Lediga jobb som Kemist i Mölndal

About the Role
We are looking for someone interested in working on separation membrane development at the startup Retein AB. You will be part of a multidisciplinary team in a small, but growing company, where each day is varied with respect to the tasks at hand. Together, we develop filters for efficient circular use of waterborne resources across a wide range of industries.
At Retein, we are passionate about closing the loop on resources such as clean water, metals, and nutrients in order to enable long-term sustainable manufacturing and use of natural resources.
Desired Skills
We seek someone with:
Prior experience in separation membrane development and membrane performance evaluation in a lab environment.
Prior experience with formulating polymers for membrane applications.
Knowledge and experience with material characterization tools such as microscopy and particle size analysis.
Prior experience from protein handling in a lab environment is preferrable.
Prior experience from waste to value initiatives is preferrable.
The desire to work closely with other members of a team, but who is also capable to perform on their own. Visa mindre

Job description
AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives- and are made to feel valued, energized and rewarded for their ideas and creativity. In AstraZeneca we set pride to drive the development in a sustainable way, in all areas of our business from influencing our suppliers through development to commercial products.
This is a consultant assignment with Randstad Life Sciences. Randstad Life Sciences is specialized in competences within Life Science. As a consultant you get a competitive salary, benefits and collective agreements. Your consultant manager ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.
Deadline 2024-03-27 - the selection process and interviews will be ongoing, so please apply as soon as possible!

Responsibilities
We are looking for a scientist in Analytical Chemistry who can provide input in the area of analytical science during the development of drug products, and can work together with us determining the quality attributes during the development of the formulations. The work includes analytical testing , documentation, and attending and presenting in project team meetings. The role is primarily laboratory based.

Qualifications
BSc or MSc typically from pharmaceutics, chemistry, or analytical science, but also other disciplines with relevant skills.
Good knowledge in written and spoken Swedish and/or English is necessary.
Scientific knowledge within analytical science,
Laboratory experience including working with computerized systems and chromatography techniques (e.g. UPLC) for detection of small molecules.

Desirable:
Experience from working within the pharmaceutical industry, this will be an advantage
Well organized, analytical, flexible and accurate.
Good team working skills are also important, together with the ability to operate independently.
Good communication skills linked to the ability to work to tight timelines are highly valued.
If you have experience from working in a GMP environment or worked in AstraZeneca or pharmaceutical industry, this will be an advantage.


About the company

Randstad
At Randstad, we see the possible in people. With business all over Sweden and in all areas of expertise, we help people find work that feels good, where they get the opportunity to develop and realize their true potential.

With close to 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry. Our mission is to become the world’s most valued working life partner. By combining our passion for people with the power of today’s technology, we support people and organizations in realizing their true potential. We call it Human Forward. Visa mindre

Job description
Research Scientist Chemistry, Compound Management


Are you a passionate scientist, eager to join a company at the forefront of sample management technologies? Would you like to contribute to the continuous improvement of life-changing projects? Perfect, we have a new challenge for you!
We are looking for a motivated and engaged team member for our Compound Management team at our vibrant R&D site at AstraZeneca in Gothenburg, Sweden.
In this role you will be responsible for the storage and timely supply of compounds to AstraZeneca’s drug discovery projects. Highly automated liquid handling systems will be employed to supply molecules to AstraZeneca scientists and partner organisations. You will be a part of the Discovery Sciences organisation, operating within a first-class scientific environment to support drug discovery across each of AstraZeneca’s Therapeutic Areas.
Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.
What you will do:
In this position, you will get the opportunity to work in a dynamic and enthusiastic environment, whilst delivering critical support to all phases of drug discovery projects and working with a broad range of chemical modalities. You will be supporting projects by providing compounds in the requested format - assay ready plates, serially diluted mother plates, formulations and solids. Bringing in new capabilities and building new processes are core activities within our group, performed in a cross-functional collaboration setting with the drug discovery projects.
You are expected to act upon day-to-day issues that occur whilst processing samples and run Compound Management development projects to ensure continuous improvement within the local team and the global department.
Why AstraZeneca?
Here we are committed to making a difference. We have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.
This is a consultant assignment with Randstad Life Sciences. Randstad Life Sciences is specialized in competences within Life Science. As a consultant you get a competitive salary, benefits and collective agreements. Your consultant manager ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Responsibilities
Designing, performing and interpreting experiments independently to investigate process improvements and evaluate new technologies.
Working closely with internal project teams to meet drug discovery needs.
Rapidly addressing customer queries with regards to Compound Management orders, software, processes and capabilities.
Achieving personal scientific visibility through project contributions, internal presentations and publications.

We work collaboratively within our Compound Management team to understand the customer needs and how to add value through our experience and capabilities. To maintain this position and provide support within agreed service levels, we actively seek ways to improve our process and exploit new technologies.
Deadline 2024-02-27 - the selection process and interviews will be ongoing, so please apply as soon as possible!

Qualifications
Essential for the role:
Compound Management is a highly collaborative group, working to tight delivery schedules - so the ability to be comfortable working at a fast, goal-oriented pace, with a team-focused attitude, is essential to being successful in the role. Furthermore, you have excellent communication skills with a proactive delivery and customer-focused approach. Explain how
We also believe that you have:
A BSc/MSc in Chemistry/Biotechnology/Chemical engineering
Excellent communication skills and high work ethics.
Excellent problem-solving skills and ability to identify and implement improvement activities.
A track record in the performance of a range of practical skills, including non-routine complex tasks, to a high level.
Passion for science, technology and innovation and understands the drug discovery process

Desirable for the role:
Previous experience of working in a compound management role and operating integrated automation equipment like liquid handlers and scheduling software is a strong merit.
Some experience with IT (/Python/Java coding) is an advantage but not a requirement.


About the company

Randstad
At Randstad, we see the possible in people. With business all over Sweden and in all areas of expertise, we help people find work that feels good, where they get the opportunity to develop and realize their true potential.
With close to 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry. Our mission is to become the world’s most valued working life partner. By combining our passion for people with the power of today’s technology, we support people and organizations in realizing their true potential. We call it Human Forward. Visa mindre

Job description
Formulation Scientist /Product Developer to AstraZeneca Gothenburg
AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
The arena:
We now have the opportunity for one or several consultants to join our team in the role as Formulation Scientist/Product Developer within the department Oral Product Development at AstraZeneca in Gothenburg. The assignment is for the year 2025 on a temporary basis.
This is a consultant assignment with Randstad Life Sciences. Randstad Life Sciences is specialized in competences within Life Science. As a consultant you get a competitive salary, benefits and collective agreements. Your consultant manager ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.
Deadline 2024-03-21 - the selection process and interviews will be ongoing, so please apply as soon as possible!

Responsibilities
Tasks and responsibilities/The role:
We are looking for a formulation scientist who can work together with us with generating and evaluating pharmaceutical technologies and formulations. The work includes development, characterization, and documentation, mainly of solid based formulations, in order to develop drug products.
The tasks include planning and implementation of experiments with the aim of generating new formulations and optimizing processes in lab and pilot scale. We are looking for both people with and without previous experience in the area.

Qualifications
Essential for the role:
MSc/BCs in chemistry, pharmacy, chemical engineering, food technology or equivalent.
Good knowledge in written and spoken Swedish and/or English is necessary
laboratory experience including working with computerized systems.
If you have experience from working within the pharmaceutical industry, medical tech, or with manufacturing equipment, this will be an advantage.
Solid materials/formulation experience is highly meriting.

Desirable requirements:
As a person, you should be well organized, analytical, flexible and accurate.
Good team working skills are also important, together with the ability to operate independently.
Good communication skills linked to the ability to work to tight timelines are highly valued.


About the company

Randstad
At Randstad, we see the possible in people. With business all over Sweden and in all areas of expertise, we help people find work that feels good, where they get the opportunity to develop and realize their true potential.

With close to 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry. Our mission is to become the world’s most valued working life partner. By combining our passion for people with the power of today’s technology, we support people and organizations in realizing their true potential. We call it Human Forward. Visa mindre

Job description
AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives- and are made to feel valued, energized and rewarded for their ideas and creativity. In AstraZeneca we set pride to drive the development in a sustainable way, in all areas of our business from influencing our suppliers through development to commercial products.


The arena:
We now have the opportunity for one or several consultants to join our team in the role as Formulation Scientist/Product Developer within the department Oral Product Development at AstraZeneca in Gothenburg. The assignment is on a temporary basis.


Tasks and responsibilities/The role:
We are looking for a formulation scientist who can work together with us with generating and evaluating pharmaceutical technologies and formulations. The work includes development, characterization, and documentation, mainly of solid based formulations, in order to develop drug products.


The tasks include planning and implementation of experiments with the aim of generating new formulations and optimizing processes in lab and pilot scale. We are looking for both people with and without previous experience in the area.


This is a consulting assignment with Randstad Life Sciences. Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.


About randstad life sciences
Randstad Life Sciences is specialized in competencies within Life Science. As a consultant with us, you get a competitive salary, benefits, and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many activities.


