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Are you an experienced Statistical Programmer with deep knowledge of clinical drug development? Would you like to be part of a fast-paced and agile global team that has direct strategic impact on drug development, empowered and trusted to innovate and experiment? Join us at AstraZeneca CVRM (Cardiovascular Renal Metabolism) Biometrics to impact a wide range of engaging projects striving to make a difference for millions of patients. Our Biometrics team consists of Statisticians, Programmers, Information and Data Scientists. We drive and contribute to optimized clinical drug development programs and access to information and scientific knowledge management.
We are now offering an exciting opportunity for a dedicated and highly motivated individual to join us in the role as Statistical Programming Associate Director, providing strategic programming leadership within CVRM Biometrics and collaborating with global product development teams. This role will be placed at AstraZeneca’s dynamic R&D strategic site in Gothenburg (Sweden), where you will work in an international environment at the forefront of clinical development.
Accountabilities:
As a Statistical Programming Strategy & Portfolio Lead, you are accountable for quality, timely and efficient delivery of project programming work and information management. This position requires profound programming experience and excellent industry knowledge to independently lead implementation of programming activities. This is a strategic leadership role with project and technical focus where you will provide subject matter expertise within the statistical programming discipline. You will oversee delivery of data according to industry standards, efficient and high-quality statistical analysis for interpretation, reporting deliverables, planning and execution of submission strategies. You will act as a specialist within cross-functional teams to deliver continuous improvement, innovation, and automation solutions.
Essential Skills/Experience:
Degree in Mathematics (i.e., Applied Math, Engineering, etc.), Statistics, Computer Science, Life Science, or equivalent experience
Advanced knowledge of the clinical development process and industry standards (e.g. CDISC)
Demonstrated statistical programming leadership expertise with ability to develop teams and individuals and lead them towards a common goal
Demonstrated influencing, planning, delivery and organizational skills as a Statistical Programming SME
Ability to provide input to functional strategies
Expertise in risk management in complicated or novel situations
Current knowledge of technical and regulatory requirements relevant to the role

Desirable Skills/Experience:
Broad experience, ideally across multiple therapeutic areas and outside of the field of Statistical Programming
Experience in regulatory submissions and interactions
Demonstrated experience designing and implementing business processes
Willingness and ability to travel



At AstraZeneca, we believe in the potential of our people, and you’ll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us. As a Statistical Programming Strategy & Portfolio Lead, Associate Director, you will play a pivotal role in harnessing our scientific capabilities to improve patients’ lives and help pioneer the future of healthcare.
This role is an office-based role with some degree of flexibility. Our vibrant office sites provide a diverse and collaborative work environment, where interactions lead to ideas and innovations, giving you and others the perfect opportunity to learn, grow and develop careers.
Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have a seat available, and we hope it’s yours. Apply today!
Welcome with your application no later than April 19th, 2026. Visa mindre

Do you have a scientific or clinical background combined with an entrepreneurial attitude and business know-how? Would you like to apply your expertise in a company where we are following the science and turn ideas into life changing medicines? Then you might be the one we are looking for!
Join the Search and Evaluation Department within Business Development and Licensing, Biopharmaceutical R&D with focus on CVRM in Gothenburg, Sweden.

Job description
The Search and Evaluation Director, Cardiovascular, Renal and Metabolism, in Business Development and Licensing is a key role in Biopharmaceuticals R&D, AstraZeneca.
You will support global Business Development initiatives and have a direct impact on the scientific strategy and portfolio.
The Search and Evaluation (S&E) group drives search efforts of external innovation throughout the Biopharma R&D community and conducts technical due diligence activities that ensure an in-depth understanding of investment opportunities and provides decision-making tools for the organization.

Who are you?
You have a strong R&D scientific and / or clinical background, business acumen and excellent communication skills as well as an ability to engage and collaborate across boundaries with an entrepreneurial attitude and delivery focus.

Major Duties and Responsibilities:
Reporting to the Head of S&E, CVRM, you will be responsible for identifying and evaluating external in-licensing opportunities from academia, biotech’s and peer-pharma including early research projects, new modality platforms, early and late clinical stage candidates and Life Cycle Management (LCM) opportunities
You will be responsible for representing the Business Development strategy at partnering meetings to identify exernal assets and opportunities.
You will integrate input from various functional areas across the organization to create high quality, clear and concise confidential evaluation reports of external assets and will provide recommendations to Head of S&E.
You will identify and evaluate key strategic collaborations and technical platform capabilities that can enhance the scientific credibility and portfolio of Biopharmaceuticals R&D CVRM.
You will works constructively with key stakeholders and cross-functional teams including commercial to ensure effective communication, efficient decision-making, to support completion of transactions with BD teams in a timely manner
You will track breakthrough innovation, ongoing clinical trials and market trends of existing external CVRM opportunities using competitive intelligence tools to identify opportunities, threats and risks in a timely manner.

Culture:
A dynamic, entrepreneurial and externally facing organization which enables an internally and externally collaborative culture with calculated risk taking.
Collaborate closely with colleagues in CVRM and BD teams, and across business to identify and exploit cross-business opportunities and embed best practice.



Education:
Advanced Degree Required (MD or PhD or PharmD).



Requirements and Qualifications:
Strong scientific reputation in drug discovery and clinical development
Basic understanding of deal making
Ability to interact and communicate effectively
Proven leadership abilities in a R & D environment
A strong understanding of clinical development experience in CVRM , demonstrating cultural sensitivity and awareness.
Extensive experience in pharmaceutical R&D, demonstrating international experience in multiple cultures and R & D environments.
Ability to think critically, creatively and to anticipate and solve problems
Ability to navigate and be successful in a fast-paced, highly-matrixed work environment



Leadership and Behaviours:
Excellent communicator who take responsibility for decisions made. Role model engagement and commitment.
Able to lead culture shift and raise the bar in performance at all levels in the organization
Able and accountable for driving business performance.
Understand the wider AstraZeneca business priorities
Appreciate that scientific expertise needs to be balanced with business leadership
Able to actively seek collaboration in a complex matrix structure



Apply with your CV and Cover letter no later than May 21st, 2025 Visa mindre

Are you an experienced drug discovery scientist with expertise in pharmacokinetics, pharmacology and drug metabolism (DMPK)? Would you like to apply your expertise in a global company that follows the science and turn ideas into life changing medicines? Then you could be the new colleague we are looking for!
We are now looking for an experienced and motivated individual to join the team as a DMPK Project Leader. The position is placed at AstraZeneca’s dynamic R&D site in Gothenburg, Sweden. Working at AstraZeneca means being entrepreneurial, following the science, scrutinizing data and details simultaneously with holistic thinking and through teamwork make progress. Your level of professional experience will be relevant for your initial career level (Associate Principal Scientist or Principal Scientist).
Respiratory & Immunology (R&I) is one of the three main therapeutic research areas within AstraZeneca. Early R&I is a global function, with research units in Gaithersburg (US), Cambridge (UK) and Gothenburg (Sweden), and delivers candidate drugs into late-stage clinical development. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and Life cycle management.
What you’ll do:
With a true passion for drug discovery you will support our portfolio within the R&I therapeutic area. In the DMPK project lead role you will work collaboratively with project representatives from other disciplines. These may include biology, antibody Discovery/Protein Engineering, medicinal chemistry, safety, clinical pharmacology, and pharmaceutical sciences, where your task is to influence candidate profiling by providing the necessary DMPK support for clinical investigations.
It is your responsibility to ensure delivery of all DMPK related activities. These include preclinical PK experiments, in vitro ADME and biotransformation to yield pharmacokinetic understanding. Furthermore, assisting design of pharmacodynamic studies that ultimately delivers a pharmacological assessment underpinning human dose prediction.
You will work on projects from candidate selection to Phase 2a. We believe that you have a solid understanding of DMPK, a working knowledge of pharmacology, and that you will be able to provide expert advice and interpretation of complex drug discovery data.
Main Duties and Responsibilities
• Communicate scientific progresses both externally and internally
• Deliver DMPK input and data to projects within agreed timelines and to the right quality
• Apply an understanding of DMPK to support/influence compound profiling, project progression and project strategy
• Define and deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made
• Contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
• Responsible for leading, coordinating and engaging with R&I DMPK colleagues in project related activities
• Prepare clear presentations related to the above for internal governance bodies

Essential requirements:
• PhD or equivalent experience in a relevant field
• Expert in DMPK sciences with profound knowledge of drug discovery and development processes
• Broad experience across different modalities (small molecules & biologics) drug development (PK & Bioanalysis)
• Experience with regulatory submissions for biologics and small molecules
• Good knowledge of all DMPK assays including the use of in silico tools for PK prediction
• Experience in project leadership
• Collaborative mindset
• Team player
• Proactive and good communication skills

Why AstraZeneca?
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.


Work policy:
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. Visa mindre

Are you a forward-thinking and curious Bioinformatician with skills in large scale omic analysis? Do you also want to improve the way we discover and develop medicines? Welcome to join AstraZeneca!
We are looking for an experienced bioinformatician to join our Data Science & Bioinformatics team. You will be part of the Translational Science and Experimental Medicine (TSEM) department in the Respiratory and Immunology therapeutic area. As a department we promote an open and collaborative atmosphere, with a culture that is both science-based and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective targets and the right patient populations.
This role is located at one of our sites in either Gothenburg (Sweden) or Gaithersburg (US).
Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions. We harness data science & AI to fast-forward our research. Making sure work born in a lab can make a real difference, every day, impacting patients’ lives across the world.
What you will do
In this role, you will work in a highly cross-functional and thriving environment together with specialists in sequencing, immunological and respiratory disease, as well as with other data science & bioinformatics experts.
For this role we are looking for an outstanding bioinformatician to enable translational science via integration of large-scale omics, clinical data, real world evidence and literature data to deliver precision medicine within our pipeline. You´ll be identifying novel targets, biomarkers and patient sub-groups through innovative data analysis approaches including utilization of clinical cohort omics data sets.
You will contribute to the identification of transformational precision medicine propositions to deliver life changing medicines to patients. You will be responsible for planning, performing and interpreting your analysis and communicate results. By applying state-of-the-art analytical methods, you will maximise the knowledge extrapolated from our growing omics data in complex diseases impacting the project progression and future treatment options for patients with unmet medical needs.
Depending on your previous experience, your initial career level will be an Associate Principal Scientist or Senior Scientist.
Essential for the role
MSc with extensive industry experience (4+ years), or preferably, PhD or equivalent in bioinformatics, data science, statistics, biostatistics, mathematics, or another similar subject area.
Substantial experience and proficiency in large-scale omics data analysis, integration and interpretation is a requirement. Omics include transcriptomics, single cell, spatial transcriptomics, proteomics (Olink, LC/MS), genomics, and other types of next generation sequencing (NGS) such as chromatin state approaches.
Excellent coding skills in Python, R, or similar language appropriate for large scale omics analysis and experience with version control (Git/Bitbucket).
A good understanding of life sciences and how omics data can be utilised to derive biological insight is required. Experience from applying this across different phases of pharmaceutical discovery and development is a preference.
Outstanding communication and collaboration skills, both with experts and non-experts, and with peers as well as stakeholders is expected. Our team is a collaborative group, so the ability to be comfortable working in a goal-oriented way, with a team focused approach is central to be successful in the role.
We believe you also have a high degree of independence and a proactive and delivery focused approach.

Desirable for the role
Experience in pharmaceutical R&D and/or Post-doc experience.
Molecular understanding of human diseases, patient stratification and biomarker-based endpoint generation, preferentially in respiratory and immunological disorders.
Understanding of in vitro and in vivo model systems and assessment of translatability.
Track record of applying bioinformatic analysis to drive projects in drug discovery or development in an industrial or academic setting. Familiarity with network analysis.
Broad experience applying machine learning methods such as random forests, clustering, dimensionality reduction in a systems biology or systems medicine context.
Working in a Linux environment, ideally with experience of cluster or cloud computing (e.g. AWS or Azure).
Experience from leading projects with internal groups/external collaborators.
Experience working within cross-functional teams.

Why AstraZeneca?
At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.
Work policy
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. Visa mindre

Are you an experienced scientist with expertise in pharmacokinetics, pharmacology and drug metabolism (DMPK)? Would you like to apply your expertise in a global company that follows the science and turn ideas into life changing medicines? Then you could be the new colleague we are looking for!
Our team is growing, and we are now looking for two motivated individuals with experience in Biologics and/or small molecule drug development and PKPD, to join us as a DMPK Project Leader, from candidate selection to registration and beyond. These positions are placed at AstraZeneca’s dynamic R&D site in Gothenburg, Sweden. Working at AstraZeneca means being entrepreneurial, following the science, scrutinizing data and details simultaneously with holistic thinking and through teamwork make progress.
Respiratory & Immunology (R&I) is one of the three main therapeutic research areas within AstraZeneca. Early R&I is a global function, with research units in Gaithersburg (US), Cambridge (UK) and Gothenburg (Sweden), and delivers candidate drugs into clinical development. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and Life cycle management.
What you’ll do?
With a true passion for drug discovery you will support our portfolio within the R&I therapeutic area as a subject matter expert. In the DMPK project lead role you will work collaboratively with project representatives from other disciplines. These may include biology, safety , clinical pharmacology, pharmaceutical sciences, antibody Discovery/Protein Engineering and medicinal chemistry, where your task is to influence candidate profiling by providing the necessary DMPK support for clinical investigations.
It is your responsibility to ensure delivery of all DMPK related activities throughout the value chain in accordance with regulatory requirements. These include preclinical PK experiments, in vitro ADME and biotransformation to yield pharmacokinetic understanding. Furthermore, assisting design of pharmacodynamic studies that ultimately delivers a pharmacological assessment underpinning human dose prediction and emerging clinical experience.
You will work as the development DMPK representative on project teams from candidate selection to registration and beyond. We believe that you have a solid understanding of DMPK, a working knowledge of pharmacology, and that you will be able to provide expert advice and interpretation of complex nonclinical and clinical data.
Main duties and responsibilities;
Communicate scientific progresses both externally and internally
Deliver DMPK input and data to projects within agreed timelines and to the right quality
Responsible for delivering and produce the nonclinical pharmacokinetic documentation to support clinical progression
Apply an understanding of DMPK to support/influence compound profiling, project progression and project strategy
Define and deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made
Contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
Responsible for leading, coordinating and engaging with R&I DMPK colleagues in project related activities
Prepare clear presentations related to the above for internal governance bodies

Your level of professional experience will be relevant for your initial career level (Associate Principal Scientist or Principal Scientist).
?Essential for the role
PhD or equivalent experience in a relevant field
Expert in DMPK sciences with profound knowledge of drug discovery and development processes
Broad experience in biologics drug development (PK & Bioanalysis)
Have PK modelling skills, experience of human PK and dose prediction, as well as an understanding of disease biology and PKPD
Experience with regulatory submissions for biologics and/or small molecules
Knowledge of all DMPK assays including the use of in silico tools for PK prediction
Experience in project leadership
Collaborative mindset
Team player
Proactive in providing expert support to project team and excellent communication skills

Why AstraZeneca?
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development. Visa mindre

Are you a passionate and experienced scientist with expertise in molecular biology and recombinant protein expression? Fuelled by our commitment to help more patients, strengthen our pipeline and grow our area. This might be your next challenge!
We are now looking for a Molecular Biologist to join us as a Research Scientist at AstraZeneca in our Protein Sciences department in Discovery Sciences. This department is based in our vibrant R&D site in Gothenburg, Sweden, and is responsible for the delivery of protein reagents to discovery projects. You will be part of a team of enthusiastic scientists to deliver deep technical and scientific expertise in Molecular Biology. This role is an opportunity to contribute to the development and execution of research strategies for the discovery of new medicines.
What you will do
In this role, you will provide key molecular biology expertise for the design and generation of DNA constructs for downstream drug discovery applications such as recombinant expression of protein reagents, reporter gene assays, cell lines, DNA libraries, and recombinant production of proteins for structure and biophysics. We are seeking a highly skilled and motivated Research Scientist to join our dynamic team. The successful candidate will deliver from the lab with construct design and high throughput construct generation.
Essential for the role
MSc in relevant scientific discipline (e.g. Molecular Biology, Genetics, or Bioinformatics), or a related discipline, with relevant experience, preferably in the pharmaceutical or biotechnology industry.
Extensive experience in high throughput cloning techniques such as Golden Gate and Gibson assembly with strong problem-solving skills.
Demonstrated proficiency with automation equipment and programming (e.g. Python) of liquid handlers (BiomekI7 or equivalent).
Demonstrated expertise in Next Generation Sequencing technology including Illumina and Nanopore sequencing with hands on experience and the ability to configure Bioinformatics pipelines.
Strong communication skills, team working and capable of bridging gaps across disciplines.

Desirable for the role
Experience working in LIMS environment and request management systems, e.g., Benchling, Geneious, demonstrated data management experience and excellent level of compliance.
Proven ability to support IT technology development projects.

