day. We operate in more than 100 countries around the world and are one of Swede... Visa mer
Job description
Are you interested in the development of pharmaceuticals and curious about what it is like to work at AstraZeneca? Do you have a summer break and would like to learn new skills in an exciting environment? Welcome with your application for Holiday Work at AstraZeneca in Gothenburg!
 
At AstraZeneca, all of our employees make a difference to patients’ lives every day. We operate in more than 100 countries around the world and are one of Sweden’s most important export companies.
 
With more than 2,400 employees from 50 countries, the vibrant Gothenburg site helps to support the entire life-cycle of AstraZeneca medicines, from drug discovery and clinical trials, to global commercialisation and product maintenance. Gothenburg is one of AstraZeneca’s three strategic, global R&D centres, alongside Cambridge and Gaithersburg, and plays a central role in our mission to deliver life-changing medicines to patients.

Responsibilities
Your placement will depend on your previous experience, education and what department you will work in. The holiday work experience will provide you with valuable insight into working in an international company within the biopharmaceutical industry. 
 
Continuing COVID-19 restrictions mean we are unable to currently accommodate as many Holiday Workers at AstraZeneca sites and, as a result, we have reduced the amount of available Holiday Worker assignments this year.
 
Please note that we have three different advertisements for holiday work at AstraZeneca this year, within IT-technology, Life Science and administrative/facility. Please apply only to the advertisement that suits your qualifications best.

Qualifications


You are currently a University student within Life Science or Engineering, e.g. chemistry, biotechnology, pharmacy etc.
You have a genuine interest and curiosity to learn new things and would like to gain insight in working in a large international company.

If you have already graduated, please visit vacancies at www.careers.astrazeneca.com.

Application
To send your application, click “Apply!”. Please attach your CV and personal letter in Swedish or English. Make sure to specify your line of interest, experience and your technical skills. You can apply even if you are not available all summer, please specify which weeks you are available.
 
All complete applications will be registered. During March, the number of summer job opportunities will be compiled, and your application will be matched against the open positions.
Randstad is responsible for the recruitment and if you are selected for the next step in the process, you will be contacted in March-April. Randstad will also contact all candidates that are not selected for holiday work via e-mail in the beginning of May.
Your employment will be with Randstad and you will have an assignment at AstraZeneca during the summer. All chosen candidates will have to go through a background check and undergo an alcohol and drug test before starting the assignment.
 
We only handle applications sent through www.randstad.se 
 
Welcome to apply latest March 14th.
 
For more information please contact Eleonor Ehrman +46733434109.

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Research Scientist, In Vivo Physiology, AstraZeneca Gothenburg

Ansök    Jan 19    Randstad AB    Molekylärbiolog
Job description The Discovery Sciences, Translational Genomics department is looking for a research scientist to be part of our in vivo physiology discipline within the Transgenic Models team. This position is based at the AstraZeneca R&D site in Gothenburg, Sweden and we are seeking a scientific and technical specialist in the animal in vivo physiology field. As a successful candidate you are experimentally focused, with strong troubleshooting skills and ... Visa mer
Job description
The Discovery Sciences, Translational Genomics department is looking for a research scientist to be part of our in vivo physiology discipline within the Transgenic Models team. This position is based at the AstraZeneca R&D site in Gothenburg, Sweden and we are seeking a scientific and technical specialist in the animal in vivo physiology field. As a successful candidate you are experimentally focused, with strong troubleshooting skills and adept at putting ideas into practice. You will perform experimental strategies and make significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards and of central importance is experience with murine in vivo experimentation. You will have good social and communication skills, be collaborative and be a strong team player. Candidates should be able to work independently and have a positive, goal oriented and problem-solving attitude. Good organizational skills are required and you should be comfortable in presenting your results. Excellent English is required, both spoken and written. This is a consultant assignment at AstraZeneca in Gothenburg.

Responsibilities
Perform studies within the in vivo physiology discipline with full engagement with stakeholders to ensure the discipline operates at the scientific forefront, using world leading technologies and infrastructure to support all core disease areas
Ensure that studies are conducted with quality, dedication and data delivered according to stipulated time lines and project requirements
Compile, interpret, present and discuss data with key project teams and stakeholders
Actively promote the in vivo physiology discipline activities to ensure visibility in the wider AstraZeneca organization
Hands on activity in the lab when required for timely project progression


Qualifications
The following skills would be an advantage:
Experience in metabolic phenotyping platforms and analysis of metabolic function in mouse models e.g. performing indirect calorimetry and intraperitoneal glucose tolerance tests (IPGTT) to diagnose metabolic function in genetically-engineered mice, phenotyping platforms such as hyperinsulinemic-euglycemic clamps.
Molecular biology expertise and a working knowledge of the latest precise genome engineering tools both in vitro and in vivo.
Expertise in the generation and characterization of transgenic animal models
Generation and use of viral vectors for in vivo genetic engineering


Minimum Requirements –Education and Experience
You should have a Ph.D degree or corresponding experience in a relevant scientific discipline with experience in drug discovery or, alternatively, a first degree and significant relevant experience in drug discovery.

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-01-27, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Galia Nyström Askarieh [email protected] or Eleonor Ehrman +46733434109

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Covid-19 Assessment Laboratory Lead, AstraZeneca Gothenburg

Ansök    Jan 8    Randstad AB    Molekylärbiolog
Job description This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours are 12pm-9pm or 2pm-11pm. Please apply only if you are satisfied you can accommodate these working hours. This is a consultant assignment at AstraZeneca in Gothenburg, starting imme... Visa mer
Job description
This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours are 12pm-9pm or 2pm-11pm. Please apply only if you are satisfied you can accommodate these working hours. This is a consultant assignment at AstraZeneca in Gothenburg, starting immediately.