Deadline: 2024-05-23, selection and interviews will be ongoing. For more information please contact Malin Fridholm at [email protected]

Responsibilities
We are looking for a formulation scientist who can work together with us with generating and evaluating pharmaceutical technologies and formulations. The work includes development, characterization, and documentation, mainly of solid based formulations, in order to develop drug products.


The tasks include planning and implementation of experiments with the aim of generating new formulations and optimizing processes in lab and pilot scale. We are looking for both people with and without previous experience in the area.

Qualifications
Essential/desirable for the role:
MSc/BSc in chemistry, pharmacy, chemical engineering, food technology or equivalent. Good knowledge in written and spoken Swedish and/or English is necessary as well as laboratory experience including working with computerized systems. If you have experience from working within the pharmaceutical industry, medical tech, or with manufacturing equipment, this will be an advantage. Solid materials/formulation experience is highly meriting.


As a person, you should be well organized, analytical, flexible and accurate. Good team working skills are also important, together with the ability to operate independently. Good communication skills linked to the ability to work to tight timelines are highly valued.


AstraZeneca is one of the world’s most exciting bio-pharmaceutical companies. From scientists to sales, lab techs to legal, we’re on a mission to turn ideas into life-changing medicines that improve patients’ lives and benefit society. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world.

About the company

Randstad
At Randstad, we see the possible in people. With business all over Sweden and in all areas of expertise, we help people find work that feels good, where they get the opportunity to develop and realize their true potential. With close to 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry. Our mission is to become the world’s most valued working life partner. By combining our passion for people with the power of today’s technology, we support people and organizations in realizing their true potential. We call it Human Forward. Visa mindre

Job description
Analytical Chemists (Scientist or Senior Scientist) – Early Product Development and Manufacturing, AstraZeneca Gothenburg


At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.


Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) across all the AstraZeneca therapy areas.
Our vision is to be “pharmaceutical science leaders, creating innovative and cost-effective solutions, shaping the diverse therapies of the future”.
We’re looking for talented and motivated analytical chemist to join one of our analytical characterization teams within Early Product Development and Manufacturing (EPDM) in Gothenburg.
You would join a highly collaborative team and together we will deliver the analytical science to product development within the early portfolio up to phase II.


This is a consulting assignment with Randstad Life Sciences. Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Responsibilities
To be successful in this role you will need a strong scientific background with good skills in written and verbal communication and the ability to engage and collaborate across boundaries with a positive problem-solving attitude and delivery focus.
This is a lab-based role where you will work collaboratively with colleagues, documenting your experiments carefully and to the right quality. You will get the opportunity to apply your excellent analytical expertise to the drug projects you are working in, contributing to the progression of these projects and drive the scientific development within the field of analytical science at AstraZeneca.


About randstad life sciences
Randstad Life Sciences is specialized in competencies within Life Science. As a consultant with us, you get a competitive salary, benefits, and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many activities.


Deadline: 2024-03-22, selection and interviews will be ongoing. For more information: Please contact Katan Ali, [email protected]

Qualifications
Required Qualifications, Skills and Experience:
-University degree (MSc, PhD) in relevant discipline, preferable with industry experience
-Scientific knowledge within analytical science and technically skilled to use chromatography with relevant detection techniques for small molecules
-You are a driven experimentalist, with a passion to deliver highly relevant and reliable data and with the ability to be influential in discussions in a wide set of communities and multi-disciplinary project teams
-Excellent communication, collaboration, networking and leadership skills & ability to lead and inspire colleagues
 
If you also have experience in one or more of the following areas – great!
-Industry experience of pharmaceutical development including oral solid dosage form development
-Experience of CMC submissions and work according to GMP
-Skilled in specific analytical techniques for small molecules, e.g. mass spectrometry, NMR, dissolution etc
-Track record and keen interest of driving development within analytical science including championing new technologies and solutions


AstraZeneca is one of the world’s most exciting bio-pharmaceutical companies. From scientists to sales, lab techs to legal, we’re on a mission to turn ideas into life-changing medicines that improve patients’ lives and benefit society. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world.

About the company

Kelly Services (UK) Limited Visa mindre

Hays / Associate Scientist/Operational Technologist - Early Product Development & Manufacturing / Gothenburg

Hays Life Science is now looking for an Associate Scientist/Operational Technologist - Early Product Development & Manufacturing for a 6-month consultant assignment at our client AstraZeneca in Gothenburg.



About AstraZeneca

At AstraZeneca, we unlock the power of What Science Can Do. Empowered to explore, every day we work towards our ultimate aim - treating, preventing, modifying and even curing complex diseases. Be part of the team where you are empowered to follow the science!

Pharmaceutical Sciences is responsible for the design and development of synthetic routes, preclinical and phase I/II formulations, encompassing both small molecules and new modalities such as mRNA and oligonucleotides, across the whole range of AstraZeneca's therapeutic areas.

The manufacturing unit within Early Product Development and Manufacture (EPDM) in Gothenburg is accountable for manufacture of early investigational medicinal products (oral solutions/suspensions, parenteral solutions, capsules, tablets and inhalers), mainly for clinical Phases I and II studies.

We are now looking for an Associate Scientist/Operational Technologist starting as soon as possible with the location Gothenburg, Sweden.



Your new role

You will have a great opportunity to learn more about pharmaceutical development working with experienced operators. This role contributes to the manufacturing of drug products in development phase for clinical studies. All the activities below will have an impact on the speed, quality and cost of the AZ development portfolio.
Practical hands-on work in our Good Manufacturing Practice (GMP) facilities with dedicated tasks in close collaboration and to support EPDM Scientist/Senior Scientist e.g. assisting GMP operators with:

* Preparation of process rooms before and after clinical manufacture
* Assembly/disassembly and cleaning of equipment
* Dispensing of API (Active Pharmaceutical Ingredients) and excipients (inactive pharmaceutical ingredients)
* Bulk packing
* Visual inspection of drug products
* Metal check of drug products
* Check of log books
* Working according to SHE (Safety Health and environment) and GMP standards

The role is intended to be used in a flexible way to resolve short-term bottlenecks. The role holder will not become fully qualified as a GMP operator but will be able to carry out much of the work expected from operators under supervision.

What you'll need to succeed

We are looking for flexible staff (temporary positions) with good team working skills. You need to be careful with following written procedures and document executed tasks. In addition, you should have an interest in science, technique and manufacturing equipment and practical hands-on work.

You must have completed your studies at upper secondary school level, e.g. in natural/technical sciences.



What you need to do now

If you're interested in this role, click 'apply now' to forward an up-to-date copy of your CV, or call us now.

If this job isn't quite right for you, but you are looking for a new position, please contact us for a confidential discussion about your career.



Additional information

BioPharmaceuticals R&D: https://www.youtube.com/watch?v=pmFx_jr2eFo
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html Visa mindre

Job description
12 Months Synthetic Organic Chemistry – Student Work Placement AstraZeneca
Locations: Gothenburg, SE
24,000 SEK/month
40 hours work/week

Please note that it is mandatory to attach official documents covering all subjects/modules studied for all years of study with grades when applicable! No cover letter i necessary.

About AstraZeneca
AstraZeneca is a global, science-led biopharmaceutical business and its innovative medicines are used by millions of patients worldwide. AstraZeneca has long been an advocate of student work placement training. AstraZeneca considers its responsibility to help promising scientists develop into the researchers of the future, by immersing them in a world of practical, lab-based science. This is achieved by aligning each student with a research team working on cutting-edge drug discovery projects. You will feel trusted and empowered to take on new challenges, but with all the help and guidance you need to succeed.

About the Programme
The Chemistry Student Work Placement Programme provides the opportunity for you to undertake a 12-month placement that will introduce you to the world of innovative drug discovery pushing the boundaries of science to deliver life-changing medicines. You’ll get to do meaningful work in a pioneering research and development driven organisation. As well as developing the skills, knowledge and network that will set you up for success, you will be among curious, passionate and open-minded people eager to learn, follow the science, helping you grow as professionals in a truly collaborative and global team.

Additional Information:
Applications are now open until 25 January 2023, with interviews to take place in March 2023. Start date 4th September 2023. Please submit your application in English.

Please inform us if you require adjustment support when contacted to schedule an interview – necessary adjustments can be made for assessment centers.
Queries can be directed to [email protected] 

Responsibilities
What you can expect:
We offer 12-month placements at AstraZeneca’s Gothenburg site in Sweden for students at Swedish institutions. The placements will provide you with the opportunity to learn about organic synthesis, oligo synthesis on solid support, conjugation techniques, purification, reaction monitoring, automation techniques, bio-catalysis, crystallisation and physical organic chemistry.  You will also have the opportunity to present your work to other chemists and wider teams that will enhance your communication skills which will all help you to develop a range of transferable skills as well as promoting and extending your proficiency as a chemist. Placement students will be hosted in the Oligonucleotide Discovery department and employed by AstraZeneca’s Early Talent partner Randstad Life Sciences.

Therapy areas
Cardiovascular, Renal and Metabolism
Respiratory & Immunology

Laboratory-based Placements
You will be embedded in one of AstraZeneca’s research teams working with world class scientists to deliver new medicines to patients. You will spend the majority of your placement working on a bespoke chemistry project and will be assigned a dedicated work placement Supervisor. You will have the opportunity to develop a range of transferable attributes including communication and presentation skills. You will also be given access to AstraZeneca’s early talent network.