Why AstraZeneca?
Always advancing our scientific knowledge and helping to shape the future of healthcare for the greatest and swiftest impact on disease. Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. We truly believe that everyone contributes with a unique set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you maximise your skills, abilities and contribution. Visa mindre

Do you have expertise in mathematical modelling and/or pharmacokinetics and pharmacodynamics? Would you like to apply your knowledge in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for to be part of the development of future treatment within respiratory and immunology.
Our team is growing, and we now have two openings for highly skilled and passionate scientists with expertise in mathematical modelling, preferably applied in the field of pharmacokinetics-pharmacodynamics (PKPD), to join the Drug Metabolism and Pharmacokinetics (DMPK) team of project leads within the Early Respiratory and Immunology (R&I) therapeutic area at AstraZeneca in Gothenburg, Sweden. Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality.
Early R&I is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into late-stage clinical development. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and life-cycle management. At AstraZeneca we are proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity toward delivering candidate drugs into late-stage development.
What you’ll do?
You have a true passion for science and will support our portfolio within the R&I therapeutic area. We believe that you have solid, hands-on experience of PKPD modeling and that you will be able to provide expert advice and interpretation of complex drug discovery data. You will deliver translational quantitative/PKPD input for a broad range of drug modalities from target identification to life-cycle management.
Main Duties and Responsibilities include:
Identify the appropriate mathematical modelling approach (e.g. traditional PKPD modelling, non-linear mixed effects modelling, quantitative systems pharmacology) to deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made
Inform and influence the design of studies, with PKPD in mind to answer relevant pharmacological questions and report results and interpretations to project teams and internal governance bodies
Design preclinical PKPD studies, contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
Integrate the appropriate data to predict human pharmacokinetics, efficacious human drug exposure, human longitudinal response (e.g. biomarker and disease effects), and human dosing regimen. This is done in close collaboration with other functions (biologists, safety scientists, clinical pharmacologist and clinical pharmacometricians)
Communicate scientific progress to internal and external stakeholders

Depending on your background, experience and skills, your initial career level will be a Senior Scientist, Associate Principal Scientist or Principal Scientist.
Essential for the role
The successful candidate is expected to have a solid PKPD understanding and hands on experience of mathematical modelling (e.g. empirical PKPD models, in vitro-in vivo translation, non-linear mixed effects models, quantitative systems pharmacology (QSP) models).
PhD or equivalent in relevant field, with a focus on mathematical modelling of PKPD data, ideally in a preclinical/translational setting
Hands-on experience with modelling software (e.g. Phoenix WinNonlin, Matlab, Monolix, R, NONMEM, or similar)
Proven scientific leadership and ability to mentor junior colleagues
Experience in project leadership and collaborative mindset
Scientific leadership evidenced by a publication track record and ability to independently lead the drafting and review of publication manuscripts
Excellent interpersonal skills, and ability to work in cross-functional teams as well as independently
Proactive and excellent communication skills

Why AstraZeneca?
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.
Work policy
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
What’s next?
This is an exciting opportunity for a talented modeller to join a strong team and support the portfolio of a major pharmaceutical company that has science at its heart whilst being based in the wonderful city of Gothenburg, Sweden. If you are ready to make a difference - apply today, and we'll make it happen together!
We welcome your application until 2024-06-16 Visa mindre

Would you like to combine your expertise in cell production and quality control with your leadership skills for the development of cell based therapies? Join us and be a key player in the build of our new Biopharmaceuticals R&D Cell Therapy department. Together we will push the boundaries of Science!
At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. Biopharmaceuticals R&D is committed to the development of next generation innovative medicines and we are building a new Cell Therapy department with the goal to establish AstraZeneca as a world-leader in Cell Therapy across disease areas within Cardiovascular, Renal and Metabolism (CVRM) and Respiratory and Inflammation (R&I). The department support the organisation with cell therapy expertise and capabilities. With an agile “biotech-like” culture, specialists in the department are working closely with experts across AstraZeneca globally to leverage the existing and emerging platforms in stem cell technologies, new modalities, universal cell lines, and CRISPR-mediated genome editing.
As a Cell Therapy bioprocessing team leader you will contribute significantly towards building a pipeline of cell therapy assets. The team will deliver in our aspirations to be differentiated within the cell therapy space and as such will have strong impact on the shape of AstraZeneca R&D.
The role is placed at AstraZeneca’s dynamic R&D site in Gothenburg, Sweden, where you will work in an international environment at the fore-front of Cell Therapy science.
What you’ll do
In this key role you will be responsible for early bioprocessing and analytical development of cell based therapy production and quality control methods at the Cell Therapy Department, BioPharmaceuticals R&D. The role will lead and support the bioprocessing and analytical development cell therapy team in delivering production and quality control methodologies to a portfolio of projects by providing relevant input and leadership for the team, ensuring the delivery of methodologies and results in line with objectives.
This will require strategic and tactical development of the team, identifying priorities, building operations and develop a suitable team and laboratory to ensure appropriate project deliveries. Responsibilities include:
Manage and lead the Bioprocessing and Analytical development team for the Cell Therapy Department, BioPharmaceuticals R&D delivering a portfolio of products by providing direction to the team and key stakeholders
Provides strategic and tactical input into the BioPharmaceuticals R&D Cell Therapy project portfolio and ensure that there is strong alignment and engagement between the Bioprocessing and Bioscience Cell Therapy teams, the project teams and sister departments
Recommends, and develops external partnerships with industrial and academic partners and leaders in the cell therapy field
Plan, design, and develop cell manufacturing methodologies to generate high quality results to support project decisions and milestones
Recruit, retain, and develop the Bioprocessing team members to build a world class team with cell therapy experience to accelerate AstraZeneca’s ambitions in cell therapy
Lead, support and adopt continuous development of cell therapy manufacturing and QC technologies within AZ that will allow AZ to accelerate its ambition and establish itself in the field
Oversee processes and standards to ensure their appropriateness and guarantee compliance to all relevant internal and external processes
Lead, influence and interact with key academic and industrial partners in support of the development and commercialization of cell therapies

Essential for the role
The right person for this role has a Ph.D. in Cell Biology, Engineering (or equivalent experience) and expertise in Cell and Gene Therapy Bioprocessing and analytical development together with significant experience of interactions with industrial and academic partners. And of course, previous line manager experience.
With your excellent interpersonal, communication and collaboration skills you have the ability to operate effectively across boundaries in a global matrix research environment to influence both internal and external stakeholders. Your passion, strong vision and drive to succeed together with key qualities like entrepreneurial working style and excellent problem-solving skills will make you an great addition to the team!
If you are well networked and have a good reputation within the Cell Therapy industry that is a plus.
So, what’s next?
Welcome with your application no later than 2 February, 2024.
Why AstraZeneca?
Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our “walk and talk” meeting trail. Visa mindre

Are you a Swedish-speaking HR professional wanting a change in life? Do you want to move abroad and use your language skills and HR knowledge in a new environment? Are you a team player that loves working in a fast paced environment giving phenomenal service to customers, then AstraZeneca and the HR Advisor role might be of interest for you!

We are looking for service-minded HR Advisors for permanent roles that would like to work abroad in one of the two offered locations, Lisboa, Portugal and Warsaw in Poland. You will be a part of the GBS People Services team and work within a phenomenal group of HR Advisors in our HR Service Desk.

The role

As an HR Advisor you will be the first point of contact for managers and employees in Sweden. We provide advice and support in a variety of HR matters. You will collaborate closely with all areas of HR (HRBP´s, specialist groups and HR generalists), to find solutions to problems. You will give advice, guidance and support through phone, e-mail and chat using a case management system.

You will respond to questions within all HR areas such as governance, labor law, agreements, recruitment and policies. Examples of questions could be about parental leave, holidays and salary payments.

This role offers you a superb opportunity to get broad experience within the HR and Payroll/Time areas and the possibility to explore a new country and office!



Typical HR tasks that you will be accountable for:

* Resolving HR queries and issues for managers and employees
* Resolve HR queries and issues in respect of Payroll and Time & Attendance
* Ensuring the delivered support is of excellent quality and in accordance with written procedures, current legal requirements and internal standards
* Prioritizing workload to achieve personal and work unit targets
* Continuously improve ways of working to develop and simplify processes and systems

Essential Requirements

* Experience of working in a customer service and technology driven environment
* Excellent communication skills required to manage a multitude of customers i.e managers, employees, inhouse skill centers and off shore center
* Experience of working within HR
* Proficient in Swedish and English - spoken and written

Desirable skills

* Knowledge of HR system - Workday
* Experience of working with payroll and time
* Knowledge in Sweden Labor Law
* Experience of ServiceNow



Join us in our unique and ambitious world. Join a dedicated global team that's powering AstraZeneca to better serve patients, every day. The fuel behind our evolving, rapidly growing enterprise, we're here to help unlock the power of what science can do and ultimately have a big impact on patients' lives.

If you are interested, apply now and let's make a difference together! We will screen and interview candidates on a continuous basis.

Last application day March 10.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. When we put unexpected teams in the same room, we fuel bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Visa mindre

At AstraZeneca, we unlock the power of What Science Can Do. Empowered to explore, every day we work towards our ultimate aim - treating, preventing, modifying and even curing complex diseases. Be part of the team where you are empowered to follow the science!
Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) across all the AstraZeneca therapy areas.
Our vision is to be “pharmaceutical science leaders, creating innovative and cost-effective solutions, shaping the diverse therapies of the future”.
The role
We’re looking for a talented and motivated Analytical Chemist to join our analytical characterization team within Early Product Development and Manufacturing (EPDM) in Gothenburg.
What You’ll do
You would join a highly collaborative team and together we will deliver the analytical science to product development within the early portfolio up to phase II.
To be successful in this role you will need a strong scientific background with good skills in written and verbal communication and the ability to engage and collaborate across boundaries with a positive problem-solving attitude and delivery focus.
This is a lab-based role where you will work collaboratively with colleagues, documenting your experiments carefully and to the right quality. You will get the opportunity to apply your excellent analytical expertise to the drug projects you are working in, contributing to the progression of these projects and drive the scientific development within the field of analytical science at AstraZeneca.
Do you have the essential qualifications?
University degree (MSc) in analytical chemistry
Scientific knowledge and experience within analytical science and technically skilled to use chromatography with relevant detection techniques for small molecules
Industry experience of working with different analytical techniques and methodologies related to pharmaceutical development, e.g. assay, organic impurities and dissolution testing of liquid and solid dosage formulations
Experience of analytical method development, analytical method validation and stability testing of pharmaceuticals in development
You are a driven experimentalist, with a passion to deliver highly relevant and reliable data and in accordance with project timelines
Excellent collaboration track record with colleagues and ability to efficiently communicate results and conclusions
Training and experience of using electronic laboratory notebooks, LIMS and working according to GMP.

Desirable for the role
Interest of driving development within analytical science including championing new technologies and solutions
Interest in developing deeper understanding related to authoring CMC aspects in regulatory submissions

So, what’s next?
We welcome your application no later than October 20th, 2023. Visa mindre

Location: Gothenburg, Sweden
Be empowered to be innovative and creative where difference is valued
If you have a Chemistry based bachelor’s or master’s degree and a desire to explore your scientific potential within a global biopharmaceutical organisation, our Chemistry Research and Development (R&D) Graduate Programme could be the perfect start to your career. You’ll gain invaluable insight, exposure and opportunities across our diverse, Research and Development organisation. We’ll accelerate your learning and help you achieve your potential as a research scientist.
About AstraZeneca
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. We are a company that genuinely follows the science and values individuals at all levels, you’ll be backed and encouraged to speak up, ask questions, and share ideas to push the boundaries of science and continuously learn and explore.
At AstraZeneca, we unlock the power of what science can do by empowering you to explore, everyday we work towards our ultimate aim – treating, preventing, modifying and even curing complex diseases.
What is the R&D Graduate programme?
Starting in September 2023, the programme lasts two years, consisting of three individual eight month placements. Each placement will provide you with fantastic insights in to drug discovery and development and the opportunity to expand your knowledge of our therapy areas.
The programme’s variety and flexibility provides you with unique exposure to expand your knowledge, skills and interest in Chemistry research and other scientific disciplines, research areas and stages of the drug discovery process. As well as helping you broaden your scientific knowledge, we’ll help you develop professional skills required to fulfill your career potential.
You will gain an invaluable blend of on-the-job experience and training. You’ll enjoy guidance and advice from a huge support network, including a mentor and dedicated programme management team. We’ll also encourage you to identify and build collaborative relationships with specialists and leaders across our organisation, and our external networks including leading academic and biotech research institutions. Together, we’ll help accelerate your development and knowledge!
Applicants applying to the Chemistry arm of the programme should have a sound knowledge of organic synthesis. Prior lab experience in this setting is advantageous, as is a knowledge of or interest in organic chemistry, formulation techniques, or common analytical techniques.
Whilst there are numerous placements to choose from, most are wet lab based placements which build on existing skillsets and support the development of new technical skills. Our Chemistry opportunities exist in organic synthetic chemistry, formulation and analytical chemistry. There are also in silico opportunities which involve the computational modelling and design of new compounds as well as wider opportunities across the R&D organization to stretch and develop you. It is expected that candidates complete at least one lab based placement related to their discipline during the course of the programme.
You will be based at the site of application throughout the duration of the 2 years, we do not offer international placements on this programme
Essential for the role
A 2:1 (UK) / GPA 3 (US) / VG Grade (Sweden) or local equivalent Bachelor’s degree, or a Master’s level qualification, in a chemistry related subject awarded in 2022 or due to be awarded before September 2023.
Knowledge of organic synthesis.
Passionate about working in drug discovery, and committed to helping to push the boundaries of science to deliver life changing medicines to patients.
Proactive problem solving and critical thinking skills.
Planning, organisational and time management skills.
Collaborative, with a partnership approach to achieving success. Visa mindre

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.
Pharmaceutical Technology and Development (PT&D) is the organization that turns brilliant science into actual medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices for new medicines and providing expert technical support to all AstraZeneca’s commercial drug substances and products to ensure we successfully supply medicines to patients.
Inhalation Product Development (IPD) sits within PT&D and is responsible for the development of inhalation products including combinations. Inhalation Product Development delivers the therapies of the future through scientific leadership in drug delivery, formulation and manufacturing the final drug product.
We are now seeking a Principal Scientist to join our outstanding team.
This role leads pressurized metered dose inhaler (MDI) and dry powder inhaler (DPI) development and on-market support activities. The ideal candidate will have development experience with drug-device combination products, including inhalation products, and a working knowledge of medical device design controls. Moreover, knowledge and experience in how suspension MDI formulations interact with the valve, can, and actuator is required. In addition, the candidate should have strong problem solving and communication skills with the drive and leadership qualities needed to deliver on project goals. Experience authoring international regulatory documents is desired.
What you’ll do
Lead a global team of functional leads comprised of, at a minimum, analytical, manufacturing, product development, and device representatives for a complex global product development program
Adhere to the Product Development Process and deliver project objectives on time and to quality and budget
Plan project activities and deliverables, in collaboration with PM, with appropriate input from IPD and BPD functions and IPD LT endorsement
Communicate project delivery and technical risks to IPD LT (and IPD PDD LT) and propose mitigations; advocate for project and product opportunities
Support global harmonization efforts across inhalation portfolio and within inhaled biologic programs
Lead project team utilizing lean tools such as communication (Tier process), investigations (PPS, Level 0), and productivity (Agile PM) tools
Lead authoring for regulatory dossiers including INDs, CTAs, briefing documents, BLAs, MAAs, etc.
Represent the IPD Product Development Team at the Pharmaceutical Team level and within functional stakeholder meetings, providing technical advice in the advancement of the development of the product
Collaborate closely with IPD functional heads on a routine basis to support rapid and agile responses to project challenges and opportunities ?

Essential Requirements
Master’s degree or equivalent professional qualification
Knowledge of the drug discovery and development process, developments within the industry and within own broad area of expertise
Understanding of local compliance systems regulations
Ability to provide guidance and advice on future strategy
Understanding of patent and IP strategies
Substantial knowledge of the product development process
Proven track record of project work in inhaled development
Excellent communication skills
Proven track record of talent development
Experience of coaching people
A habit of driving continuous improvement??
Excellent written and verbal communication and presentation skills in English?

Desirable requirements
Excellent negotiation, collaboration and interpersonal skills
Ability to analyse and interpret complex situations and provide clear strategic directions for others

Why AstraZeneca
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.
Öppen för alla
Vi fokuserar på din kompetens, inte dina övriga förutsättningar. Vi är öppna för att anpassa rollen eller arbetsplatsen efter dina behov. Visa mindre

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.
Pharmaceutical Technology and Development (PT&D) is the organization that turns brilliant science into actual medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices for new medicines and providing expert technical support to all AstraZeneca’s commercial drug substances and products to ensure we successfully supply medicines to patients.
Inhalation Product Development (IPD) sits within PT&D and is responsible for the development of inhalation products including combinations. Inhalation Product Development delivers the therapies of the future through scientific leadership in drug delivery, formulation and manufacturing the final drug product.
We are now seeking a Principal Scientist to join our outstanding team.
This role leads pressurized metered dose inhaler (MDI) and dry powder inhaler (DPI) development and on-market support activities. The ideal candidate will have development experience with drug-device combination products, including inhalation products, and a working knowledge of medical device design controls. Moreover, knowledge and experience in how suspension MDI formulations interact with the valve, can, and actuator is required. In addition, the candidate should have strong problem solving and communication skills with the drive and leadership qualities needed to deliver on project goals. Experience authoring international regulatory documents is desired.
What you’ll do
Lead a global team of functional leads comprised of, at a minimum, analytical, manufacturing, product development, and device representatives for a complex global product development program
Adhere to the Product Development Process and deliver project objectives on time and to quality and budget
Plan project activities and deliverables, in collaboration with PM, with appropriate input from IPD and BPD functions and IPD LT endorsement
Communicate project delivery and technical risks to IPD LT (and IPD PDD LT) and propose mitigations; advocate for project and product opportunities
Support global harmonization efforts across inhalation portfolio and within inhaled biologic programs
Lead project team utilizing lean tools such as communication (Tier process), investigations (PPS, Level 0), and productivity (Agile PM) tools
Lead authoring for regulatory dossiers including INDs, CTAs, briefing documents, BLAs, MAAs, etc.
Represent the IPD Product Development Team at the Pharmaceutical Team level and within functional stakeholder meetings, providing technical advice in the advancement of the development of the product
Collaborate closely with IPD functional heads on a routine basis to support rapid and agile responses to project challenges and opportunities ?

Essential Requirements
Master’s degree or equivalent professional qualification
Knowledge of the drug discovery and development process, developments within the industry and within own broad area of expertise
Understanding of local compliance systems regulations
Ability to provide guidance and advice on future strategy
Understanding of patent and IP strategies
Substantial knowledge of the product development process
Proven track record of project work in inhaled development
Excellent communication skills
Proven track record of talent development
Experience of coaching people
A habit of driving continuous improvement??
Excellent written and verbal communication and presentation skills in English?