The COVID-19 Laboratory Lead will be responsible for the day to day running of the COVID-19 screening operation, and will report to the Swedish Covid-19 Assessment Laboratory Head. Some of the hours overlaps with other appointed lab lead(s) working in other shifted pattern.

Responsibilities
As a Laboratory Lead you will ensure team delivery of service in line with the predefined standard operating procedures (SOPs). You will be responsible for the planning of the daily activities, maximizing the people and equipment resources at hand. You will ensure both laboratory staff and data analysis staff have the information they need to perform their work by holding regular team meetings and conveying information from other stakeholders. You are expected to actively work in the lab as a part of the team, thereby gaining insight to everyday challenges and supporting the team in decision making.

Qualifications
Excellent communication skills
Enjoys working with people in an agile environment
Training new people
Previous experience in planning lab work
Previous experience in working under SOPs and local and national regulations
Previous experience as a team leader is desirableWork in BSL1 and BSL2 lab with pervious experience of aseptic technique preferred.
Work with human biological specimens. HepB Vaccination advised.
Work with infectious samples, ideally experience that may contain SARS-Cov-2 would be desirable
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team.
Experience with RT-PCR data analysis would be desirable
Experience of liquid handling automation would be desirable

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity. 

Application
2021-01-17, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Elenor Ehrman, +46733434109, or Galia Nyström Askarieh, [email protected] 

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Covid-19 Assessment Laboratory Scientist, AstraZeneca Gothenburg

Ansök    Jan 8    Randstad AB    Molekylärbiolog
Job description This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours are 6am-2pm, 10am-6pm or 4pm-11pm. Please apply only if you are satisfied you can accommodate these shift patterns. This is a consultant assignment at AstraZeneca in Gothenburg, sta... Visa mer
Job description
This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours are 6am-2pm, 10am-6pm or 4pm-11pm. Please apply only if you are satisfied you can accommodate these shift patterns. This is a consultant assignment at AstraZeneca in Gothenburg, starting immediately.

Responsibilities
This role covers responsibilities in two main areas: the Sample Handling Laboratories and the Molecular Biology Laboratories. Applicants can specify a preference to work in either area, or to flex across both.

Qualifications
Sample Handling: Scientists working in the Sample handling Laboratories are responsible for all process stages from arrival of human assessment specimens (currently saliva or nasal swabs) at the sample handling labs to the transfer of virally inactivated samples to the adjacent molecular biology labs. This work is performed to Biological Safety Level 2 (BSL2) in LAF containment facilities with appropriate PPE. Prior experience of working with infectious biological material to BS2 and with PPE is a key requirement for working in the sample handling laboratories.

Primary responsibilities include: visually inspecting specimens for packaging integrity (correct intact number of barrier layers, no evidence of leakage/spillage); assessment suitability (e.g., rejecting samples not properly labelled, containing foreign matter, incorrect volumes etc.); ensuring they are accounted for on the specimen manifest; following inspection, the removal of specimen transport tubes from the kit packaging; scanning into the LIMS system; and transfer to racks for further processing in suitably contained liquid handling automation. Tube to plate transfer, sample lysis and inactivation will be performed on the automation, and once completed the plates will be transferred to the adjacent molecular biology laboratories. On occasion this process may be run manually requiring experience with manual pipetting. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:
Work in BSL2 lab with pervious experience of aseptic technique preferred
Work with human biological specimens. HepB Vaccination advised
Work with infectious samples, ideally experience that may contain SARS-Cov-2 would be desirable
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team
Experience of liquid handling automation would be desirable


Molecular Biology: Scientists working in the Molecular Biology Laboratories are responsible for all process stages from fully automated RNA extraction and RT-PCR workflows to the delivery of PCR based results to data analysts. This work is performed to Biological Safety Level 1 (BSL1) with appropriate PPE. Applicants should be comfortable performing this process while using PPE.

Primary responsibilities include: the operation of Beckman I series robotics to perform automated magnetic bead RNA extraction procedures; tracking samples through the LIMS system; RT-PCR reaction setup including manual pipetting as well as automated plate preparation using benchtop automation equipment; setting up molecular assays on qPCR instruments; and inspection and exporting of primary and QC results for subsequent downstream analysis by Data/QC analysts. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:
Work in BSL1 lab with previous experience of automation and molecular biology techniques preferred
Work with human biological specimens. HepB Vaccination advised
Work with samples which may contain SARS-Cov-2 would be desirable
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team
Experience with RT-PCR data analysis would be desirable

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity. 

Application
2021-01-17, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Elenor Ehrman, +46733434109, or Galia Nyström Askarieh, [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Covid-19 Assessment Laboratory Data Analyst, AstraZeneca

Ansök    Jan 8    Randstad AB    Molekylärbiolog
Job description This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours for this role is 12pm- 9pm or 2pm-11pm. Please apply only if you are satisfied you can accommodate these working hours. This is a consultant assignment at AstraZeneca in Gothenburg,... Visa mer
Job description
This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours for this role is 12pm- 9pm or 2pm-11pm. Please apply only if you are satisfied you can accommodate these working hours. This is a consultant assignment at AstraZeneca in Gothenburg, starting immediately.

Responsibilities
This role covers responsibilities in two main areas: the Analysis of PCR data generated from human specimens to assess the presence/absence of SARS-Cov-2 virus and generation of the data at the Molecular Biology Laboratories.

Qualifications
Analysis of PCR data: Primary responsibilities include: liaising with Covid-19 Assessment Laboratory Scientists to receive exported PCR data; data QC analysts of PCR data and correct tracking and recording of the analysis in the appropriate LIMS database (utilising a proprietary off the shelf data analysis package).