Qualifications
Who can apply?
Join the Undergraduate Student Work Placement Programme and be part of making a difference, making connections, and gaining the tools and experience to open doors and fulfil your potential. We are looking for students completing either their Bachelor’s or Master’s degree at a Swedish institution who have a right to work in Sweden for 12 months without the need of additional work permits. In all our programmes we look for individuals who have drive, enthusiasm, strong team working skills and a desire to learn. Specific requirements are listed below.

Essential requirements:
BSc or MSc or equivalent students in any Chemistry aligned course at a Swedish University.
You must have completed at least two years of your university education and be returning to complete your studies after this opportunity ends.
 Performing at a high level, with the potential to achieve a pass with distinction (Väl godkänd).
 Applicants must have the eligibility to work in Sweden for 12 months from September 2023. 
 Students will be expected to take a study break from their education to participate in the programme, this will need to be arranged by the student at their institution. Please ensure that you receive the approval to take a study break from your university. 

AstraZeneca embraces diversity and equality of opportunity and is committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. Applications to join the team from all 

About the company
AstraZeneca is a global, science-led biopharmaceutical business and its innovative medicines are used by millions of patients worldwide. AstraZeneca has long been an advocate of student work placement training. AstraZeneca considers its responsibility to help promising scientists develop into the researchers of the future, by immersing them in a world of practical, lab-based science. This is achieved by aligning each student with a research team working on cutting-edge drug discovery projects. You will feel trusted and empowered to take on new challenges, but with all the help and guidance you need to succeed. Visa mindre

Job description
Randstad Life Sciences is specialized in competencies in Life Science. As a consultant with us, you get a competitive salary, benefits, and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies and industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Responsibilities
We at Randstad Life Sciences are currently looking for scientists in their early careers for future full-time consultant positions.

You will work for one of our clients and your tasks will differ depending on the assignment. Many positions are lab-based, where you will acquire competencies for independent work in an industry setting. This could include experimental design, data handling, risk assessments, and cross-discipline work. You will also get the possibility to develop your communication and presentation skills further. 

We are also looking for candidates who are interested in working in office-based positions in the later stages of the drug development process.

Qualifications
You have an educational background in Life Science, e.g. chemistry, biotechnology, pharmacy, etc.

Your personal qualities are important and to succeed as a consultant at Randstad Life Sciences you should be driven, well organized, and quality-focused. You also need to be passionate about science, curious, and open-minded. Moreover, you should be a team player with good communication skills. It is also important that you are open to trying new roles and that you easily adapt to new situations.

For us, all competence and skills in the labor market must be utilized. We welcome all applicants and strive for diversity.

Application
We only accept applications through the portal.

2022-10-29, selection and interviews will be ongoing. 

About the company
Randstad Life Sciences is specialized in competencies within Life Science. As a consultant with us, you get a competitive salary, benefits, and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many activities.

With more than 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry and offers staffing, consulting and recruitment solutions in all areas of expertise. We also offer interim management, executive search and outplacement services. We have a broad network of clients and candidates, which means we convey hundreds of jobs within different industries all over Sweden. Our ambition is to be the best employer in the market.

By combining our passion for people with the power of today’s technology, we help people and organizations to reach their true potential. We call it Human Forward. Visa mindre

Job description
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

The arena
Are you interested in a challenging opportunity within the Development Quality function in one of the world’s leading pharmaceutical companies?

The Development Quality function is responsible for quality oversight of the pharmaceutical development activities in AstraZeneca. We are now looking for a Quality Advisor with GMP focus to our Gothenburg team. AstraZeneca’s pharmaceutical development organizations manage all facets of the process of turning a molecule into a medicine which can be safely and effectively used by patients. The Quality Advisor role has a broad range of responsibilities to ensure all internal and external requirements are fulfilled for the AstraZeneca projects in the development phase.

Responsibilities
The role
As a Quality Advisor, you will work with early product development manufacturing and packaging teams and be responsible for Development Quality release of externally manufactured Drug Product and Investigational Medicinal Product for clinical trials. You are expected to assure that activities and processes across the development chain are delivered to appropriate standards to meet regulatory expectations and assure product integrity and acceptability.

You will develop and maintain a knowledge of the quality regulations and guidelines applicable to your area and a deep scientific understanding of the products that you are supporting. In your role you will have interactions with internal and external stakeholders.

Typical Accountabilities:
CSV, validation 
Qualification of GMP instrument /equipments.
Decommissioning of GMP instruments /equipment.
Responsible for quality Release of manufactured Drug Product, Investigational Medicinal Product for clinical trials
Providing quality input to Manufacturing, Packaging, Labelling & Distribution activities
Providing proactive quality advice to support the development, implementation and continuous improvement of GMP quality systems across the Clinical Supply functions and support implementation of agreed global standards
Support the pharmaceutical development functions with investigations of deviations, changes and other quality and compliance decisions in the development projects
Provide appropriate Quality Assurance input to business improvement projects
Operate as part of a global organisation with an integrated mindset to create an organisation with common processes and ways of working.


Qualifications
Minimum requirements – Education and Experience
BSc or MSc in pharmacy or engineering (specializing in Pharmaceuticals) with at least 3 years’ experience of working within a pharmaceutical GMP environment
Requirement to have AstraZeneca experience
Broad understanding of Quality Systems and GMP and related activities to Investigational Medicinal Product (IMP)
Comprehensive understanding of the pharmaceutical/drug development process
Good communicator with experience of interacting effectively across interfaces
Understanding of Project Management processes
Fluent in written and spoken English



Preferred requirements
Experience preferably within a pharmaceutical manufacturing organization
Good team working and networking skills
Capable of making effective decisions
Demonstrate drive and energy in the role to make a difference
Demonstrate a high degree of personal credibility


Application
For more information: 
Please contact Yonis Ismail, 
yonis.ismail @randstad.se

About the company
About randstad life sciences 
Randstad Life Sciences is specialized in competencies within Life Science. As a consultant with us, you get a competitive salary, benefits, and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many activities.

With more than 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry and offers staffing, consulting and recruitment solutions in all areas of expertise. We also offer interim management, executive search and outplacement services. We have a broad network of clients and candidates, which means we convey hundreds of jobs within different industries all over Sweden. Our ambition is to be the best employer in the market.

By combining our passion for people with the power of today’s technology, we help people and organizations to reach their true potential. We call it Human Forward. Visa mindre

Job description
Sourcing Project Coordinator, AstraZeneca Gothenburg

Are you looking for an opportunity to build your project management experience whilst working with external suppliers around the world to deliver our exciting pipeline of medicines to patients? Then the role of Sourcing Project Co-ordinator could be the one for you!

Pharmaceutical Technology and Development (PT&D) apply science and technology that turns concepts into actual medicines which help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

Clinical Manufacturing and Supply (CM&S) within PT&D provides an agile and flexible end-to-end Clinical Supply Chain that manufactures, outsources and delivers supplies and services to hundreds of thousands of patients across the globe.

CM&S are now looking for Sourcing Project Coordinators, to join our Global Sourcing function. We are seeking those who embrace change, show great initiative, flexibility and a willingness to learn. We are keen to receive applications from recent graduates and those with some project management & outsourcing experience.

Responsibilities
As a Sourcing Project Coordinator, you will both lead activities and support Sourcing Project Managers in the sourcing of services and goods required by Pharmaceutical Technology & Development and Pharmaceutical Science from external suppliers in support of global projects for AstraZeneca. These projects span support of technical development through to Clinical Supply. For this opportunity, the role will have a focus on Drug Substance Development and Manufacturing.

Qualifications
Minimum Requirements
Bachelors/Masters degree in a Chemistry or Chemical Engineering discipline.
Experience of working within a Research Development and Manufacturing environment and working with external providers.
Appropriate depth of technical knowledge for the activity being sourced (i.e. with direct experience of drug substance development and manufacture) to be able to fully understand any risks to delivery and make the best use of the technical experts on the team to make effective decisions.
Understanding quality principles and cGMP requirements.

Desirable skills
Project management experience
Supplier relationship management skills
Good networking and communication skills
Exhibits a high degree of personal credibility


Application
Deadline: 2022-09-16, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information:
Please contact Veronika Knudsen, [email protected]

About the company
Randstad Life Sciences is specialized in competencies within Life Science. As a consultant with us, you get a competitive salary, benefits, and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many activities.

With more than 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry and offers staffing, consulting and recruitment solutions in all areas of expertise. We also offer interim management, executive search and outplacement services. We have a broad network of clients and candidates, which means we convey hundreds of jobs within different industries all over Sweden. Our ambition is to be the best employer in the market.

By combining our passion for people with the power of today’s technology, we help people and organizations to reach their true potential. We call it Human Forward. Visa mindre

Job description
Synthetic Chemist – Expert on library & PROTAC synthesis

Do you have hands-on experience and a deep expertise with the synthesis of chemical libraries? Are you interested to further push the boundaries of automated and parallel synthesis at a company where we are committed to lifelong learning, growth and development? Welcome to AstraZeneca!