Desirable requirements
Excellent negotiation, collaboration and interpersonal skills
Ability to analyse and interpret complex situations and provide clear strategic directions for others

Why AstraZeneca
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare. Visa mindre

Do you have expertise in Clinical Research and Development combined with a deep understanding of the medical and scientific aspects of drug development? Are you ready to apply your expertise in a global company that pushes the boundaries of science with potential to impact million patients’ lives around the globe? Join us to develop the ground-breaking medicines of the future for Cardiovascular, Renal and Metabolic diseases!
At AstraZeneca, we work without barriers between functions at the cutting-edge of clinical science, it’s a place to rethink the future of medicine to answer some of the most complex unmet patient needs. That’s why we love it – this is the place to make a greater impact!
We are now expanding and offer the opportunity for a Physician or Scientist to join our Late Cardiovascular, Renal and Metabolism (CVRM) clinical development teams. The role will be at Director or Senior Director level depending on your previous experience. In Late CVRM you will be working cross-functionally in a truly international environment with opportunities to meet and discuss with key opinion leaders, medical and scientific experts as well as commercial and regulatory functions. You will join a team of leading specialists, driven to pursue scientific and clinical knowledge. And there’s no better place to learn - from the science, from each other and from our successes and failures. AstraZeneca is a place of opportunity with the support you need to thrive and grow.
The positions can be based at either of our dynamic global R&D site in Gothenburg Sweden or Warsaw Poland.
What you’ll do
Our therapy area aligned groups of physicians and scientists provide clinical guidance and scientific leadership for clinical development programs within AstraZeneca's global organization. This is a global role providing medical and scientific expertise in cross functional global teams to develop medicines through design, conduct and reporting of clinical studies within Cardiovascular, Renal, Metabolic, and/or Hepatic Diseases. You will work closely with the Global Clinical Head (GCH) to develop the medicine to its full potential.
In addition to collaborating seamlessly and efficiently with colleagues globally across AstraZeneca R&D, the work involves interactions with external medical experts, Regulatory Authorities, Ethics Committees, Marketing Companies and Investigators/Sites. You will also maintain a high degree of awareness on new and emerging medical and scientific development, contribute to publications and present at congresses. Additional responsibilities include:
Providing strategic medical and scientific knowledge and supporting design, initiation, execution, completion, interpretation and reporting of clinical studies
Accountability for medical and ethical components of studies including patient safety on study level in compliance with Good Clinical Practice (GCP) and regulatory requirements
Delivery of the clinical and scientific components of all relevant study documents (e.g. Protocol, Statistical Analysis Plan, Informed Consent Form)
Accountability for ensuring safety surveillance on a study level including the process for Adverse Events (AE)/ Serious AE reporting
Depending on experience, you may work as a GCH delegate across several studies and can be the clinical representative on indication Global Product Team and other sub-teams

Essential for the role
Medical (M.D.) or Scientific (Ph.D.) degree in relevant area
Good general medical knowledge preferably in nephrology, cardiology, metabolic diseases, or NASH (by specialty training or specific research experience)
Significant academic or pharmaceutical industry experience in clinical research
Excellent English, both spoken and written
Willing to be office based at one of our AstraZeneca sites in Gothenburg or Warsaw

With your excellent interpersonal, communication, and collaboration skills you have the ability to operate effectively across boundaries in a global matrix research environment to influence both internal and external stakeholders.
Desirable for the role
Demonstrated 3+ years clinical research expertise in relevant therapy area in study design, protocol development, monitoring and implementing clinical trials, interpreting and reporting trial results
Clinical expertise in one of our core therapy areas
Good understanding of clinical trials methodology, biostatistics, global regulatory environment and pharmacovigilance
An understanding of pharmaceutical industry R&D, particularly of major clinical milestones and of the factors which influence drug development
An understanding of the interplay between clinical, commercial objectives, drug safety and regulatory requirements



Where can I find out more?
CVRM at AstraZeneca: https://www.astrazeneca.com/our-therapy-areas/cardiovascular-renal-and-metabolism.html
AstraZeneca in Gothenburg: https://www.astrazeneca.com/our-science/gothenburg.html
AstraZeneca in Warsaw: https://careers.astrazeneca.com/poland
Life at AstraZeneca : https://careers.astrazeneca.com/inclusion-diversity
Why AstraZeneca?
AstraZeneca is a global, innovation-driven biopharmaceutical company proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity. There’s no better place to see what science can do. Visa mindre

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.
Pharmaceutical Technology and Development (PT&D) is the organization that turns brilliant science into actual medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices for new medicines and providing expert technical support to all AstraZeneca’s commercial drug substances and products to ensure we successfully supply medicines to patients.
Inhalation Product Development (IPD) sits within PT&D and is responsible for the development of inhalation products including combinations. Inhalation Product Development delivers the therapies of the future through scientific leadership in drug delivery, formulation and manufacturing the final drug product.
We are now seeking a Principal Scientist to join our outstanding team.
This role leads pressurized metered dose inhaler (MDI) and dry powder inhaler (DPI) development and on-market support activities. The ideal candidate will have development experience with drug-device combination products, including inhalation products, and a working knowledge of medical device design controls. Moreover, knowledge and experience in how suspension MDI formulations interact with the valve, can, and actuator is required. In addition, the candidate should have strong problem solving and communication skills with the drive and leadership qualities needed to deliver on project goals. Experience authoring international regulatory documents is desired.
What you’ll do
Lead a global team of functional leads comprised of, at a minimum, analytical, manufacturing, product development, and device representatives for a complex global product development program
Adhere to the Product Development Process and deliver project objectives on time and to quality and budget
Plan project activities and deliverables, in collaboration with PM, with appropriate input from IPD and BPD functions and IPD LT endorsement
Communicate project delivery and technical risks to IPD LT (and IPD PDD LT) and propose mitigations; advocate for project and product opportunities
Support global harmonization efforts across inhalation portfolio and within inhaled biologic programs
Lead project team utilizing lean tools such as communication (Tier process), investigations (PPS, Level 0), and productivity (Agile PM) tools
Lead authoring for regulatory dossiers including INDs, CTAs, briefing documents, BLAs, MAAs, etc.
Represent the IPD Product Development Team at the Pharmaceutical Team level and within functional stakeholder meetings, providing technical advice in the advancement of the development of the product
Collaborate closely with IPD functional heads on a routine basis to support rapid and agile responses to project challenges and opportunities ?

Essential Requirements
Master’s degree or equivalent professional qualification
Knowledge of the drug discovery and development process, developments within the industry and within own broad area of expertise
Understanding of local compliance systems regulations
Ability to provide guidance and advice on future strategy
Understanding of patent and IP strategies
Substantial knowledge of the product development process
Proven track record of project work in inhaled development
Excellent communication skills
Proven track record of talent development
Experience of coaching people
A habit of driving continuous improvement??
Excellent written and verbal communication and presentation skills in English?

Desirable requirements
Excellent negotiation, collaboration and interpersonal skills
Ability to analyse and interpret complex situations and provide clear strategic directions for others Visa mindre

Salary: Competitive
Location: Södertälje & Gothenburg, Sweden
Apply and advance your technology skills to drive digital health and develop life-changing medicines.
About AstraZeneca
Within AstraZeneca IT, we’re at the forefront of discovering and driving digital health and workplace automation to ensure our teams can continue to develop life-changing medicines. And as a member of our Technology Graduate Leadership Programme, you’ll play a huge part in helping drive our innovation.
Here our work has a direct impact on patients – transforming our ability to develop life-changing medicines. We empower the business to perform at its peak and lead a new way of working, combining cutting-edge science with leading digital technology platforms and data. All with a passion to impact lives through data, analytics, AI, machine learning and more.
We truly value our Graduate talent, their experience, knowledge, ideas and who they are. So here, you’ll be empowered to jump in, take the initiative and be part of meaningful project teams to make an impact and deliver real value for our patients and our business.
About the role
As the next wave of technology leaders, you’ll use your skills and influence to deliver technology solutions and help improve the way we operate, serve customers and enable our teams to do their best work. Because here, we truly value your knowledge, experience and ideas. So, you’ll always be encouraged to take the initiative to help drive our technology capabilities and make meaningful impact for our business, and our patients.
We’ve been busy building and developing our technology which is now enabling our transformation to become a digital and data-led enterprise. There’s never been a better time to join us as we bring our digital strategy to life. There’s a huge opportunity to develop, explore and thrive during our next chapter.
Starting in September 2023, the Technology Leadership Graduate Programme begins with three individual eight-month placements. Each placement will provide you with extraordinary insights into our business, and the chance to influence our future direction. If successful during the first 2 years, you will then consolidate your learning and experience in your third year in the programme.
Working alongside diverse, talented peers in an inclusive, supportive environment, the Programme will have you moving through different rotations to hone your skills, develop as a leader, and get where you want to go. Supported by expert managers and mentors to develop life-changing skills and set you up for success.
The pace is fast, and the levels of challenge and responsibility are high, but we always have fun doing it. So, if you’re ready to pursue your passion for technology-led science and challenge the status quo to kickstart your career and make an impact, then we can’t wait to have you on our team.
Essential Requirements
A bachelor’s or master’s level qualification in Technology, Engineering, Science, or a Pure science subject such as Mathematics and Physics, awarded in 2022, or due to be awarded in 2023
The ability to identify and drive innovation and fresh thinking
Passion for Technology
A collaborative approach, and work effectively in a team
A valid passport and willingness to travel, if required
Fluent English language skills

Why join us?
We’re a network of entrepreneurial self-starters who contribute to something far bigger. There’s a diversity of expertise in our Technology group that’s unique to AstraZeneca – it allows us to dive deep into exploring new leading-edge technology. We enable AstraZeneca to perform at its peak by delivering world-class technology and data solutions. Our work unlocks the potential of science.
We optimise and evolutionise AstraZeneca by maximising efficiencies and finding new ways to drive productivity. From automation to data simplification. We’re not afraid to take ownership and run with it.
Empowered with unrivalled freedom. A place to be open and transparent – we speak up, think creatively and share ideas. Our diverse contributions help us to make better decisions. But we have a constant drive to innovate, and an appreciation for high standards. It takes challenging the status quo to add value in our ever-evolving environment. We love it here because put simply, we make a meaningful impact.
Technology at AstraZeneca is a home for purposeful disruptors!
So, what’s next?
Are you already imagining yourself joining our team? Good, because we’d love to hear from you! Click the link to apply and we’ll be in touch as soon as we can.
Applications Open: 24 January 2023
Applications Close: 26 March 2023
Shortly after you submit your application, you will be asked to complete an online assessment (SHL). If shortlisted, you will then be invited to a video interview and finally a full day virtual assessment day.
Our virtual assessment day will be held on 16th May 2023.
You can find out more about the Technology Leadership Programme here: https://careers.astrazeneca.com/technology-leadership-programme Visa mindre

(2 year Fixed Term Contract)
Location: SWE (Gothenburg)
Competitive salary and benefits
Bring out the best in each other, and yourself, by working together as one
In our dynamic environment, be supported by the brightest minds working together side by side. Agile and collaborative, we work cross-functionally, as well as externally, to thrive at pace.
We are currently looking to recruit a Post-Doctoral Researcher in Early Chemical Development (ECD) to work on the development and application of membrane technology for manufacture of our medicines. This is a fixed term 24 month contract as part of a major European grant working towards the sustainable manufacture of pharmaceuticals. You will join our team in ECD, Pharmaceutical Sciences (PS) on our Gothenburg Campus.
As a dedicated BioPharmaceutical Research & Development organisation, we accelerate promising early-stage assets and lifecycle management programmes. From discovery to late-stage development, we always follow the science.
Pharmaceutical Sciences is a function within the AstraZeneca Biopharmaceuticals R&D unit that creates innovative, efficient solutions by transforming molecules into investigative medicines meeting unmet needs of future patients. The function has four departments: Early Chemical Development, Advanced Drug Delivery, Early Product Development and Manufacturing, and Data Science and Modelling. Our wide-ranging portfolio of projects includes traditional small molecules, nucleotide-based therapies and nano medicines across AstraZeneca’s therapy areas.
Early Chemical Development (ECD) is a world class CMC department with responsibility for early phase process development and scale up of new chemical entities (NCEs). The department’s responsibilities span from early engagement with Discovery Chemistry groups through to manufacture of Phase II Clinical material, and our key skill areas include Analytical Chemistry, Crystallisation, Isotope Chemistry, Large-Scale Laboratory (Kilo-Lab) Manufacturing, Process Chemistry, Process Design, Process Engineering, Route Design and Separation Science.
What you’ll do
To deliver on AZ’s ambitions in sustainability we’re looking for a hardworking, creative and experienced membrane specialist to join the team and develop the use of membrane processes to support the manufacture of molecules. Membrane technology is recognised as a low energy, efficient process that could provide the opportunity to lower solvent use and reduce energy usage compared to more traditional, batch separation techniques (e.g. liquid-liquid extraction).
You’ll work to discover and develop new applications of membranes in the pharmaceutical industry. As part of a Horizon Europe Eternal consortium project, you will represent AZ and collaborate with a range of academic and industrial partners. You’ll join a vibrant community of over 100 industrial Post Docs working in AstraZeneca on exciting science projects.
The individual will have process engineering experience in membrane research and will utilise this to develop approaches to: Solvent swaps to replace distillations; Product recovery from waste streams; Recovery and reuse of solvent. A passion for working in new scientific areas and developing solutions to technical and project challenges is a key requirement for the role. By driving innovation, helping to secure intellectual property, and contributing to presentations and publications you will develop your own profile and improve AstraZeneca’s scientific reputation.
Main Duties and Responsibilities
Investigate the use of membranes for: Solvent swaps to replace distillations; Product recovery from waste streams; Recovery and reuse of solvent.
Develop ways of working and best practice for applying organic solvent nanofiltration membranes for a given process
Develop membrane applications into processes, considering the effects on the environmental footprint and potential regulatory impact.
Consider the wider impact of membranes on AstraZeneca sustainability targets.
Contribute to development and implementation of a strategy to deliver membrane processes within Early Chemical Development.
Work as a member of cross-functional teams, with a large degree of independence representing own department or area of expertise
Enhance AZ’s scientific reputation by publishing high calibre research, engaging with our external Horizon Europe partners and building professional networks

Essential criteria
Minimum requirement of Bachelor’s degree with a science or engineering background and will hold a PhD/DPhil with a membrane separation focus or have equivalent experience.
Experience of organic solvent nanofiltration application.
A passion for chemical engineering and for applying new technologies.
Practical lab skills, including analytical techniques to support impurity and solvent tracking.
Ability to use literature databases e.g. SciFinder, Reaxys
Sound understanding of the early drug development process.
Experience of leading own work.
Either experience relevant to synthetic development of drug delivery systems or a strong interest in developing knowledge and experience in this area

Desirable criteria
Awareness of wider application of membranes in the pharmaceutical industry.
Good collaboration skills.
Excellent communication skills across interfaces of subject area, culture, and expertise both internally and externally.
Ability to develop and analyse multiple solutions to problems
Ability to use modelling packages e.g. MatLab, Aspen
Lab-based pharmaceutical industry and/or process development experience, using a broad range of practical techniques
Strong self-development focus, with an interest in learning about new scientific areas

Why AstraZeneca
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development. Visa mindre

Associate Principal Scientist / Senior Scientist Bioinformatician - Translational Science and Experimental Medicine.
Are you a forward-thinking and curious Bioinformatician with skills in large scale omic analysis or experience in clinical omic analysis? Do you also want to improve the way we discover and develop medicines? Welcome to join AstraZeneca!
We are looking for experienced Bioinformaticians to join our Bioinformatics Immunology team. In this role you will be part of our Translational Science and Experimental Medicine (TSEM) department with an open and collaborative atmosphere - and a culture that is both science-based and patient-focused. This role is located at one of our sites in either Gothenburg (Sweden) or Gaithersburg/Waltham (US).
Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions. We harness digital, data science & AI to fast-forward our research. Making sure work born in a lab can make a real difference. Everyday, impacting patients’ lives across the world.
What you will do
In this role, you will work in a highly cross-functional and thriving environment together with specialist in sequencing, immunological disease, as well as data science & bioinformatics experts. You will be using e.g. machine learning techniques and network biology to integrate and analyse omic and clinical data to deliver precision medicine within immunology drug development, as well as identify novel patient groups through data mining of large cohort omic data sets. Utilisation of e.g. knowledge graphs to identify life-cycle management indications is also included in the role.
Depending on your previous experience, your initial career level will be an Associate Principal Scientist or Senior Scientist.
Essential for the role
You will apply your great skills in omic analysis, with an emphasis on analysing dynamic omic sets such as e.g. transcriptomics and proteomics generated in a clinical setting to derive biological insight and you have a MSc with extensive industry experience, or preferably, PhD or equivalent in bioinformatics, life sciences, statistics, mathematics or another similar subject area. A good knowledge level in life sciences will be a minimum requirement.
We also believe you have:
Track record of applying bioinformatic analysis to drive projects in drug discovery or development in an industrial or academic setting
Broad experience applying ML methods such as random forests, clustering, dimensionality reduction in a systems biology or systems medicine context
Programming proficiency and experience with relevant software tools such as R or Python, version control (Git/Bitbucket)
Good understanding of network biology and data integration

Our team is a collaborative group, so the ability to be comfortable working in a goal-oriented way, with a team focused approach is central to be successful in the role. Furthermore, you have great communication skills, a high degree of independence and a proactive and delivery focused approach.
Desirable for the role
Experience in pharmaceutical R&D and knowledge of relevant disease areas, and experience in precision medicine
Working in a Linux environment, ideally with experience of cluster or cloud computing (e.g. AWS or Azure)
Post-doc experience or otherwise relevant data science research experience

Why AstraZeneca?
AstraZeneca is a global, BioPharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious disease. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, it is safe to share and learn from each other – ours is an inclusive environment. Where difference is recognised and uniqueness is valued. Visa mindre

Are you a forward-thinking and curious Bioinformatician with skills in large scale omic analysis or experience in clinical omic analysis? Do you also want to improve the way we discover and develop medicines? Welcome to join AstraZeneca!
We are looking for experienced Bioinformaticians to join our Bioinformatics Immunology team. In this role you will be part of our Translational Science and Experimental Medicine (TSEM) department with an open and collaborative atmosphere - and a culture that is both science-based and patient-focused. This role is located at one of our sites in either Gothenburg (Sweden) or Gaithersburg/Waltham (US).
Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions. We harness digital, data science & AI to fast-forward our research. Making sure work born in a lab can make a real difference. Everyday, impacting patients’ lives across the world.
What you will do
In this role, you will work in a highly cross-functional and thriving environment together with specialist in sequencing, immunological disease, as well as data science & bioinformatics experts. You will be using e.g. machine learning techniques and network biology to integrate and analyse omic and clinical data to deliver precision medicine within immunology drug development, as well as identify novel patient groups through data mining of large cohort omic data sets. Utilisation of e.g. knowledge graphs to identify life-cycle management indications is also included in the role.
Depending on your previous experience, your initial career level will be an Associate Principal Scientist or Senior Scientist.
Essential for the role
You will apply your great skills in omic analysis, with an emphasis on analysing dynamic omic sets such as e.g. transcriptomics and proteomics generated in a clinical setting to derive biological insight and you have a MSc with extensive industry experience, or preferably, PhD or equivalent in bioinformatics, life sciences, statistics, mathematics or another similar subject area. A good knowledge level in life sciences will be a minimum requirement.
We also believe you have:
• Track record of applying bioinformatic analysis to drive projects in drug discovery or development in an industrial or academic setting
• Broad experience applying ML methods such as random forests, clustering, dimensionality reduction in a systems biology or systems medicine context
• Programming proficiency and experience with relevant software tools such as R or Python, version control (Git/Bitbucket)
• Good understanding of network biology and data integration
Our team is a collaborative group, so the ability to be comfortable working in a goal-oriented way, with a team focused approach is central to be successful in the role. Furthermore, you have great communication skills, a high degree of independence and a proactive and delivery focused approach.
Desirable for the role
• Experience in pharmaceutical R&D and knowledge of relevant disease areas, and experience in precision medicine
• Working in a Linux environment, ideally with experience of cluster or cloud computing (e.g. AWS or Azure)
• Post-doc experience or otherwise relevant data science research experience
Why AstraZeneca?
AstraZeneca is a global, BioPharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious disease. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, it is safe to share and learn from each other – ours is an inclusive environment. Where difference is recognised and uniqueness is valued.
What’s next?
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application (including CV and cover letter).
Where can I find out more?
Follow AstraZeneca on LinkedIn: https://www.linkedin.com/company/1603/
Follow AstraZeneca on Instagram: https://www.instagram.com/astrazeneca_careers/?hl=en
Read more about BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html Visa mindre