Key Requirements for this role:
Experience in RT-PCR data analysis
Previous experience of data analysis software and use of LIMS and databases desirable
Attention to detail, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team


Molecular Biology: Scientists working in the Molecular Biology Laboratories are responsible for all process stages from fully automated RNA extraction and RT-PCR workflows to the delivery of PCR based results to data analysts. This work is performed to Biological Safety Level 1 (BSL1) with appropriate PPE. Applicants should be comfortable performing this process while using PPE.
Primary responsibilities include: the operation of Beckman I series robotics to perform automated magnetic bead RNA extraction procedures; tracking samples through the LIMS system; RT-PCR reaction setup including manual pipetting as well as automated plate preparation using benchtop automation equipment; setting up molecular assays on qPCR instruments; and inspection and exporting of primary and QC results for subsequent downstream analysis by Data/QC analysts. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:
Work in BSL1 lab with previous experience of automation and molecular biology techniques preferred
Work with human biological specimens. HepB Vaccination advised
Work with samples which may contain SARS-Cov-2 would be desirable
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity. 

Application
2021-01-17, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Elenor Ehrman, +46733434109, or Galia Nyström Askarieh, [email protected] 

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
Ansök

Covid-19 Assessment Laboratory Scientist, AstraZeneca Gothenburg

Ansök    Nov 17    Randstad AB    Molekylärbiolog
Job description This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours are 7am-4pm or 12pm to 9pm. Please apply only if you are satisfied you can accommodate these shift patterns. This is a constultant assignment at AstraZeneca, Gothenburg. Responsibi... Visa mer
Job description
This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours are 7am-4pm or 12pm to 9pm. Please apply only if you are satisfied you can accommodate these shift patterns. This is a constultant assignment at AstraZeneca, Gothenburg.

Responsibilities
This role covers responsibilities in two main areas: the Sample Handling Laboratories and the Molecular Biology Laboratories. Applicants can specify a preference to work in either area, or to flex across both. 

Qualifications
Sample Handling: Scientists working in the Sample handling Laboratories  are responsible for all process stages from arrival of human assessment specimens (currently saliva or nasal swabs) at the sample handling labs to the transfer of virally inactivated samples to the adjacent molecular biology labs. This work is performed to Biological Safety Level 2 (BSL2) in LAF containment facilities with appropriate PPE. Prior experience of working with infectious biological material to BS2 and with PPE is a key requirement for working in the sample handling laboratories.

Primary responsibilities include: visually inspecting specimens for packaging integrity (correct intact number of barrier layers, no evidence of leakage/spillage); assessment suitability (e.g., rejecting samples not properly labelled, containing foreign matter, incorrect volumes etc.); ensuring they are accounted for on the specimen manifest; following inspection, the removal of specimen transport tubes from the kit packaging; scanning into the LIMS system; and transfer to racks for further processing in suitably contained liquid handling automation. Tube to plate transfer, sample lysis and inactivation will be performed on the automation, and once completed the plates will be transferred to the adjacent molecular biology laboratories. On occasion this process may be run manually requiring experience with manual pipetting. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:
Work in BSL2 lab with pervious experience of aseptic technique preferred
Work with human biological specimens. HepB Vaccination advised
Work with infectious samples, ideally experience that may contain SARS-Cov-2 would be desirable
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team
Experience of liquid handling automation would be desirable


Molecular Biology: Scientists working in the Molecular Biology Laboratories  are responsible for all process stages from fully automated RNA extraction and RT-PCR workflows to the delivery of PCR based results to data analysts.  This work is performed to Biological Safety Level 1 (BSL1) with appropriate PPE. Applicants should be comfortable performing this process while using PPE.

Primary responsibilities include: the operation of Beckman I series robotics to perform automated magnetic bead RNA extraction procedures; tracking samples through the LIMS system; RT-PCR reaction setup including manual pipetting as well as automated plate preparation using benchtop automation equipment; setting up molecular assays on qPCR instruments; and inspection and exporting of primary and QC results for subsequent downstream analysis by Data/QC analysts. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:
Work in BSL1 lab with previous experience of automation and molecular biology techniques preferred
Work with human biological specimens. HepB Vaccination advised
Work with samples which may contain SARS-Cov-2 would be desirable
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team
Experience with RT-PCR data analysis would be desirable 

 
For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity. 

Application
2020-11-26, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Elenor Ehrman, +46733434109, or Galia Nyström Askarieh, [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Covid-19 Assessment Laboratory Manager, AstraZeneca Gothenburg

Ansök    Nov 17    Randstad AB    Molekylärbiolog
Job description This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Hours are Tuesday to Saturday 8am-5pm. Please apply only if you are satisfied you can accommodate these shift patterns. This is a consultant assignment at AstraZeneca, Gothenburg. Responsibilities This role is responsible for the general operational running and maintenance of the AstraZeneca Covid-19 Assessment Laboratories. Primary... Visa mer
Job description
This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Hours are Tuesday to Saturday 8am-5pm. Please apply only if you are satisfied you can accommodate these shift patterns. This is a consultant assignment at AstraZeneca, Gothenburg.

Responsibilities
This role is responsible for the general operational running and maintenance of the AstraZeneca Covid-19 Assessment Laboratories.

Primary responsibilities include: ensuring the laboratories are fit for use, being adequately maintained, with operational equipment and with adequate stocks of consumables and PPE. The manager will also ensure the lab is regularly cleaned and that waste is removed and disposed of safely and will be accountable for writing and ensuring appropriate SOPs are written and kept up to date. Furthermore this person will also be required to precure laboratory consumables and equipment, maintaining a daily inventory of materials and work closely with the AZ onsite lab management team to ensure the current and future a constant consumables/equipment needs are met. To facilitate this manager will liaise with AstraZeneca staff responsible for site Biosafety/SHE, automation, procurement and security.