We are seeking a specialized Synthetic Chemist that will play an important part in our iLAB team, focusing on the synthesis of chemical libraries. You have the opportunity to drive and extend the parallel synthesis capabilities within a state-of-the-art automation platform at AstraZeneca in Gothenburg and directly impact drug discovery projects across various therapeutic areas.

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. With our ground-breaking pipeline comes a bright future - a secure job, exciting opportunities and varied work. You will be valued. Not only for your unique contribution, skills and background, but because we recognize people are our greatest asset. Here we are dedicated to being a Great Place to Work.

Responsibilities
This is an exciting role where you will drive the application of cutting-edge synthetic methodologies in the context of automated chemistry using robotic equipment at the AstraZeneca iLab in Gothenburg. You will synthesize chemical libraries working in close collaboration with drug hunters across various scientific disciplines to change the way we pursue drug discovery. You will work at the intersection of modern hit-finding technologies and parallel medicinal chemistry. You will furthermore contribute to the continuous improvement of the iLab by evaluating and incorporating new synthesis technologies.

In your daily work you will troubleshoot laboratory-based problems and make a significant contribution to the delivery of the team. As Synthetic Chemist, you will maintain access to the best internal and external science and enhance business reputation internally and externally through peer-reviewed publications and oral/poster presentations.

Qualifications
Essential for the role:
You’re a chemist with a track record of applying innovative chemistry solutions, with resulting impact in project delivery. You also have:
Ph.D. in chemistry with relevant experience in synthetic organic chemistry or M.Sc. with minimum 5 years of experience in synthetic organic chemistry.
Hands-on experience with library synthesis and automated synthesis is highly desirable.
Expertise in theoretical and practical organic synthesis, retrosynthesis, compound route design, purification and analytical sciences.
Expertise in liquid handling technologies is a plus.
Knowledge of targeted protein degradation (PROTACs, molecular glues) is highly desirable.
Advanced knowledge of modern chemical literature, chemical technologies and applying new ideas to project delivery.
A track record of driving innovation in chemistry related sciences.

The successful candidate should be motivated to work effectively in hardworking teams and demonstrate ability to work across scientific fields to get results. We also believe that our candidate will have effective levels of communication, a scientific drive and a high interest in working with organic chemistry and molecular biology techniques.

Desirable in the role:
Experience in the development of modern synthetic transformations.
Experience in reaction optimization.
Experience in the analysis and visualization of data.
Knowledge in designing high-throughput chemistry and/or library synthesis experiments using bespoke design software.
Knowledge of medicinal chemistry.
Knowledge of modern drug modalities in the context of targeted protein degradation


Application
Deadline: 2022-08-06, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information:
Please contact Birgitta Nyström [email protected]

Why AstraZeneca Gothenburg?
Our spectacular campus in Gothenburg is one of AstraZeneca’s three strategic science centers. The site is home to over 2,500 employees, from over 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. The site itself is designed with collaboration in mind: from the Coffee Lab to the gym, we have built a series of environments where innovation can happen.

Does this sound like your next challenge? Apply today!

Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.movetogothenburg.com/
About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many activities.

Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre

Job description
AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services.


AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.


The arena:
We now have the opportunity for one consultant to join our team in the role as Formulation Scientist/Product Developer within the department Oral Product Development at AstraZeneca in Gothenburg.



Responsibilities
We are looking for a formulation scientist who can work together with us with generating and evaluating pharmaceutical technologies and formulations. The work includes development, characterization and documentation, in order to develop drug products. The tasks include planning and implementation of experiments with the aim of generating new formulations and optimizing processes in lab and pilot scale. We are looking for both people with and without previous experience in the area.

Qualifications
Minimum requirements:
MSc or PhD in chemistry, pharmacy, chemical engineering, food technology or equivalent. Good knowledge in written and spoken Swedish and/or English is necessary as well as laboratory experience including working with computerized systems. If you have experience from working within the pharmaceutical industry, this will be an advantage.

Desirable requirements:
As a person, you should be well organized, analytical, flexible and accurate. Good team working skills are also important, together with the ability to operate independently. Good communication skills linked to the ability to work to tight timelines are highly valued.


For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2022-08-18, welcome with your application at www.randstad.se.



About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre

Job description
Master thesis in advanced mass spectrometry - Approach by Chemistry or AI modelling 


If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us!

Thesis type: 30/60 credits
Project start: August/September 2022
Student location: On Site, Gothenburg Sweden
Contact persons AstraZeneca: Gustaf Hulthe, Mats Josefson, and  Fritz Schweikart  


Mass Spectrometry fragmentation is a very attractive approach to investigate chemical structures as MSMS can be done directly on any component in a complex mixture and as very little material is used compare to NMR or IR. However, data is more difficult to interpret compared to NMR and IR, and to reach understanding of more details of the molecule, several fragmentation methods have to be combined. 

Responsibilities
In this work, we will systematically investigate available fragmentation methods and apply them on selected test compound. We have several advances MS instrument to work with, together filling almost all commercial available ways of MS-fragmentation. For test substances, we can choose freely among our substance library of ca 1 million compounds to highlight similarities and differences of fragmentation. The work is both practical and theoretical with the aim to gain considerable insight in approaches to structure analysis by MS. 

Qualifications


 A strong knowledge in organic and physical chemistry is desirable as much discussion will be focused around comparing kinetically and thermodynamically favorable degradation pathways. The goal is to build understanding of the various fragmentation methods to predict how new structures would fragment through the tested routes. 
An alternative approach to a strong focus on chemistry, can be to build machine learning models, to explain the differences between fragmentation methods by artificial intelligence. This approach will implement some published MSMS fragmentation models and apply transfer learning with your measured data, to make a model that proposes fragmentation spectra from any molecule when using the studied fragmentation methods. 

If there are two students these two approaches can be applied in parallel. Otherwise we chose the approach which best fit the background of the student. 

Application
Deadline: 2022-04-03 , selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information:
Please contact Veronika Knudsen [email protected] 

About the company
 With more than 2,400 employees from 50 countries, the vibrant Gothenburg site helps to support the entire life-cycle of AstraZeneca medicines, from drug discovery and clinical trials, to global commercialisation and product maintenance. Gothenburg is one of AstraZeneca’s three strategic, global R&D centres, alongside Cambridge and Gaithersburg, and plays a central role in our mission to deliver life-changing medicines to patients.

At AstraZeneca we are guided in our work by a strong set of values, and we’re resetting expectations of what a bio-pharmaceutical company can be. By truly following the science, we pioneer new methods, new thinking and bring unexpected teams together. From scientists to sales, lab techs to legal, we’re on a mission to turn ideas into life-changing medicines that transform lives. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you’re swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person. Visa mindre

We are looking for a talented Biophysicist who is interested to join our passionate team - with proven track record in biophysics and label-free or microscopy-based methods.
Here you will have the opportunity to develop a next generation label free biosensing method. With science at its heart, we offer a place where breakthroughs in the lab are rapidly transformed into innovative services and products that help to tackle the challenges of drug development.
Share our passion to develop better tools for drug development to answer the constantly increasing complexity and challenges of drug development. With our high paced development processes, you will be able to implement your results into products and services and help our customers to overcome todays challenges in their drug development projects.
InSingulo is based in the vibrant ecosystem of the BioVentureHub Gothenburg, that is integrated at the heart of AstraZenecas strategic R&D center in Gothenburg. With our neighbors in the GoCo Health Innovation City, Sahlgrenska Science park, Chalmers- and Gothenburg university InSingulo is part of the vivid life science community in and around Gothenburg.
more information will be found here:
www.insingulo.com
www.azbioventurehub.com
www.businessregiongoteborg.se/goteborgs-naringsliv/branscher-i-fokus/life-science/branschfakta-life-science
www.movetogothenburg.com
Do you want to be a part of our journey?
Profile and qualifications:
· PhD/Postdoc in Biophysics
· Documented experience with microscopy-based method
· Documented experience conducting biophysical experiment with proteins
· Experience in image and data analysis
· Programming experience in one of the languages Matlab/Python/GNU Octave/R
· Solid understanding of receptor-ligand binding kinetics
· Curiosity to learn and develop new methods in a multidisciplinary team
· Knowledge of drug development are advantageous Visa mindre

Job description
Quality Assurance Advisor

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

The arena
Are you interested in a challenging opportunity within the Development Quality function in one of the world’s leading pharmaceutical companies?

The Development Quality function is responsible for quality oversight of the pharmaceutical development activities in AstraZeneca. We are now looking for 3 Quality Advisors with GMP focus to our Gothenburg team. AstraZeneca’s pharmaceutical development organizations manage all facets of the process of turning a molecule into a medicine which can be safely and effectively used by patients. The Quality Advisor role has a broad range of responsibilities to ensure all internal and external requirements are fulfilled for the AstraZeneca projects in the development phase.

Responsibilities
The role
As a Quality Advisor, you will work with early product development manufacturing and packaging teams and be responsible for Development Quality release of internally or externally manufactured Drug Product and Investigational Medicinal Product for clinical trials. You are expected to assure that activities and processes across the development chain are delivered to appropriate standards to meet regulatory expectations and assure product integrity and acceptability.