Pioneer a new future to meet global healthcare challenges
At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality.
Pharmaceutical Technology and Development (PT&D) is the organization that turns brilliant science into actual medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices for new medicines and providing expert technical support to all AstraZeneca’s commercial drug substances and products to ensure we successfully supply medicines to patients.
Innovation Strategies & External Liaison (IS⪙) sits within PT&D, and we believe innovation is the key to long term sustainability of PT&D ’s value contribution to AstraZeneca and patients. IS⪙ is expanding its focus towards digital innovations by designing projects that together form a basis for a digital twin across PT&D and Operations, and we aim to connect with other areas in the business well. This is an opportunity to take part in shaping the future by developing excellence in internal and external collaboration.
We have a great opportunity for a Director, Business Development.
The role holder will be part of teams driving the evaluation of IS⪙’s broad innovation pipeline and new science and technology opportunities and will be accountable for managing the design, set-up of agreement and maintenance of all contracts with external partners related to science and innovation activities such as academic institutions, external technology providers and vendors providing support to prototyping and feasibility studies alongside all business development activities and engagements both internal and external.
What you’ll do
You will provide business development support in the development of IS⪙ business cases for the progression of innovation projects through the IS⪙ pipeline from ideation to implementation including but not limited to relationship and stakeholder management, identification and scouting of external opportunities and new strategic engagements with key potential and current partners.
The role requires developing a transparent and efficient contract pipeline; from initial request and project scoping through legal negotiation (IP, confidentiality, warranties, indemnities, liability etc.) to post-signature management and ongoing obligations and deliverables.
You will scope, negotiate and draft legal agreements and bespoke contracts with external partners such as academic institutions, external technology providers and vendors providing support to prototyping and feasibility studies; as well as any other innovation-driven activities in PT&D.
You will provide professional legal services and advice for contract negotiation and risk management considerations and obligations, where appropriate, liaise with Legal and Patent experts. Leading technical and financial scope related negotiations with external partners in collaboration with other expertise, understanding and managing the business opportunities arising from co-development together with external providers of digital twin-type software, including the training of digital twins by AstraZeneca data.
Other responsibilities include but are not limited to:
Acting as first point of contact for the escalation of any issues at suppliers/partners and drive business improvement by collecting and providing feedback on supplier and our own performance
Establishing productive connections with other functions within AZ (e.g., Legal, Procurement, Sourcing function within R&D).
Ensuring consistency of working practices and risk taking through networking with other colleagues active in the externalisation area.
Providing advice and support as necessary regarding externalisation activities to other functions within PT&D
Contributing to the establishment of an industry leading global model for active technology hunting and evaluation of opportunities coming out from universities, start-ups and other commercial actors
Acting as ambassador for creativity and innovation and facilitate wider understanding how PT&D can influence patient value.
Ensuring that all work is performed in accordance with appropriate Safety, Health & Environment, Quality and Compliance standards.

Essential Requirements
A solid scientific background in the pharmaceutical industry such as a BSc/MSc qualification in one of the main scientific areas is an advantage.
Proven and extensive experience of externalisation/commercialisation of technologies including set up of spin-out companies, licensing and exploitations strategies.
Proven and solid experience in the drafting and negotiation of a wide variety of legal agreements with particular focus on externalisation, innovation and commercialisation.
A track record of delivery of complex projects particularly in the externalisation area (ideally experience of working across a number of pharmaceutical fields and involvement in business development and externalisation activities).
Demonstrate ability to liaise effectively internally and externally and to influence across several functional areas.
Strong strategic and entrepreneurial thinking.

Desirable Requirements
Excellent team working and networking skills.
Strong analytical and objective thinking skills.
Ability to think beyond boundaries of own job and company, challenges status quo and seeks opportunities for business improvement.
Capable of making effective decisions, acts courageously and communicates with conviction and inspiration at all levels. Demands excellence (sets high bar) and delivers.
Demonstrate a high degree of personal credibility

Why AstraZeneca
At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare. Visa mindre

ABOUT ASTRAZENECA
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development, and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives and are made to feel valued, energised and rewarded for their ideas and creativity.
ABOUT OUR RESEARCH DATA AND ANALYTICS TEAM
The Research Data & Analytics Team within R&D IT is a global team of highly experienced data, AI and technology professionals who are passionate about delivering innovative products and services. Our mission is to transform the way the R&D discovers and develops medicines through data, analytics, and AI. To achieve this, we partner with scientific teams to deliver the groundbreaking capabilities, products and platforms that accelerate the discovery of life-changing medicines.
SCIENTIFIC COMPUTING PLATFORM
The Scientific Computing platform (SCP) is a foundational capability for HPC and scaled computing solutions. Embedded within the Research D&A organisation it is central to analytics products focused on computational chemistry, imaging, multi-OMICs, structural biology, data science and AI.
The SCP team is accountable for the end-to-end delivery of high-performance analytics products, with an emphasis on augmenting the HPC experience. We combine modern HPC with a powerful DevOps stack and cloud-native technologies to power research and development at AstraZeneca.
ABOUT THE PLATFORM
We are looking for highly skilled engineers to join our team developing a modern, scalable scientific computing and AI platform. You will be a member of an agile DevOps team, working together to design and build platform services and also end-to-end solutions supporting the computational needs of leading scientists.
Are you passionate about the "High-Performance" in HPC? The successful candidate will bring deep knowledge in one or more technologies relating to HPC and contribute to specific projects in those areas of expertise, while also having the opportunity to gain broad knowledge across other technology areas. These may include Infrastructure as Code (IaC), container technology, or integration with public cloud providers.
Key Accountabilities
Depending on interests and background, responsibilities may include
Deploying new applications and services to private or public cloud, using IaC, configuration management and CI/CD
Operational support for the platform and deployed services, including direct engagement with end-users
Architecting solutions for new scientific workflows, building on platform capabilities with opensource software or vendor partnerships
Acting as an agile team to define objectives and requirements with customers. Creating implementation proposals and iterating design, test and build cycles to deliver valuable services
Creating architecture diagrams, documenting processes and conducting product demonstrations and knowledge transfer



Candidate Knowledge, Skills, and Experience
Bachelor's degree or higher in a quantitative or engineering field (computer science, computational biology, bioinformatics, engineering, among others); OR equivalent work experience
Hands-on experience operating and/or engineering large-scale computing environments
Understanding of Linux system administration, the TCP/IP stack, and storage subsystems
HPC technologies including batch schedulers (e.g. SLURM), parallel file systems (e.g. GPFS) and high-speed networks (e.g. InfiniBand)
Scripting using Bash and Python
Operating and consuming virtualised private cloud resources (e.g. OpenStack)
The HashiCorp ecosystem of products for cloud automation: Consul, Vault and Nomad, along with Terraform and Packer
Test driven development, and testing frameworks such as pytest, testinfra, reframe HPC
Software installation tools such as Easybuild, Spack, and environment modules for maintaining large collections of software versions
Configuration management tools (e.g. Ansible, salt, puppet)
Container technology and container schedulers (e.g. Docker and Singularity, Nomad and Kubernetes)
CI/CD GitHub/GitLab Actions



Desirable skills
Experience with application profiling and performance tuning
Operation and configuration of public cloud computing infrastructure (e.g. AWS, Azure, GCP)
Proven development experience with a variety of programming languages (e.g. Java/C++, Python/Ruby/Perl, , AWS)



SO, WHAT NEXT?
If reading the above has tickled your senses and you’re ready to join us, hit the apply button and we look forward to reviewing your application soon. Visa mindre

About AstraZeneca:
AstraZeneca is a global, science-led, patient-centred biopharmaceutical company focusing on discovering, developing, and commercialising prescription medicines for some of the world’s most serious diseases. But we’re more than a global leading pharmaceutical company. At AstraZeneca, we are dedicated to being a Great Place to Work and empowering employees to push the boundaries of science, fuelled by their entrepreneurial spirit. There’s no better place to make a difference in medicine, patients, and society.
About the Postdoc Programme:
Bring your expertise, apply your knowledge, follow the science, and make a difference. AstraZeneca’s Postdoc Programme is for self-motivated individuals looking to deliver exciting, high-impact projects in a collaborative, engaging and innovative environment. You'll work with multidisciplinary scientific teams from a diverse set of backgrounds and a world-class academic mentor specifically aligned to your project. Our postdocs are respected as specialists, encouraged to speak up, and supported to share their research at conferences, publish papers, achieve their goals, and make a difference to our patients.
This is a 3-year programme, with an initial 2-year period and 1-year, merit-based extension.
About the Opportunity:
In Early Respiratory & Immunology (R&I) we are rewriting the future of these patients, evolving from pure symptom control to clinical disease modification, remission and, one day, cure! To achieve this, we tackle core disease mechanisms to slow down or stop disease, and we focus on earlier and more intelligent interventions where we implement precision medicine from the start to ensure we target patients that will respond to and benefit from treatment.
We now have a Postdoctoral Fellow Opportunity, which involves testing the hypothesis that Specialised Pro-resolving lipid Mediators (SPMs), a recently described class of lipid mediators, have the potential to resolve airway inflammation in asthma and additional respiratory diseases. SPMs have been proposed to actively resolve acute inflammatory responses and promote healing and restitution, but our understanding of SPM biosynthesis and function in the human lung remains rudimentary. The key objectives for the Postdoc will be to (1) identify the key SPMs produced in human lung tissue in response to physiologically relevant stimuli and (2) establish their biological actions in human and guinea pig lung tissue explants, airways, and cell models.
What is involved in the role?
The Postdoc will apply advanced LC/MS methodology to identify SPMs generated in human lung tissue explants and cell cultures challenged with disease-relevant stimuli. The expression of lung enzymes involved in SPM synthesis and receptors mediating their actions will be studied using targeted PCR panels as well as RNA sequencing. Gene expression data will be complemented with protein analysis by Western Blot and other immune assays. Data obtained in the human lung explants will be compared with data from similar experiments in guinea pig lung tissue, which may enable studies addressing SPM production in response to allergy challenges and pharmacological intervention in vivo. Finally, you will use lung tissue explants, isolated small airways, and cells (e.g. mast cells and macrophages) to determine if SPMs can actively arrest ongoing inflammatory responses. Functional endpoints to be studied include airway contraction, cell migration and activation, and mediator production. Single or multiplexed immunoassays will be used to detect cytokines, alarmins, and growth factors. There may also be an opportunity to study the effect of selected SPMs in a novel high-resolution guinea pig airway inflammation in vivo model.
At AstraZeneca Gothenburg, you will be mentored by Dr Henric Olsson, Head of Target Science in Translational Science and Experimental Medicine (TSEM) within the Early R&I organisation. You will join a team of dedicated Target Scientists on a mission to understand disease mechanisms at the molecular level closing the gap between bench science and bedside clinical practice.
You will also have the opportunity to work at Karolinska Institutet, where you will have the support of a leading academic advisor, Prof Sven-Erik Dahlén, a world-leading expert with more than 40 years of active translational research on lipid mediators in the context of respiratory diseases. You will have access to an impressive network of supporting academic experts at Karolinska, and there will be ample opportunity to tap into the Karolinska research community with lab meetings, scientific seminars, and participation in post doc training programmes.
This is a unique opportunity where you as a Postdoc will divide your time spent between AstraZeneca´s vibrant Gothenburg site and Karolinska Institutet in Stockholm, Sweden.
Qualification, Skills & Experience:
Essential Requirements
PhD in biochemistry, cell biology, biomedicine, pharmacology, or a related field.
Good understanding of inflammation or respiratory disease biology, including cell types, molecular pathways, and mechanisms.
Solid understanding of and experience with standard laboratory techniques and methodologies, such as mRNA analysis (PCR) and Western Blot.
Good bioinformatics and data science skills, and a strong ability to analyse and present generated data.
Strong ability to disseminate results and findings to the wider research community (scientific papers and oral presentations).



Desirable Requirements
Experience with mediator analysis by liquid chromatography/mass spectrometry (LC/MS).
The ability to articulate scientific hypotheses and address them experimentally.
Strong communication and networking skills.
Flexibility and the ability to adapt to and work efficiently in different research environments (AstraZeneca and Karolnska).
Experience with pharmacologic in vitro bioassays and/or in vivo models.



Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you! Visa mindre

Do you have a passion for or experience in tissue clearing and high-resolution 3D imaging? Would you like to apply your expertise to impact the development of advanced stem cell therapies in a company that follows the science and turns ideas into life-changing medicines? Then this postdoc opportunity at AstraZeneca might be the one for you!
About AstraZeneca:
AstraZeneca is a global, science-led, patient-centred biopharmaceutical company focusing on discovering, developing, and commercialising prescription medicines for some of the world’s most serious diseases. But we’re more than a global leading pharmaceutical company. At AstraZeneca, we‘re dedicated to being a Great Place to Work and empowering employees to push the boundaries of science and fuel their entrepreneurial spirit. There’s no better place to make a difference in medicine, patients, and society.
About the Postdoc Programme:
Bring your expertise, apply your knowledge, follow the science, and make a difference. AstraZeneca’s Postdoc Programme is for self-motivated individuals looking to deliver exciting, high-impact projects in a collaborative, engaging and innovative environment. You'll work with multidisciplinary scientific teams from a diverse set of backgrounds and a world-class academic mentor specifically aligned to your project. Our postdocs are respected as specialists, encouraged to speak up, and supported to share their research at conferences, publish papers, achieve their goals and make a difference to our patients.
This is a 3-year programme, with an initial 2-year period and 1 year merit-based extension.
About the Opportunity:
We are looking for a Postdoctoral Fellow to fulfil our primary objective of determining the 3D morphological phenotype of tissues with cell transplants and study how the microenvironment affects maturation and integration of grafted cells. Specifically, you will study the local response to various phenotypes of progenitor cells and how this influences safety and efficacy endpoints. Multiplex labeling will be optimized to enable inclusion of markers specific for graft maturation as well as host inflammation and neovascularization. You will deploy AI-based algorithms to spatially determine and quantitate cell types to allow comprehensive investigation of how different cell preparations, transplantation techniques and immune suppression strategies affect graft properties and cell therapeutic outcomes.
As our post doc you will lead the develop of staining and clearing protocols for multiple organs. Find solutions to process tissues with and without cell transplants for 3D optical high-resolution imaging best suited to capture potential structural differences between cell graft and host. You will support in the development of AI-based algorithms to quantify volume of graft, vascularization and, from a safety perspective, possible pathological lesions.
Cell therapy is an evolving field with various different cell types being explored for possible disease treatments. Understanding the molecular mechanisms involved in local tissue response to cell therapy grafts is fundamental for our ability to deliver new safe and efficacious drugs. Newly developed advanced imaging methodologies provide tools to study the interaction between cell therapy products and their target tissues in ways previously not possible. High-resolution 3D imaging of whole organs enables us to spatially study how cell graft and host tissue interact short term and develop over time, under different types of immunomodulatory therapies. This knowledge is pivotal to ensure short- and long-term survival of grafts while avoiding adverse events such as aberrant graft differentiation and systemic side effects of excessive immune suppression.
The primary scientific hypothesis is that local tissue microphysiology and cell response have a pivotal effect on graft survival and subsequent development into functional tissue.
Qualification, Skills & Experience:
Essential Requirements
PhD in molecular biology, biomedical sciences, biophysics or related disciplines, preferably with a focus on molecular imaging.
Extensive technical knowledge of multiplex immunostaining and imaging techniques
In-depth understanding of histology/morphology and the physiology involved
Proven experience in optical clearing techniques



Desirable Requirements
Experience in high resolution imaging e.g., optical projection tomography, light-sheet fluorescence microscope
Experience working with AI based image analyses and using imaging software e.g., Imaris and Arivis
Curious, problem solving team player



Why Should You Apply?
This role is a great opportunity if you are interested in imaging techniques, scientific challenges, and networking. In Imaging and Data Analytics we have multimodal imaging capabilities and are either imaging, informatic or data scientists and are involved in many different projects in different disease areas. We are constantly working with new imaging approaches where you will take the lead in developing high resolution 3D imaging suitable for development of future medicines.
You will be working with imaging and data experts in the Imaging and Data Analytics team, supervised by Dr Elin Sand, Associate Director and team lead of Tissue Imaging Sciences at AstraZeneca. You will also work with our academic scientific partners, Professor Ulf Ahlgren and Tomas Alanentalo from Umeå university, to achieve high resolution 3D imaging of cell grafts in host organs. Professor Ahlgren’s research group has pioneered the development of optical 3D imaging for studies of large tissues.
Ready for an exciting, rewarding challenge? Good, because we can´t wait to hear from you!
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Visa mindre

Do you have expertise in, or passion for, novel catalytic methods for synthesis? Would you like to apply your knowledge to impact the development of novel chemical probes in a company that follows the science and turns ideas into life-changing medicines? Then AstraZeneca might be the one for you!
About AstraZeneca:
AstraZeneca is a global, science-led, patient-centred biopharmaceutical company focusing on discovering, developing, and commercialising prescription medicines for some of the world’s most serious diseases. But we’re more than a global leading pharmaceutical company. At AstraZeneca, we‘re dedicated to being a Great Place to Work and empowering employees to push the boundaries of science and fuel their entrepreneurial spirit. There’s no better place to make a difference in medicine, patients, and society.
About the Postdoc Programme:
Bring your expertise, apply your knowledge, follow the science, and make a difference. AstraZeneca’s Postdoc Programme is for self-motivated individuals looking to deliver exciting, high-impact projects in a collaborative, engaging and innovative environment. You'll work with multidisciplinary scientific teams from a diverse set of backgrounds and a world-class academic mentor specifically aligned to your project. Our postdocs are respected as specialists, encouraged to speak up, and supported to share their research at conferences, publish papers, achieve their goals and make a difference to our patients.
This is a 3-year programme, with an initial 2-year period and 1-year merit-based extension.
About the Opportunity:
In the position, you would have an excellent opportunity to acquire and hone interdisciplinary skills in emerging technologies involving automation-enabled high throughput experimentation, photoredox chemistry, flow chemistry and chemical probes which is a highly valuable set for a career in pharmaceutical industry.
Within AstraZeneca’s Early Cardiovascular, Renal and Metabolism (CVRM) medicinal chemistry department, we strive to employ novel chemical methodologies and emerging technologies to support and accelerate drug discovery programs.
We are looking for a Postdoctoral Fellow who will lead a project involving high throughput experimentation to develop photoredox-mediated, catalytic methodologies to access reactive functionalities on non-planar scaffolds. Transformations would then be adopted to multistage flow chemistry allowing streamlined preparation of selective, covalent probes and further biological profiling.
You will be supervised by Mateusz Plesniak, Senior Scientist of Medicinal Chemistry at AstraZeneca. You will also receive academic guidance and mentorship from Daniele Leonori, Professor of Organic Chemistry at RWTH-Aachen University.
You will have the chance to create a high-quality publication. First, this would involve developing synthetic methodology discovered internally to yield reactive functionalities on aliphatic scaffolds and adaptation to the multistage flow chemistry. The second part involves the preparation of the library of chemical probes using the project methodology and application in selective amino acids targeting using MS-based proteomics.
Qualification, Skills & Experience:
Essential Requirements
PhD in Synthetic Organic Chemistry, Medicinal Chemistry, or a related field
Solid background in synthetic organic chemistry, inert atmosphere techniques, purification, and structural elucidation techniques such as NMR
In-depth knowledge and understanding of photoredox catalysis and/or radical chemistry
A solid track record of research, proven by high-impact publications in peer-reviewed journals, patents and/or talks at scientific meetings