Qualifications


Work in BSL1 and BSL2 labs with previous experience of wearing appropriate PPE
Attention to detail to ensure effective management of the lab, strictly adhering to SOPs and local and national regulations
Working and communicating across a fast-paced cross organisational team
Previous experience of laboratory management would be highly desirable

 
For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2020-11-26, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Elenor Ehrman, +46733434109, or Galia Nyström Askarieh, [email protected]

About the company
 Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Covid-19 Assessment Laboratory Data Analyst , AstraZeneca

Ansök    Nov 17    Randstad AB    Molekylärbiolog
Job description This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours for this role is 12pm to 9pm. Please apply only if you are satisfied you can accommodate these working hours. This is a consultant assignment at AstraZenca, Gothenburg. Responsibil... Visa mer
Job description
This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours for this role is 12pm to 9pm. Please apply only if you are satisfied you can accommodate these working hours. This is a consultant assignment at AstraZenca, Gothenburg.

Responsibilities
This role covers responsibilities in two main areas: the Analysis of PCR data generated from human specimens to assess the presence/absence of SARS-Cov-2 virus and generation of the data at the Molecular Biology Laboratories.

Qualifications
Analysis of PCR data: Primary responsibilities include: liaising with Covid-19 Assessment Laboratory Scientists to receive exported PCR data; data QC analysts of PCR data and correct tracking and recording of the analysis in the appropriate LIMS database (utilising a proprietary off the shelf data analysis package).

Key Requirements for this role:
Experience in RT-PCR data analysis
Previous experience of data analysis software and use of LIMS and databases desirable
Attention to detail, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team


Molecular Biology: Scientists working in the Molecular Biology Laboratories are responsible for all process stages from fully automated RNA extraction and RT-PCR workflows to the delivery of PCR based results to data analysts. This work is performed to Biological Safety Level 1 (BSL1) with appropriate PPE. Applicants should be comfortable performing this process while using PPE.
Primary responsibilities include: the operation of Beckman I series robotics to perform automated magnetic bead RNA extraction procedures; tracking samples through the LIMS system; RT-PCR reaction setup including manual pipetting as well as automated plate preparation using benchtop automation equipment; setting up molecular assays on qPCR instruments; and inspection and exporting of primary and QC results for subsequent downstream analysis by Data/QC analysts. Individuals will receive full technical and safety training for this whole process which will be performed to strictly defined COVID-19 specific SOPs.

Key Requirements for this role:
Work in BSL1 lab with previous experience of automation and molecular biology techniques preferred
Work with human biological specimens. HepB Vaccination advised
Work with samples which may contain SARS-Cov-2 would be desirable
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team
Experience with RT-PCR data analysis would be desirable

 For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity. 

Application
2020-11-26, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Elenor Ehrman, +46733434109, or Galia Nyström Askarieh, [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Covid-19 Assessment Laboratory Lead, AstraZeneca Gothenburg

Ansök    Nov 17    Randstad AB    Molekylärbiolog
Job description This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours for this role is 12pm to 9pm. Please apply only if you are satisfied you can accommodate these working hours. This is a consultant assignment at AstraZeneca, Gothenburg.  The COVID... Visa mer
Job description
This facility will be used for high throughput screening for COVID-19 screening of AstraZeneca Key Workers. Staff within this laboratory will be expected to work a shift pattern to enable 16 hours a day operation across 5 days a week – Tuesday to Saturday. Hours for this role is 12pm to 9pm. Please apply only if you are satisfied you can accommodate these working hours. This is a consultant assignment at AstraZeneca, Gothenburg. 

The COVID-19 Laboratory Lead will be responsible for the day to day running of the COVID-19 screening operation, and will report to the Swedish Covid-19 Assessment Laboratory Head. Some of the hours overlaps with other appointed lab lead(s) working in other shifted pattern. 

Responsibilities
As a Laboratory Lead you will ensure team delivery of service in line with the predefined standard operating procedures (SOPs). You will be responsible for the planning of the daily activities, maximizing the people and equipment resources at hand. You will ensure both laboratory staff and data analysis staff have the information they need to perform their work by holding regular team meetings and conveying information from other stakeholders. You are expected to actively work in the lab as a part of the team, thereby gaining insight to everyday challenges and supporting the team in decision making.

Qualifications
Excellent communication skills
Enjoys working with people in an agile environment
Training new people
Previous experience in planning lab work
Previous experience in working under SOPs and local and national regulations
Previous experience as a team leader is desirableWork in BSL1 and BSL2 lab with pervious experience of aseptic technique preferred
Work with human biological specimens. HepB Vaccination advised
Work with infectious samples, ideally experience that may contain SARS-Cov-2 would be desirable
Attention to detail to ensure chain of custody of all samples, strictly adhering to SOPs
Working and communicating across a fast-paced cross organisational team
Experience with RT-PCR data analysis would be desirable
Experience of liquid handling automation would be desirable

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2020-11-26, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Elenor Ehrman, +46733434109, or Galia Nyström Askarieh, [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Thesis work: Evaluation of a CRISPR-Cas9 patient centric model

Ansök    Okt 22    Randstad AB    Molekylärbiolog
Job description Evaluation of a CRISPR-Cas9 patient centric in vitro cardiovascular model for drug discovery Thesis work: 30 credits, starting in January At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collabo... Visa mer
Job description
Evaluation of a CRISPR-Cas9 patient centric in vitro cardiovascular model for drug discovery
Thesis work: 30 credits, starting in January

At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

In this role you will be at the forefront of innovative medicines working with experts across global multi-disciplinary teams in the fields of precise genome engineering, omics technologies, cardiac and stem cell biology, to evaluate and utilize novel complex cardiovascular in vitro models.

This role will be within a global R&D department, Clinical Pharmacology and Safety Sciences, supporting all AZ therapy areas from early stage to late stage drug discovery to bring safe and efficacious medicines to patients.