You will develop and maintain a knowledge of the quality regulations and guidelines applicable to your area and a deep scientific understanding of the products that you are supporting. In your role you will have interactions with internal and external stakeholders.

Typical Accountabilities:
Responsible for quality Release of manufactured Drug Product, Investigational Medicinal Product for clinical trials
Providing quality input to Manufacturing, Packaging, Labelling & Distribution activities
Providing proactive quality advice to support the development, implementation and continuous improvement of GMP quality systems across the Clinical Supply functions and support implementation of agreed global standards
Support the pharmaceutical development functions with investigations of deviations, changes and other quality and compliance decisions in the development projects
Providing quality advice and approval of documentation related to equipments, facilities, IT systems and instruments e.g. maintenance, calibration, validation and change control
Provide appropriate Quality Assurance input to business improvement projects
Operate as part of a global organisation with an integrated mindset to create an organisation with common processes and ways of working.


Qualifications
Minimum requirements – Education and Experience
MSc in pharmacy or engineering (specializing in Pharmaceuticals) with at least 3 years’ experience of working within a pharmaceutical GMP environment
Broad understanding of Quality Systems and GMP and related activities to Investigational Medicinal Product (IMP)
Comprehensive understanding of the pharmaceutical/drug development process
Good communicator with experience of interacting effectively across interfaces
Understanding of Project Management processes
Fluent in written and spoken English

Preferred requirements
Experience preferably within a pharmaceutical manufacturing organization
Good team working and networking skills
Capable of making effective decisions
Demonstrate drive and energy in the role to make a difference
Demonstrate a high degree of personal credibility


Application
Deadline: 2022-02-02 , selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information:
Please contact Birgitta Nyström [email protected] or Jimmy Wadie [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many activities.

Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre

Job description
Global Labelling Delivery Manager – Packaging & Artworks, 1 year contract

Do you have regulatory experience and knowledge within labeling combined with excellent communicating and negotiating skills? Would you like to apply your expertise in a global company where we work together across boundaries to make the impossible a reality? Then come and join us in the Global Labeling Group!

The Global Labeling Group (GLG) at AstraZeneca is part of the Global Regulatory Affairs organisation and focuses on both the preparation and maintenance of labeling documents for prescribing information, patient information and regulatory information on packages for Health Authority approval, as well as creating and updating packaging components for our medicines. We are covering products for the EU and US markets.

We are now looking for a passionate colleague to join our team on a 12 month contract as a Global Labeling Delivery Manager. The role can be based at AstraZeneca’s dynamic R&D site in Gothenburg.

Responsibilities
The Global Labeling Delivery Manager is responsible for the regulatory role towards creation of the printed material for products under development, updating of existing artworks for already marketed products, liaising with Marketing Companies in Europe as well as packaging sites within production.

What you’ll do
Ensure all work is performed in accordance with established procedures, regulatory requirements and GxPs.
Ensure proper version control and document integrity of packaging component labeling, printed labeling artworks and other assigned labeling documents via proofreading.
Assist in responding to labeling-related queries from various functional areas
Assist Global Labeling team in resolution of labeling issues as needed
Coordinates the development and lifetime maintenance of packaging component labeling for commercial products.
Point of contact for the management of all labeling/artwork requests that require market/regulatory approval in US and EU centralised procedure, such as the creation, approval, and implementation of commercial printed labeling in collaboration with various functions.


Qualifications
Essential for the role
University Degree in Science or related discipline
Relevant pharmaceutical experience, including regulatory experience, preferably working with labeling
Knowledge of labeling regulations and guidance
Multi-cultural awareness and sensitivity; demonstrated experience effectively communicating and negotiating in diverse cultures

Desirable for the role
Experience in packaging labeling development and/or maintenance.


Application
Deadline: 2022-02-02 , selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information:
Please contact Kerstin Karlsson [email protected] or Veronika Knudsen [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many activities.

Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre

Job description
Couple droplet drying kinetics to CFD simulation of spray dryer
Spray drying, Computational fluid dynamics, transport phenomena

Are you currently pursuing a master’s degree with a burning interest in pharmaceutical development and computation fluid dynamics? Then this master’s thesis project at AstraZeneca might be of interest to you!

The thesis is aimed for: Master's students
Program area:   Chemistry/modelling
Student Location: AstraZeneca Gothenburg, Sweden
Start: January 2022 to June 2022, or as agreed with the student

A focus for AstraZeneca Gothenburg is to develop inhaled drugs for the treatment of respiratory diseases such as asthma. A critical domain in this work is to produce active pharmaceutical ingredients (API) particles with appropriate properties e.g. size and morphology, where spray drying is one of efficient formulation platforms. To this end, enabling the quantitative prediction of spray drying process will provide us an efficient tool to optimize and accelerate the development process.

Responsibilities
This project aims to coupling drying kinetics to CFD simulation to enable the predict of particle properties e.g. morphology for various spray dryers across scales.

Responsibilities include building and improving CFD simulations on OpenFOAM based on existing CFD works on ANSYS Fluent. Coupling droplet drying kinetics models based on heat and mass transfer to CFD simulation to resolve particle formation at individual particle level will be a critical part of the work.

Validating the simulations with available experimental data will also be included.

The work is to be conducted from January to June 2022, or as agreed with the student.

Qualifications
Essential Requirements
Experience computational fluid dynamics
Solid understanding in transport phenomena and mathematical modelling
Experience in computer programming e.g. C++, python
Pursuing a master’s degree in a relevant engineering discipline
Excellent problem solving skills  

Desirable Requirements
Experience in working in the labs


Application
 Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only handle applications sent through Randstad’s website.

All chosen candidates need to pass a background check and an alcohol and drug test before starting the project.

Deadline for application: 2021-12-15

For more information: Veronika Knudsen [email protected] or Kerstin Karlsson [email protected] 

About the company
 AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity. Visa mindre

Job description
Characterisation of nozzles for Spray Drying of Inhaled medicines
Spray drying, particle size measurement, atomisation

Are you currently pursuing a master’s degree with a burning interest in pharmaceutical development and pharma industry? Then this master’s thesis project at AstraZeneca might be of interest to you!

The thesis is aimed for: Master's students
Program area:  Chemistry/modelling
Student Location: AstraZeneca Gothenburg, Sweden
Start: January 2022 to June 2022, or as agreed with the student

A focus for AstraZeneca Gothenburg is to develop inhaled drugs for the treatment of respiratory diseases such as asthma. A critical domain in this work is to produce active pharmaceutical ingredients (API) particles with appropriate properties e.g. size and morphology, where spray drying is one of efficient formulation platforms. To this end, understanding the relationship between material properties, processing conditions, and product characteristics of spray drying process is an essential component.

Responsibilities
This project aims to characterize the droplet distribution and correlate their characteristics to spray dried particles.

Responsibilities include using advanced particle sizing techniques, e.g. laser diffraction, to measure the size distribution of droplets produced by different atomization nozzles at different conditions e.g. air-to-liquid ratios. This will be accompanied by characterising spray dried powder properties using e.g. scanning electron microscope, in order to build the relationship between material properties, processing conditions and product characteristics. 

If it is of interest, student will also have the option to perform CFD simulations of the atomization process and validate the simulations with experimental data

The work is to be conducted from January to June 2022, or as agreed with the student.

Qualifications
Essential Requirements
Experience in working in the labs
Solid understanding in transport phenomena 
Pursuing a master’s degree in a relevant engineering discipline
Excellent problem solving skills  

 
Desirable Requirements
Understanding of particle sizing, particle image velocimetry
Experience programming e.g. Python, Matlab
Experience in CFD


Application
Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only handle applications sent through Randstad’s website.

All chosen candidates need to pass a background check and an alcohol and drug test before starting the project.

Deadline for application: 2021-12-15

For more information: Veronika Knudsen [email protected] or Kerstin Karlsson [email protected]

About the company
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity. Visa mindre

Job description
Investigation and optimization of mixed-mode chromatography for the analysis of pharmaceutical analytes dissolved in neat or high content of organic solvent

Thesis project: 30 credits (VT22)
Student location: AstraZeneca, Gothenburg, Sweden
Start: January 2022
Supervisors: Ass. Prof. Morgan Stefansson [email protected], Senior Scientist Anna Granfors [email protected]

Background
At AstraZeneca a robot allowing automatic sample preparation has been developed and is also hyphenated to a chromatographic separation system for analysis. Methanol is used as dissolving medium creating a mismatch to the generally employed reversed phase systems. After initial tests, using a combination of fundamentally different retention mechanisms of the separation column, results showed great potential for its use. The separation column is packed with particles enabling hydrophobic as well as ion exchange interactions, usually called mixed-mode, and by a proper choice of chromatographic conditions the sample incompatibility can be overcome.

Project plan
The objective of this thesis plan is to investigate chromatographic parameters available, e.g.
Mobile phase composition and gradient elution settings (ionic strength, composition, pH, slope etc.)
Type of separation medium
Separation selectivity and analyte detectability, including injection volume
Robustness
Analysis time for high sample throughput

After screening of these and other parameters, an optimization aiming for a general procedure and fitting the automatic sample preparation system would be a great step forward. Finally, an application of a drug product would prove the case.