Desirable Requirements
Expertise in photoredox catalysis and/or radical chemistry
Basic knowledge of Chemical Biology principles
Knowledge or experience of flow chemistry
Proven track record of problem solving and delivery in organic chemistry/medicinal chemistry
Ability to work independently and in multidisciplinary teams, showing strong levels of collaboration and communication within teams and across departments
Strong passion for chemistry and scientific curiosity



Ready for an exciting, rewarding challenge? Apply today! Visa mindre

Be empowered to be innovative and creative where difference is valued
Join a place built on innovation and creativity. Where different views and perspectives are welcomed and valued. An environment that champions inclusion, and teams that reflect the diversity of the communities that we serve.
It propels each of us forward, harnessing our differences to unlock challenges and bring new solutions. Unleash your curiosity and entrepreneurial spirit to uncover new insights that challenge conventions.
Here we are forever pushing the boundaries as we feel comfortable spotting opportunities, making quick decisions and taking sensible risks
This role focusses on the development and leadership of externally focused AI innovation capabilities and processes. On behalf of R&D, leading a small team (1-2 people) and large network of volunteers to define areas of focus where AI innovation is required, and engage with the external network of start-ups and commercial vendors to attract, develop and deploy innovative solutions creating value that otherwise would not have been possible.
Typical Responsibilities
Lead a DS&AI; central program (Center of Excellence) for externally focused AI innovation capabilities and processes, on behalf of R&D
Work with AZ AI subject matter experts (SMEs) and vendors to understand AI trends
Reflect the R&D data and AI strategic direction for future capability needs to the external AI innovation ecosystem
Develop, execute and refine an AI playbook for R&D
Work with AI experts to evaluate external solution providers for fit to R&D AI capability needs
Secure engagement from R&D stakeholders to the process and to invest in solution providers
Create and execute innovative business models that meet the needs of both R&D and solution providers
Monitor a portfolio of projects initiated under the AI playbook process, reporting on value
Excite the external ecosystem of start-ups, vendors, peer-organizations, demonstrating that AZ is a partner of choice
Establish external and internal networks to ensure identification and capture of relevant opportunities. Attend relevant external meetings and conferences to search for and identify opportunities
Manage a team to deliver the above, gaining commitment where volunteer task-force delivery is required

People management (direct/indirect reports)
Up to 30, matrix manager
Up to 1-2 direct reports

Essential
Experience in leading multiple, large, international, multi-functional project teams of senior professionals.
Broad knowledge of pharmaceutical business, process and activities
Knowledge of deal structures and legal principles
Experience working with start-up
Extensive experience in Business Strategy and Portfolio within a pharmaceutical or clinical background
Strong analytical skills and ability to ascertain the relevant issues from large masses of information.
Strong interpersonal and team leadership skills
Experience and effectiveness in the presentation of written and oral business cases to the most senior AZ Management.
Numerate and having financial literacy
Proven negotiation skills and experience of working in an intense deal environment.
Gravitas and experience to create a positive relationship with third parties as an AZ Ambassador.

Desirable
Masters degree, e.g. MBA
Expert reputation within the business and industry
Knowledge of AI concepts
Knowledge of R&D principles and processes
Good knowledge of disease areas, and drug development activities and commercial processes and especially within AZ. Existing deep scientific knowledge and an established external network in a relevant therapy area is an advantage

Why AstraZeneca?
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential.
Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.
So, what’s next?
Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.
Where can I find out more?
Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/
Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en Visa mindre

Do you have in depth knowledge within Regulatory Affairs and want to develop your skills within project management?
At AstraZeneca, we offer you a unique experience to work in cross functional teams with all phases of drug development, from clinical trials to marketing authorization applications worldwide. You will lead the end-to-end planning, coordination and execution of our submissions and contribute to regulatory submission strategy. Does this match your skills and ambitions for the future? Then join us to develop future treatments in the Vaccines and Immunology Therapies Areas.
At AstraZeneca, we are more than 65.000 people in over 100 countries. Our aim is simply to positively impact patients’ lives together, as our pipeline of innovative medicines consistently grows. As an industry leading Regulatory function, we’re focused and committed to the development of our products as well as to our people. We provide an open and supportive space to explore, learn and develop across all regulatory roles and levels, with the aspiration to make AstraZeneca the place to build your career in Regulatory. Moreover, by introducing a Regulatory academy and laying out a development path, we want to accelerate your professional and personal growth.
The role
We are now seeking new members to join our Regulatory Affairs Management team within the Vaccines and Immunology Therapies Areas, in the roles as Regulatory Affairs Managers (RAM) / Associate Regulatory Affairs Directors (ARAD). These roles will be based at AstraZeneca’s dynamic R&D site in Gothenburg, Sweden. With employees from more than 50 countries, our Gothenburg site is a truly inspiring place to work.
What you’ll do
Working in the roles as Regulatory Affairs Managers (RAM) / Associate Regulatory Affairs Directors (ARAD), you will have a unique opportunity to work in cross functional teams, with all phases of drug development across geographic regions
With your knowledge, you will contribute to regulatory submission strategy, identify submission risks and opportunities, while leading simple through more complex regulatory applications and managing procedures through approval.
Your main accountabilities/responsibilities:
Lead and/or contribute to the planning, preparation, and delivery of submissions of varying complexity throughout the product’s life cycle from either a global and/or regional perspective.
Provide regulatory input/ expertise on procedural and documentation requirements as defined by Health Authorities for assigned deliverable(s) including submission delivery strategy of all dossiers and all application types per market and/or region and review of documents, e.g., response documents, study protocols, periodic safety reports
Lead multi-disciplinary project teams
Support operational and compliance activities for assigned regulatory tasks
Provide coaching, mentoring and knowledge sharing within the regulatory skill group
Contribute to and lead process improvement
Identify regulatory risks and propose mitigations to appropriate member of cross functional teams



Do you have the essential qualifications for these roles?
To be successful in these roles, we believe that you have a University degree in science or a related field. A minimum of 2 years of regulatory experience within the biopharmaceutical industry or at a health authority is needed to apply for the role as Regulatory Affairs Manager. To be considered for the more senior role as Associated Regulatory Affairs Director, a deeper understanding of Regulatory Affairs, proven leadership and project management skills are required. Both roles require drug development knowledge.
We believe that you possess good project management skills as well as leaderships skills and that you have excellent written and verbal communication skills. If you have previous experience in leading multi-disciplinary project teams, this will be an advantage.
If you are ready to invest in yourself and your regulatory career, then this is the right challenge for you.
So, what’s next?
Are you already imagining yourself joining us? Good, because we can’t wait to hear from you! Visa mindre

Are you a Statistical Programmer with deep knowledge within clinical development? Would you like to be part of a fast-paced and agile team that has direct strategic impact on drug development, empowered and trusted to innovate and experiment? Join us at AstraZeneca Late-Stage CVRM (Cardiovascular Renal Metabolism) Biometrics to impact a wide range of engaging projects striving to make a difference for millions of patients.
At AstraZeneca, we work at the cutting edge of science to develop the ground-breaking medicines of the future – here we do things that have never been done before. We put patients first and strive to meet their unmet needs worldwide.
Our Biometrics team consists of Statisticians, Programmers and Information Scientists. We drive optimized clinical program designs, deliver data for analysis, reporting and submissions, plan and perform statistical analyses and interpretation, and drive access to information and scientific knowledge management.
We are now offering an exciting opportunity for a dedicated and highly motivated individual to join us in the role as Senior Statistical Programming within Late CVRM Biometrics.
Depending on your experience, you may contribute to more strategic planning, quantitative decision making, act as specialist in our contact with external providers and partners, mentoring more junior staff, lead projects and be involved in developing programming tools, standards and processes.
The role is placed at AstraZeneca’s dynamic R&D site in Gothenburg, Sweden, where you will work in an international environment at the fore front of clinical development.
What you’ll do
As a Senior Statistical Programmer you will act delivery focused with responsibility for statistical programming deliverables with quality and timeliness, following established standards and processes. This position requires high technical skills and thorough industry knowledge to independently perform the tasks while using judgement about seeking guidance in complex situations.
Essential for the role
Degree in Mathematics (i.e., Applied Math, Engineering, etc), Statistics, Computer Science, Life Science or equivalent
Excellent SAS programming skills including macro language
Expertise in clinical data standards (CDISC)
Proficient knowledge of the clinical development process



Desirable for the role
Proven planning and organisational skills
Expertise in multiple programming software such as R or Python



Why AstraZeneca?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.
You will be offered a competitive salary and excellent benefits, such as extra paid Holiday, Private Medical Benefits, On-site exercise and much, much more.
So, what’s next?
Are you already imagining yourself joining us? Good, because we can’t wait to hear from you!
Welcome with your application (CV and cover letter) no later than September 11th, 2022. We will review the applications continuously so please apply at your earliest convenience.
Where can I find out more?
Our dedicated Biometrics landing page is: https://careers.astrazeneca.com/biometrics
Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html Visa mindre

Do you have expertise in, and passion for, Software Engineering? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? If so, AstraZeneca might be the one for you!
ABOUT ASTRAZENECA
AstraZeneca is a global, innovation-driven BioPharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious disease. But we’re more than one of the world’s leading pharmaceutical companies.
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.
ABOUT OUR IT TEAM
Here our work has a direct impact on patients – transforming our ability to develop life-changing medicines. We empower the business to perform at its peak and lead a new way of working, combining cutting-edge science with leading digital technology platforms and data. All with a passion to impact lives through data, analytics, AI, machine learning and more. Join us at a crucial stage of our journey in becoming a digital and data-led enterprise. Make the impossible possible by building partnerships and ecosystems, creating new ways of working
and driving scale and speed to deliver exponential growth. Focused and committed, and backed with the investment to succeed, we’re driving cross-company change to disrupt the entire industry. Ours is a place to innovate, take ownership and run with it. You’re trusted to explore and to find new solutions, experimenting with leading-edge technology and grappling with challenges in a modern technology environment that might never have been tackled before. It’s a dynamic and challenging environment to work in – but that’s why we like it. There are countless opportunities to learn and grow, whether that’s exploring new technologies in hackathons, or transforming the roles and work of colleagues, forever. Shape your own path, with support all the way. Diverse minds that work cross-functionally and inclusively together. Be part of a team that has the backing to innovate, disrupt an industry and change lives.
ABOUT THE ROLE?
We have an exciting opportunity for a dynamic, Senior Software Engineer, specializing in imaging informatics to join our growing R&D IT team. The imaging estate at AZ is large, complex, and utilized, in one form or another, across all science units, TAs, and phases of drug development, from discovery to late science. The biomedical imaging platform has been developed to facilitate multi-domain image data management including collection, storage, processing, search, and distribution. You will take a senior engineering role in the design and implementation of platform components supporting multiple integrated workstreams in the areas of our core imaging platform for storage and processing of images and auxiliary projects to support specialized imaging domains and use cases.
Key Responsibilities
As a senior imaging Software Engineer you are responsible for the design and build of imaging platform components supporting all imaging domains including (Pathology, Radiology, Microscopy, Mass Spectrometry, and In-vivo imaging domains)
You are expected to interact with business analysts and other stakeholders to interpret requirements for platform components and solicit additional requirements as needed, research new technologies, and implement innovative solutions in a highly independent manner.
Senior engineers at AstraZeneca are expected to support and mentor less experienced developers and technical support staff such as project managers, business analysts, and software test engineers.
You are responsible for monitoring and maintenance of platform systems and integration of existing systems; also, for maintaining system’s performance to meet or exceed industry and internal standards.
You are responsible for implementation of software in a secure manner to meet or exceed industry and internal security standards.
You are expected to be a vocal senior contributor to Scrum meetings like daily scrum, backlog refinement, sprint retrospective, etc…



ESSENTIAL SKILLS & EXPERIENCE REQUIRED?
Software development experience.
Solid object-oriented design principles with knowledge of software design patterns as highly desirable.
Ability to analyse user requirements, software, and code.
Python and/or Java programming languages with ability and willingness to pick up one or the other as needed.
Strong skills desirable.
Cloud development experience with strong preference for AWS. Familiarity with the following AWS service stack preferred: S3, Lambda, Glue, Athena, ECS, Cloudwatch.
AWS certification a major plus.
Strong commitment to testing with experience in unit testing libraries – experience with behaviour driven development practices and principles a strong plus.
Ability to work with GIT version control in a team development environment.
CI/CD methods and principles using Jenkins or similar tool set.
Experience with Agile software development methodology, especially Scrum.
Knowledge of an image informatics data domain such as medical imaging and DICOM a major plus.
Integrity and trust -- unwavering commitment to "doing the right thing".
Good communication and facilitation skills.
Good written and verbal skills, fluent English. Visa mindre

Clinical Pharmacometrician in Respiratory & Immunology
Do you have experience and expertise in mathematical modelling and simulation, PKPD and its application in drug development? Do you also share our passion to explore possibilities of science to change lives? If yes, your next challenge might be this role at AstraZeneca!


This is an opportunity for a talented and engaged individual to join our growing Clinical Pharmacology and Quantitative Pharmacology team and develop as a Clinical Pharmacometrician supporting large and small molecule projects across full development within the therapy area of Respiratory & Immunology.


AstraZeneca is a world-leading pharmaceutical company, we focus on discovering and developing medicines that make a real difference to millions of patients. Within the Clinical Pharmacology and Safety Sciences (CPSS) function, we have a state-of-the-art quantitative clinical pharmacology group with a diverse and uniquely skilled team of clinical pharmacometricians and clinical pharmacology scientists.


Thrive in an energizing environment where challenging work goes hand in hand with development. With opportunities, recognition and bright minds, there’s no better place to unlock learning and build a long-term career.


What you’ll do:
You will work closely with clinical pharmacology scientists, physicians and other scientists and apply modelling to support the design and interpretation of clinical studies and influence key decisions in early and late clinical development.


The work includes integration of relevant data, such as dose information, pharmacokinetics, biomarkers and clinical endpoints within and across studies, compounds and development stages. Supporting informative trial designs using simulations and efficient modelling statistics is an important focus area for us. In collaboration with clinical pharmacology scientists, you’ll represent Clinical Pharmacology and Quantitative Pharmacology and be responsible for identifying and executing modelling to support model informed drug development. You will communicate your findings to other scientists within and outside of AstraZeneca and publish them in peer reviewed journals.
Requirements:


PhD or equivalent (M.Sc/Pharm.D.) level expertise in quantitative modelling , e.g. knowledge in mathematics and statistics applied to life sciences
Working knowledge of pharmacokinetics and its clinical application
Background and an understanding of clinical pharmacology aspects of drug development, preferably in both the small and large molecule setting
Experience with PK/PD analysis and statistical (pharmacometric) tools such as Phoenix Winnonlin, Nonmem, R
Biological understanding of disease and drug action
Good oral and written communication skills

Desirable for the role:


Recognized scientific expertise demonstrated by scientific publishing in the field of clinical pharmacology
Early or late phase clinical development experience/awareness.