Responsibilities
Drug-induced cardiovascular toxicity is one of the leading causes of drug attrition during preclinical and clinical development. We are in need of better predictive in vitro tools with patient centric focused potential that allow detection of adverse cardiac liabilities early on in the drug discovery process. CRISPR-Cas9 technologies will be utilized in human iPS cells to study single nucleotide polymorphisms (SNPs) located within a key calcium signaling gene in the heart critical for excitation-contraction coupling. Differentiation of gene-edited iPS cells to cardiomyocytes followed by their characterization and pharmacological evaluation will ultimately allow us to understand if polymorphisms in key cardiac genes in the general population that are asymptomatic impact on drug-induced cardiac function. From this cutting-edge work there is the potential for publication in high-impact journals.  

Qualifications
Essential Requirements
Bioscience background
Mammalian cell culture experience
Molecular biology
Willingness to learn and work on novel breakthrough technologies


Desirable Requirements
Fluorescent microscopy
Cellular transfections
Flow cytometry


Application
Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only accept applications through Randstad’s website.

Deadline for application: 2020-11-05, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Kerstin Karlsson [email protected] or Linnea Öster [email protected]

About the company
Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our “walk and talk” meeting trail.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. Visa mindre
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Senior Scientist NGS/Transcriptomics AstraZeneca Gothenburg

Ansök    Sep 8    Randstad AB    Molekylärbiolog
Job description The NGS/Transcriptomics team is a creative group working on the development and application of nucleic acid “omics” technologies and processes to generate smart data that will enrich our understanding of drug pharmacology, target mechanisms, model systems, patients and disease, and is fully aligned with AstraZeneca’s strategy of Growth through Innovation.  We are looking for a Molecular Biologist based in the Gothenburg area with significa... Visa mer
Job description
The NGS/Transcriptomics team is a creative group working on the development and application of nucleic acid “omics” technologies and processes to generate smart data that will enrich our understanding of drug pharmacology, target mechanisms, model systems, patients and disease, and is fully aligned with AstraZeneca’s strategy of Growth through Innovation. 

We are looking for a Molecular Biologist based in the Gothenburg area with significant Next Generation Sequencing experience. This role requires significant experience in NGS laboratory practice, additionally the individual will have outstanding team working skills and a proven track record of working collaboratively to ensure scientific excellence and robust delivery to science projects. Are you motivated by challenging the boundaries of science? Would you like to contribute directly to AZ’s strategy of growth through Innovation? Then please Join us at our R&D site in Gothenburg, Sweden. This is a consultant assignment, starting immediately. 

Responsibilities
This role is a scientific specialist in the NGS/Transcriptomics area - a hands-on lab-based role at the forefront of NGS /Transcriptomics technology with a focus on effective delivery, troubleshooting and putting ideas into action. In this role, you will implement NGS methods tools and strategies applied to a wide range of clinical and preclinical projects across a range of diseases, species and drug modalities.

We will rely on you to:
• Have significant scientific expertise within the NGS/Transcriptomics field
• Be actively involved in the planning and execution of NGS projects
• Adopt innovative NGS/Transcriptomics processes developed by the team
• Build strong collaborative relationships with the project investigators, key stakeholders, project bioinformaticians and data scientists to ensure the smooth running of projects
• Make a meaningful contribution to the practical delivery of projects in accordance with Safety Health & Environment requirements and in compliance with all AstraZeneca Corporate responsibility policies

Qualifications
Essential Requirements:
• Ph.D. degree or corresponding experience in a relevant scientific discipline
• Significant hands on experience with a range of Next Generation Sequencing /Transcriptomics technologies including RNA-Seq, DNA-Seq, genotyping methodologies
• This experience will cover all relevant aspects from hypothesis generation, through experimental design and execution, RNA and DNA extraction, sample and library preparation, sequencing, data handling, post sequencing QC and trouble shooting.
• Research experience in Pharma/Biotech, medical or academic institutions
• Excellent organizational and communication skills.

Desired qualifications:
• A track record of peer-reviewed high-quality publications and scientific presentations
• A proven understanding of statistics, quantitative data analysis, data mining and knowledge of LIMS systems

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2020-09-20, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Galia Nyström, [email protected] or Eleonor Ehrman, +46733434109

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Molecular Biologist COVID-19 project AstraZeneca

Ansök    Maj 28    Randstad AB    Molekylärbiolog
Job description Now we have an exciting opportunity to join the Covid-19 project at AstraZeneca as a Molecular biology technician with start in August. Responsibilities This role will involve fully automated RNA extraction and RT-PCR workflows. Applicants should be comfortable performing this while using PPE. This role will require individuals to work in teams of two-three to operate Beckman I series robotics to perform automated magnetic bead RNA extract... Visa mer
Job description
Now we have an exciting opportunity to join the Covid-19 project at AstraZeneca as a Molecular biology technician with start in August.

Responsibilities
This role will involve fully automated RNA extraction and RT-PCR workflows. Applicants should be comfortable performing this while using PPE. This role will require individuals to work in teams of two-three to operate Beckman I series robotics to perform automated magnetic bead RNA extraction procedures and track sample through the LIMS system. Followed by performing the RT-PCR reaction setup including manual pipetting as well as automated plate preparation using benchtop automation equipment. Following plate preparation, lab technicians/scientists will be responsible for taking the samples once they are ready for analysis and setting up the assay on the qPCR instrument. This role is critical to the screening workflow and individuals will be assigned to a specific assessment method and trained on it extensively. This role will be equipped with the required PPE for the level of exposure and will have to strictly adhere to the specific testing method COVID-19 Testing SOP.

Qualifications
Key Requirements for this role:
Work in BSL1 lab with previous experience of automation and molecular biology techniques preferred.
Work with human biological specimens. HepB Vaccination advised.
Work with samples which may contain SARS-Cov-2.
Attention to detail to ensure chain of custody of all samples
Working and communicating across a fast-paced cross organisational team.
Strictly following SOPs.
Alternative pattern shift work


For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2020-07-05, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Galia Nyström [email protected] or Eleonor Ehrman +46733434109. 
Please keep in mind, e-mail applications will not be considered. Register your profile at Randstad's webpage and send in your application there. 