Responsibilities
The project plan is roughly divided into:
Installation, introduction and LC basic literature studies 
Screening of chromatographic parameters + relevant literature 
Optimization and application
Compilation of thesis and eventual complements 
Presentation in person or digital at AstraZeneca, Mölndal


Qualifications
Requirements:
M. Sc. student in chemistry or related fields
Prior knowledge in analytical chemistry and separation science is desirable


Application
Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only handle applications sent through Randstad’s website.

All chosen candidates need to pass a background check and an alcohol and drug test before starting the project.

Deadline for application: 2021-10-03

For more information: Veronika Knudsen [email protected] or Kerstin Karlsson [email protected]

About the company
At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of  coffee or a stroll on our “walk and talk” meeting trail. AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. Visa mindre

Job description
Thesis work at AstraZeneca Gothenburg


Are you a master’s student looking for thesis work with start spring 2022? Are you interested in the pharmaceutical industry? 

Responsibilities
AstraZeneca offers 30 and 60 credit thesis work within different areas of the company.  They are looking for motivated master students passionate about science and willing to learn a broad range of new techniques.



Qualifications


Currently enrolled as a student within a technical, scientific, IT or other relevant field
A strong interest in pharmaceuticals or the pharmaceutical industry
Open and comprehensive scientific mindset.
Written and oral communication skills in English
Ability to work collaboratively across boundaries and problem solve in the absence of complete information.


Application
Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only handle applications sent through Randstad’s website.


This is a general advertisement for thesis work at AstraZeneca Gothenburg. Specific advertisements for the thesis projects will be published during September-October. Are you interested in doing your thesis work at AstraZeneca, we recommend that you apply here already today!

All chosen candidates need to pass a background check and an alcohol and drug test before starting the project.


Deadline for application: 2021-10-31

For more information: Veronika Knudsen [email protected] or Kerstin Karlsson [email protected]



About the company
 About AstraZeneca
At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners.


Our way of life is to foster a working environment that nurtures collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our "walk and talk" meeting trail. Visa mindre

Job description
Application of amorphous classification system and glass forming ability in pre-formulation design of small organic molecules

Do you want to study about the importance of solid state in preformulation of drug candidate molecules in the company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be of interest to you!

Program area: Chemistry and Physics
Student Location: AstraZeneca Gothenburg, Sweden
Start: Autumn 2021 (flexible start)
Supervisor: Dr. Okky Putra and Dr. Phil Corner (Solid state senior scientists, Early Product Development and Manufacture, Pharmaceutical Sciences) and  Prof. Lars Öhstrom (Department of Chemistry and Chemical Engineering, Chalmers Tekniska Högskola)

Opportunity
We have an exciting opportunity for a Master’s student to determine amorphous classification system and glass forming ability of small organic molecules in relation to their developability in pre-formulation research. This opportunity can be expanded to include building a database and applying it to simulation and machine learning that is used for pre-formulation research.


Background
Determination of amorphous classification system and glass forming ability of small organic molecules: Amorphous classification system and glass forming ability are important parameters in pre-formulation of the drug molecules and also in informing alternative solid forms for development, i.e. co-amorphous systems. However, there is no systematic database for these parameters. The aim of this research project is to determine the value of these parameters accurately in a systematic manner for small organic molecules that are typically used in pharmaceutical development. This database can be further used for machine learning and simulation in pre-formulation research.



Responsibilities
Task and methodology
Thermal analysis including DSC (Differential Scanning Calorimetry) and TGA (Thermo Gravimetric Analysis) measurements
Database building


Qualifications
Basic understanding of solid state chemistry and its related techniques


Application
Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only handle applications sent through Randstad’s website.

All chosen candidates need to pass a background check and an alcohol and drug test before starting the project.

Deadline for application: 2021-09-12

For more information: Kerstin Karlsson [email protected] or Veronika Knudsen [email protected].



About the company
At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.


Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of  coffee or a stroll on our “walk and talk” meeting trail. AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. Visa mindre

Clinical Supply Study Lead for 1-year consulting assignment

Hays Life Science is now recruiting a Clinical Supply Study Lead for a 1-year consulting assignment at AstraZeneca in Gothenburg. If you find this role interesting please submit your CV in English asap, deadline is July 8th.

The assignment
Can you envision using your supply chain knowledge to lead clinical supplies for global clinical studies? Would you like to apply your expertise to impact the development of medicines to patients? Then AstraZeneca is the place for you!

We have exciting opportunities for two hardworking Clinical Supply Study Leads (CSSL) to join our team in Gothenburg, Sweden. This is a key role within our Clinical Manufacturing and Supply teams and involves running a portfolio of studies across all phases of a drug development programme ensuring on time delivery to patients.

In Pharmaceutical Technology and Development (PT&D), we are the bridge which turns forward-thinking science into actual medicines that help millions of people around the world. We work across the entire value chain, crafting and delivering active ingredients, formulations and devices required to support new medicines - from supplies for use in early toxicology studies and clinical trials, to developing the technology to ensure drugs can be scaled up for commercial manufacture.

Role description
As a Clinical Supply Study Lead, you will project manage the delivery of clinical supplies effectively and consistently, and input to the balance of costs and any risks to supply. You will also lead the Study Drug Working Group and contribute to the Supply Chain Team Meetings, enabling continuous cross-functional dialogue with both internal and external partners on study design requirements and associated changes.

We will rely on you to:
* Monitor the budget for your individual study supply activities and materials for the project, including packaging, labelling and distribution costs
* Work within GMP Quality Management Systems, ensuring that you actively handle any deviations, complaints and change controls
* Manage the Interactive Response Technology (IRT) system, to execute demand and supply planning
* Take ownership for inventory management, including any rework and recalls, extensions of shelf life and expiry date management, or stock destruction
* Ensure effective communication with project teams and key partners across a global network
* Support risk management of individual studies with proactive mitigation of risks that potentially impact the quality or delivery of supplies

Essential for the role
We believe that you have a Bachelor's Degree in a scientific or business subject area, alternatively equivalent experience. This is complemented by experience from a supply chain environment or pharmaceutical industry.Collaboration is key in this role, and you have great interpersonal skills. You have a track record of driving successful collaborations across locations and specialist fields.

You also possess:
* A holistic knowledge of end to end supply chain activities
* Proven experience of demand planning and forecasting
* Solid experience in running projects and in?uencing customer demands
* Track record of previous risk identification and management
* Proficient IT skills with an ability to adapt and operate in bespoke multiple systems

We truly believe that everyone contributes with a unique set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you maximise your skills, abilities and contribution.

Desirable for the role
* Awareness of GMP (Good Manufacturing Practice) and GCP (Good Clinical Practice)
* Knowledge of clinical development processes relevant to the supply of clinical materials
* Knowledge and understanding of Lean
* Experienced in handling Quality Events (Deviations, Change Controls, Complaints) Visa mindre

Job description
We have an open temporary consulting position for a Scientist/Senior Scientist in Packaging Development, based within Inhalation Product Development, at AstraZeneca in Gothenburg. This role will support across the entire Pharmaceutical Technology & Development portfolio covering inhaled as well as oral products. The preferred starting date is August 2021 or earlier and will have a duration until end of September 2022.

You will contribute to our projects from Phase 1 to the transfer to Commercial Manufacture by delivering of our packaging projects in a diverse, multi-skilled department including interactions with our packing partners in Commercial Operations.

Responsibilities
Manage packaging support to pharmaceutical development projects, applying specialist knowledge and expertise to achieve project targets in a timely fashion and to agreed quality standards
Leading cross-functional packaging coordination networks
Employ your understanding of packaging regulations and ensure that work is performed in accordance with appropriate safety (SHE), quality and compliance standards, e.g. GMP
Assess and report data with a clear understanding of its reliability; interpret finding and draw authoritative conclusions and recommendations so that their significance can be appreciated
Generate and review regulatory submission documents, plans, protocols and reports ensuring that the project objectives are met
To work with colleagues across AstraZeneca and partner organisations to ensure suitable scientific input and influence decision making


Qualifications
Has an expert understanding of the principles and concepts in relation to pharmaceutical packaging
Knowledgeable about packaging materials (e.g. polymers) and their barrier properties
Demonstrated ability to lead packaging aspects of pharmaceutical product development
Experience of preparing regulatory documentation
Experience working with internal and external partners including CMOs, vendors and academia
Ability to assess, review and report data from own work, with a clear understanding of its reliability. Interpret findings and draw authoritative conclusions and recommendations so that their significance can be appreciated.
Work as a member of multi-functional teams, with a large degree of independence representing own department or area of expertise.
Experience working with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Manufacturing Practice (GMP)


Personal Skills and Capabilities:
Good team working skills
Effective communication skills
Work collaboratively across boundaries

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2021-05-18, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Eleonor Ehrman +46733434109 or Birgitta Nyström [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre

Job description
We are curious, creative, and open to new ideas and ways of working. Above all, we are passionate about science and driven to always put patients first. Join AstraZeneca and apply your expertise in a company that are following the science and turn ideas into life changing medicines. We have an exciting opportunity for a talented Scientist to be based in Gothenburg, Sweden for a consulting assignment.