Why AstraZeneca?
We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. It drives us to work together as one global team to achieve our goals. A supportive place where all are encouraged and achievement is recognised. Strengthening our knowledge through constructive feedback and coaching, as well as collaborating with the best.
If this sounds like the job and workplace for you – apply today! Visa mindre

Follow the science to explore and innovate
Here we are committed to making a difference. We have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.
How we do it
We are always listening and learning from people who live with the diseases our medicines treat. It enables us to better understand their needs and, ultimately, diagnose and design the right treatments to impact patients’ lives.
Why we love it
Ultimately, it’s more than a job. We know that our work impacts people with serious conditions, many of whom have no other alternatives. That’s what drives us – the potential to impact over one billion patients worldwide.
At Late Respiratory & Immunology (Late R&I), we’re driven by innovation and our dedication to make a real-life difference in patients’ lives. That difference starts with you. We are part of the BioPharmaceutical R&D unit. Here, you will get the opportunity to work in a truly international environment and meet and discuss with key opinion leaders, other medical colleagues and authorities in basic science, as well as commercial, regulatory, and other functions.
What you’ll do
As a Clinical Research Physician, you will provide clinical mentorship and scientific leadership for clinical development programs within AstraZeneca's global organization. You will operate in a wide range of aspects in pharmaceutical medicine and lead a multitude of contacts with health authorities, colleagues and marketing companies within and outside of AstraZeneca.
You will impact clinical project teams and assist the Global Clinical Head (GCH) with the design and interpretation process, as well as establishing clear design objectives for clinical programs and studies.
We rely on you to:
Build positive relationships and networks with internal and external scientific specialists and opinion leaders
Work closely with colleagues in other functions including Patient Safety, Regulatory Affairs, Biometrics, and Clinical Operations
Be involved primarily in Late Stage (Ph2b and later) clinical programmes and additionally collaborate with clinical colleagues supporting Early Stage programs as well as Medical Affairs colleagues
Provide medical input into the content of core labelling texts and medical support for commercial activities, as well as the scientific component of the pricing and value strategy
Provide expert medical input into the preparation of regulatory documents and interactions with health authorities
Provide expert analysis and interpretation of data from ongoing studies and from the literature
Prepare and present publications at scientific meetings and congresses



Essential for the role
We believe that you are a fully qualified physician (MD or MD PhD) with pharmaceutical industry experience in late stage clinical drug development. Respiratory, Allergy & Immunology background is desirable. Willingness to travel nationally and internationally as needed for the role is expected.
You also possess:
Extensive experience in the design, execution and interpretation of Late Stage clinical trials in the Respiratory area or other therapeutic area/ specialty in clinical development
Asthma/COPD knowledge
Drug development experience
Phenomenal interpersonal skills
Excellent verbal and written communication skills in English

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey.
So, what’s next?
Are you already imagining yourself joining us? Good, because we can’t wait to hear from you!
For more information please contact: [email protected] Visa mindre

Hire location: Cambridge (UK), Gothenburg (SWE) or Gaithersburg (US)
Competitive salary and Benefits
Be empowered to be innovative and creative where difference is valued
Join a place built on innovation and creativity. Where different views and perspectives are encouraged and valued.
An environment that champions inclusion, and teams that reflect the diversity of the communities that we serve.
It propels each of us forward, harnessing our differences to unlock challenges and bring new solutions. Unleash your curiosity and entrepreneurial spirit to uncover new insights that challenge conventions.
Here we are forever pushing the boundaries as we feel comfortable spotting opportunities, making quick decisions and taking sensible risks
The AI and Analytics team within Astrazeneca’s R&D Data Science and AI group is where great things happen in applying sophisticated algorithms and techniques to some of the hardest problems in the discovery and development of new medicines.
The team demonstrates a blend of scientific, problem solving, and quantitative skills to develop and deliver innovative methods addressing critical problems in Astrazeneca’s R&D environment.
Our team of data scientists & informaticians work right next to our other scientists, allowing them to be close to the questions that matter and work on a broad range of the most promising opportunities quickly.
As a Senior Health Data Scientist, you will be part of a rapidly growing team of Healthcare and Visual Analytics expert focusing on analysing and manipulating routinely collected patient-level data from healthcare settings to generate insights that brings innovative medicines to patients faster.
In this role, you will use patient-level databases including claims, EMR, and registry data to develop innovative data science solutions across multiple therapeutic areas (Respiratory, Cardiovascular, Renal and Metabolism) in clinical drug development.
To achieve this, you will scout new technologies/methods/data assets and work in a highly multidisciplinary environment with world leading clinicians, data scientists, biological experts, statisticians and IT professionals.
You will deal with a flexible and varied portfolio of challenges that could include – but are not limited to:
Understanding the patient journey in real world data to optimize patient treatment pathways
Working with drug project teams to find the right sites/investigators in which to run a clinical trial
Researching and developing Machine learning models on multi-modal data to identify digital biomarkers further our understanding of disease
Developing advanced visualisation and visual analytics of routinely collected healthcare data

Accountabilities
Utilises Real World Data (EHR, Claims, Registry & observational data) to support multi-functional projects in R&D and develops advanced data science/informatics solutions across multiple therapeutic areas (Respiratory, Cardiovascular, Renal and Metabolism).
Develops novel analytics solutions where off-the-shelf methodologies do not fit.
Work multi-functionally with multiple partners across R&D to deliver innovative scientific solutions to enable drug projects to optimally utilise large observational datasets and support critical business decisions
Collaborates with the Healthcare and Visual Analytics team to provide technical input to strategic decisions on RWE data strategy, platforms and capability build
Develops working practices to ensure that work is delivered to robust quality standards
Ensures own work is compliant within Clinical Development
Independently keeps own knowledge up to date and learns from senior team members, proposing appropriate training courses for personal development.

Essential
BSc or MSc in a Life Science, Computer Science or equivalent experience
Disease/therapy area and/or biological sciences domain knowledge
Demonstrated experience in method development and application using statistical languages (such as R, Julia or python) and database languages (e.g. )
Experience in EMR/Health IT, disease registries, and insurance claims databases
Knowledge of clinically relevant public and commercial Real world data assets
Superb communication skills with the ability to work with others to achieve objectives
A passion to apply advance analytics/machine learning to tackle difficult problems in drug development using Real world Data

Desirable
PhD in a Life Science or Computer Science preferred
Expertise with clinical data standards, medical terminologies and controlled vocabularies used in healthcare data and ontologies
Use of Machine Learning and Artificial Intelligence in the generation of hypotheses from patient level data
In-depth experience of working in a global organization with complex/geographical context
Strong track record of delivering and managing multi-disciplinary informatics projects
Multiple published papers and/or patents, contribution to external open source projects
Experience in advanced visualisation and visual analytics of routinely collected clinical/healthcare data Visa mindre

Be empowered to be innovative and creative where difference is valued
Join a place built on innovation and creativity. Where different views and perspectives are welcomed and valued. An environment that champions inclusion, and teams that reflect the diversity of the communities that we serve.
At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.
Pharmaceutical Technology and Development (PT&D) is the bridge which turns brilliant science into actual medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.
Our global Clinical Program Supply Chain team is growing, and we are now looking for a Clinical Supply Planner to join our team. Maybe you are one of them? This is a relatively new role in our organization, and you will have a fantastic opportunity to shape & develop the role to drive maximum value for the organization.
As a Clinical Supply Planner you will translate the programme level demand into a supply plan and execute the plan. This will be accomplished by developing and executing optimized plans inline with the Clinical Supply Chain Strategy. You will work closely with Clinical Supply Chain Programme Leads (CSPL) and Clinical Study Leads to match demand & supply and ultimately deliver lifechanging medicines to patients.
Accountabilities include:
Translating demand in to supply plans, which meet the inventory strategy set out by the Programme Lead (CSPL)
Providing forecasts to our supply chain partners for each of the bill of material levels in the supply chain
Executing the supply plan to ensure kits are available to meet patient demand, placing orders with a range of supply chain partners, tracking progress & escalating issues, ensuring timely release of materials through co-ordination of supply chain team
Owning inventory; Creating and allocating material to match individual study demand & maintaining accurate stock keeping records

Required Skills & Knowledge
Degree in supply chain related or drug development discipline or equivalent qualification or experience
In depth knowledge of R&D supply chain and drug development processes
Knowledge of pharmaceutical production, supply chain principles, good manufacturing practice, Food and Drug Administration requirements (or equivalent) and Customs rules and regulations
Proficient IT skills and an aptitude for systems
Excellent analytical skills and an interest in using data to drive decisions
Super user for our key supply planning tools

Additional Requirements
Demonstrated technical skills and mindset in supply chain management including supply planning & inventory management
Experience of supply chain management tools
Good understanding of the principles of risk
Good influencing, negotiating and problem-solving skills, including across functional, geographical and cultural boundaries
Demonstrated experience of training and coaching colleagues
Excellent written and verbal communication skills

With our ground-breaking pipeline, the outlook is bright. Be proud to be part of a place that has achieved so much, yet is still moving forward. There’s no better time to join our global, growing enterprise as we lead the way for healthcare and society. Visa mindre

Location: Gothenburg, (Sweden)
Salary: Competitive, with excellent benefits package
Fuel your curiosity, feel valued and follow the science!
If you have a bachelor’s or master’s degree and a desire to explore and develop your skills in data science and artificial intelligence within a global biopharmaceutical organisation, our Data Science and AI Graduate Programme could be the perfect start to your career. You’ll gain invaluable insight, exposure and opportunities across our diverse, Research and Development organisation. We’ll accelerate your learning and help you achieve your potential.
About AstraZeneca
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.
A company that genuinely follows the science and values individuals at all levels, you’ll be backed and encouraged to speak up, ask questions, and share ideas to push the boundaries of science and continuously learn and explore.
Embrace the novel opportunity to work at a business that puts patients first. Working with data and an agile mindset in our constantly changing business, we help uncover solutions that power the business to better harness the science and get it to market. It means we play our part in reaching patients in need and influencing outcomes.
Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. With more than 2,400 employees from over 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.
What does the programme involve?
The two-year programme will start in September 2022, consisting of three individual eight-month placements. Each placement will provide you with fantastic insights and experience in our use of machine learning, AI and data science to advance drug discovery and development. You’ll work closely with peers, mentors and experts to develop a broad set of skills, knowledge and experience that will help develop your professional capabilities and pave the way for your future.
As a valued member of our team, you’ll discover how we harness the potential of Data Science, Machine Learning and Artificial Intelligence to accelerate our science, and move our research projects forward. You could be contributing to detecting safety risks, designing novel molecules, optimising clinical trial design and processes, or developing new models for use in high profile drug discovery and development projects. As well as helping you broaden your industry and technical knowledge, we’ll help you develop ‘soft’ skills required to fulfil your career potential.
You will gain an invaluable blend of on-the-job experience and coaching. You’ll enjoy guidance and advice from a huge support network, including a mentor and dedicated programme manager. We’ll also encourage you to identify and build collaborative relationships with specialists and leaders across our organisation, and our external networks including leading academic and biotech research institutions.
Together, we’ll help accelerate your development and knowledge!
Essential requirements
A bachelor’s or master’s degree in a quantitative science focused subject including Maths, Physics, Statistics, computer science and software engineering awarded in 2021, or due to be awarded in 2022.
Experience of applying data science, artificial intelligence, machine learning, statistics, computational biology, computational chemistry, bioinformatics or cheminformatics techniques.
Knowledge of the design and application of machine learning or statistical models.
Experience in using multiple data-centric programming languages to enable big data analysis (e.g. Python).
Enthusiastic and passionate advocate for the potential of data science and AI to make an impact.
Proactive problem solving and critical thinking skills.
Planning, organisational and time management skills.
Collaborative, with a partnership approach to achieving success.
Available to start in September 2022.

Together, we push the boundaries of science to deliver life-changing medicines to patients around the world!
Where can I find out more?
Data Science and AI Graduate Programme: https://careers.astrazeneca.com/data-sciences-and-ai-graduate-programme
AstraZeneca Gothenburg: https://www.astrazeneca.com/our-company/our-locations/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
What next?
After you submit your application, you will be asked to complete a gamified test (Pymetrics), as well as an online assessment (SHL). If shortlisted, you will be invited to a virtual technical interview, w/c 4th April, for successful candidates, this will be followed up with a full day virtual assessment day w/c 25th April.
You can find out more about our application process here https://youtu.be/0CuUY9d_WtU
Our virtual assessment days will be held week commencing 25 April 2022. Visa mindre

Making safer antisense oligonucleotide (ASO) therapeutics by identification and molecular characterization of novel ASO:protein interactions driving toxicity
Innovate to change the world!
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. A place for bold disruptors shifting from academia to industry, this is where you can think differently to cut through the noise, add value, and bring fresh thinking to our teams and projects. Collaborating across functions and international borders, you’ll share knowledge and combine strengths to take your skills, and our science, to the next level.
About the Postdoc Programme
AstraZeneca’s Postdoc Programme is for self-motivated individuals looking to tackle exciting, high impact projects in a collaborative and innovative environment.
Working with peers and professionals from a diverse set of backgrounds, together with a world class academic mentor aligned specifically to your project, you’ll be respected as a specialist, and encouraged to speak up. You’ll lead a novel and innovative research project at the interface of drug discovery and biopharmaceutical development in a multi-disciplinary scientific environment. Empowered and supported to drive the success of your project, publish papers, achieve your goals and make a difference to our patients!
Running alongside your research project, our postdoc training program will help you learn about drug discovery and development from industry leaders working in our innovative research laboratories and organization.
About the Opportunity
Propelled by several recent regulatory approvals, the area of therapeutic oligonucleotides is rapidly expanding with an increasing number of research collaborations between biotechs, pharma companies and academia. Several recent publications have demonstrated key roles of ASOs interacting with a range of extra- and intracellular proteins, influencing both efficacy and toxicity. This postdoc project will dissect molecular details of protein:ASO interactions, how this impacts ASO function, and will investigate tissue-specificity by which proteins affect ASO properties. You will establish and adapt a range of methodologies ranging from proteomic/genomic analysis to high resolution microscopy and functional genetics.
You will spend most of the time in the labs of AstraZeneca Gothenburg, working alongside and with AZ scientists, postdocs and PhD students. AstraZeneca is investing broadly in solving many of the remaining knowledge gaps and challenges in the design and safety assessment of ASO therapeutics. With several colleagues working on related ASO questions, an inspiring and thriving working environment has been created to push the boundaries of science through successful and impactful publications.
Between AstraZeneca and the MRC Toxicology unit, we have created a virtual lab group with regular meetings and journal clubs. The postdoc will have the opportunity to work with academics during lab visits to University of Cambridge, allowing integration with the vibrant Cambridge bioscience community. We assume that you will take active part in these interactions to learn from others and serve as an inspiration to more junior colleagues.
Essential Education and Experience
We are looking for a strong communicator who is curious and collaborative, and is able to work independently, with a result oriented, problem solving attitude.
Required:
PhD in biochemistry, molecular biology or cell biology
Hands-on wet lab experience using standard lab-based techniques of molecular cell biology with expertise in any of the following areas:
Biochemistry
Cell biology
RNA biology
Strong publication record and experience in scientific writing
Curious and collaborative team player
Fluent in spoken and written English

Desirable:
Hands-on wet lab experience of one or several of the following experimental areas:
Cellular imaging
RNA: protein interactions
Genomics
Proteomics
Chemical biology

This is a 3-year programme. 2 years will be a Fixed Term Contract, with a 1-year extension which will be merit based. Visa mindre

Interaction on an Individual Cell Level using Deep Learning Based Sequence Modelling.
Innovate to change the world!
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. A place for bold disruptors shifting from academia to industry, this is where you can think differently to cut through the noise, add value, and bring fresh thinking to our teams and projects. Collaborating across functions and international borders, you’ll share knowledge and combine strengths to take your skills, and our science, to the next level.
About the Postdoc Programme
AstraZeneca’s Postdoc Programme is for self-motivated individuals looking to tackle exciting, high impact projects in a collaborative and innovative environment.
Working with peers and professionals from a diverse set of backgrounds, together with a world class academic mentor aligned specifically to your project, you’ll be respected as a specialist, and encouraged to speak up. You’ll lead a novel and innovative research project at the interface of drug discovery and biopharmaceutical development in a multi-disciplinary scientific environment. Empowered and supported to drive the success of your project, publish papers, achieve your goals and make a difference to our patients!
Running alongside your research project, our postdoc training program will help you learn about drug discovery and development from industry leaders working in our innovative research laboratories and organization.
About the Opportunity
This postdoc project will be based within Pharmaceutical Sciences, a branch of AstraZeneca’s R&D that specializes in getting the active drug molecule to where it needs to go. The Advanced Drug Delivery department is in turn concerned with nanomedicine development and runs a variety of projects to investigate nanoparticle engineering and nanoparticle interactions with biological systems.
The performance of nanomedicine delivery systems is dependent on their ability to optimally interact with cellular membranes, enter the cells using endocytosis, and deliver their cargo to the cell cytoplasm by promoting endosomal escape. For each of these processes there is cell-to-cell variation. The end goal in this project is to understand and predict this variation by developing deep learning-based sequence models which allow us to predict the time and magnitude of response to nanoparticle treatment, for every freely moving cell in a population. This information should further be fed into the experimental work to extract mechanistic knowledge about what is required for successful delivery of nanomedicine cargo.
In close collaboration with experienced lab and data scientists, you will have ownership of the entire modeling and analysis pipeline ranging from experimental work to advanced predictive modelling to drafting of manuscripts for publication.
Essential Education and Experience
You may hold a PhD in cell biology, biotechnology, physiology or equivalent scientific field with hands on experience with machine learning, and/or a PhD in Maths, Physics, Statistics or Computer Science with a strong curiosity about cell biology.
Required:
A passionate relationship to science, a collaborative demeanor, and the desire to help build the best working environment possible
Hands-on experience with data science and machine learning, including multivariate data analysis, data processing and visualization
Considerable experience of implementation of deep learning models in python or similar programming language enabling fast model development
Extensive experience with in-vitro cell culture and cell biological methods
Advanced microscopy, laboratory automation, high-content biology (robotic microscopy and image analysis). Preferred candidates will have a high technical aptitude and be able to demonstrate experience in most or all of these areas

Desirable:
Proven track record to drive innovative research through internalization of new techniques and technology, as well as forming internal and external collaborations
Track record of scientific excellence, with a strong publication record and engagement with the scientific community through both conferences and collaborations
Supervisory skills and experience
Knowledge of endocytosis, intracellular trafficking pathways and relevant intracellular signaling
Excellent communication skills in English (written and spoken)

This is a 3-year programme. 2 years will be a Fixed Term Contract, with a 1-year extension which will be merit based. Visa mindre

To improve metabolic function via enzyme supplementation gene therapy
AstraZeneca is a global, science-led, patient-centered biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious disease. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we 're dedicated to being a Great Place to Work where you are empowered to push the boundaries of science and fuel your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society.
About the Postdoc Programme
Bring your expertise, apply your knowledge, follow the science and make a difference!
AstraZeneca’s Postdoc Programme is for self-motivated individuals looking to take on exciting, high impact projects in a collaborative and innovative environment.
Working with peers and professionals from a diverse set of backgrounds, together with a world class academic mentor aligned specifically to your project, you’ll be respected as a specialist, and encouraged to speak up. You’ll lead a novel and innovative research project at the interface of drug discovery and biopharmaceutical development in a multi-disciplinary scientific environment.
You’ll be empowered and supported to drive the success of your project, publish papers, achieve your goals and make difference to our patients.
Running alongside your research project, our postdoc training program will help you learn about drug discovery and development from industry leaders working in our cutting edge research laboratories and organization.
About the Opportunity
Your project will focus on designing and developing a next generation gene therapy modality targeting genetic disorders using Phenylketonuria (PKU) as a proof-of concept. PKU is a rare inherited disorder that in which the amino acid phenylalanine builds up in the body, caused by loss-of function mutations in the phenylalanine hydroxylase (PAH) gene.
You will explore different strategies for in vivo delivery of the PAH enzyme using genome engineering and gene delivery technologies. Treatment concepts will be interrogated and validated in human stem cell based in vitro systems to optimize their therapeutic potential.
In your daily work you will be responsible for designing and performing experiments such as cell-based in vitro assays, designing chimeric protein constructs, assessment of enzyme function in vitro and in disease relevant in vivo models. Independently, you will assess and present data to support project progression and publication.
You will be working at the cutting edge of cell and gene therapy technologies to design and develop a treatment strategy for unmet clinical need. Your scientific findings will have a significant impact on biopharmaceutical development processes and platforms that are sought at improving patient experience and convenience in using life-saving medicines. While making a significant contribution to bringing better medicines to life, you will also have the opportunity to showcase your work at prestigious scientific conference and in high impact peer-reviewed journals. Collaborating with brilliant colleagues from across AstraZeneca's groundbreaking R&D facilities, your passion and drive will accelerate the project.
Qualification, Skills & Experience
Required:
PhD in Medicine, Hematology, Cell Biology, Biochemistry, or Molecular Biology
Expertise in mouse models and in vivo work, ideally with a knowledge of in vivo models relevant to hematology
Experience with basic molecular biology techniques, such as PCR, immunodetection, etc.
Understanding of basic genetic engineering techniques
Demonstrated experience of publishing scientific papers in peer reviewed journals
Ability to work independently, take own initiatives and have positive, goal oriented and problem solving attitude
Excellent communication skills and interpersonal skills, with a collaborative mindset