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Senior Research Scientist at AstraZeneca Gothenburg

Ansök    Sep 3    Randstad AB    Molekylärbiolog
Job description Translational Genomics is seeking a senior researcher to be part of the Transgenic Models team. The position is available from Jan 2021 to July 2021 for a skilled and motivated cell and molecular biologist with experience and state-of-the-art knowledge in transgenic mouse model development & technology. This is a consultant assignment at AstraZeneca in Gothenburg. Responsibilities The scientist will be expected to contribute in this area t... Visa mer
Job description
Translational Genomics is seeking a senior researcher to be part of the Transgenic Models team. The position is available from Jan 2021 to July 2021 for a skilled and motivated cell and molecular biologist with experience and state-of-the-art knowledge in transgenic mouse model development & technology. This is a consultant assignment at AstraZeneca in Gothenburg.

Responsibilities
The scientist will be expected to contribute in this area this from a lab-based perspective and make significant contribution to the practical delivery of project goals. It is essential to have good social and communication skills, be collaborative and be a strong team player. Candidates should be able to work independently and have a positive, goal oriented and problem-solving attitude. Good organisational skills are required, and you should be comfortable in presenting your results. Excellent English is required, both spoken and written.

Qualifications
You should have a Ph.D. degree or corresponding experience in a relevant scientific discipline with experience in drug discovery or, alternatively, a first degree and significant relevant experience in drug discovery.

The following skills are highly desirable:
Molecular biology expertise and experience of working with mouse embryonic stem cells.
Working knowledge of the latest precise genome engineering tools both in vitro and in vivo.
Expertise in the generation and characterization of transgenic animal models



The following skills would be an advantage:
Experience in metabolic phenotyping platforms and analysis of metabolic function in mouse models
Experience of preclinical mouse models for therapeutic gene editing delivery and efficacy approaches.



For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2020-09-15, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Galia Nyström, [email protected], or Eleonor Ehrman, +46733434109 

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Sample Preparation Technician AstraZeneca Göteborg

Ansök    Aug 18    Randstad AB    Molekylärbiolog
Job description This is an exciting opportunity to work with Covid-19 screening for a consultant assignment at AstraZeneca starting immediately. This role is responsible for confirming that the human biological specimens delivered to the designated assessment area are accounted for on the specimen manifest. Primary responsibilities will be the removal of specimen transport tubes from the kit packaging according to the safety guidelines outlined in COVID-1... Visa mer
Job description
This is an exciting opportunity to work with Covid-19 screening for a consultant assignment at AstraZeneca starting immediately.

This role is responsible for confirming that the human biological specimens delivered to the designated assessment area are accounted for on the specimen manifest. Primary responsibilities will be the removal of specimen transport tubes from the kit packaging according to the safety guidelines outlined in COVID-19 Specimen Receiving SOP, while using necessary PPE. Identifying samples that may be compromised or do not meet established acceptability criteria according to defined processes and procedures will also be a critical part of this role (e.g., not properly labelled, open tubes, empty tubes etc.). Personnel in this position will be required to sort samples as needed into racks, pipette samples into 96 well plates, complete viral inactivation steps and enter required information in a LIMS system. Individuals will be trained on a specific sample preparation procedure that is compatible with the downstream assay method and they will also receive training and guidance on proper, safe handling and processing of samples according to a specific COVID-19 Specimen Processing SOP that is applicable. Initially this process will be mostly manual but during the assignment increasing levels of benchtop automation will be deployed and individuals will be required to flex between manual and automated work stations. These roles report to an AstraZeneca sample preparation shift leader for operational leadership.

Responsibilities
Key Requirements for this role:
Work in BSL2 lab with pervious experience of aseptic technique preferred.
Work with human biological specimens. HepB Vaccination advised.
Work with samples which may contain SARS-Cov-2.
Attention to detail to ensure chain of custody of all samples
Working and communicating across a fast-paced cross organisational team.
Strictly following SOPs.
Alternative pattern shift work


Qualifications
BSc or MSc in Molecular biology, biotechnology or similar. Experience of qPCR is an advantage.

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2020-08-31, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Galia Nyström [email protected] or Eleonor Ehrman +46733434109. 

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Research Scientist RIA Bioscience AstraZeneca Gothenburg

Ansök    Jan 28    Randstad    Molekylärbiolog
Job description AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.   We are... Visa mer
Job description
AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
 
We are currently looking for a scientist with excellent laboratory skills to join the Bioscience COPD IPF Department within the Respiratory, Inflammation and Autoimmunity Innovative Medicine Unit in Gothenburg, Sweden. You will be joining one of 3 teams within the department that is currently supporting both early and late stage respiratory projects. This is a temporary position lasting for six months. 

Responsibilities
As part of the team you will execute in vitro experiments as well as support analysis from both in vitro and in vivo studies to progress our drug discovery projects and publishable scientific insights. You are encouraged to actively take part of scientific discussion to add valuable input in experiment design, data interpretation to drive projects and techniques.
 
This is a lab-based role where you will be involved in multiple ongoing projects with responsibility to analyse samples from experiments/studies from various cells and tissues for both in vitro-, in vivo- and from patient studies. We are looking for someone with experience in immunoassays (such as ELISA, MSD, Luminex etc), preparation of RNA from cells and tissues, expression analysis (Taqman) and western blots.

Accountabilities
To be an effective team member in supporting drug discovery projects to meet their objectives.
To conduct where appropriate in parallel more than one area of work to agreed timelines
Can contribute to writing peer-reviewed publications, abstracts and patents. 
Responsible for ensuring that their scientific knowledge influences project progression in accordance with portfolio priorities.