Drug Product Delivery (DPD) within Pharmaceutical Technology & Development is the sole internal AstraZeneca department that packs, labels and distributes investigational medicinal products to clinical trial patients. We support launched, pre-launched and products under development within all our therapeutic areas. We work in a fast paced environment where flexibility and agility enable us to deliver high value to early phase clinical trials.

Responsibilities
The Scientist role will be a flexible role within Drug Product Deliveries three operational skill areas. Material Management, Pack Label and Distribution. We work in a environment where flexibility and agility enable us to deliver high value to early phase clinical trials. To complement our existing team, candidates with the following experiences is of interest:


Logistic experience from a complex supply chain organisation
Knowledge / expertise in working with automated/semi-automated equipment in an operational environment
Drug Product Knowledge including management of Item/article and lot/batch management to ensure traceability on items/articles in a patient kit including a drug product, packaging material and patient labels from the pharmaceutical industry

Main Duties and Responsibilities
The role holder will contribute to the DPD organization applying their expertise in the complex and regulated GMP environment. The work is focused on being a flexible operational scientist within at least two skills. As a scientist you will Perform and document all the operational work according to written procedures and GMPs with manual and/or automated systems/equipment. Be engaged in the development and improvement of internal processes and manage deviations. Be responsible for writing of GMP and SHE procedures within own skill areas and will be responsible for related training and compliance activities. As required maintain defined facilities or equipment according to GMP standards and be proactive to contribute to projects/activities through applying specialist knowledge within appropriate areas.

Qualifications
BSc/MSc in chemistry/pharmacy/engineering or equivalent experience. Preferably 5 years’ experience within pharmaceutical development
Great understanding of principles, applications and management of SHE and GMP in an R&D environment
Understanding the disciplines in Drug Product Delivery, Supply Chain and Pharmaceutical development in order to contribute to an effective Supply Chain organization
Demonstrated ability to work with teams in a culturally diverse, complex and changing environment most internally but to some extent externally
Curious and innovative mindset with problem solving ability - resolve issues with minimal guidance
Good written and verbal English communication and understanding


Application
2021-04-22 selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Linnea Öster [email protected]

About the company
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Randstad Life Sciences is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre

Job description
Do you enjoy applying statistics and mathematics to biological problems? Would you like to help develop life changing medicines? Then AstraZeneca might be of interest to you!

A Bayesian analysis workflow for pre-clinical experiments
Thesis work: 30 credits

At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

Responsibilities
As an MSc student in the Quantitative Biology group in Gothenburg, you will be part of a large team of statisticians and bioinformaticians and will have the opportunity to collaborate with colleagues across sites in Sweden, the UK and the USA. You will improve both your programming and statistical skills to tackle challenges in our drug development pipeline. The focus will be on developing a flexible workflow to detect trends and anomalies amongst studies, and to explore and evaluate the effect of different prior distributions on the Bayes factor. We aim to reduce the number of animals used in future experiments.

Background
Sample size calculations are carried out before conducting an experiment to determine the minimum sample size required to detect an effect of a given size with a certain level of confidence. Determining an effect size can be challenging at times. The Bayesian approach uses prior knowledge on the distribution of the effect as opposed to a single value in the frequentist setting. Other than the effect size, the distribution of the data in different groups in a study can be deduced from previous similar studies. Thus the prior knowledge of each treatment group including the vehicle group will be used to inform future studies.  This enables us to evaluate the uncertainty of the parameters. 

After the experiment has been conducted, biologists are often interested to determine if a new compound lead to an improvement compared to existing drugs. The use of the p-values to reject or fail to reject a null hypothesis is common. As an alternative the Bayes factor (Kass and Raftery, 1995) is used to measure the weight of the evidence of one hypothesis, say, alternative, over the null hypothesis. Thus, rather than reject or fail to reject a null hypothesis, the Bayes factor provides weight of the evidence as given by data. Interpretation of Bayes factor is also provided in literature see Jeffreys (1961) and Raftery (1995).

Qualifications
Essential Requirements
• Competence in mathematics
• Basic programming (R, Stan, python or similar) and statistical skills
• Enjoy working as part of a team at AstraZeneca’s site in Gothenburg

Desirable Requirements
• A basic understanding of biology would be a great asset

Application
Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only accept applications through Randstad’s website.

Deadline for application: 2020-04-26, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Kerstin Karlsson [email protected] or Eleonor Ehrman +4673-343 41 09.

About the company
Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our “walk and talk” meeting trail.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised Visa mindre

Job description
Do you enjoy applying statistics and mathematics to biological problems? Would you like to help develop life changing medicines? Then AstraZeneca might be of interest to you!

Guiding experimental design and statistical evaluation for optimal use of animals in pre-clinical research
Thesis work: 30 credits

At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

Responsibilities
As an MSc student in the Quantitative Biology group in Gothenburg, you will be part of a large team of statisticians and bioinformaticians and will have the opportunity to collaborate with colleagues across sites in Sweden, the UK and the USA. You will improve both your programming and statistical skills to tackle challenges in our drug development pipeline.

The goals of this thesis are 1/ to provide an overview of existing techniques combining efficacy and dose-response endpoints; 2/ to design an experiment with joint efficacy and dose-response endpoints as a demonstrator; 3/ to propose a standard workflow for future use (e.g. an R package). This thesis will lead to a poster and potentially a publication.

Background
The “3Rs” (Replacement, Reduction and Refinement) is a framework for conducting more humane animal research. Continuously optimizing the use of animals through advancements in study design and analysis constitutes a key pillar within this framework. AstraZeneca uses “Good Statistical Practice” (GSP) rules and guidelines to ensure adherence to the 3Rs.

In drug discovery, the goal is to demonstrate the efficacy and safety of candidate drugs before moving into man in clinical studies. As such, pre-clinical experiments in animal models are generally conducted to address the pivotal questions “Is the drug demonstrating a significant effect?” as well as “If so, what is the drug´s potency?”. The former question is typically answered using statistical approaches such as pairwise comparison to a control, whereas the latter is addressed by quantitative pharmacokinetic-pharmacodynamic modelling on basis of an assumption about the underlying drug concentration-response relation. Regularly, however, an optimal design for either of these endpoints might be sub-optimal for the other (e.g. number of drug dose levels vs number of animals in each group), which can necessitate follow-up studies with additional use of animals.

In accordance with the 3Rs principles, there is considerable interest in combining efficacy and dose-response endpoints through an optimally balanced study design. Bayesian models are well suited to this and in addition, there is the possibility to use the results in a formal Bayesian decision making process.

Qualifications
Essential Requirements
• Interest in applying statistical and mathematical modelling
• Some familiarity with R, python, MATLAB or similar is required
• Enjoy working as part of a team at AstraZeneca’s site in Gothenburg

Desirable Requirements
• Basic knowledge of biology/physiology

Application
Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only accept applications through Randstad’s website.

Deadline for application: 2020-04-26, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Kerstin Karlsson [email protected] or Eleonor Ehrman +4673-343 41 09.

About the company
Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our “walk and talk” meeting trail.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. Visa mindre

Job description
Do you enjoy applying statistics and mathematics to biological problems? Would you like to help develop life changing medicines? Then AstraZeneca might be of interest to you!

Tackling missing data in high throughput protein expression experiments
Thesis work: 30 credits 

At AstraZeneca, we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

Responsibilities
As an MSc student in the Quantitative Biology group in Gothenburg, you will be part of a large team of statisticians and bioinformaticians and will have the opportunity to collaborate with colleagues across sites in Sweden, the UK and the USA. You will improve both your programming and statistical skills to tackle challenges in our drug development pipeline. Working alongside the team you will contribute to our work on proteomics with the goal of assessing suitability of therapeutic candidates for further experimental follow-up.  You will improve both your programming and statistical skills to tackle challenges in our drug development pipeline.

Background
Proteomics data generated from mass spectrometry (MS) experiments are very complex and deep data. These experiments are usually carried out in relatively few samples compared to other omics experiments. Processing the data is extremely complex and there is no standard way to quality control or analyse the data. There are often missing values and there is large variation within and between experimental batches. This affects how the data may be analysed. Analysis usually takes the form of comparing relative protein abundance between two experimental conditions. Missing data and variance may bias this comparison if not properly controlled for.

Two classes of missingness include: ‘missing at random’ i.e. due to the way the peptides are selected for MS protein quantification; and another is ‘below detection level’. In our experiments it is especially important to understand whether compound treatment resulted in successful degradation of the target protein.  It is also necessary to determine if there are any off-target effects which may indicate toxicity. 

We can harness the data from untreated cells to understand which proteins are ‘usually’ expressed in a specific cell line. ‘Usually’ should include housekeeping genes which are ubiquitously expressed and others which follow temporal or cell type specific expression patterns. We can derive an underlying probability distribution/matrix for the presence or absence of an individual protein or for clusters of proteins (that may share the same regulatory factors). Thus, we should be able to better inform our prediction of types of missingness based on protein identity or cluster identity. We should also be able to impute missing values and derive a probability score for that imputed value based on prior knowledge.

Variation within and between batches of the same experiment is a challenge when normalizing and quality checking the data with the ultimate aim of combining all the data into a single analysis.  Differences due to the inherent variation of the experimental system may lead to spurious associations with treatment. There are many methods which have been derived to analyse RNA expression data which takes the experimental variation into account.  It is unclear whether the assumptions of these analytical methods are satisfied by the data generated by MS protein quantification experiments. There may be an opportunity to build on existing methods or to develop a new method.