Desirable:
Experience with biochemistry and enzyme activity assays
Experience in stem cell culture and differentiation
Knowledge of hematopoiesis and hands-on in vitro culture experience of hematopoietic stem cells or other relevant cell types
In vivo nucleic acid delivery and gene modification experience
Keen interest in gene and cell therapy development
Good organizational, data management and documentation skills

This is a 3-year programme. 2 years will be a Fixed Term Contract, with a 1-year extension which will be merit based. Visa mindre

We are now recruiting a Global Clinical Operations Program Director (GPD) to the Clinical Operations function of Late Stage Development Cardiovascular, Renal and Metabolic therapy area in BioPharmaceuticals R&D.
What you’ll do
Do you want to be part of a great and passionate team in drug development? In the Clinical Operations function we operationalize the science that brings medicines to market to improve the lives of millions of patients worldwide. Humbleness for the mission but an attitude to win are true characteristics for members of our group.
The Global Clinical Operations Program Director (GPD) has a global remit with a broad span of responsibilities and stakeholders across the enterprise, providing role modelling project leadership and management for cross-functional teams. The scope is mainly Phase 3 development or medicines already on the Market, but the program may include studies in all phases of drug development. The GPD also leads clinical submission teams in support of regulatory marketing applications and post registration product maintenance phases. On top, the GPD may manage improvement or change projects within clinical operations or spanning multiple business areas.
The GPD will provide input and support to the Senior GPD in preparation for governance interactions, responsible for the planning and delivery of a defined clinical program of studies and/or clinical activities to scope, quality, budget, time; managing resource and risk.
In the GPD role you are expected to be able to work independently and be comfortable to prioritize the work for yourself and your team to meet business objectives. You will also mentor and support people development as appropriate. GPDs are early adopters for new ways of working and act as ambassadors for change when leading teams.
This role is sitting in Late Stage Development Cardiovascular, Renal and Metabolic therapy area in BioPharmaceuticals R&D and can be based at AstraZeneca’s dynamic R&D sites in Gaithersburg (US) or Gothenburg (Sweden).
Essential for the role:
University degree, preferably in medical or biological sciences or discipline associated with clinical research (Advanced degree is preferred)
Strong experience from within the pharmaceutical industry or similar large multinational organization
Proven knowledge of clinical operations, project management tools and processes
Previous experience of clinical development / drug development process in various phases of development and therapy areas
Experience from leading clinical projects and deliverables or similar expertise from other areas of drug development (such as pharmaceutical development).
Ability to mentor, develop and educate staff
Proven leadership promoting motivation and empowerment of others in order to accomplish individual, team and organizational objectives
Skilled & experienced in change management
Ability to look for and champion more efficient and effective methods/processes of delivering Clinical Development focusing on key performance metrics around reliability, productivity, cost and quality
Excellent written and verbal communication skills, negotiation, collaboration and interpersonal skills with ability to work effectively with others at all levels of the organization
Demonstrated ability to set and manage priorities, resources, performance targets and project initiatives in a regional and local environment
Integrity and high ethical standards

Desirable for the role:
Project management certification is desirable but not mandatory
Knowledge of process improvement methodology such as Lean Sigma/Change Management is desirable but not mandatory
Regulatory submission experience

Why AstraZeneca?
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare. Visa mindre

Are you a Statistical Programmer with deep knowledge within clinical development? Are you also a skilled leader that wants to challenge your strategic mindset and management skills in a fast-paced and agile global team? If yes, join us at AstraZeneca Late-Stage CVRM (Cardiovascular Renal Metabolism) Biometrics and get access to our extensive capabilities and comprehensive pipeline where you’ll be involved in a wide range of engaging projects aiming to make a difference for millions of patients.
At AstraZeneca, we work at the cutting edge of science to develop the ground-breaking medicines of the future – here we do things that have never been done before. We put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality, by doing the right things. We truly understand science and use our unique scientific capabilities to deliver what we believe to be one of the most productive pipelines in the industry. And we do something that truly matters – using our skillset to make an important difference to society and patients across the globe. We get to make a profound impact with research that makes a clear and tangible difference.
We are now offering an exciting opportunity for a talented and highly motivated individual to join us in the role as Director Statistical Programming within Late CVRM Biometrics.
This role will be based at AstraZeneca’s dynamic R&D sites in Gothenburg (Sweden).
What you’ll do
As the Director Statistical Programming, you are accountable for the management of Programming on the therapeutic area/sub-therapeutic area level. In this role, you will provide significant input to the strategy of Programming and own the strategy for TA Programming.
As Director, you will report directly to the Head of Programming, Metabolism. You will lead managers so to be successful in this role, strong leadership skills are crucial as well as a proven track record of managing a global team. The role also include establishing and ensure statistical programming, reporting, and clinical data standards for functional staff within a global organization.
Essential for the role
Degree in Mathematical (i.e., Applied Math, Engineering, etc), Statistical, Computer Science, Life Science, or equivalent
Thorough knowledge of the clinical development process from development, launch through life cycle management
Ability to influence strategically and persuade tactfully to obtain desired outcomes while maintaining effective, positive, organizational relationships
Thorough knowledge of industry trends
Experience in leading highly successful global teams
R&D mindset
Business Acumen and experience of influencing and controlling budgets
Expert stakeholder management skills on a functional level

Desirable for the role
Broad experience, ideally across multiple therapeutic areas and outside of the field of Statistical Programming
Willingness and ability to travel

Why AstraZeneca?
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare. Visa mindre

Make a more meaningful impact to patients’ lives around the globe
With our ground-breaking pipeline, the outlook is bright! Be proud to be part of a place that has achieved so much, yet is still moving forward. There’s no better time to join our global, growing enterprise as we lead the way for healthcare and society.
Pharmaceutical Technology and Development (PT&D) is the bridge which turns brilliant science into actual medicines that help millions of people. We work across the entire value chain, crafting and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.
Our global Clinical Program Supply Chain team is growing, and we are now looking for Clinical Supply Planner to join our team. This is a fantastic opportunity to shape & develop the role to drive maximum value for the organisation.
What you'll do
As a Clinical Supply Planner you will translate the programme level demand into a supply plan and execute the plan. This will be accomplished by developing and executing optimized plans inline with the Clinical Supply Chain Strategy. You will work closely with Clinical Supply Chain Programme Leads (CSPL) and Clinical Study Leads to match demand & supply and ultimately deliver life changing medicines to patients.
Accountabilities include:
Translating demand in to supply plans, which meet the inventory strategy set out by the Programme Lead (CSPL)
Providing forecasts to our supply chain partners for each of the bill of material levels in the supply chain
Executing the supply plan to ensure kits are available to meet patient demand
Placing orders with a range of supply chain partners
Tracking progress & escalating issues
Ensuring timely release of materials through co-ordination of supply chain team
Owning inventory; Creating and allocating material to match individual study demand & maintaining accurate stock keeping records

Required Skills & Knowledge
Degree in supply chain related or drug development discipline or equivalent qualification or experience
In depth knowledge of R&D supply chain and drug development processes
Knowledge of pharmaceutical production, supply chain principles, good manufacturing practice, Food and Drug Administration requirements (or equivalent) and Customs rules and regulations
Proficient IT skills and an aptitude for systems
Excellent analytical skills and an interest in using data to drive decisions
Super user for our key supply planning tools

Additional Requirements
Proven technical skills and mindset in supply chain management including supply planning & inventory management
Experience of supply chain management tools
Good understanding of the principles of risk
Good influencing, negotiating and problem-solving skills, including across functional, geographical and cultural boundaries.
Proven experience of training and coaching colleagues
Excellent written and verbal communication skills
Be part of crafting the next phase of Operations’ journey towards the 2025 strategy! Build on our foundations of high performance through agility, responsiveness, reliability and efficiency to deliver our new modalities and complex pipeline to market at speed. Backed by an encouraging team, be part of accelerating our operational excellence with innovations in cutting-edge science, Lean ways of working and fast changing digital technologies. Visa mindre

Do you have a medical degree and an extensive clinical and research background? Would you like to combine your leadership skills with your understanding of the medical aspects of drug development in a global company that follows the science and turns ideas into life changing medicines? Join us at AstraZeneca to discover future treatment of Cardiovascular, Renal and Metabolic diseases!
At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person. We are now offering opportunities in our groups within both Early and Late CVRM (Cardiovascular, Renal and Metabolism). The positions are based at our global R&D site in Gothenburg, Sweden.
In CVRM you will be given the opportunity to work in a truly international working environment, with opportunities to meet and discuss with key opinion leaders, other medical colleagues and experts in basic science, as well as commercial and regulatory functions.
Our therapy area aligned groups of physicians and scientists provide clinical guidance and scientific leadership for clinical development programs within AstraZeneca's global organization. Clinical Research Physician is a global role providing medical expertise in cross functional global teams to develop medicines through design, conduct and reporting of clinical studies. The role holder also interacts with external medical experts and regulatory agencies as well as contributes to publications, presents at congresses and works with the AZ Global Clinical Lead to develop the medicine to its full potential.
What you’ll do
As a clinical Research Physician, you will conduct clinical trials, including the design, monitoring, data interpretation and reporting. An important task is to ensure that all clinical studies operate to the highest ethical and safety standards and in compliance with Good Clinical Practice (GCP) and regulatory requirements.
As a Clinical Research Physician, you will support the clinical project team and assist the Global Clinical Lead (GCL) with the design & interpretation process, establishing clear design objectives for clinical programs and studies. You will provide medical input into the content of core labelling texts and medical support for commercial activities, as well as the scientific component of the pricing and value strategy. You will also provide medical and scientific expertise as well as tactical and strategic medical input to the development of AstraZeneca’s compounds.
This is an opportunity to join a team of leading specialists, driven to pursue scientific knowledge. And there’s no better place to learn - from the science, from each other and from our failures. We feel that AstraZeneca is a place of opportunity with the support you need to thrive and grow. You can move around, try different areas and develop new skills.
Working here, your innovative discoveries will ultimately have the potential to reach billions of patients’ in need, all across the globe. That’s why we love it – this is the place to make a greater impact.
Essential for the role
Medical Degree
Board certification in a relevant specialty
Fluent in written and spoken English
Team player with strong collaboration skills
Communication and presentation skills

Desirable Requirements
Board certification in, nephrology, cardiology, pediatrics
Board certification in cardiology with a special interest in heart failure
PhD degree
Experience from clinical research
Experience from pharmaceutical industry R&D work.
IT/big data experience Visa mindre

Do you have expertise in, and passion for, quantum chemistry and quantum computers? Would you like to apply your expertise to expand the applicability of current state of the art hardware to demonstrate potential quantum advantage in real-world chemistry problems? Then AstraZeneca might be of interest to you!
Pharmaceutical Sciences at AstraZeneca is a member of Next ApplicationS of Quantum Computing (NEASQC) a European Union Quantum Flagship funded program. We will develop and implement novel quantum chemistry algorithms to explore quantum effects on chemical reactivity. As part of this program we are looking for a Postdoc in Quantum Computing. This is a fixed term position for two years in Pharmaceutical Sciences, BioPharmaceutical R&D Gothenburg, Sweden.
What’s in it for you? You will get the opportunity to engage with key internal and external stakeholders to identify and validate impactful solutions to provide scientific leadership and drive innovation in applied quantum computing. You will simply be at the forefront of the quantum revolution within AstraZeneca turning ideas into life changing medicines for patients!
Who are you? We think that you who will accept the challenge have a PhD in quantum chemistry. You have strong knowledge about quantum computers and a strong track record of programming with experience of quantum simulation packages like QISKIT. At AstraZeneca you will fit right in if you thrive on team work, networking, communication and the ability to influence both people and science.
Would you like some more details about the role before applying? As a Postdoc you will be part of the Data Science and Modelling department. The department is responsible for developing data science and artificial intelligence (AI) methods to accelerate the digital transformation of the Pharmaceutical Sciences research unit. Your main responsibility will be to ensure the AstraZeneca deliverables to the NEASQC program. Visa mindre

Advances in digitalization, data and advance analytics are changing industries at pace with the pharma industry showing signs of movement
The Digital Health Market will grow exponentially over the next 3 years, with new applications in digital showing in phase 3 studies significant benefits for patients including overall survival in Cancer.
AstraZeneca would like to leap frog in this area and has prioritized digital in R&D as a critical strategic area of focus by 2025, as part of the overall company strategy. Digital Health R&D’s ambition is to transform healthcare, powered by digital, science and collaborations, to deliver the healthcare outcomes and experience that patients care about the most. The Digital Health R&D journey incorporates 3 key stages
Stage 1 – foundational, reimagine how we work, maximizing the use of digital, data and analytics to transform processes within R&D to gain significant benefits on speed of the portfolio (goal 9 months acceleration), productivity (goal -20% reduction in cost per patient), quality at source, patient experience and probability of success.
Stage 2 – advanced, redefine clinical trials and digital health to improve overall patient experiences and outcomes, example redefining patient populations, remote clinical trials, patient apps to reduce/manage adverse events and improve patient outcomes (OS), using data from EHMr and RWE instead of control arms, and through PROs and continuous patient monitoring, creating new end points enabling studies in earlier stages of disease (ctDNA changes) prolonging significantly patients’ lives
Stage 3 – future-readiness, reimagine healthcare, examples, AZ as a healthcare provider beyond medicines for certain indications (example: Breast Cancer, proving monitoring, predictive analytics and therapies for improved outcomes), full integration of Multiomics (imaging, genomics, proteomics …) to better predict and significantly improve patients’ health

The Information Analytics Specialist leverages the capabilities of Digital Health R&D Self-Service Analytics to respond quickly to business demands on analytics and insights. Provide support on planning, directing and overseeing a wide range of analyses, related to current and future improvements within R&D. As an expert, develops and monitors a range of projects involving insights and analytics. Recognised expert within own field and often first point of contact for specialist queries.
Primary Responsibilities for this role will include (but not limited to):
The Information Analytics Specialist provides data analysis support to the business by assisting with rapid development of reports and/or dashboards to monitor program and operational performance.
Promote self-service analytics for customer adoption, understanding and use of data through best practices and expertise.
Supports design of programmatic analyses and reporting capabilities in addition to business requirement definition for new analysis and performs ad-hoc data analysis as directed.
As a subject matter expert, this position supports data quality and data stewardship functions to maintain data accuracy and identify new metrics.
Drives collaboration and insights through use of analytics that will identify opportunities, support decision making, and improve business performance.
Partners with key stakeholders to ensure analytic resources and development are aligned with business priorities.
Leads the communication of derived insights, through appropriate visualization techniques including data storytelling and user-centered design.
Applies business requirement gathering techniques in conjunction with stakeholders to identify issues and formulate solutions.
Applies analytical techniques to prospect for business insights and find patterns in data which could be valuable for the business.

Education, Qualifications, Skills and Experience
Essential
Thrives in a fast-paced work environment, comfortable with complexity and uncertainty at times, lots of humour, dedication to deliver outcomes and motivated by the opportunity to rethink our approach to healthcare.
Undergraduate degree required (Analytics, Business Intelligence, Information Systems, Mathematics, Statistics, Science, Finance, Operations, Supply Chain, or related area).
2+ years of data analysis experience.
Demonstrated expert level understanding of data analytics, business analysis, and data visualization.
Strong background in Microsoft Power BI or similar software (e.g. Tableau, Qlik)
Advanced Microsoft Excel skills.
Understanding of the concepts and application of data modelling.
Comfort and skills operating in a heavily matrixed organizations with excellent skills and intuition to manage the needs of various stakeholders.
Ability to rapidly grasp concepts and excellent ability to handle complexity by simplifying it and providing clear directions to the team.
Well-developed communication skills, able to create clarity from ambiguity
Passion for Patients and Customers, representing the needs of multiple customers in decision making

Desirable
Intermediate knowledge of preferred.
Understanding of Python/R
Solid Project management skills, including managing vendors, budgets, timelines and risks
Experience on bringing innovation that is solving complex and multi-dimensional issues from an operational, technical, financial and human perspective Visa mindre

At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges! We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.
The role: As a Discovery Safety Scientist/Specialist, in Respiratory & Immunology (R&I) Safety, within Clinical Pharmacology and Safety Sciences. If you’re looking for a role where you can bring your combination of your experience in biology/toxicology/pharmacology, respiratory/immunology science and drug discovery, this is the role for you!
Respiratory & Immunology (R&I) Safety is a leading respiratory safety organization that develops and integrates innovative safety science with toxicology excellence to drive the design, selection and successful development of novel treatments for patients with respiratory disease.
We are a diverse international department comprised of project toxicologists, discovery safety specialists, respiratory safety professional and experimental scientists. We work collaboratively and develop and apply cutting edge technologies such as tissue organoids, microphysiological systems, multi-omics, state-of-the-art imaging and artificial intelligence, and push the boundaries of predictive safety science with our mission in mind: to discover safe innovative medicines for the patients that need them.
What you'll do:
Contribute to the discovery of innovative treatments for Respiratory & Immunological (R&I) diseases.
Be responsible for the safety strategy and input to multi-disciplinary drug-hunting project teams. You will lead drug safety teams to influence project decision making with the aim to deliver molecules with the “Right Safety” profile.
Develop innovative solutions and research proposals based on strategic needs versus the discovery project portfolio, to pursue cutting edge science and technologies in order to optimize and influence safety assessment of novel drug targets.
Design project-specific in vitro and in vivo strategies to predict, assess and mitigate target- and delivery-related safety risks and execute through internal and external experimental capabilities.
Engage with world-class experts across our organization to develop, refine and implement experimental strategies to ensure that teams make the right decisions regarding safety risks. You will operate across international boundaries within CPSS and across R&D functions in AstraZeneca to lead and manage projects and partners.



Education/Experience Requirements:
PhD in cell biology, toxicology, pharmacology, systems biology or related field, and a strong publication record demonstrating scientific excellence, with 3+ years of proven experience.