Qualifications
Essential Requirements
A PhD or BSc/MSc with relevant experimental experience.  
Good social and communication skills and to be a strong team player.
Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude. 
Hands-on experience in cell culturing and immunoassays such as Western blots, ELISA.
Good organisational skills are required. 
Excellent English is required, both spoken and in writing. 

 
The following skills are highly desirable
Experience in the use of immunological, pharmacological, cellular or molecular methods relevant to the study of respiratory disease.
Experience in the use of in vitro, in vivo or ex vivo research methods relevant to the study of mechanisms underlying respiratory disease.


For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2020-02-02, selection and interviews will be ongoing. The position may be filled before the last day.

For more information:  Galia Nyström Askarieh, consultant manager,  [email protected] or Kerstin Karlsson, consultant manager, [email protected].



About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Senior Research Scientist Cellular Assay Development Gothenburg

Ansök    Feb 20    Randstad    Molekylärbiolog
Job description At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe. As a Senior Research Scientist in ... Visa mer
Job description
At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.

As a Senior Research Scientist in cellular assay development in Gothenburg, Sweden, you’ll play a pivotal role in channelling our scientific capabilities to make a positive impact on changing patients’ lives. You will work within Discovery Sciences, part of AstraZeneca’s BioPharmaceuticals organisation, which focuses on scientific advances in established and emerging medicine formats and drug discovery technologies across therapeutic areas including, respiratory and inflammation (RIA), cardiovascular and metabolism (CVRM).

We have an exciting opportunity for you to join Discovery Sciences’ Discovery Biology Department as a lab-based scientist in the Cellular Assays Team developing state-of-the-art cell-based screening assays and detailed biological mechanism-of-action studies to support projects in all phases of AstraZeneca’s drug discovery pipeline with a significant focus in RIA and CVRM disease areas.

Specifically, the successful candidate will take a lead scientific role in applying their skills using imaging technologies and developing high content assays.

Responsibilities
 Lab-based scientist utilizing expertise in cellular assay development; independently designing, developing and validating assays for implementation in drug discovery projects, while incorporating the views of others
 Work in partnership with colleagues in the High Throughput Screening and Mechanistic Biology & Profiling teams and across the organisation 
 Design and implement work-plans to agreed timelines to meet project objectives, including delivery of more than one agreed area of work in parallel
 Be an effective member of Drug Discovery Project Teams, contributing novel ideas and using judgement and knowledge to influence the work of the project
 May lead one or more aspects of scientific discipline within the team
 Maintain an awareness of current developments in the literature and contribute to the continuous capability enhancement process by identifying opportunities where improvements can be made
 Achieve personal scientific visibility through project contributions and internal presentations at departmental or functional meetings; and external scientific visibility through poster and oral conference presentations and authorship on peer-reviewed publications


Qualifications
Essential Requirements
 PhD in Biology, Pharmacology, Cell biology or a related discipline or a BSc/MSc degree with significant relevant experience, preferably in the pharmaceutical or biotechnology industry
 Strong experience in cellular biology techniques applied to development of physiologically relevant cellular assays 
 Expertise in the design, development and validation of cellular imaging assays for compound profiling
 Experience in advanced and automated fluorescent based imaging platforms
 Experience in use and development of scripts for quantitative image analysis  


Desirable Requirements
 A practical understanding of a wide range of cellular assay methods and technologies (e.g., fluorescence, luminescence, target engagement techniques, plate-based automation) as applied to a range of biological targets for compound profiling and screening
 Good publication records in peer-reviewed journals preferably in the field of RNA degradation biology
 Excellent problem-solving skills, strong delivery focus and communication skills
 Research experience in RIA and/or CVRM diseases
 Excellent team working and networking skills with experience of interacting effectively across interfaces of discipline, culture, and expertise

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2020-03-05, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.
For more information: Kerstin Karlsson [email protected] or Eleonor Ehrman +46733434109. 

About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Senior Research Scientist RIA Bioscience AstraZeneca Gothenburg

Ansök    Jan 27    Randstad    Molekylärbiolog
Job description AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.   The Ar... Visa mer
Job description
AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
 
The Arena
We are currently looking for a scientist with excellent laboratory skills to join the Bioscience COPD IPF Department within the Respiratory, Inflammation and Autoimmunity Innovative Medicine Unit in Gothenburg, Sweden. You will be joining one of 5 teams within the department that is currently supporting both early and late stage respiratory projects.

Responsibilities
Main Duties and Responsibilities
As part of the team you will design and execute in vitro experiments as well as support analysis from both in vitro and in vivo studies to progress our drug discovery projects and publishable scientific insights. You will be encouraged to actively take part of scientific discussion to add valuable input in experiment design, data interpretation to drive projects and techniques.

This is a lab-based role where you will be involved in multiple ongoing projects with responsibility to design and set up in vitro assays with both cell lines and cells from patients. We are looking for someone with experience in cell culture, immunoassays such as Western blots, ELISA, MSD, Luminex etc. This is a temporary assignment, lasting for 7 months.

Your accountabilities:
To be an effective team member in supporting drug discovery projects to meet their objectives.
To conduct where appropriate in parallel more than one area of work to agreed timelines.
Can contribute to writing peer-reviewed publications, abstracts and patents.
Responsible ensuring that scientific knowledge influences project progression in accordance with portfolio priorities.


Qualifications
Requirements for the role
A PhD and relevant experimental experience.
Hands-on experience in cell culture, immunoassays such as Western blots, ELISA.
Excellent English is required (both written and verbal). 



Preferred experience and key factors
Experience in the use of immunological, pharmacological, cellular or molecular methods relevant to the study of respiratory disease.
Experience in the use of in vitro, ex vivo research methods relevant to the study of mechanisms underlying respiratory disease.
Hands-on experience working with epithelial cells and primary leukocytes.
Good social and communication skills and to be a strong team player.
Being able to work independently, take own initiatives and have a positive, goal oriented and a problem-solving attitude. 
Good organisational skills are required.