Qualifications
Essential Requirements
• Competence in mathematics
• Basic programming and statistical skills
• Enjoy working as part of a team at AstraZeneca’s site in Gothenburg

Desirable Requirements
• A basic understanding of biology would be a great asset

Application
Randstad Life Sciences is cooperating with AstraZeneca in this recruitment process. We only accept applications through Randstad’s website.

Deadline for application: 2020-04-26, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

For more information: Kerstin Karlsson [email protected] or Eleonor Ehrman +4673-343 41 09.

About the company
Our Gothenburg site is one of AstraZeneca's three strategic science centers. We thrive in a multinational environment working cross-functionally across the globe with AstraZeneca colleagues as well as academic and industry partners. Our way of life is to foster a working environment that nurtures, collaboration, openness and innovation. Therefore, we have created space for meetings, socializing and relaxation, where spontaneous meetings can give birth to new innovations. The unexpected ideas or thoughts that can come from a chat over something as simple as a cup of coffee or a stroll on our “walk and talk” meeting trail. 

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised. Visa mindre

Job description
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But they're more than one of the world's leading pharmaceutical companies. At AstraZeneca, they are proud to have a phenomenal workplace culture that encourages innovation and collaboration. There, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

For a consultant position, Randstad Life Sciences is now looking for a motivated individual to take on the role as Drug Metabolism and Pharmacokinetic (DMPK) Design Leader (DDL) for 12 months. Alternatively, it is an opportunity for a highly talented indivudal with less specific experience to assist an experienced DDL whilst training for the role. The DDL role is a strategic and scientific role where you will work closely with Medicinal Chemistry, Bioscience and representatives from other functions in drug discovery. You will influence chemical drug design by optimizing the ADMET (absorption, distribution, metabolism, excretion, toxicity) for compounds within projects. In addition to oral drugs, the task is also to optimize inhalation properties for projects aiming for this route of administration.

The successful applicant will contribute to RIA drug design teams by providing DMPK expertise and input to the design of new compounds. This includes analysis of ADMET and efficacy data and to develop a strategy for how to improve these and subsequently influence project progression.

You are expected to have understanding of DMPK and chemistry to be able to provide advice and interpretation of complex drug discovery data.

Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Responsibilities
Lead DMPK-related activities and the optimisation of compounds by balancing the properties associated with absorption, distribution, clearance, elimination and lung targeting to ensure that DMPK challenges are thoroughly assessed and resolved
Deliver DMPK input and data to projects within agreed timelines and to the right quality
Accountable together with Medicinal Chemistry, Bioscience and Safety, for compound design and effective cross-discipline optimization and Design-Make-Test-Analysis (DMTA) cycles in drug discovery
Apply an understanding of DMPK and physicochemical properties to support/influence compound design, project progression and project strategy
Responsible for leading, coordinating and engaging with RIA DMPK colleagues in project related activities
Prepare clear presentations related to the above for internal governance bodies


Qualifications
Formal training or proven experience of working with pharmacokinetics and drug metabolism.
PhD or equivalent experience in a relevant discipline (Medicinal, Organic or Physical Chemistry or bio-pharmaceutics/pharmacokinetics)
Understanding of correlations between physicochemical characteristics and their influence on DMPK properties and subsequent design of new compounds.
Experience from drug discovery cross-functional work and compound/project progression is desirable
Ability to engage and collaborate across boundaries with a problem solving attitude and focus on delivery

For us at Randstad, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2020-01-14, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: please contact Eleonor Ehrman, Consultant Manager [email protected] .

About the company
With more than 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry and offers staffing, consulting and recruitment solutions in all areas of expertise. We also offer interim management, executive search and outplacement services. We have a large network of clients and candidates, which means that we convey hundreds of jobs within different industries all over Sweden. Our ambition is to be the best employer in the market. 

By combining our passion for people with the power of today’s technology, we help people and organizations to reach their true potential. We call it Human Forward. Visa mindre

Job description
AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

The arena
AstraZeneca now has the opportunity for 2-3 consultants to join their team in the role as Formulation Scientist/Product Developer within the department Global Product Development at AstraZeneca in Gothenburg. The assignment is for 12 months.

Responsibilities
The role
We are looking for a formulation scientist who can work together with the team at AstraZeneca generating and evaluating pharmaceutical technologies and formulations (advanced drug delivery). The work includes development, characterization and documentation, in order to develop drug products. 


The tasks include planning and implementation of experiments with the aim of generating new formulations and optimizing processes in lab and pilot scale. We are looking for both people with and without previous experience in the area.

Qualifications
Minimum requirements 
MSc or PhD in chemistry, pharmacy, chemical engineering, food technology or equivalent. Good knowledge in written and spoken Swedish and/or English is necessary as well as laboratory experience including working with computerized systems. If you have experience from working within the pharmaceutical industry, this will be an advantage. 


As a person, you should be well organized, analytical, flexible and accurate. Good team working skills are also important, together with the ability to operate independently.  Good communication skills linked to the ability to work to tight timelines are highly valued. 
Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.


For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2019-11-18, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information: Eleonor Ehrman, consultant manager, +4673-343 41 09 or Kerstin Karlsson, consultant manager, [email protected].



About the company
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus! Visa mindre

Job description
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But they're more than one of the world's leading pharmaceutical companies. At AstraZeneca, they are proud to have a phenomenal workplace culture that encourages innovation and collaboration. The employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity. 
 
For a consultant position, we at Randstad Life Sciences are looking for a motivated and mathematically inclinded individual to take on take on the role as Drug Metabolism and Pharmacokinetics (DMPK) Modelling and Simulation (M&S) Scientist for 12 months. As a DMPK M&S scientist you will be providing project teams with directions for applying computational biology and mathematical modelling approaches to predict efficacious dosage in human populations. This is done by evaluation of pharmacokinetic/pharmacodynamic (PKPD) relationships in the context of mainly respiratory disease through integration of biological data from various sources. You will work closely with the biologist and collegues in the DMPK department in drug discovery and development projects. You are expected to have a skill in mathematical modelling and an understanding of biology. In addition, you are expected to independently gather the information that you need for your work and have the aspiration and ability to quickly learn new scientific aspects of DMPK.

Randstad Life Sciences is specialized in competences within Life Science. As a consultant with us, you get a competitive salary, benefits and collective agreements. Your consultant manager is always there for you and ensures that you get varying and developing assignments at different companies, within different industries. At Randstad Life Sciences, your personal development is in focus, and you are offered a large network and many social activities.

Responsibilities
The overall responsibility is to develop and execute translational PKPD strategies in drug projects from the point of target selection up to Phase 2 clinical trials. This means setting up mechanistic PKPD models that accommodate, to an appropriate level, established knowledge and working hypothesis of the target and disease biology. These will be  progressively developed and refined to include definitions of the extent of drug target engagement that is anticipated to be required to see efficacy in Phase 2 trials, hence underpinning the human dose prediction. In achieving this goal you are likely to encounter and develop the following elements.
Develop and apply physiologically-based pharmacokinetic models for various inhaled drug modalities.
Collaborate with drug project biologists to articulate the drug project hypothesis by means of constructing a mathematical model. Use this model to evaluate hypothesis around target/disease biology with particular focus on defining quantitative relationships between drug exposure, target engagement and downstream biomarker changes.
Develop and apply physiologically-based pharmacokinetic models for various inhaled drug modalities.
Proactively, leverage and integrate public and proprietary clinical and non-clinical data from various sources, and suggest experiments that can provide key missing elements for the PKPD models.
Make predictions of therapeutic dosing regimens in human by suggesting the anticipated human dose, dosing interval or timing in relation to disease progression or key events.
Conduct bespoke PK data analysis including prediction of drug-drug interactions and whole body physiologically based PK (PBPK) modelling. Prepare clear presentations related to the above for internal governance bodies.


Qualifications
Ph.D. or equivalent in Engineering, Mathematics, Physics or a related field, preferably with pharmaceutical industry experience.
Knowledge and experience of physiologically-based pharmacokinetic/pharmacodynamic modelling.
Expert in computer science and skilled in modelling tools such as R, Matlab etc.
Aspiration to learn new scientific domains beyond mathematics and computer science to have ability to operate as DMPK generalist.
Ability to engage and collaborate across boundaries with a problem solving attitude and focus on delivery.

For us, it is important that all competence and skills in the labor market are utilized. We welcome all applicants and strive for diversity.

Application
2020-01-14, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.


For more information,  please contact Eleonor Ehrman, Consultant Manager, [email protected].



About the company
With more than 600 000 employees in 38 countries, Randstad is the global leader in the HR services industry and offers staffing, consulting and recruitment solutions in all areas of expertise. We also offer interim management, executive search and outplacement services. We have a large network of clients and candidates, which means that we convey hundreds of jobs within different industries all over Sweden. Our ambition is to be the best employer in the market. 

By combining our passion for people with the power of today’s technology, we help people and organizations to reach their true potential. We call it Human Forward. Visa mindre