Essential Skills/Abilities:
Solid understanding of the drug discovery and development process from the pharmaceutical industry, with an appreciation of fields within and outside safety and toxicology, and preferably a track record of successful contributions to progression of drug discovery projects.
Strong communication, presentation and influencing skills across levels/fields.
Highly motivated, innovative, reliable scientist, with collaborative attitude, who solves problems in a goal-focused fashion.
Knowledge/experience in the respiratory/immunology field will be considered an advantage.
Experience in designing and/or executing safety strategies in drug discovery projects will be considered an advantage.
Experience with design and execution of in vitro and/or in vivo experiments to determine the effects of therapeutics (e.g. monoclonal antibodies, oligonucleotides, peptides, etc) on biological systems.
Experience of working with biologics and knowledge of relevant regulatory guidelines.
A collaborator that contributes to an open, positive, collaborative working

Benefits:
AstraZeneca is a leading company in the healthcare industry, with a mission to enrich the lives of others. It’s our business to support healthy living, not only for our patients, but also for our employees. Our benefits program is flexible enough to meet employees’ varying needs, offers valuable choices, and is highly competitive climate.

Why AstraZeneca?
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Visa mindre

PhD project title: Patient population stratification towards personalized treatment discovery for Chronic Kidney Disease
AstraZeneca R&D, Gothenburg, Sweden will be the Host institution for this PhD position.
Generic presentation of TrainCKDis:
The TrainCKDis project is an EU-funded initiative to foster and train early stage researchers to better understand and tackle the challenges related to chronic kidney disease (CKD) and improving patients’ lives. TrainCKDis will provide an innovative, multidisciplinary, and intersectoral training programme, able to prepare top-level young scientists to develop creative solutions for CKD. The proposed 15 research projects will address key challenges: i) the identification of genetic and epigenetic modifiers that predispose patients to CKD progression, ii) the identification of pathways and biomarkers for monitoring CKD progression and iii) the identification of novel therapeutic targets to improve the limited treatments for CKD. TrainCKDis gathers top European laboratories, companies, hospitals, and associations involved in the treatment of CKD. Early Stage Researchers will thus benefit from an outstanding interdisciplinary platform integrating nephrology, epidemiology, genetics, cell biology, high-throughput screening, system biology, and metabolomics experts.
Objectives/Description of PhD programme:
Chronic Kidney Disease is highly complex and heterogeneous and includes a wide range of etiologies with a multitude of underlying molecular processes in the kidney. Furthermore, the kidney tissue is structurally heterogeneous and comprised of more than 25 different cell types. These factors make development of treatments for CKD very challenging.
This exciting PhD project will use human omics data and advanced data analysis algorithms to group patients into subtypes and characterize underlying biological pathways in the cell type-specific context that will advance our biological understanding of CKD and open new opportunities for drug discovery leading to personalized treatments.
The successful candidate will conduct bioinformatics analyses of omics (transcriptomics, proteomics, metabolomics) data as well as perform wet-lab experiments to functionally characterize and validate the findings, and will develop a unique combination of both computational and experimental skills. In addition to their individual scientific project, they will benefit from further continuing education, which includes scientific and transferable skills courses, participation in workshops and conferences, and secondments to partner labs.
The successful candidate will be hired for 3 years, full time, and enrolled in the PhD Program of Charité – Universitätsmedizin Berlin graduate school upon meeting the qualifications of admission.
Advantages: As EU-funded project, TrainCKDis offer attractive salary to recruited researchers. To find more details, please read the information note of the European Commission.
Eligibility:
1. To be eligible for recruitment, you must – at the date of recruitment – be within the first four years (full-time equivalent research experience) of your research career and not have a doctoral degree. Full-time equivalent research experience is measured from the date when you obtained the degree entitling you to embark on a doctorate (either in the country in which the degree was obtained, or in the country in which you are recruited), even if a doctorate was never started or envisaged. You may therefore be required to provide documentation proving your eligibility for recruitment.
2.You must not have resided or carried out your main activity (e.g. work, studies) in the country where you apply for more than 12 months in the 3 years immediately before your recruitment date. Holidays are not counted.
TrainCKDis project has received funding from the European Union’s Horizon 2020 research and
innovation programme under the Marie Sk?odowska-Curie grant agreement N°860977.
Essential Requirements
Master’s Degree or equivalent in biomedical (Medical, Biological, Pharmaceutical sciences, Molecular Biology) or quantitative disciplines (Bioinformatics, Biostatistics, Computational Biology, Epidemiology)
Excellent written and spoken English
Strong communication and collaboration skills
Scientific curiosity, creativity, motivation

Desirable Requirements
Working knowledge of kidney biology and disease
Experience in omics data analysis, biostatistics, machine learning, R coding
Peer-reviewed publications



Additional information
The Marie Sk?odowska-Curie Actions offer attractive salary and working conditions. The successful candidates will receive a salary in accordance with the national legislation of the recruiting institution and the Marie Sk?odowska-Curie Actions regulations for early stage researchers. Exact salary will be confirmed upon appointment.
In addition to their individual scientific projects, all ESR will benefit from further continuing education, which includes scientific skills courses, transferable skills courses, as well as active participation in workshops and conferences and secondments to partner labs.
Each ESR will be hired for 3 years, full time.
The European IMGENE training network wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Visa mindre

Job Description
Are you an in vitro DMPK scientist with expertise in Absorption, Distribution, Metabolism and Elimination (ADME) of oligonucleotides? Would you like to apply your expertise in a company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!
Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are committed to the development of next generation innovative medicines and are currently building a cross-functional oligonucleotide capability for the treatment of diseases across therapy areas.
As part of the expansion within the therapeutic oligonucleotides area, we are now recruiting a senior in vitro ADME scientist to join the Drug, Metabolism and Pharmacokinetics (DMPK) department within Research and Early Development Cardiovascular, Renal and Metabolism (CVRM). The position is placed at AstraZeneca’s dynamic R&D site in Gothenburg, Sweden.
CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into clinical development. CVRM DMPK interacts with other functions in supporting CVRM projects along the value chain, from target selection all the way to launch and life cycle management. We hope that you will be the one to help us increase our capability regarding ADME and Bioanalysis of oligonucleotide therapeutics!
What you’ll do
As a senior in vitro ADME scientist you will be part of a team at the forefront of DMPK science working with all aspects of drug disposition, from whole body, tissues to subcellular drug handling, and relating exposure to drug effects. We are accountable for the breadth of the CVRM drug portfolio, and this role will enhance our team in the area of oligonucleotide therapeutics. You will have the opportunity to contribute to the discovery of new life changing medicines for patients and demonstrate and witness what science can do. Responsibilities include:
Be responsible for designing, conducting, interpret and reporting of in vitro ADME studies for nucleotide drugs. You will apply state of the art in-vitro DMPK science, including the use of 3D-cell cultures, across drug discovery and development to support design and project progression.
Provide scientific leadership by leading and driving collaborations with key academic centers and by presenting work through lectures and publications in top-tier scientific journals.
Identify improvements in technologies that can be successfully applied to a highly competitive drug discovery or development paradigm that contributes to achievement of short and long term business goals and influences strategic direction.
May be part of cross-functional work-streams and lead the development and implementation of DMPK scientific strategies, and act as a catalyst for scientific debate within the AstraZeneca science community

Essential for the role
PhD or equivalent in relevant discipline, and at least three years of experience relevant to the position
Background in Pharmacy, Biology, Biochemistry, Medical Biosciences or similar relevant discipline.
Versatile in in vitro laboratory skills (e.g. handling and culturing of primary human hepatocytes and other human cells and tissues, molecular biology methods and image analysis, enzyme and transporter kinetic studies)
Broad knowledge about ADME processes and relevant in vitro models of drug disposition. Track record in development, characterization and application of translatable in vitro models beyond small molecule drugs
Excellent understanding of design and interpretation of in-vitro studies with oligonucleotide drugs is desired, experience from metabolic disease in vitro models is a strong advantage
Knowledge in omics technologies and bioinformatics
Experience in bioanalytical techniques, e.g. LC-MS
Scientific leadership, evidenced by a publication track record
Excellent interpersonal skills and good communication skills in English, both verbal and in writing
Strong ability to engage and collaborate across boundaries with a problem-solving attitude and focus on delivery.
Experience from industry environment is a plus, but not mandatory.
Expertise in automation equipment and automated processing would be advantageous

This is an exciting opportunity for a talented oligonucleotide ADME scientist to join a strong team at the forefront of DMPK science. You will get the opportunity to innovate and support the oligonucleotide portfolio of a major pharmaceutical company that has science at its heart and a tremendously strong pipeline whilst being based in the wonderful city of Gothenburg, Sweden. Visa mindre

We’re looking for talented scientists to join our innovative academic-style Postdoc. From our centre in Gothenburg, Sweden, you’ll be in a global pharmaceutical environment, contributing to live projects right from the start. You’ll take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in cutting edge laboratories. It’s a newly expanding programme spanning a range of therapeutic areas across a wide range of disciplines.
What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career. This is an exciting area that hasn’t been explored to its full potential, making this an opportunity to make a real difference to the future of medical science.
About the Opportunity:
This position offers high involvement in improving future clinical trials in nonalcoholic steatohepatitis (NASH) patients; being part of a wide network of experts in the fields of NASH, mathematical modelling and clinical development; maintaining a competitive theoretical research output by providing access to a unique selection of clinical longitudinal nonalcoholic fatty liver disease (NAFLD) cohorts and building upon previous in-house developed mathematical models.
This postdoc opportunity involves the application of mathematical methodology, including combined Markov & quantitative systems pharmacology (QSP) modelling and machine learning, to unique clinical longitudinal NAFLD cohorts. The aim is to unveil previously unknown predictive patient-specific factors important for NASH disease progression to inform and optimize clinical development with respect to patient selection, clinical trial duration, as well as human dose prediction.
This is a collaborative project across multiple functions within AstraZeneca R&D, and support will be provided by experts within each function, by renowned academic experts in the field of NAFLD as well as the academic supervisor in this project, Prof. Rohit Loomba (UCSD US), one of the most prominent leaders of NAFLD in the world. This project also offers the opportunity of a secondment with Prof. Loomba at UCSD (University of California in San Diego).
This strong network of experts will help to ensure a high impact publication track record. Thus, the position offers the ability to maintain a competitive theoretical research output. Mentoring of master students and teaching is not required for this position but encouraged and supported.
Our primary objective is to improve the design and evaluation of future clinical NAFLD/NASH trials by developing a framework to predict fibrosis progression using external clinical cohorts, pharmacometric methodology and fit-for-purpose machine learning.
Education and Experience
Essential:
PhD in Applied Mathematics, Statistics, Pharmacometrics or a related field
Programming experience within R/Matlab
Experience with applied statistical modelling

Desirable:
Hands-on experience of working with biological or clinical data
Experience in longitudinal, mixed effects and/or Markov modelling
Scientific excellence as shown by previous work, publication list or references from scientific mentors
Prior understanding of the drug-development process

Required Skills and Capabilities:
Strong computation and programming skills (in R, Matlab or other relevant language)
Proficiency within applied statistical modelling, such as longitudinal, nonlinear mixed effects and/or Markov modelling methods
Excellent written and oral communication skills and ability to work and communicate across disciplines
Curious and passionate about using quantitative methods to advance medicine

This is a 3-year programme. 2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based. The role will be based in Gothenburg, Sweden, with a competitive salary on offer Visa mindre

Do you have experience in regulatory writing within the pharmaceutical area, enjoy flexible working and leading the authoring of clinical documents for the NDA and MAA? Would you like to apply your expertise to make an impact at a company where we work together across global boundaries to turns ideas into life changing medicines? If so, we welcome you to join us at AstraZeneca!


We are looking for a Associate Director/Senior Medical Communications Scientist to join a great team in Gothenburg, Sweden, who wants to play a part in our everyday work to make a difference for our patients. This is an exciting opportunity to author complex documents and submissions, take on strategic responsibilities and lead global authoring teams.

Our critical, core drug development expertise is at the heart of our three vibrant scientific centres in Gothenburg (Sweden), Cambridge (UK) and Gaithersburg (US). Our strategy and ability to transform our portfolio means we have a late stage pipeline that presents incredible opportunities to push the boundaries of science to deliver life-changing medicines.


What you’ll do:
As a Medical Communications Scientist (MCS), you will provide expert communications leadership to late stage drug projects and drive strategic medical writing, advocating communications excellence in your team. The MCS ensures that NDA/BLA/MAA/JNDA/CN/ROW clinical documents align with project strategies, meet regulatory requirements and adopt best communications practices. The role will afford you flexibility in ways of working.


Accountabilities as MCS:
Lead development of the clinical submission communication strategy for a new product, liaising with senior project staff
Prospectively develop a storyboard for the submission and identify how the proposed prescribing information will be supported
Lead the authoring of clinical documents for the NDA and MAA
- Author the most complex and important documents (eg, Clinical Overviews, Briefing documents for regulatory authorities and Advisory Committees)
- Lead a team of medical writers (internal and external) to deliver
- Ensure alignment of clinical submission documents with the proposed prescribing information
- Represent medical writing on the high-level, cross-functional submission team



Essential in the role:
Solid experience in writing regulatory documents at study-level (eg, Clinical Study Reports), with a good understanding of pharmaceutical drug development. You will be ready to progress authoring more complex documents such as regulatory submissions within a global, strategic role.


As well as:
MSc or PhD within Life Science or equal education
Demonstrated regulatory writing experience gained within the pharmaceutical/medical industry/CRO.
Willingness to undertake domestic and international travel as required by the project.



A desirable requirement is that you have CTD Submission experience.


Why AstraZeneca?
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work and bringing unexpected teams together! Visa mindre

Are you an expert in bioanalysis of oligonucleotides and mass spectrometry? Would you like to apply your expertise in a company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!
Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. We are committed to the development of next generation innovative medicines and are currently building a cross-functional oligonucleotide capability for the treatment of diseases across therapy areas.
As part of the oligonucleotide capability build expansion, we are now recruiting a Bioanalysis Expert to join the Drug, Metabolism and Pharmacokinetics (DMPK) department within Research and Early Development Cardiovascular, Renal and Metabolism (CVRM). The position is placed at AstraZeneca’s dynamic R&D site in Gothenburg, Sweden.
CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into clinical development. CVRM DMPK interacts with other functions in supporting CVRM projects along the value chain, from target selection all the way to launch and life cycle management. Are you the one to help us increase our capability regarding ADME and Bioanalysis of oligonucleotide therapeutics?
What you’ll do
As a Bioanalysis Expert you will be part of a team at the forefront of oligonucleotide drug discovery focusing on the biological fate of molecules in preclinical species and humans. You will be an expert in your area, providing significant scientific input on bioanalysis of oligonucleotide drugs and conjugates to project teams. This is a lab-based role where you will provide scientific leadership by developing, perform and deliver high quality bioanalysis of oligonucleotide therapeutics and their metabolites in various matrices. You will drive development of bioanalytical techniques and methodologies in parallel with supporting non-clinical in vitro and in vivo studies with quantitative analysis. In this role, you will get the opportunity to contribute to the discovery of new life-changing medicines for patients and both demonstrate and witness what science can do. Responsibilities include:
Develop and implement quantitative bioanalytical methods for oligonucleotides
Influence study design to define the exposure and kinetics of the drug substances
Plan and report all work to appropriate standards (Good Laboratory Standard, GLS) and keep project teams appraised of findings
Identify new approaches and technologies that would improve our ability to support projects
Drive the science of relevant areas of research
Write manuscripts and publish research together with external/internal collaborators

Essential for the role
PhD or equivalent in relevant subject area, and at least five years’ experience relevant to the position
Background in analytical chemistry, biochemistry or similar relevant subject area.
Advanced technical skills in use of liquid chromatography-mass spectrometry (LC-MS) for analysis of oligonucleotides, including a track record of analysing oligonucleotide-based drugs in a variety of matrices
Technical skills to operate, perform regular maintenance, and elementary trouble shooting of LC-MS/MS instruments
Excellent hands-on skills of sample preparation of biological matrices for quantification of drugs, including method development
Scientific leadership, evidenced by a publication track record
Good communication skills in English, both verbal and in writing
Excellent interpersonal skills and strong ability to engage and collaborate across boundaries with a problem-solving attitude and focus on delivery.

Desirable for the role
Experience from industry environment is a plus, but not mandatory.
Expertise in automation equipment and automated processing would be advantageous

This is an exciting opportunity for a talented oligonucleotide bioanalysis scientist to join a strong team at the forefront of DMPK science, to innovate and support the oligonucleotide portfolio of a major pharmaceutical company that has science at its heart and a tremendously strong pipeline whilst being based in the wonderful city of Gothenburg, Sweden. Visa mindre

Do you have experience of working with Regulatory Information and would like to work in a global team environment? Are you interested in a new challenge in the ever-changing environment called RIMs (Regulatory Information Management System)? Then this role is something for you!


At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We are now looking for a Regulatory Information Manager to join our team in Gothenburg, Sweden.


The Regulatory Information Team is a part of Global Regulatory Affairs that works with bringing together technology, processes and resources to enable AstraZeneca’s regulatory strategy. We maintain Regulatory Information in line with legal requirements and company objectives and oversee Regulatory systems, business processes and compliant usage to ensure that the objectives of the regulatory information are met. The RIM team partners with individual system and information owners within Regulatory to ensure the overall strategy for RIM. Another important task is partnering with our IT organization and other Business functions as well as with vendors to influence health authority and industry innovation. There is an extensive collaboration with all business units creating regulatory information across the entire value chain, from development through marketing, maintenance and pharmacovigilance.


Main duties and responsibilities
As a Regulatory Information Manager, you will be an expert in end-to-end tracking and documentation, which includes set-up, follow up and documentation of regulatory submissions and approval information. You will also be an expert in understanding Health Authority legislation interpretation as well as the regulatory requirements regarding licenses and clinical trials aspects of tracking and life-cycle management. To be successful in this role you will have to show a demonstrated ability to work collaboratively in a global team environment and have good project management skills. You need the ability to work independently and to set and manage priorities, resources, performance targets and project initiatives in a global environment. It is important that you can demonstrate an understanding of the characteristics in building successful supplier relationships, monitors Service Level Agreements (SLAs) and manages routine quality, resource and performance issues to resolution.


Essential Requirements
Minimum 1-year hands-on experience with tracking of regulatory information
University degree or equivalent experience in life sciences or technical field
Ability to provide global expertise on requirements for tracking of regulatory submissions and approvals
Ability to assess data, documentation and processes for regulatory impact/compliance with relevant regulations and guidance and clearly communicate requirements to immediate stakeholders
Ability to use project management principles and techniques
Experience from planning of large and complex business activities
Demonstrates a broad working knowledge of process improvement methodologies, tools, techniques and their application
Excellent English written and verbal communication skills



Desirable Requirements


Experience of system administration for validated applications within a regulated environment
Knowledge of AstraZeneca submission, publishing, approval processes, tools and standards
Experience in using publishing and tracking applications
Ability to manage change with a positive approach to the challenges of change for self, team and the business. Sees change as an opportunity to improve performance and add value to the business
Good problem and conflict resolution skills Visa mindre