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2020-02-02, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.
For more information: Kerstin Karlsson [email protected] or Galia Nyström [email protected] 

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.


Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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Scientist/Senior Scientist at AstraZeneca, Gothenburg

Ansök    Okt 31    Modis Sweden AB    Molekylärbiolog
We are now seeking for a Research Scientist / Senior Research Scientist to the Stem & Primary Cell Team at AstraZeneca Gothenburg. This opening is a consultant assignment for 12 months. About the customer: AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture tha... Visa mer
We are now seeking for a Research Scientist / Senior Research Scientist to the Stem & Primary Cell Team at AstraZeneca Gothenburg. This opening is a consultant assignment for 12 months.

About the customer:

AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity

Are you a dedicated and curious Stem Cell Scientist? Would you like to join us on our journey where your contributions will have a profound impact on R&D using the latest engineering techniques?

An exciting opportunity is now available for you to join our Stem & Primary Cell Team. We are part of the Discovery Sciences department, responsible for the generation of novel cellular models to support projects in all phases of the drug discovery pipeline.  We have a focus on target identification, target validation, disease model generation and the therapeutic use of stem cells.

You will be based in Gothenburg Sweden, where your main focus will be set on culturing, genetically engineering and differentiating stem cells for cellular model development and their potential use as therapeutics.

The role

Leveraging your strong knowledge and experience in stem cell biology and tissue culture you will have the opportunity to work with cutting edge cellular models of disease. This includes culture of induced pluripotent stem cells (iPSCs) as a platform for differentiating to disease relevant cellular lineages relevant to the diseases and conditions that are the focus of research at AstraZeneca Gothenburg.

The role is focused on laboratory-based activities, applying your knowledge and skills to drive project delivery, participate actively in problem solving and, where relevant, deliver cross disciplinary support based on your experience. Your biggest impact will be through significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards.

It is essential to have good social and communication skills, be collaborative and a strong team player. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude. Good organisational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Tasks

• To culture iPSCs to generate cellular models of human disease biology
• To apply existing differentiation protocol, and where relevant contribute to development of new protocols, to deliver cells and cellular models for drug discovery activities.

The following skills are highly desirable:

• Experience in iPSC culture and quality control
• Application of differentiation protocols for generation of complex stem-cell based cell models
• Qualification and validation of cellular models using imaging techniques
• Molecular Biology and Cell line engineering

Minimum experience

• For the Research Scientist role, you should hold a B.Sc. or M.Sc. degree with corresponding experience in a relevant scientific discipline with experience in cell culture.
• For the Senior Research Scientist role, you should either hold a Ph.D. in Cellular Biology or a related degree or have significant relevant experience working in a cell culture environment.

 

Please submit your application by attaching your CV and personal letter in English (interviews are held continuously).

If you have any questions about the assignment, do not hesitate and contact Markus Dahl ([email protected]).

Modis is a staffing & recruiting company and is part of the Adecco Group, the world´s leading HR-solutions provider across 60 countries. This scale and scope ensures Modis is truly a global community. Our mission is to be the Leading Professional Services Company by finding the right match between you as a candidate and you as a customer. We are a team with various and complementary backgrounds within Life Science, Engineering and Technology. We can ensure that we understand our customer needs and we can ensure that we understand the competence-profiles of our applicants and candidates. Visa mindre
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Senior Research Scientist Stem & Primary Cell Team AstraZeneca

Ansök    Okt 30    Randstad    Molekylärbiolog
Job description AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity Are you... Visa mer
Job description
AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity


Are you a dedicated and curious Stem Cell Scientist? Would you like to join us on our journey where your contributions will have a profound impact on R&D using the latest engineering techniques?


An exciting opportunity is now available for you to join our Stem & Primary Cell Team. We are part of the Discovery Sciences department, responsible for the generation of novel cellular models to support projects in all phases of the drug discovery pipeline. We have a focus on target identification, target validation, disease model generation and the therapeutic use of stem cells. 


You will be based in Gothenburg Sweden, where your main focus will be set on culturing, genetically engineering and differentiating stem cells for cellular model development and their potential use as therapeutics.


The role
Leveraging your strong knowledge and experience in stem cell biology and tissue culture you will have the opportunity to work with cutting edge cellular models of disease. This includes culture of induced pluripotent stem cells (iPSCs) as a platform for differentiating to disease relevant cellular lineages relevant to the diseases and conditions that are the focus of research at AstraZeneca Gothenburg. 


The role is focused on laboratory-based activities, applying your knowledge and skills to drive project delivery, participate actively in problem solving and, where relevant, deliver cross disciplinary support based on your experience. Your biggest impact will be through significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards.


It is essential to have good social and communication skills, be collaborative and a strong team player. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem-solving attitude. Good organisational, data management and documentation skills are required, and you should be comfortable in presenting your results. English language is required, both spoken and in writing.

Responsibilities
Tasks
To culture iPSCs to generate cellular models of human disease biology
To apply existing differentiation protocol, and where relevant contribute to development of new protocols, to deliver cells and cellular models for drug discovery activities.


Qualifications
The following skills are highly desirable:
Experience in iPSC culture and quality control
Application of differentiation protocols for generation of complex stem-cell based cell models
Qualification and validation of cellular models using imaging techniques
Molecular Biology and Cell line engineering


Minimum experience:
For the Research Scientist role, you should hold a B.Sc. or M.Sc. degree with corresponding experience in a relevant scientific discipline with experience in cell culture.


For the Senior Research Scientist role, you should either hold a Ph.D. in Cellular Biology or a related degree or have significant relevant experience working in a cell culture Environment.

Application
2019-11-19, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Contact Galia Nyström, Consultant Manager, [email protected] or Kerstin Karlsson, Consultant Manager, [email protected]. 

About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre
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